Type receptors vitronectin. Medical search. Frequent questions

Using fluorescent activated cell sorter and immunoprecipitation analyses, we established that the vitronectin receptor integrins alphavbeta5 and alpha8beta1, but not alphavbeta3, are expressed on neonatal rat astrocytes. (nih.gov)
Our data demonstrate that unstimulated primary neonatal rat astrocytes attach to vitronectin, utilizing integrins alphavbeta5 and alpha8beta1, and that this attachment is regulated by PAI-1. (nih.gov)
Integrins are transmembrane receptors that help cell-cell and cell-extracellular matrix (ECM) adhesion. (wikipedia.org)
Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. (wikipedia.org)
Several types of integrins exist, and one cell generally has multiple different types on its surface. (wikipedia.org)
Integrins are found in all animals while integrin-like receptors are found in plant cells. (wikipedia.org)
Ligands for integrins include fibronectin, vitronectin, collagen and laminin. (wikipedia.org)
We provide a complete integrin binding peptide array to help researchers to quickly identify the types of integrins on the cell surface. (biomaterialsusa.com)
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)

Human CD41 is a member of a major platelet transmembrane glycoprotein complex (CD41/CD61) which mediates platelet aggregation and adhesion by serving as the receptor for fibrinogen and von Willebrand factor, fibronectin and vitronectin. (ancell.com)

The CD51/CD61 complex mediates adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin. (thermofisher.com)
The platelet integrin GP IIb-IIIa (also referred to as α IIb-β) is a calcium-dependent heterodimer complex that can bind fibronectin, fibrinogen, vWF, and vitronectin. (medscape.com)

Based on all the results, the increased resistance to trypsinization of C2C12, LF, HaCaT, and VSMC cells on amine PPs can be explained most probably by a non-specific cell adhesion such as electrostatic interaction between the cells and amine groups on the material surface, rather than by the receptor-mediated adhesion through serum-derived proteins adsorbed on the PPs. (nature.com)
Osteoclasts (OCs) and other cells of the mononuclear phagocyte system possess receptors for adhesive proteins present in the extracellular matrix. (ox.ac.uk)
CD23 belongs to the C\type (calcium\dependent) lectin\like (CTLD) superfamily of proteins and is a trimer in its membrane\bound form. (treatmentforprostatecancer.info)
HTR6 is a serotonin receptor whose activity is mediated by G proteins that stimulate adenylate cyclase. (abic2004.org)
First, we characterized the cell surface receptors for matrix proteins on stem cells and identified specific proteins that will support adhesion and growth of the cells. (ca.gov)
Based on our characterization of cell surface receptors for matrix proteins on stem cells completed in the first year, we went on to test specific, purified proteins that will support adhesion and growth of the cells. (ca.gov)
Our approach is to first understand how hESC interact with extracellular matrix materials by analyzing candidate adhesive substrate proteins and integrin receptors that mediate attachment, survival, proliferation and differentiation. (ca.gov)

Both OCs and FBGCs expressed the alpha-chains of the vitronectin receptor (CD51) and of the VLA-2 (CDw49b) and VLA-4 (CDw49d) molecules as well as their respective beta-chains, gpIIIa (CD61) and CD29. (ox.ac.uk)
CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)

There are several subtypes of melanocortin receptors, each having a distinct ligand specificity profile and tissue localization. (lookformedical.com)
HGF was able to support monocyte-osteoclast differentiation in the presence of receptor activator for nuclear factor kappaB ligand as evidenced by the formation of numerous multinucleated tartrate-resistant acid phosphatase and vitronectin receptor positive cells which formed F-actin rings and were capable of lacunar resorption. (ox.ac.uk)

Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

E5555 is a potent protease-activated receptor (PAR-1) antagonist targeting the G-coupled receptor and modulating thrombin-platelet-endothelial interactions. (uea.ac.uk)
PECAM-I, GP IIb/IIIa antigen, and activity with PAC-1, GPIb, thrombospondin, vitronectin receptor expression, and formation of platelet-monocyte aggregates were also significantly reduced by E5555. (uea.ac.uk)
Selective blockade of platelet receptors suggests unique antiplatelet properties of E5555 as a potential addition to current antithrombotic regimens. (uea.ac.uk)
Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells. (ox.ac.uk)
Mutations in the ITGB3 gene can also cause another rare bleeding disorder called platelet-type bleeding disorder 16. (medlineplus.gov)
Approximately 80,000 GP IIb-IIIa receptors are present on the surface of each platelet. (medscape.com)

Kapinsky M, Torzewski M, Büchler C, Duong CQ, Rothe G, Schmitz G: Enzymatically degraded LDL preferentially binds to CD14(high) CD16(+) monocytes and induces foam cell formation mediated only in part by the class B scavenger-receptor CD36. (exbio.cz)

Alessio M, Roggero S, Bussolino F, Saitta M, Malavasi F: Characterization of the murine monoclonal antibody NL07 specific for the human thrombospondin receptor (CD36 molecule). (exbio.cz)

LM and FN interact more efficiently with collagen type I than with collagen IV or elastin 90% of the available Coll I in the decellularized lung matrix forms a complex with LM. (biolamina.com)
Expression profiling revealed a set of genes that were significantly upregulated in all cell populations, including growth factors (insulin-like growth factor 1 and hepatocyte growth factor), extracellular matrix components (collagen type V and vitronectin) and proteases (matrix metalloproteinase 1 and members of the plasmin-based proteolytic cascade, e.g. (reviewofoptometry.com)

It is also involved in the anchoring of osteoclasts to the mineral of bone matrix via the vitronectin receptor, which has specificity for osteopontin. (crispr-reagents.com)

CD61, also known as integrin ß3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. (biolegend.com)

IgEs conversation Ginsenoside Rg3 with CD23 modulates both IgE production and functional activities.CD23 is a noncanonical immunoglobulin receptor, unrelated to receptors of other antibody isotypes. (treatmentforprostatecancer.info)

Mouse monoclonal to CD64.CT101 reacts with high affinity receptor for IgG (FcyRI), a 75 kDa type 1 trasmembrane glycoprotein. (researchatlanta.org)

Attachment of the neonatal astrocytes to vitronectin was inhibited (85%) in an additive manner by neutralizing anti-alphavbeta5 and anti-beta1 antibodies. (nih.gov)

Although various studies have assessed OPN protein levels in several tumor types, a broad survey of OPN expression in human neoplasia under the same experimental conditions has not been carried out. (aacrjournals.org)
the latter are ligands for several of the above matrix protein receptors. (ox.ac.uk)
The ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. (medlineplus.gov)
Impedance-based biosensors allowed ESR4 to show that only the glycosylated host protein vitronectin binds YadA (Meuskens et al. (europa.eu)
ESR11 studied the complex between the human adenovirus type 5 penton base capsid protein and its integrin receptor by cryo-electron microscopy, leading to a preliminary structure of the interaction of the complex, as well as a 4 Å structure of the penton base. (europa.eu)
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
Immunoglobulin E (IgE) is usually a glycosylated protein belonging to the immunoglobulin family and plays Ginsenoside Rg3 a central role in allergic disease, exerting its effector functions through two receptors: FcRI and CD23 [2]. (treatmentforprostatecancer.info)
CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. (exbio.cz)
After Metacore network evaluation of the 21 protein, eight appear inside the same network, keratins regulated by estrogen receptors primarily. (abic2004.org)

Vitronectin is an abundantglycoprotein found in serum and the extracellular matrix and promotes celladhesion and spreading, inhibits the membrane-damaging effect of the terminalcytolytic complement pathway, and binds to several serpin serine protease inhibitors. (creativebiomart.net)

Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)

IL-6 stimulates vitronectin gene expression in vivo. (mcmaster.ca)
Abnormalities in either gene or in the assembly of the complex result in an abnormal or deficient receptor and, consequently, in disease. (medscape.com)

