Type component of laminin laminin. Medical search. Frequent questions

MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. (prospecbio.com)
IMs are found in the space between the tissue stroma cells and contain, among other components, fibrillar collagens and fibronectin. (nature.com)
Myocardial deposition of collagen molecules (types I, III, and IV) and other ECM components (fibronectin, laminin) was analyzed by immunohistochemical techniques using specific monoclonal antibodies. (cun.es)
WKY, 0.96 +/- 0.06 mumol/L/g dry weight/100 g body weight), 4) a lesser presence of collagen fibers, and 5) a lesser presence of collagen IV, fibronectin, and laminin. (cun.es)
Antibodies to TIGR/MYOC, fibronectin, laminin, type IV collagen, or thrombospondin were used to determine the extracellular localization of TIGR/MYOC. (nih.gov)
Solid phase binding assays using 125I-recombinant TIGR/MYOC and types I and IV collagens, fibronectin, and laminin were done to examine the association of TIGR/MYOC with these proteins and to identify a specific TIGR/MYOC binding site within fibronectin. (nih.gov)
TIGR/MYOC colocalized with fibronectin, laminin, and type IV collagen, but not thrombospondin in both dexamethasone and dexamethasone/ascorbate-treated HTM cultures and in TM-1 cultures transfected with TIGR/MYOC cDNA. (nih.gov)
In solid phase binding assays, 125I-TIGR/MYOC bound fibronectin but not laminin or type IV collagen. (nih.gov)
TIGR/MYOC can associate with components of the ECM via interactions with the Hep II domain of fibronectin. (nih.gov)
The major components of the ECM are interstitial collagens (types I and III), membrane collagen (type IV), and non-collagenous glycoproteins, such as laminin and fibronectin. (vin.com)
MMP-2 , along with MMP-9, belongs to the gelatinase group of MMP's which have three repeats of a type II fibronectin domain inserted in the catalytic domain. (southernbiotech.com)
Most cells have integrins that bind to components of the extracellular matrix, like collagen, fibronectin or laminin. (rcsb.org)

The α6 subunit binds to extracellular BP180, CD151 and laminin-322. (wikipedia.org)
BPAG2, or (bullous pemphigoid antigen 2), is a transmembrane protein that exists adjacent to integrins, BPAG2 has domains that bind to plectin, integrin β4 subunit in the cytoplasm and integrin α6 and laminin-332 in the extracellular space. (wikipedia.org)
Laminin consists of a 220 kD subunit, which is disulfide-linked into larger complexes or even into the structural scaffolding of the basement membrane itself. (biogenex.com)
ELAV - like1 , methyltransferase like 7A , dolichyl-phosphate mannosyltransferase , laminin subunit beta-1 , gremlin 1 , BCL6 corepressor-like 1 , and three genes of unknown identity. (biomedcentral.com)
Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit. (rupress.org)
Furthermore, these results suggest that the sequences comprising peptides GD-3 and GD-4 use an integrin as a receptor, of which the beta 1 integrin subunit is a component for these various cell types. (rupress.org)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

According to a common concept of thrombosis and hemostasis, damage or injury of a vessel wall and ensuing exposure of extracellular matrix components to the blood stream triggers platelets from the circulation to become adherent and to assemble into a thrombus, thus limiting the extravasation of blood ( 1 , 2 ). (frontiersin.org)
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
SPARC (secreted protein,acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-matrix interactions, cellular proliferation and differentiation, and the expression of genes encoding extracellular matrix components. (silverchair.com)
The main reported mechanisms involve cell adhesion molecules (CAMs) and extracellular matrix components. (bvsalud.org)

This pioneering hydrogel sets a new benchmark in the field, containing fully defined components, including medical grade collagens, laminin-511 E8 fragments, and hyaluronic acid. (labx.com)
Collagenases degrade triple-helical fibrillar collagens, which are the main components of bone and cartilage. (periobasics.com)
Stromelysins [MMP-3, MMP-10, MMP-11, and MMP-7 (also known as matrilysins)] are small proteases that degrade components of the ECM, although not the triple-helical fibrillar collagens. (periobasics.com)

ECM was prepared to a protein concentration of 8-12 mg/mL (in DMEM), containing laminin as a major component, collagen type IV, heparin sulfate proteoglycan, entactin, and other minor components. (sigmaaldrich.com)

