Type of drug targets. Medical search. Frequent questions

Some of the key companies in the epilepsy pipeline drugs market are Praxis Precision Medicines Inc, EpyGenix Therapeutics Inc, Neurocrine Biosciences Inc, Bio-Pharm Solutions Co Ltd, Q-State Biosciences Inc, Taysha Gene Therapies Inc, UCB SA, Jazz Pharmaceuticals Plc, SK Biopharmaceuticals Co Ltd, and AfaSci Inc. (globaldata.com)
The validation of newer approaches based on microRNA targeting and gene therapy strategies, as well as the discovery of novel pathophysiological mechanisms and targets through genetic technology, may lead to the development of additional novel AF therapies. (nature.com)
In melanoma, the most common BRAF mutation is called V600E (may also be V600K/R/M/D/G). Patients with a BRAF V600 mutation may benefit from the addition of targeted therapies known as BRAF inhibitors. (facingourrisk.org)
Some targeted therapies can cause specific side effects to the skin, hair, and nails. (cancer.net)
The following are some of the types of targeted therapies that may affect the skin. (cancer.net)
First, a gene signature is validated to accuratelyidentify the pathways that are activated in a particular tumor sample in orderto match those to the mechanism of specific drug therapies. (drugdiscoverynews.com)
New drugs that specifically target the mutated genes responsible for cancer growth have shown great success in extending the lives of patients, with far fewer side effects than conventional anti-cancer therapies. (uclahealth.org)
In a study published March 29 in the journal Science Signaling, the team demonstrates their use of network-scale proteomic experiments and mathematical analyses to build a "system-wide" view of how signaling mutations cause leukemia and to identify points of susceptibility that can be targeted by "cocktail" therapies to prevent drug resistance. (uclahealth.org)
Understanding this complex network of events is critical to designing new molecularly targeted anti-cancer therapies to simultaneously target the primary mutation while preventing the development of secondary, resistance-conferring mutations, and we now have additional tools to do this. (uclahealth.org)
The future of molecular therapies, researchers say, relies on targeting multiple events simultaneously, making it exponentially more difficult for tumor cells to develop the mutations required to escape the effect of drug therapy. (uclahealth.org)
This is somewhat analogous to anti-HIV drug cocktail therapies that target the inhibition of multiple viral-replication steps. (uclahealth.org)
There is some overlap between these two types of cancer treatments since some targeted therapies work through the immune system. (dignityhealth.org)
For targeted therapies to work, you must have the cancer gene mutation or protein that needs to be targeted. (dignityhealth.org)
Therapies for treating glioblastoma brain cancer can be delivered with greater precision and existing drugs can be used in new ways. (news-medical.net)

September 15, 2023 - Vaccine targets six flu strains. (nih.gov)
July 27, 2023 - Trial results show that engineered T cells can effectively target mesothelin, a protein found on many solid tumors. (nih.gov)
June 27, 2023 - The investigational drug vorasidenib substantially slowed the growth of tumors in people with low-grade gliomas that had mutations in the IDH1 or IDH2 genes. (nih.gov)
June 1, 2023 - ComboMATCH will comprise numerous phase 2 precision medicine cancer treatment trials that aim to identify promising drug combinations that can advance to larger clinical trials. (nih.gov)
May 15, 2023 - NIH-funded clinical trial will determine safety, tolerability of experimental drug. (nih.gov)

December 28, 2022 - A clinical trial led by NCI has resulted in FDA approval of the immunotherapy drug atezolizumab (Tecentriq) to treat advanced alveolar soft part sarcoma. (nih.gov)
Targeted therapy and immunotherapy are specific types of cancer medications. (cancer.net)
This information explains changes to the skin, included related changes to hair, nails, and eyes, that can happen during treatment with targeted therapy or immunotherapy. (cancer.net)
Immunotherapy is a type of biological therapy that helps your body fight cancer by stimulating the immune system or helping it identify "hidden" cancer cells. (dignityhealth.org)
If targeted therapy or immunotherapy is not an option for your type and stage of cancer, ask your doctor if you are a candidate for a clinical trial at Dignity Health. (dignityhealth.org)
St. Joseph's Cancer Institute offers advanced care through immunotherapy and targeted therapy in Stockton and the surrounding areas. (dignityhealth.org)

