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  • Metabolism
  • The pig is emerging rapidly as a biomedical model for energy metabolism and obesity in humans because it shares several similarities with humans: omnivorous habits, propensity to sedentary behaviour and fattening, and similar metabolic and cardiovascular features [ 10 - 13 ]. (hindawi.com)
  • obese
  • The incidence of overweight and obesity is dramatically rising and, according to WHO predictions, approximately 2.3 billion of people will be overweight and more than 700 million will be obese by the year 2015 ( http://www.who.int/features/factfiles/obesity/en/index.html ). (hindawi.com)
  • Such state in human medicine is called leptin resistance , the failure, in obese individuals with elevated leptin levels, for suppressing feeding and mediating weight loss [ 17 , 18 ] due to LEPR polymorphisms associated with food preferences and obesity [ 19 ]. (hindawi.com)
  • evidence
  • Our data, together with evidence from other studies, suggest that body fat accumulated in the upper body segment may contribute to the adverse metabolic consequence. (diabetesjournals.org)
  • fatty
  • Nonalcoholic fatty liver, also a component of the metabolic syndrome, is the most common liver abnormality in the U.S. and may lead to hepatic fibrosis, cirrhosis, and death ( 2 ). (pnas.org)
  • Nonalcoholic steatohepatitis (NASH) is a type of Nonalcoholic fatty liver disease (NAFLD) , a condition in which fat accumulates in the liver. (gi-north.com)
  • PCOS
  • A common definition and definite treatment plan for PCOS does not exist, mainly due to the fact that the aetiopathogenesis of this syndrome still seems to be unclear. (ijpsonline.com)
  • Due to the polysymptomatic nature of this syndrome and lack of consensus on its diagnostic criteria there is a strong need of finding a reliable biochemical or molecular marker, which would facilitate making the accurate diagnosis of PCOS. (nih.gov)
  • testosterone
  • The relationship between obesity and low testosterone levels in men is complex and apparently bidirectional. (springer.com)
  • By contrast, obesity predicts low total and free testosterone levels. (springer.com)
  • The relationship between obesity and low testosterone levels appears to be complex and multifactorial. (springer.com)
  • This review will focus on the recent findings on the relationship between testosterone levels and obesity. (springer.com)
  • leptin
  • Large subcutaneous fat cell size was strongly related to plasma leptin levels in non-diabetic and in type 2 diabetic subjects. (diva-portal.org)
  • Here we investigated whether nutritive and genetic inhibition of the central IKKβ/NF-κB pathway in DIO- and leptin-deficient mice improves these metabolic impairments. (diabetesjournals.org)