Because type IV collagen and laminin are proteins found exclusively in the basement membrane, the antibodies to these two proteins selectively and specifically recognize basement membrane components. (biogenex.com)
Laminin proteins are integral components of structural scaffolding in animal tissues. (sigmaaldrich.com)
Matriglycan is indeed a scaffold for multiple laminin-G (LG) domain-containing extracellular matrix proteins (e.g. laminin, agrin, and perlecan) and it has the remarkable capacity to be tuned during skeletal muscle development and regeneration. (enmc.org)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

This laminin product was isolated from mouse Engelbreth-Holm-Swarm tumor. (sigmaaldrich.com)

BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)

Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. (sigmaaldrich.com)

They associate with type IV collagen via entactin and perlecan and bind to cell membranes through integrin receptors, dystroglycan glycoprotein complexes and Lutheran blood group glycoproteins. (sigmaaldrich.com)

Hemidesmosomes can be categorized into two types based on their protein constituents. (wikipedia.org)
P1a, tetraspanin protein CD151, BPAG1e, or bullous pemphigoid antigen isoform e, and BPAG2 (also known as BP180 or type 17 collagen). (wikipedia.org)
Although the lupus band appears to colocalize with type VII collagen, the noncollagenous-1 (NC1) domain of this protein does not represent the target antigen for circulating antibodies in systemic lupus erythematosus patients without clinical blistering. (medscape.com)
Laminin 5 (Ln5) is an extracellular matrix protein that plays an important role in cell migration and tumor invasion. (spandidos-publications.com)
Initial studies demonstrated that rabbit antimouse type VII collagen antibodies, as well as rabbit antibodies raised against human recombinant protein type VII collagen, were able to induce blisters in mice. (medscape.com)
Induction of an active model of autoimmunity against type VII collagen in a hairless mouse strain (SKH1) revealed that regulatory T cells, which have been identified for their ability to inhibit the development of autoimmune diseases, do not inhibit the development of autoantibodies against the self-protein mouse-type VII collagen. (medscape.com)
Epidermolysis bullosa acquisita (EBA) is an autoimmune disease, manifested by autoantibodies that target type VII collagen, the major protein of anchoring fibrils and the one that connects the epithelial basement membrane to the dermis. (medscape.com)
Oncogenic KRAS-Induced Protein Signature in the Tumor Secretome Identifies Laminin-C2 and Pentraxin-3 as Useful Biomarkers for the Early Diagnosis of Pancreatic Cancer. (lsbio.com)
Laminin IV domain is also found in the perlecan protein, an integral component of basement membranes, which serves also as an attachment substrate for cells, but it is not found in short laminin chains (alpha4 or beta3). (embl.de)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)
The major structural protein of basement membrane, collagen type IV, in the lens capsule was substantially altered in the absence of SPARC. (silverchair.com)
Strong binding of the LRR-containing construct was detected with the major ECM protein laminin. (ku.dk)
Moreover, in addition to our understanding of the glycosylation of dystroglycan, much insight has also been gained into the functional roles of dystroglycan, not only in the bran and muscle, but also in other cells types, and the implication that the defective processing of this protein has with respect to role in Lassa fever virus infections. (enmc.org)
They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)

Patients with nonbullous systemic lupus erythematosus often have circulating antibodies to various components of the BMZ (including bullous pemphigoid antigens 1 and 2), which may have a role in formation of the lesional lupus band (ie, granular antibody deposition at the BMZ in normal-appearing skin). (medscape.com)
In patients with systemic lupus erythematosus without vesiculobullous eruptions, an increase of circulating antitype VII collagen antibodies may precede the onset of type 1 bullous systemic lupus erythematosus. (medscape.com)
In addition, solutions of these peptides or antibodies generated against these peptides inhibited laminin-mediated HT-1080 cell adhesion. (rupress.org)
Epidermolysis bullosa acquisita is caused by antibodies targeting type VII collagen, the major component of anchoring fibrils that connect the basement membrane to dermal structures. (medscape.com)
[ 7 ] The failure of rabbit antimouse type VII collagen antibodies to induce blisters in C5-deficient mice supports a role for complement activation in the disease pathogenesis. (medscape.com)

The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. (embl.de)
There are dozens of types of integrins, each with a specific task. (rcsb.org)