The researchers showed that three genes are associated with uric acid levels in the fruit fly model, and these potentially could be pursued as new targets for drug development. (sciencedaily.com)
To further validate the results pathway study was performed to identify the involvement of the coding genes in type II diabetes. (researchgate.net)
The genes obtained from this study showed a significant involvement in causing the disease, which may be used as a potential drug target. (researchgate.net)
Targeted therapy is a treatment that targets the specific genes, proteins, or the tissue environment that contributes to cancer growth and development. (cancer.net)
Targeted therapy uses drugs that target genes and proteins associated with cancer to stop the progression of the disease. (dignityhealth.org)
Ultrasonic drug and gene delivery from nanocarriers have tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly noninvasive means [ 7 ]. (hindawi.com)

The U.S. Food and Drug Administration today granted accelerated approval to Rozlytrek (entrectinib), a treatment for adult and adolescent patients whose cancers have the specific genetic defect, NTRK (neurotrophic tyrosine receptor kinase) gene fusion and for whom there are no effective treatments. (fda.gov)
However, we detected histone H3 methylation and acetylation in the leptin receptor gene, Lepr, following treatment with both drugs. (nih.gov)
Read about cancer treatment options listed by gene mutation, type of cancer and type of treatment. (facingourrisk.org)
These cancer cells typically have gene changes that allow for treatment with targeted drug therapy, so it has a better outlook. (medicalnewstoday.com)
This type of cancer treatment may be a good option if you have certain breast , colon , and lung cancers , as well as melanomas that contain the BRAF gene mutation. (dignityhealth.org)
The U-M-developed drug targets the labels that come from the activity of a gene called MLL1. (sciencedaily.com)
With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)
As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. (hindawi.com)
These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers. (hindawi.com)
Strategies have been advised that nanoparticles can be used to deliver drug/gene to targeted tissues [ 4 ]. (hindawi.com)
Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
Therefore, the development of novel visible ultrasonic responsive nanosized drug/gene carriers is necessary. (hindawi.com)
Furthermore, as targeted delivery carriers, gene/drug-loaded nanocarriers can release their associated payload upon insonation. (hindawi.com)

We're seeing continued advances in the use of biomarkers to guide drug development and the more targeted delivery of medicine," said FDA Acting Commissioner Ned Sharpless, M.D. "Using the FDA's expedited review pathways, including breakthrough therapy designation and accelerated approval process, we're supporting this innovation in precision oncology drug development and the evolution of more targeted and effective treatments for cancer patients. (fda.gov)
These findings may provide prognostic biomarkers and robust targets for drug development, according to a panel of proteogenomics experts. (genomeweb.com)
Evaluation of the suitability of 19 pharmacogenomics biomarkers for individualized metformin therapy for type 2 diabetes patients. (cdc.gov)

Its drug release characteristics perform well in photothermal therapy, indicating that black phosphorus nano drugs can improve the biological safety and applicability of drugs in new tumor targeted therapy. (frontiersin.org)
In recent years, tumor-targeted therapy has been appearing as a promising therapeutic choice for cancer treatment. (hindawi.com)

In recent years, substantial efforts have been invested in developing treatments that target the underlying mechanisms of AF, and several new compounds are under development. (nature.com)
In recent years, substantial efforts have been invested in developing novel treatments that target the underlying molecular determinants of atrial fibrillation, and several new compounds are under development. (nature.com)
Newswise - BUFFALO, N.Y. - While breakthrough treatments have emerged for several cancers over the last two decades, driving striking improvements in survival and other clinical outcomes, too little is known about the risk of therapy-related hematologic cancers following targeted and immunotherapeutic approaches. (newswise.com)
Increasing developments to novel treatments requires a controlled microenvironment that is accomplished only through the implementation of therapeutic agents whose side-effects can be avoided with targeted drug delivery. (wikipedia.org)
A new fruit fly model that mimics diseases associated with high uric acid levels, such as gout and kidney stones, has revealed new targets for developing treatments for these diseases. (sciencedaily.com)
Alarmingly, more than 20 percent of the United States population has elevated uric acid levels, and existing drug treatments frequently have adverse side effects, contraindications or interactions with other drugs. (sciencedaily.com)
While many children survive leukemia, the most common type of pediatric cancer, the treatments are harsh and outdated. (lls.org)
These treatments target specific genetic characteristics of the tumor cells. (msdmanuals.com)

SP - 54 EP - 68 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 17 IS - 1 N2 - OBJECTIVE AND BACKGROUND: Inhibition of acetylcholinesterase (AChE) has gained much importance since the discovery of the involvement of peripheral anionic site as an allosteric regulator of AChE. (unboundmedicine.com)

