• Chattopadhyay SK, Baroudy BM, Holmes KL, Frederickson TN, Lander MR, Hartley HCM Ill, Hartley JW (1989) Biological and molecular genetic characteristics of a unique MCF virus that is highly leukemogenic in ecotropic virus-negative mice. (springer.com)
  • When adult mice of susceptible strains are infected with FV, their spleens rapidly enlarge because of virus-induced polyclonal proliferation of erythroid precursor cells ( 19 - 21 ). (pnas.org)
  • In a study of vaccinated mice, it was possible to identify the immunological epitopes required for protection against the virus, thus determining the types of immunological responses necessary or required for protection against it. (wikipedia.org)
  • We found suppressed BM5 provirus copies and increased type I IFNs in the spleen from IDO knockout (IDO −/− ) and 1-methyl- d-l -tryptophan-treated mice compared with those from wild-type (WT) mice. (jimmunol.org)
  • In addition, neutralization of type I IFNs in IDO −/− mice resulted in an increase in LP-BM5 viral replication. (jimmunol.org)
  • To our knowledge, the present study is the first report to observe suppressed virus replication with upregulated type I IFN in IDO −/− mice, suggesting that modulation of the IDO pathway may be an effective strategy for treatment of virus infection. (jimmunol.org)
  • By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. (greenmedinfo.com)
  • However, anecdotal evidence from fauna parks in southeast Queensland suggests that up to 80% of mortalities in captive koalas may be attributable to lymphoma and a variety of leukemias (J. J. Hanger, unpublished data). (asm.org)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • By cytokine pattern analysis, the induced CD4 + T cells were of the T helper cell 1 type. (rupress.org)
  • Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. (wikipedia.org)
  • The results of this comprehensive survey found that the overall lipid content of these viruses mostly matched that of the plasma membrane, which was considerably different from the total lipid content of the cells. (asm.org)
  • Biochemical and antibody-based analyses of the replication cycle and proteins found in the virions have revealed many details of the molecular interactions between human immunodeficiency virus (HIV) and its host ( 20 ). (asm.org)
  • The host cell then treats the viral DNA as part of its own genome, transcribing and translating the viral genes along with the cell's own genes, producing the proteins required to assemble new copies of the virus. (wikipedia.org)
  • Within a species, the viruses isolated can display considerable diversity of biological properties. (springer.com)
  • Specific major histocompatibility complex (MHC) class I and II alleles are necessary for recovery, as is a non-MHC gene, Rfv-3, which controls virus-specific antibody responses. (pnas.org)
  • It is believed that at one point an ancestral virus mistakenly incorporated the c-Src gene of its cellular host. (wikipedia.org)
  • However, antibody responses also appear essential for resistance against certain viruses such as enterovirus ( 9 ) and rabies virus ( 10 ), and there are numerous examples of antibodies curing or preventing viral infections ( 11 - 17 ). (pnas.org)
  • Cancer Care & Treatment Learn about prevention, detection, diagnosis, treatment and more by your cancer type. (osu.edu)
  • For example, it is shown that successful passive antibody therapy is dependent on MHC type because of the requirement for T cell responses. (pnas.org)
  • used electrospray ionization mass spectrometry (ESI-MS) to compare the lipid composition of HIV with that of total cell membrane and suggested that HIV buds from a unique or specialized type of lipid raft ( 8 ). (asm.org)
  • The expression of these Src family members are not the same throughout all tissues and cell types. (wikipedia.org)
  • Most likely this resolution depends on the specific virus and host involved, and often more than one aspect of the immune response is important, if not essential. (pnas.org)