Type VII collagen, a component of anchoring fibrils, is also targeted in epidermolysis bullosa acquisita (EBA). (medscape.com)
[ 3 ] IgG autoantibodies specific for anchoring fibrils (type VII collagen) of the skin basement membrane have a heterogeneous subclass and light-chain composition, and their complement-activating capacities do not correlate with the inflammatory phenotype. (medscape.com)
The major structural component of anchoring fibrils is type VII collagen, the autoantigen of epidermolysis bullosa acquisita. (uni-luebeck.de)
Summarizing progress in each, she described improvement in levels of collagen VII, an important deficit in most types of EB, that were achieved with fibroblast injections that improved levels of collagen VII and anchoring fibrils in a study published in 2008 . (medscape.com)

residues 2,110-3,060) of the A chain of murine-derived laminin has been shown to promote heparin binding, cell adhesion, and neurite outgrowth. (rupress.org)
Laminin has active domains for collagen binding, cell adhesion, heparin binding, and neurite outgrowth fragment. (sigmaaldrich.com)

Integrin α6β4 operates as a laminin-332 receptor. (wikipedia.org)
The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)

The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
Laminin is an extracellular matrix multidomain trimeric glycoprotein and is the main non-collagenous component of basal lamina that supports adhesion, proliferation and differentiation. (sigmaaldrich.com)
Laminin is a large molecular weight glycoprotein present only in basement membranes in almost every animal tissue. (embl.de)
Dystroglycan is a core and essential component of the dystrophin-glycoprotein complex of muscle and brain, making vital links between the cytoskeleton and laminin in the extracellular matrix. (enmc.org)

abstract = "The glomerular basement membrane (GBM) is an important component of the kidney's glomerular filtration barrier. (wustl.edu)

Dermochlorella stimulates the formation of main skin components such as collagen, elastin and laminin and prevents their degradation. (dermacolindia.in)

Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)
Therefore, laminin appears to have multiple, independent sequences in the G domain that serve a similar cell adhesion promoting function for different cell types. (rupress.org)

Analysis of these interactions by surface plasmon resonance spectroscopy revealed similar kinetics and affinities of binding of the LRR-containing construct to human and murine laminin-111, with calculated dissociation constants of 1.0 and 1.5 μM, respectively. (ku.dk)

Corning BioCoat Matrigel Matrix Cellware is effective for the attachment and differentiation of both normal and transformed anchorage dependent epithelial and other cell types including neurons and oligodendrocytes. (daigger.com)
however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. (biomedcentral.com)
UC-MSCs were then cultured in the IPC induction and differentiation medium in the presence of laminin 411. (biomedcentral.com)
Our results demonstrate that laminin 411 acts as a potent differentiation inducer of IPCs from UC-MSCs via the Pdx1 and Ngn3 signaling pathways. (biomedcentral.com)
The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)

Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
Laminin is composed of both A, B1 and B2 chains, which are connected by many disulfide bonds. (sigmaaldrich.com)
The different laminin chains share a 600-residue domain I/II which oligomerises into a rod-like coiled-coil structure forming the long arm of laminins. (embl.de)
It has a biosynthetic function and catalyses the hypobromous acid-mediated formation of specific covalent sulfilimine (S[dbnd]N) bonds, which cross-link type IV collagen chains in basement membranes. (ku.dk)

A subset of patients have variations in which either IgG autoantibodies bind the central triple-helical collagenous (NC2) domain of type VII collagen, or immunoglobulin A (IgA), rather than IgG, targets type VII collagen. (medscape.com)
Furthermore, detailed biochemical and cell biological analyses have finely mapped the biosynthetic pathways leading to the glycosylation of dystroglycan that enable it to bind to laminin. (enmc.org)

Type 1 hemidesmosomes are found in stratified and pseudo-stratified epithelium. (wikipedia.org)
Type 1 hemidesmosomes have five main elements: integrin α6β4, plectin in its isoform 1a, i. e. (wikipedia.org)
Type 1 hemidesmosomes are found in stratified and pseudostratified epithelial tissue. (wikipedia.org)
Type 2 hemidesmosomes contain integrin α6β4 and plectin without the BP antigens. (wikipedia.org)
Hemidesmosomes have two membrane-spanning components: Integrin α6β4 and BPAG2. (wikipedia.org)
Laminin 5 is another well-characterized anchoring filament-lamina densa component of hemidesmosomes. (uni-luebeck.de)

In addition to providing biomechanical support to the islets, ECM components are required for β-cell development, proliferation, survival, and proper insulin secretion. (nature.com)
It has already been established that a transient increase of transforming growth factor β1 (TGF-β1) in the liver promotes fibrosis with the formation of extracellular matrix (ECM) components and suppresses hepatocyte proliferation. (vin.com)

In canine epidermolysis bullosa acquisita, the immunoglobulin G (IgG) autoantibodies also target the type VII collagen noncollagenous (NC1) domain, which shares greater than 80% homology in amino acid sequence with the human NC1 domain. (medscape.com)
Autoantibodies specific for type VII collagen alter the dermoepidermal junctional adhesion and lead to dermoepidermal separation. (medscape.com)
Patients with autoantibodies to laminin 5 show the clinical phenotype of cicatricial pemphigoid. (uni-luebeck.de)