This treatment targets specific genetic changes found in types of stomach adenocarcinoma and may help slow cancer growth. (medicalnewstoday.com)
Digital lifestyle treatment improves long-term metabolic control in type 2 diabetes with different effects in pathophysiological and genetic subgroups. (cdc.gov)
Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes. (cdc.gov)

June 27, 2020 Progression of kidney disease in type 1 diabetes is correlated with increased amounts of uric acid. (sciencedaily.com)

Tinea Pedis (Athlete Foot) (Infectious Disease) - Drugs in Development, 2021 Summary Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Tinea Pedis (Athlete Foot) Drugs In Development, 2021. (reportsnreports.com)

Traditionally, clinical development of new cancer drugs in pediatric populations is not started until development is well underway in adults, and often not until after approval of an adult indication," said Richard Pazdur, M.D., director of the FDA's Oncology Center of Excellence and acting director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research. (fda.gov)
In this Review, we discuss the mechanistic rationale for the development of new anti-AF drugs, the molecular and structural motifs that they target, and the results obtained in experimental and clinical studies. (nature.com)
This report evaluates G-protein-coupled receptor family C group 5 member D (GPRC5D) from an industry perspective for its suitability as a tumor-specific target for cancer therapy based on its expression profile and preclinical and clinical safety and efficacy data of the various drug modalities employed for discovery and development of GPRC5D-targeted therapy candidates. (bharatbook.com)
A drug that reduces uric acid levels was tested in a multi-institution randomized clinical trial. (sciencedaily.com)
Biovitrum have firmly established this enzyme to be a target for the treatment of metabolic diseases and now have a candidate enzyme inhibitor in clinical development. (pharmiweb.com)
A detailed analysis of more than 1,700 terminated / withdrawn / suspended clinical studies of the drug candidates. (ipsnews.net)
A practice-changing study, NRG Oncology clinical trial NRG-RTOG 9802, has demonstrated, for the first time, a survival benefit of adjuvant chemotherapy following radiotherapy over radiotherapy alone in certain subgroups of patients with high-risk, low-grade glioma (WHO classification: LGG, grade II), a type of brain tumor that originates from glial cells. (news-medical.net)
Clinical Spectrum of LMNA-Associated Type 2 Familial Partial Lipodystrophy: A Systematic Review. (cdc.gov)
New clinical screening strategy to distinguish HNF1A variant-induced diabetes from young early-onset type 2 diabetes in a Chinese population. (cdc.gov)

The FDA has approved targeted therapy drugs for the treatment of some people with the following types of cancer. (cancer.gov)
Some targeted therapy drugs are listed more than once because they have been approved to treat more than one type of cancer. (cancer.gov)
List of Targeted Therapy Drugs Approved for Specific Types of Cancer was originally published by the National Cancer Institute. (cancer.gov)
We hypothesized that increased immune surveillance after treatment with these drugs could halt clonal evolution and reduce risk of therapy-related hematologic cancers - specifically, myelodysplastic syndrome or acute myeloid leukemia," says Dr. Thota, Assistant Professor of Oncology in the Department of Medicine. (newswise.com)
Experimental analysis was also conducted on the characterization ability, drug release, and targeted therapy of nanomedicine. (frontiersin.org)
Targeted therapy uses targeted drugs to maintain a high concentration of the drug in the tumor area, improving the killing efficiency of cancer cells while avoiding damage to other normal cells. (frontiersin.org)
Doctors may not treat GISTs immediately, but surgery and targeted therapy are the main options if they do. (medicalnewstoday.com)
What is targeted therapy? (cancer.net)
If your doctor prescribes a targeted therapy, ask what side effects to expect and how they will be treated. (cancer.net)
This common type of targeted therapy focuses on a molecule known as epidermal growth factor receptor (EGFR). (cancer.net)
Another type of targeted therapy that may cause skin problems includes drugs that block a protein called vascular endothelial growth factor (VEGF). (cancer.net)
Below is a list of common targeted therapy drugs that can cause skin related problems. (cancer.net)
TORONTO-Targeted toward developing a more personalized-andmore effective -therapy for cancer patients, Canadian company Axela and Irvine,Calif.-based OvaGene Oncology have agreed to a molecular diagnosticspartnership aimed at developing and marketing a test to discover the bestweapon to kill ovarian cancer, one of the deadliest forms of cancer. (drugdiscoverynews.com)
The type of cancer, its stage, and the type of therapy will determine where and how you will receive the treatment. (dignityhealth.org)
Your recovery plan after cancer therapy will depend on the type of therapy, dose, your side effects, and your overall health. (dignityhealth.org)
Morphine is the primary drug used to manage severe and chronic pain, with 3 to 4 percent of adults in the U.S. receiving long-term opioid therapy. (technologynetworks.com)
They can pass through blood capillary walls and cell membrane walls to deliver drugs [ 8 ], thereby reducing the side effect and enhancing the curative effect of cancer therapy [ 9 ]. (hindawi.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), Pompe disease, and recently Batten disease (neuronal ceroid lipofuscinoses, CLN2). (medscape.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), and Pompe disease. (medscape.com)

