METHODS: Normal-risk allogeneic (C57BL/6 to BALB/c) and syngeneic (BALB/c to BALB/c) corneal transplantations were performed and occurrence and time course of hem- and lymphangiogenesis after keratoplasty was observed, by using double immunofluorescence of corneal flatmounts (with CD31 as a panendothelial and LYVE-1 as a lymphatic vascular endothelium-specific marker). (ox.ac.uk)
No immunosuppressed isogeneic (ISO) and allogeneic (ALO) rats mixture offered as control. (pkc-inhibitor.com)
This study focused on the comparison of autologous and allogeneic immune response to iPSC-derived cells and isogeneic parental somatic cells used for reprogramming. (biomedcentral.com)
PURPOSE: To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve long-term graft survival. (ox.ac.uk)
Inhibition of hem- and lymphangiogenesis (afferent and efferent arm of an immune response) after normal-risk corneal transplantation improves long-term graft survival, establishing early postoperative hem- and lymphangiogenesis as novel risk factors for graft rejection even in low-risk eyes. (ox.ac.uk)
In sufferers after transplantation of arterial allografts without immunosuppression we are able to look for a higher occurrence of graft related problem as graft ruptures, graft aneurysm thrombosis or development [2]. (pkc-inhibitor.com)
Genetically identical1
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains. (lookformedical.com)
Modulation of the NO pathway during short or prolonged blood reperfusion following ischaemia in a heterotopic rat heart transplantation model. (ox.ac.uk)
Experiments were performed using a modified Lewis to Lewis heterotopic abdominal heart transplantation with a total ischemic time of 3 hours followed by 1 or 24 hours of blood reperfusion (n = 12). (ox.ac.uk)
Grafts1
There are two types of skin grafts: The more common type involves removing a thin layer of skin from a healthy part of the body (the donor section). (wikipedia.org)
Mice1
Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes. (uc.edu)
Donor3
RESULTS: No blood or lymph vessels were detectable immediately after normal-risk transplantation in either donor or host cornea, but hem- and lymphangiogenesis were clearly visible at day 3 after transplantation. (ox.ac.uk)
Both vessel types reached donor tissue at 1 week after allografting and similarly after syngeneic grafting. (ox.ac.uk)
The induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) both have the potential to differentiate into all cell types in the body, and this gives great hope for solving the problem of the shortage of donor organs [ 5 ]. (biomedcentral.com)
Abdominal2
Methods: For hypoglossal-facial anastomosis (HFA) over a Y-tube (HFA-Y-tube) the proximal stump of the hypoglossal nerve was entubulated and sutured into the long arm … of a Y-tube (isogeneic abdominal aorta with its bifurcation). (iospress.com)
Bottom line Both immunosuppressed protocols with tacrolimus (administration from time 1 or from time 7 pursuing transplantation) could actually suppress severe cell- and antibody-mediated rejection of cryopreserved abdominal aortic allografts prepared relative to our brand-new standardized scientific protocol. (pkc-inhibitor.com)
Alternatively there's a good long-term patency rates no aneurysmal development in sufferers after simultaneous body organ and arterial order PKI-587 transplantation with triple immunosuppression postoperatively [10,11,12]. (pkc-inhibitor.com)
This interdisciplinary journal publishes papers relating the plasticity and response of the nervous system to accidental or experimental injuries and their interventions, transplantation, neurodegenerative disorders and experimental strategies to improve regeneration or functional recovery and rehabilitation. (iospress.com)
Recipient1
Aortal wall structure infiltration by immunocompetent cells (MHC II+ cells of recipient origins) was analyzed on time 30 after transplantation. (pkc-inhibitor.com)
Skin1
We observed that iPS-fibro elicited a high level of NK-cell degranulation and cytotoxicity, while isogeneic parental skin fibroblasts used to obtain iPSCs barely triggered an NK-cell response. (biomedcentral.com)
Time1
The long time required to obtain a new iPSCs line, as well as to differentiate it into the desired cell type, is also worthy of emphasis [ 8 ]. (biomedcentral.com)
Model1
We established an isogeneic cell model consisting of parental dermal fibroblasts, fibroblast-like iPSC-derivatives (iPS-fibro) and iPS-fibro lacking beta-2-microglobulin (B2M). (biomedcentral.com)
Week1
Furthermore, we confirmed a chance of delaying the administration of low-dose tacrolimus after an arterial transplantation for a week without any detrimental impact on both types of rejection [14]. (pkc-inhibitor.com)
Cell types1
Ischemia-reperfusion models of both cell types showed upregulated pro-inflammatory and downregulated cell metabolism pathways. (bvsalud.org)