The interactions with the various BM components differentially affect β-cells, although the underlying mechanism is largely unknown. (nature.com)
The Reinhardt laboratory is interested in components and mechanisms involved in the biogenesis, function and pathological aspects of the extracellular matrix and its interactions with cells. (mcgill.ca)
Currently, it is unknown whether and which domain(s) [i.e. leucine-rich repeat domain (LRR), immunoglobulin domains, peroxidase domain, von Willebrand factor type C domain] of PXDN interact with the polymeric networks of the extracellular matrix (ECM), and how these interactions integrate and regulate the enzyme's cross-linking activity, without imparting oxidative damage to the ECM. (ku.dk)
In this study, we probed the interactions of four PXDN constructs with different domain compositions with components of a basement membrane extract by immunoprecipitation. (ku.dk)

MMP-2 has shown specificity to breakdown collagen types I, II, and III as well as the extracellular matrix component aggrecan. (southernbiotech.com)

This is caused by mutations in integrin α6β4, laminin 322 and BPAG2. (wikipedia.org)
Mutations that affect the GBM's collagen α3α4α5(IV) components cause Alport syndrome (kidney disease with variable ear and eye defects) and its variants, including thin basement membrane nephropathy. (wustl.edu)
Mutations in LAMB2 that impact the synthesis or function of laminin α5β2γ1 (LM-521) cause Pierson syndrome (congenital nephrotic syndrome with eye and neurological defects) and its less severe variants, including isolated congenital nephrotic syndrome. (wustl.edu)
The very different types of kidney diseases that result from mutations in collagen IV vs. laminin are likely due to very different pathogenic mechanisms. (wustl.edu)
It was defined, Laminin A (LMNA) gene point mutations in HGPS individuals. (journalmc.org)

LS-F33142 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Human LAMC2 / Laminin Gamma 2 in samples of Plasma, Serum and Tissue Homogenates. (lsbio.com)

Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)

Suitable for final Laminin concentrations up to 200ug/ml. (sigmaaldrich.com)
Researchers can adjust the types and concentrations of the individual components, creating the optimal extracellular environment for their specific target cells. (labx.com)

It is based upon a Sandwich assay principle and can be used to detect levels of LAMC2 / Laminin Gamma 2 as low as 0.094 nanograms per millilter. (lsbio.com)
Each laminin is a heterotrimer assembled from alpha, beta and gamma chain subunits, secreted and incorporated into cell-associated extracellular matrices. (embl.de)

Data on histological type, clinical stage, smoking status, gender and patient age were collected from medical records. (spandidos-publications.com)
These novel finding highlights a potential clinical application of laminin 411 induced-IPCs in the treatment of T1DM, which calls for further studies. (biomedcentral.com)

Immunization of type VII collagen in athymic nude SJL mice did not induce an autoimmune response, whereas the repletion of T cells from type VII collagen-immunized wild-type mice to the thymic mice showed autoantibody production and resulted in a blistering disease phenotype, supporting the role of T cells in the induction of epidermolysis bullosa acquisita. (medscape.com)

A lterations in the lamin (type A and B), the main fibroid component of the nuclear laminin eukaryote cells, give rise to a series of diseases known as laminopathies. (fundacionareces.es)
Additionally, alterations in the nuclear laminin Parkinson's disease suggest that they participate in neurodegenerative processes. (fundacionareces.es)
LMNA gene encodes laminin A and laminin C. Laminin type A is an important structural component nuclear membrane. (journalmc.org)
1][4] Most types of intermediate filaments are cytoplasmic, but one type, the lamins, are nuclear. (pearltrees.com)

TissueFab ® - Low endotoxin GelMA-UV Laminin kit enables the precise fabrication of 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine. (sigmaaldrich.com)

Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)

The N-terminal short arms consist of rod-like elements (domain III and V) formed by tandem arrays of laminin-type EGF modules and several globular domains: domains IV and domain VI (laminin N-terminal). (embl.de)

Perturbations in the ability of dystroglycan to interact with laminin have severe implications for human disease. (enmc.org)
This wealth of information has led to a new understanding of how the defective interaction between of dystroglycan and laminin leads to disease. (enmc.org)

Y-27632 inhibits keratocyte-to-myofibroblast transition, and its topical application after a superficial lamellar keratectomy elicits an altered wound healing response, with evidence of an embryonic-type deposition of collagen fibrils. (molvis.org)

