• The epoxyeicosatrienoic acids or EETs are signaling molecules formed within various types of cells by the metabolism of arachidonic acid by a specific subset of Cytochrome P450 enzymes termed cytochrome P450 epoxygenases. (wikipedia.org)
  • ENPP7 is a new name for an old enzyme whose activity was originally identified in 1969 by Nilsson as a type of sphingomyelinase that hydrolyses sphingomyelin to ceramide in the intestinal tract. (wikipedia.org)
  • ENPP7 is the only enzyme that has a type of phospholipase C activity against sphingomyelin. (wikipedia.org)
  • That is, cell stimulation causes DHA to be released from the sn-2 position of their membrane-bound cellular phospholipid pools through the action of a Phospholipase A2-type enzyme and the subsequent attack of the released DHA by CYP450 epoxidases. (wikipedia.org)
  • Publications] Ishizaki,J.: 'CDNA cloning and sequence determination of rat membraneーassociated phospholipase A2' Biochem.Biophys.Res.Commun.162. (nii.ac.jp)
  • Enzymes (molecular weight 13-150 KDa) make-up 80-90% of viperid and 25-70% of elapid venoms: digestive hydrolases, L-amino acid oxidase, phospholipases, thrombin-like pro-coagulant, and kallikrein-like serine proteases and metalloproteinases (hemorrhagins), which damage vascular endothelium. (wikipedia.org)
  • Phospholipases A2 (PLA2s) EC 3.1.1.4 are enzymes that release fatty acids from the second carbon group of glycerol. (wikipedia.org)
  • Publications] Inada,M.: 'Preferential distribution of group IIーlike phospholipase A2 in mononuclear phagocytic cells in rat spleen and liver' Eur.J.Biochem. (nii.ac.jp)
  • Publications] Tojo,H.: 'Spleen phospholipase A2' Methods Enzymol.197. (nii.ac.jp)
  • Molecular dissection of the underlying signaling mechanism by a combined biochemical, pharmacological, and genetic approach demonstrates that this BCR-controlled integrin-mediated adhesion requires the (consecutive) activation of Lyn, Syk, phosphatidylinositol 3-kinase, Bruton's tyrosine kinase (Btk), phospholipase C (PLC)gamma2, IP3R-mediated Ca2+ release, and PKC. (nih.gov)
  • Our laboratory has recently identified the M-type phospholipase A 2 receptor (PLA 2 R) as a major antigenic target in IMN, 8 and we have demonstrated that autoantibodies reactive with this protein are sensitive and specific for the disease. (asnjournals.org)
  • Several other types of lipase activities exist in nature, such as phospholipases and sphingomyelinases, however these are usually treated separately from "conventional" lipases. (wikipedia.org)
  • and, they represent several types of protein folds and catalytic mechanisms, most of them are built on an alpha/beta hydrolase fold and employ a chymotrypsin-like hydrolysis mechanism using a catalytic triad consisting of a serine nucleophile, a histidine base, and an acid residue (usually aspartic acid). (wikipedia.org)
  • OBJECTIVE: To determine the localisation and level of expression of human type IIa secretory phospholipase A2 (sPLA2) in the synovium of rheumatoid arthritis (RA), osteoarthritis (OA), and non-arthritic (NA) patients and to examine the relation between sPLA2 and histological features of inflammation. (garvan.org.au)
  • MS-HRM analysis of the PLA2R1 locus in patients with different types of leukemia indicated an average methylation of 28.9% ± 17.8%, compared to less than 9% in control subjects. (beds.ac.uk)
  • A microsatellite polymorphism associated with the PLC1 (phospholipase C) locus: identification, mapping, and linkage to the MODY locus on chromosome 20. (biomedsearch.com)