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  • cardiac
  • If not treated, advanced heart valve disease can cause heart failure , stroke , blood clots, or death due to sudden cardiac arrest (SCA). (nih.gov)
  • descending aortic replacement
  • Because the morbidity and mortality associated with open surgical repair of descending aortic replacement are much greater in the elderly population, there has been increasing interest in treating this group of patients with aortic stent grafting as an alternative to open repair. (ahajournals.org)
  • atherosclerotic
  • Disease not only develops in the elderly due to degenerative and atherosclerotic disease related to smoking and hypertension risk factors but also the young with various genetic aortopathies such as Marfan syndrome. (springer.com)
  • There is a paucity of population-based data on subclinical atherosclerotic disease in arterial beds other than the coronary arteries in persons with diabetes ( 2 ). (diabetesjournals.org)
  • Lauer MS (2007) Primary prevention of atherosclerotic cardiovascular disease: the high public burden of low individual risk. (springer.com)
  • Light to moderate alcohol consumption is associated with a lower atherosclerotic burden of aortic plaque. (greenmedinfo.com)
  • rupture
  • Regardless of their location, aortic aneurysms are dangerous because of the risk that they will rupture, causing life-threatening bleeding or hemorrhage. (nyp.org)
  • 7 Nevertheless, TAA rupture is more common in the elderly, and as detailed in the sections that follow, type B aortic dissections, PAUs, and IMHs are more frequently seen in older patients. (ahajournals.org)
  • Atherosclerosis
  • Aortic aneurysms are believed to be caused by the gradual weakening of the artery due to atherosclerosis, arterial narrowing and hardening from cholesterol plaque build-up. (imaginis.com)
  • Krantz JS, Mack WJ, Hodis HN et al (2004) Early onset of subclinical atherosclerosis in young persons with type 1 diabetes. (springer.com)
  • Ohyama Y, Ambale-Venkatesh B, Noda C et al (2017) Aortic arch pulse wave velocity assessed by magnetic resonance imaging as a predictor of incident cardiovascular events: the MESA (multi-ethnic study of atherosclerosis). (springer.com)
  • Diabetes increases mortality by two- to fourfold from atherosclerosis-related causes, including coronary artery disease, stroke, and peripheral artery disease ( 1 ). (diabetesjournals.org)
  • Thoracic aortic aneurysms are most often caused by atherosclerosis, a hardening of the arteries that damages the artery's walls. (heartcareforyou.in)
  • aneurysm formation
  • As the blood-filled space between the layers expands, it can weaken the aortic wall resulting in an aneurysm formation or the flap of the tear can block off critical blood vessels going to the bowels, kidney, or legs. (nyp.org)
  • Medial degeneration leads to weakening of the aortic wall, which in turn results in aortic dilatation and aneurysm formation. (ahajournals.org)
  • Echocardiography
  • The aortic valve (AV) provides a paradigm for valvular structural specialization and tissue dynamics, as viewed by echocardiography and bioreactor models ( Figure 1 A). The direction of flow during systole allows the valve cusps to open as the blood flows across the open AV leaflets. (ahajournals.org)
  • genetic
  • 1,6 The extent of genetic heterogeneity is likely to become more evident as more families with thoracic aortic aneurysms are studied. (ahajournals.org)
  • Previous studies have determined that other types of MYH11 genetic alterations can cause thoracic aortic disease to be inherited in families. (redorbit.com)
  • Bicuspid Aortic Valve (BAV) is the most common congenital heart malformation in adults, but very little is known about the genetic causes or risk factors for adverse outcomes. (clinicaltrials.gov)
  • Using pharmacological and genetic approaches, our laboratory and other research groups established the protective role of α-CGRP in various cardiovascular diseases such as heart failure, experimental hypertension, myocardial infarction, and myocardial ischemia/reperfusion injury (I/R injury). (frontiersin.org)
  • blood vessels
  • Cerebrovascular disease refers to a group of conditions that affect blood flow and the blood vessels in the brain. (uofmhealth.org)
  • Disease progression is characterized by a process of thickening of the valve leaflets and the formation of calcium nodules-often including the formation of actual bone-and new blood vessels, which are concentrated near the aortic surface. (ahajournals.org)
  • morbidity
  • The less invasive approach presented with longer times of cardiopulmonary bypass, aortic clamping and mechanical ventilation than sternotomy, however without prejudice to the length of stay in intensive care unit, time of hospital discharge and morbidity. (bjcvs.org)
  • Mortality
  • Recent literature suggests a significant improvement in the mortality rate (4% to 9%) and incidence of paraplegia (3%) for descending thoracic aortic resections for thoracic aortic aneurysms (TAAs) at high-volume aortic centers. (ahajournals.org)
  • Assessing mortality risk in very low birthweight infants: a comparison of CRIB, CRIB-II, and SNAPPE-II," Archives of Disease in Childhood: Fetal and Neonatal Edition , vol. 89, no. 5, pp. (hindawi.com)
  • graft
  • After the first year, there is continued patient attrition due to co-existent cardiovascular disease but no further graft losses. (biomedcentral.com)