In genetic and acquired hypertension, a structural remodeling of the nonmyocyte compartment of myocardium, including the accumulation of fibrillar collagen and other components of the extracellular matrix (ECM) within the interstitium, represents a determinant of pathologic hypertrophy that leads to ventricular dysfunction. (cun.es)

While some islet BM components are produced by endothelial cells (ECs), the source of others remains unknown. (nature.com)
Thus, we hypothesized that pericytes regulate β-cells through the production of BM components. (nature.com)
We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)
In practice, the term "cell culture" now refers to the culturing of cells derived from multicellular eukaryotes , especially animal cells, in contrast with other types of culture that also grow cells, such as plant tissue culture , fungal culture, and microbiological culture (of microbes ). (wikipedia.org)
The bioink kit can be used with most extrusion-based bioprinters, are biodegradable, and are compatible with human mesenchymal stem cells (hMSCs) and other diverse cell types. (sigmaaldrich.com)
The mesohyl includes a noncellular colloidal mesoglea with embedded collagen fibers, spicules and various cells, being as such a type of mesenchyme. (pearltrees.com)
Structure of intermediate filament Intermediate filaments (IFs) are cytoskeletal components found in the cells of vertebrate animal species,[1][2] and perhaps also in other animals, fungi, plants, and unicellular organisms. (pearltrees.com)

One large category of liver injury in dogs is that associated with pathological copper accumulation, which can be the major mechanism of hepatocyte damage or may be a component of a "two-hit" phenomenon making what might have been inconsequential injury into a progressive process. (merckvetmanual.com)

Molecules on the surface of some B-lymphocytes and macrophages, that recognize and combine with the C3b, C3d, C1q, and C4b components of complement. (bvsalud.org)

This unique feature opens up new possibilities for culturing a wide range of tissue types. (labx.com)
In addition to connective tissue and ECM components, proteinase inhibitors such as α1-proteinase inhibitor, antithrombin-III and α2-macroglobulin are selectively cleaved by MMPs. (periobasics.com)
Y-27632 eye drops (or vehicle only) were administered to eyes after a superficial keratectomy, and the tissue was examined by immunohistochemistry for α-SMA, collagen types I, II, and III, and keratan sulfate. (molvis.org)

We have innovated Dermacol Makeup Cover for Masses which is water-proof and suitable for all skin types. (dermacolindia.in)

This study was conducted to define the potential sequence(s) originating from the G domain of laminin with any of these functional activities. (rupress.org)
Other MMPs, known as membrane-type MMPs (MT-MMP), are linked to the plasma membrane either by a transmembrane domain or by a glycosyl-phosphatidyl inositol linkage, attached to the hemopexin domain. (periobasics.com)

MatriMix's ability to facilitate excellent cell organization and accurately replicate in vivo conditions makes it the ultimate solution for culturing difficult to grow cell types and drug screening. (labx.com)

Another type of MMPs are called as the MT-MMPs (Membrane Type Matrix Metalloproteinases) that are localized to the cell surface. (periobasics.com)

In surgical pathology, laminin can be used as a marker to demonstrate morphologic change of basement membrane, which is helpful for interpreting the invasion of malignant tumors. (biogenex.com)

Genetic or acquired diseases that cause disruption of hemidesmosome components can lead to skin blistering disorders between different layers of the skin. (wikipedia.org)
Different components of this complex have been identified as autoantigens in autoimmune bullous skin diseases. (uni-luebeck.de)

In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)

Anatomy7

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes4

Disciplines and Occupations1

Information Science2

Fibronectin12

Subunit7

Extracellular matrix components4

Collagens3

Proteoglycan1

Proteins5

Engelbreth-Holm-Swarm1

Heparan sulfate proteoglycans1

Gelatin1

Entactin1

Protein15

Antibodies5

Integrins2

Anchoring fibrils4

Neurite outgrowth2

Receptor2

Glycoprotein4

Abstract1

Elastin1

Cell adhesion2

Murine1

Differentiation5

Chains4

Bind2

Hemidesmosomes6

Proliferation2

Autoantibodies3

Interactions4

Aggrecan1

Mutations5

Quantitative1

Adhesion5

Concentrations2

Gamma2

Clinical2

Phenotype1

Nuclear4

Constructs1

Gene1

Globular1

Disease2

Deposition of collagen1

Fibrillar1

Cells8

Major1

Complement1

Tissue3

Suitable1

Domain2

Organization1

Surface1

Demonstrate1

Diseases2

Contrast1