A key component of the ICM niche are the extracellular vesicles (EVs), produced by distinct cell types, that carry and transfer key molecules that regulate target cells and modulate cell renewal or cell fate. (bvsalud.org)

Compared with untreated controls, insulin treatment (5IU to 20IU) significantly upregulated mRNA expression levels of its receptors, insulin receptor and insulin-like growth factor 1 receptor, as well as genes involved in cell migration. (reviewofoptometry.com)

Native humanmonomeric Vitronectin prepared from fresh human plasma using nondenaturingchromatography. (creativebiomart.net)
Human CD23 is usually a calcium\dependent (C\type) lectin\like domain name that has apparently lost its carbohydrate\binding capability. (treatmentforprostatecancer.info)
The calcium\binding site classically required for carbohydrate binding in C\type lectins is usually absent in human CD23 but is present in the murine molecule. (treatmentforprostatecancer.info)
We found that the HGF receptor, c-Met, is expressed by the CD14(+) monocyte fraction of human peripheral blood mononuclear cells (PBMC). (ox.ac.uk)

The strong correlation between pathological stage and OPN across multiple tumor types suggests a role for OPN in tumor progression. (aacrjournals.org)

This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)

Nuclear receptor coregulator SMRT/SMRTER. (wfleabase.org)

Attachment to vitronectin was also inhibited in a dose-dependent manner by the type I plasminogen activator inhibitor (PAI-1), a serine protease inhibitor. (nih.gov)
Type 1 plasminogen activator inhibitor is not an acute phase reactant in rats. (mcmaster.ca)

CD155, known as poliovirus receptor (PVR) or nectin-like 5, is a 70 kD type I transmembrane glycoprotein. (biolegend.com)

In addition, we examined whether these substrates will support differentiation of retinal pigmented epithelial cells, an important, clinically relevant cell type that is currently in clinical trials for eye disease. (ca.gov)
This surface proved to be efficient at supporting growth of undifferentiated hESC as well as differentiation of useful cell types. (ca.gov)

The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. (assaygenie.com)

In this study, we identified the integrin receptors that mediate attachment of primary neonatal rat astrocytes to vitronectin. (nih.gov)
The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. (nature.com)

mESCs lack major integrin receptors for collagens but express high levels of functional receptors for LM and FN. (biolamina.com)

For example, GzB expression in urothelial carcinoma was implicated in promoting tumour cell invasion, whereas its expression in nasal-type NK/T lymphomas was found to correlate with increased apoptosis. (biomedcentral.com)

Of these, just 3 are previously identified receptors: one has been verified by pull-down experiments. (europa.eu)

Further, binding companions could be cell-type-specific, adding to the complexity of the neurofibromin interactome. (abic2004.org)

Furthermore x3 cells type tridimensional colonies with differential morphologies when cultivated in matrigel. (crispr-reagents.com)
Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by β 3 integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization. (rupress.org)

Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor and is ranked the eighth leading cause of cancer worldwide. (nature.com)
The id of somatic mutations in that wide spectral range of tumors, including types not really connected with NF1, signifies that neurofibromin will probably play an integral role in tumor beyond what's apparent in the tumor predisposition symptoms NF1. (abic2004.org)

Hepatocyte growth factor (HGF) and M-CSF signal through tyrosine kinase receptors and phosphorylate common transducers and effectors such as Src, Grb2, and PI3-Kinase. (ox.ac.uk)

Anatomy6

Organisms1

Diseases1

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes16

Information Science3

Integrins11

Fibronectin and vitronectin1

Fibrinogen2

Proteins7

CD512

Ligand2

Adhesion1

Platelet6

Scavenger receptor1

Thrombospondin1

Collagen2

Osteoclasts1

IIIa1

Antibody1

Monoclonal1

Antibodies1

Protein9

Binds1

Ligands3

Gene2

Molecules1

Insulin1

Human4

Progression1

Upregulation1

Nuclear1

Plasminogen activator2

Glycoprotein1

Differentiation2

Subunits1

Attachment2

Functional1

Found1

Previously1

Cell Type1

Cells2

Tumor2

Factor1