This is the third time the agency has approved a cancer treatment based on a common biomarker across different types of tumors rather than the location in the body where the tumor originated. (fda.gov)
There are several different types, including adenocarcinoma, squamous cell carcinoma, and gastrointestinal stromal tumors (GISTs). (medicalnewstoday.com)
These types of tumors are uncommon . (medicalnewstoday.com)
A Ludwig Cancer Research study has dissected how radiotherapy alters the behavior of immune cells known as macrophages found in glioblastoma (GBM) tumors and shown how these cells might be reprogrammed with an existing drug to suppress the invariable recurrence of the aggressive brain cancer. (news-medical.net)

Figure 7: Ion channel bioprocessing and trafficking as potential targets for drug development. (nature.com)
It is now very necessary to identify the new potential targets for the drugs which not only control the disease but also can treat it. (researchgate.net)
new potential targets for the drugs which not only contro l the disease bu t also can treat it. (researchgate.net)

The targets of the epilepsy pipeline drugs market are Gamma-Aminobutyric Acid Type A Receptor Subunit (GABA, Voltage Gated Sodium Channel, Cannabinoid Receptor 2, Cannabinoid Receptor 1, Potassium Voltage Gated Channel Subfamily KQT Member 2, Potassium Voltage Gated Channel Subfamily KQT Member 3, Sodium Channel Protein Type 8 Subunit Alpha, Sodium Channel Protein Type 1 Subunit Alpha, 5-Hydroxytryptamine Receptor, and Serine/Threonine Protein Kinase mTOR. (globaldata.com)
The key targets in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1, Tyrosine Protein Kinase JAK2, Tyrosine Protein Kinase BTK, Interleukin 2 Receptor, Programmed Cell Death Protein 1, Alpha 1 Antitrypsin, Cells Expressing B Lymphocyte Antigen CD20, Interleukin 2 Receptor Subunit Beta, Macrophage Colony Stimulating Factor 1 Receptor, and Tyrosine Protein Kinase ITK/TSK among others. (globaldata.com)
The key mechanisms of action in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1 Inhibitor, Tyrosine Protein Kinase JAK2 Inhibitor, Tyrosine Protein Kinase BTK Inhibitor, Interleukin 2 Receptor Agonist, Alpha 1 Antitrypsin Replacement, Cytotoxic To Cells Expressing B Lymphocyte Antigen CD20 , Interleukin 2 Receptor Subunit Beta Antagonist, Programmed Cell Death Protein 1 Agonist, Tyrosine Protein Kinase ITK/TSK Inhibitor, and CD40 Ligand Inhibitor among others. (globaldata.com)
GPRC5D is a type C seven-pass transmembrane protein. (bharatbook.com)
These are protein-based drugs that target certain molecules on the surface of cancer cells to destroy them. (dignityhealth.org)
Our crystal structures of this novel type of protease are providing information on how the rhomboid protease acts to cleave protein targets in the membrane. (ualberta.ca)
The drug specifically targets markers on histones, the protein "spools" that DNA coils around to create structures called chromatin. (sciencedaily.com)
Currently, the only antiviral drug available targets influenza M2 protein ion channel is not completely effective. (cdc.gov)
To provide a basis for developing novel ion channel-blocking compounds, we investigated the properties of influenza D virus M2 protein (DM2) as a drug target. (cdc.gov)
An example of a fusion protein is the drug etanercept , which fuses a cytokine receptor with an antibody. (msdmanuals.com)

After that, γ-Fe 2 O 3 -NPs were coated with PEG and combined with DOX to form nanocarriers (NC) for drug delivery. (rsc.org)
Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. (hindawi.com)
Besides, nanocarriers decorated with targeting moiety can adhere to targeted tissues, which can promote intracellular uptake of drug delivery vehicles. (hindawi.com)
Although the system of ultrasound-mediated drug delivery with nanocarriers has many advantages, there are still many challenges. (hindawi.com)

The team applied these approaches in the study of leukemias driven by the Bcr-Abl mutation, a mutation that has been successfully targeted by the well-known drug Gleevec. (uclahealth.org)

Type II diabetes is a chronic condition that affects the way our body metabolizes sugar. (researchgate.net)
type II diabetes. (researchgate.net)
Obesity and comorbid type 2 diabetes are two frequent and growing global problems. (pharmiweb.com)
Rhomboid function has been linked to breast cancer, and type 2 diabetes. (ualberta.ca)
To treat diabetes directly, rather than manage its symptoms, doctors need a way to get drugs to cells that produce insulin. (stanford.edu)
Loci for insulin processing and secretion provide insight into type 2 diabetes risk. (cdc.gov)
Prediction of type 2 diabetes using genome-wide polygenic risk score and metabolic profiles: A machine learning analysis of population-based 10-year prospective cohort study. (cdc.gov)
Understanding the Pathogenesis, Therapeutic Targets/Drug Action and Pharmacogenetics of Type 2 Diabetes: Is there a Future for Personalised Medicine? (cdc.gov)

Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of the medication in the remaining tissues. (wikipedia.org)
But there's a major obstacle: The growth triggered by the drug is willy-nilly, affecting tissues not just in the pancreas but throughout the body. (stanford.edu)

Here we study the use of three novel cucurbit[n]uril (CB[n])-type compounds synthesized by Dr. Lyle Isaacs. (umd.edu)
The CB-type compounds significantly increased the solubility of a large variety of drugs across therapeutic fields. (umd.edu)
This coupled with host toxicity and drug bioactivity data indicate that these CB[n]-type compounds may be invaluable contributions to the toolbox of excipients and DDSs currently available. (umd.edu)
Graduate students, from left, Long Luu and Lien Nguyen, with U. of I. chemistry professor Steven Zimmerman, developed drug compounds that target three pathways associated with myotonic dystrophy type 1. (illinois.edu)
In the context of the United States' National Institutes countries of Health Roadmap for medical research, an initiative through public-private has been created to develop molecular libraries in order collaboration to facilitate the identification of drug targets and screening of compounds, to focus on structural biology, and to promote the development of bioinformatics, computational biology and nanomedicine. (who.int)
Fusion proteins are compounds that are produced in the laboratory and combine or "fuse" two different proteins with desirable immune-modifying and disease-fighting traits to form a single drug. (msdmanuals.com)

Current standard treatment for all of these cancer types relies on drugs that stimulate the immune system - tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs), in the case of NSCLC, RCC and melanoma, and immunomodulatory imide drugs (IMiDs), in the case of multiple myeloma. (newswise.com)
Some of them target specific immune system cells to help them fight cancer cells, while others release a toxic substance into the targeted cancer cells, which kills them. (dignityhealth.org)
These target the signals between the cells of the immune system involved in pain and swelling, known as inflammation. (mayoclinic.org)

We remain committed to encouraging the advancement of more targeted innovations in oncology treatment and across disease types based on our growing understanding of the underlying biology of diseases. (fda.gov)
This nanocarrier will be developed in the future with various drug carrier systems for targeted nuclear treatment of cancer and other related diseases. (rsc.org)
Programme Outcomes will include (1) fundamental knowledge of viral/human interactions, (2) potential therapeutic target sites and therapeutic agents for the specific viruses under study, (3) the development of novel therapeutic agents relevant to human non-communicable diseases and (4) the development of a viral-based delivery system for prophylactic or therapeutic use in a range human diseases. (hrc.govt.nz)
This fruit fly model could be used to investigate their role further and could help identify new drugs for the numerous diseases linked to uric acid accumulation. (sciencedaily.com)
She stated that this approach of using genetically anchored evidence to integrate different studies and different data types has delivered across the board of complex diseases, from cancer to infectious diseases such as COVID-19. (genomeweb.com)
Several agencies including WHO, and various public- assessment of identified private partnerships, have identified gaps in translational gaps research for Type II and Type III diseases as well as the need to establish a publicly accessible compound library for these diseases. (who.int)
WHO, through the Special Programme, is analysing the feasibility of a public chemical library for Type III diseases. (who.int)

We've rationally designed something to target multiple pathways, which is contrary to the traditional thinking in medicinal chemistry, where you have one target, one drug," said University of Illinois chemistry professor Steven Zimmerman , who led the research with graduate students Lien Nguyen and Long Luu. (illinois.edu)

Several chemoinformatics approaches were used in this study, reporting four multi-target inhibitors: MCULE-7149246649-0-1, MCULE-6730554226-0-4, MCULE-1176268617-0-6 and MCULE-8592892575-0-1 with high binding energies that indicate better AChE inhibitory activity. (unboundmedicine.com)
This edition of 'Emerging Drug Discovery Targets' features a potent histone deacetylase inhibitor from Norvartis for the treatment of cancer, two new approaches to metabolic disorders and VEGFR-1 as a target for rheumatoid arthritis. (pharmiweb.com)
A detailed analysis on the cost saving potential of drug repurposing approaches, as compared to the traditional de novo drug development methods. (ipsnews.net)
These new approaches for sorting out the complexities of cancer cells involve building a wiring diagram of the interconnections or "crosstalk" in cancer cells that will help scientists overcome drug resistances. (uclahealth.org)

This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. (wikipedia.org)
The development of bioinformatics technology has enabled nanomedicine to play a significant role in drug delivery systems. (frontiersin.org)
Therefore, based on the characteristics of black phosphorus two-dimensional nanomedicine, experimental designs were conducted on its nanosheet preparation, polyethylene glycol modification, and anti-tumor drug loading. (frontiersin.org)

The U.S. Food and Drug Administration has awarded Rare Pediatric Disease Designation (RPDD) for diffuse intrinsic pontine glioma (DIPG) and Orphan Drug Designation for treatment of malignant glioma to OKN-007, an investigational drug discovered at the Oklahoma Medical Research Foundation and being developed by Oblato, Inc. (news-medical.net)

In preclinical models, we found that a synthetic molecule called TETi76 was able to target and kill the mutant cancer cells both in the early phases of disease--what we call clonal hematopoiesis of indeterminate potential, or CHIP--and in fully developed TET2 mutant myeloid leukemia. (news-medical.net)
When implementing a targeted release system, the following design criteria for the system must be taken into account: the drug properties, side-effects of the drugs, the route taken for the delivery of the drug, the targeted site, and the disease. (wikipedia.org)
Morquio syndrome (mucopolysaccharidosis type IV [MPS IV]) is a rare lysosomal storage disease (LSD) that is inherited in an autosomal-recessive fashion. (medscape.com)
Our research centers around studying membrane proteins involved in disease, using X-ray crystallography and other biophysical techniques, to reveal structural, functional and mechanistic details of membrane proteins that could one day aid in the development of new drugs and vaccines targeted towards membrane proteins. (ualberta.ca)
Disease-modifying antirheumatic drugs (DMARDs). (mayoclinic.org)
Today, CQ-resistant falciparum malaria is set criteria for the selection of patients, the being reported from all countries in which administration of a standard treatment regi- the disease is endemic except for few foci men of the appropriate drug, and daily par- in central America north of the Panama Ca- asitological blood examination for the nal, Haiti and the Dominican Republic [ 5 ]. (who.int)
and, the State Unintentional Drug Overdose Reporting System (SUDORS) with funding support from the Centers for Disease Control and Prevention (CDC). (cdc.gov)

The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. (wikipedia.org)

Although evidence exists regarding the distribuition of AnxAs in the visual system, their exact roles and the exact cell types of the eye where these proteins are expressed are not wellunderstood. (drugdiscoverytoday.com)
Membrane proteins are key targets for the drug development. (ualberta.ca)

This chapter discusses the hallmarks of liver fluke related CCA and explores insights into drug target possibilities. (bvsalud.org)

The Switzerland-based startup is also developing multiomics visualization and interpretation software to support drug discovery and biomarker ID. (genomeweb.com)

There are two kinds of targeted drug delivery: active targeted drug delivery, such as some antibody medications, and passive targeted drug delivery, such as the enhanced permeability and retention effect (EPR-effect). (wikipedia.org)

People are slowly discovering that drugs that hit multiple targets are actually better. (illinois.edu)

Several types (classes) of immunotherapeutic drugs have been developed. (msdmanuals.com)

There are some similarities and differences in side effects between these types of cancer medications compared to chemotherapy drugs. (cancer.net)

The approval marks a new paradigm in the development of cancer drugs that are "tissue agnostic. (fda.gov)
There is a significant decrease in the productivity of the drug development pipeline due to low drug solubility and high toxicity. (umd.edu)
The Epilepsy Drugs in Development market research report provides an overview of the Epilepsy pipeline landscape. (globaldata.com)
The report provides comprehensive information on the therapeutics under development for Epilepsy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA), and molecule type. (globaldata.com)
Our target audience includes business development personnel, senior management and researchers within the drug development sector as well as bioscience investors and analysts. (pharmiweb.com)

This information is crucial to assist with de novo drug design. (ualberta.ca)

Small-molecule drugs are often taken in pill form. (dignityhealth.org)

Figure 3: Molecular basis for Ca 2+ -related arrhythmic activity in AF, and possible molecular targets. (nature.com)

Biotin functionalized CB[7] showed cytotoxicity specifically in cells overexpressing the biotin receptor upon targeted delivery of oxaliplatin. (umd.edu)
However, recent developments have highlighted the fact that drugs can interact with binding sites on the receptor molecule that are distinct from the orthosteric site, known as allosteric sites. (nih.gov)
Figure 6: Drugs targeting ryanodine receptor function through improved FKBP12.6 binding and domain zipping. (nature.com)
One way to actively target solely diseased tissue in the body is to know the nature of a receptor on the cell for which the drug will be targeted to. (wikipedia.org)

These data support several shared transcriptional targets of Li and VPA, and provide evidence suggesting leptin signaling as an epigenetic target of two mood stabilizers. (nih.gov)

VPA-mediated effects on histones are well established, whereas the Li effects constitute a novel mechanism of transcriptional derepression for this drug. (nih.gov)

Passive targeting is achieved by incorporating the therapeutic agent into a macromolecule or nanoparticle that passively reaches the target organ. (wikipedia.org)
The particles obtain this property due to the hydrophobic interactions that are natural to the reticuloendothelial system (RES), thus the drug-loaded nanoparticle is able to stay in circulation for a longer period of time. (wikipedia.org)
Active targeting of drug-loaded nanoparticles enhances the effects of passive targeting to make the nanoparticle more specific to a target site. (wikipedia.org)

A new study by researchers in Cleveland Clinic's Taussig Cancer Institute and Lerner Research Institute describes a novel class of targeted cancer drugs that may prove effective in treating certain common types of leukemia. (news-medical.net)
Atrial fibrillation is the most common type of cardiac arrhythmia, and is responsible for substantial morbidity and mortality in the general population. (nature.com)
Moreover, common targeted therapeutic drug formulations have weak stability in malignant tumor leukemia, and their application effects are limited. (frontiersin.org)
CHAMPAIGN, Ill. - Efforts to treat myotonic dystrophy type 1, the most common form of muscular dystrophy, are in their infancy. (illinois.edu)
Adenocarcinoma is the most common type of stomach cancer, accounting for around 9 in 10 cases . (medicalnewstoday.com)
It is less common than the intestinal type. (medicalnewstoday.com)
Perihilar CCA is the most common type and accounts for 50-60% of CCA cases. (bvsalud.org)

These nanoparticles would be loaded with drugs and targeted to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with healthy tissue. (wikipedia.org)
The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue. (wikipedia.org)
This helps maintain the required plasma and tissue drug levels in the body, thereby preventing any damage to the healthy tissue via the drug. (wikipedia.org)
Advances in the field of targeted drug delivery to cardiac tissue will be an integral component to regenerate cardiac tissue. (wikipedia.org)
angiogenic conditions, making them an important target in ocular tissue homeostasis. (drugdiscoverytoday.com)

Targeted intervention in the control of accidental drug overdoses by children. (cdc.gov)
Recent data show that drug overdoses at work are increasing. (cdc.gov)
This disturbing trend has been identified in Massachusetts, where the state's Department of Public Health recently released a report showing that unintentional drug overdoses were the leading cause of workplace death in Massachusetts in 2016 and 2017. (cdc.gov)

Specifically we are studying lactoferrin-binding receptors, which may provide novel targets for antigen engineering in vaccine design. (ualberta.ca)

Researchers have identified a brain mechanism that could be a drug target to help prevent tolerance and addiction to opioid pain medication, such as morphine, according to a study by Georgia State University and Emory University. (technologynetworks.com)
In this study, we investigated the protective effect and mechanism of nine lupane- and ceanothane-type triterpenoids isolated from jujube ( Ziziphus jujuba Mill. (mdpi.com)

Boldface indicates significant difference in statistical comparison of baseline characteristics in the corresponding drug-resistance group to drug-susceptible cases. (cdc.gov)

Emerging Drug Discovery Targets " provides a twice monthly summary of some of the most exciting breaking information recently featured by the pharmaceutical analysts, LeadDiscovery . (pharmiweb.com)
Please feel free to pass this mail onto colleagues that may benefit from registration to Emerging Drug Discovery Targets . (pharmiweb.com)

A detailed assessment of the current market landscape of companies offering drug repurposing services. (ipsnews.net)
Resis- assessment of in vivo drug response in P. tance to antimalarial drugs has been de- falciparum were developed shortly after scribed for 2 of the 4 species of human the first reports of CQ resistance in this malaria parasites, Plasmodium falciparum species [ 1 ]. (who.int)

In vitro bioactivity studies were conducted using Motor1 complexed with several anticancer drugs and biotin functionalized CB[7] complexed with oxaliplatin. (umd.edu)
Motor1 and 2 significantly increased the solubility of drugs from many different therapeutic fields, such as paclitaxel (anticancer), cinnarizine (antihistamine), and 17a-ethynyl estradiol (hormone). (umd.edu)
Bioactivity assays using anticancer drugs paclitaxel albendazole, camptothecin and PBS-1086 complexed in Motor1 resulted in significant cytotoxicity in HeLa cells. (umd.edu)
Chronic exposure to cisplatin, a potent anticancer drug, causes irreversible kidney damage. (mdpi.com)

Entrectinib is a type of targeted drug. (cancerresearchuk.org)

The report has identified the players in the field and presents a competitive landscape analysis of stakeholders and a pipeline review based on the specific profiles of drug candidates and companies active in the field. (bharatbook.com)
The report features an extensive study of the current market landscape and future opportunities for players offering services for repurposing / repositioning / reprofiling of drug candidates. (ipsnews.net)

Its low toxicity, high efficiency, and controllable drug release advantages make it have good application effects. (frontiersin.org)

DSN: CC37.HSPHANES.DRUGS ABSTRACT Introduction HISPANIC HEALTH AND NUTRITION EXAMINATION SURVEY, 1982-84 Mexican Americans Cuban Americans Puerto Ricans The Hispanic Health and Nutrition Examination Survey (HHANES) was conducted from July 1982 through December 1984. (cdc.gov)

Targeted delivery is believed to improve efficacy while reducing side-effects. (wikipedia.org)

Grace Dy, MD , will be the discussant for "New Antibodies, New Targets: Are We Making Progress? (newswise.com)

Cancers are named for the area in which they begin and the type of cell they are made of, even if they spread to other parts of the body. (healthline.com)

These drugs may be prescribed for colorectal cancer, head and neck cancer, lung cancer, and pancreatic cancer. (cancer.net)

In a new study, researchers report they have added new capabilities to an experimental drug agent that previously defeated only one of DM1's many modes of action. (illinois.edu)
Now, a multidisciplinary team of researchers at UCLA has developed a "roadmap" of the complex signaling processes involved in cancer that could lead to new methods for diagnosing and overcoming such drug resistance. (uclahealth.org)
Researchers from IRB Barcelona, the University of Barcelona (UB) and the Sant Joan de Déu Research Institute - Hospital Sant Joan de Déu (SJD) have set up Gate2Brain, a company based on a novel technology developed at IRB Barcelona to transport drugs into the brain. (news-medical.net)
They will share the drug with any other researchers who want to try the technique. (sciencedaily.com)
In a study published online Dec. 6 in Cell Chemical Biology , Stanford researchers used that fact to selectively deliver a drug to beta cells. (stanford.edu)
In other words, researchers might be able boost the number of beta cells in the pancreas, but in the process they'd get lots of other cell types to replicate as well. (stanford.edu)

Cancer drugs can destabilise mouse genomes for generations. (nationalgeographic.com)

Anatomy5

Organisms29

Diseases6

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes77

Disciplines and Occupations12

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Information Science21

Health Care2

Therapies14

20235

Immunotherapy6

Genes6

Gene14

Biomarkers3

Tumor targeted therapy2

Treatments8

Neurological disorders1

Genetic3

20201

20211

Clinical9

Therapy19

Tumors4

Potential targets3

Protein10

Nanocarriers4

Mutation1

Diabetes8

Tissues2

Compounds6

Immune system3

Diseases7

Pathways1

Approaches4

Nanomedicine3

Investigational drug1

Disease7

Biological1

Proteins2

Insights1

Biomarker1

Antibody1

Multiple targets1

Immunotherapeutic1

Chemotherapy drugs1

Development5

Novo drug1

Small molecule1

Molecular1

Receptor4

Epigenetic1

Histones1

Nanoparticle3

Common7

Tissue5

Overdoses3

Novel targets1

Mechanism2

Characteristics1

Discovery2

Assessment2

Anticancer4

Entrectinib1

Candidates2

Toxicity1

Abstract1

Efficacy1

Antibodies1

Cancers1

Lung cancer1

Researchers6

Cancer drugs1