Type b lactic acidosis. Medical search. Frequent questions

The older related and now withdrawn drug phenformin carried a much higher risk of lactic acidosis. (wikipedia.org)

In their classic 1976 monograph, Cohen and Woods classified the causes of lactic acidosis according to the presence or absence of adequate tissue oxygenation. (medscape.com)
The causes of lactic acidosis are listed in the chart below. (medscape.com)

4 mmol/L. It is the most common cause of metabolic acidosis and can be associated with an anion gap metabolic acidosis or mixed acid-base disorder. (logicalimages.com)
Lactic acidosis is characterized by elevated blood lactate levels, acidemia, electrolyte disturbances, an increased anion gap, and an increased lactate/pyruvate ratio. (pdr.net)
If a large amount of the bowel is affected, expect to see a lactic acidosis and an anion gap on the CHEM-7. (dummies.com)
Small differences in corrections for anion gap, different types of analytical process. (biomedcentral.com)
The accumulation of lactic acid in blood can cause true acidosis with a large anion gap, a characteristic of glycogen-storage disease type I. (medscape.com)

The management of lactic acidosis is targeted toward treating the cause. (healthnews.com)
During the terminal phase of his disease, he required multiple hospitalizations for management of lactic acidosis and other complications of his MM. No other cause of his elevated lactate levels was identified. (elsevierpure.com)

The development of lactic acidosis depends on the magnitude of hyperlactatemia, the buffering capacity of the body, and the coexistence of other conditions that produce tachypnea and alkalosis (eg, liver disease, sepsis). (medscape.com)
Although comorbidities such as liver, kidney, and heart diseases are strongly associated with lactic acidosis, trauma or adverse reaction to medication can also contribute to the development of lactic acidosis. (healthnews.com)

In basic terms, lactic acid is essentially a carbohydrate within cellular metabolism and its levels rise with increased metabolism during exercise and with catecholamine stimulation. (medscape.com)
Lactic acidosis, on the other hand, is associated with major metabolic dysregulation, tissue hypoperfusion, the effects of certain drugs or toxins, and congenital abnormalities in carbohydrate metabolism. (medscape.com)
Congenital lactic acidosis is secondary to inborn errors of metabolism, such as defects in gluconeogenesis, pyruvate dehydrogenase, the tricarboxylic acid (TCA) cycle, or the respiratory chain. (medscape.com)
It is a form of metabolic acidosis, in which excessive acid accumulates due to a problem with the body's oxidative metabolism. (wikipedia.org)
The human metabolism produces about 20 mmol/kg of lactic acid every 24 hours. (wikipedia.org)
In "type A" lactic acidosis, the production of lactate is attributable to insufficient oxygen for aerobic metabolism. (wikipedia.org)
Type B lactic acidosis - Due to drug- or toxin-induced impairment of cellular metabolism, ischemia, nutritional deficient state, or rarely malignancy. (logicalimages.com)
Because of slow metabolism of D-lactic acid, systemic absorption leads to elevated plasma D-lactic acid levels and metabolic acidosis. (logicalimages.com)
Lactic acidosis is a medical condition driven by heightened levels of lactic acid in the bloodstream caused by an inadequate supply of oxygen to the body tissue or an altered metabolism mediated by drugs or toxins. (healthnews.com)
On the other hand, lactic acidosis type B is a rare type resulting from altered metabolism by drugs or toxins. (healthnews.com)
Lactic acid is produced when oxygen levels become low in cells within the areas of the body where metabolism takes place or in response to sympathetic overactivity related to epinephrine-type substances or exercise. (mountsinai.org)
Thiamine is an essential component of cellular metabolism and its deficiency results in potentially life-threatening events and profound lactic acidosis through anaerobic metabolism. (thieme-connect.de)
Lactic acidosis results from overproduction of lactate, decreased metabolism of lactate, or both. (msdmanuals.com)
D-lactic acid is normally produced in small quantities as the product of carbohydrate metabolism by bacteria in the colon. (msdmanuals.com)
What are the mechanisms of lactate metabolism and lactic acidosis? (ebmedicine.net)

In rare chronic forms of lactic acidosis caused by mitochondrial disease, a specific diet or dichloroacetate may be used. (wikipedia.org)
Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria. (ox.ac.uk)

The diagnosis is made on biochemical analysis of blood (often initially on arterial blood gas samples), and once confirmed, generally prompts an investigation to establish the underlying cause to treat the acidosis. (wikipedia.org)
Primary metabolic acidosis/alkalosis or primary respiratory acidosis/alkalosis: how does diagnosis proceed from this initial characterization? (ebmedicine.net)
In order to successfully treat this syndrome, early diagnosis and simultaneous treatment of the imbalance of lactic acid levels and the underlying malignancy are necessary. (bvsalud.org)
In 2014, the American College of Genetics and Genomics issued an updated practice guideline on the diagnosis and management of types Ia and Ib. (medscape.com)

Does high-dose metformin cause lactic acidosis in type 2 diabetic patients after CABG surgery? (touchcardio.com)
Lactic acidosis due to metformin is a fatal metabolic condition that limits its use in patients in poor clinical condition, consequently reducing the number of patients who benefit from this medication. (touchcardio.com)
High-dose metformin (1,000 mg twice daily with insulin) does not cause lactic acidosis in type 2 diabetic patients after coronary artery bypass surgery. (touchcardio.com)
Metformin ( Glucophage ) is the only biguanide available in the United States and is generally the first choice for oral treatment of type 2 diabetes mellitus . (medicinenet.com)
Type 2 Diabetes - What Is Metformin? (liquid-nutrition-vitamins.com)
Metformin is the most popular drug for the treatment of type 2 diabetes. (liquid-nutrition-vitamins.com)
Because of these explanations, organizations that focus on diabetes suggest Metformin should be the primary solution for type 2 diabetes (diabetes mellitus). (liquid-nutrition-vitamins.com)
metformin is contraindicated in patients with acute or chronic metabolic acidosis. (pdr.net)
metformin should not be used in patients with lactic acidosis. (pdr.net)
Certain medications used concomitantly with metformin may also increase the risk of lactic acidosis. (pdr.net)
When metformin is implicated as the cause of lactic acidosis, metformin plasma concentrations more than 5 mcg/mL are generally found. (pdr.net)
Ved diabetes type 2 er anbefalingen at førstevalget er metformin . (nhi.no)
Metformin er det mest brukte antidiabetikum, og det midlet som anbefales ved oppstart av medikamentell behandling dersom du har diabetes type 2. (nhi.no)
Many people with type 2 diabetes start with the oral drug metformin (Glucophage) to help meet their blood sugar level goals. (everydayhealth.com)
Metformin-GA tablets are used for the treatment of type 2 diabetes which usually only occurs in adults and does not need insulin but does not respond to diet and exercise. (mydr.com.au)
Metformin-GA can also be used in patients with type 1 diabetes mellitus where insulin alone is not enough to control blood glucose levels. (mydr.com.au)
Metformin-associated lactic acidosis. (medscape.com)
If glycemic control needs to be improved with medication in persons with type 2 diabetes, metformin should be prescribed because it can efficiently lower glycemic levels, is linked to losing weight and fewer occurrences of hypoglycemia, and is generally less expensive than other options. (aafp.org)
Metformin is usually prescribed as first line therapy for type 2 diabetes mellitus (DM2). (biomedcentral.com)
In patients with type 2 diabetes, long-term metformin treatment and smoking are associated with higher chances of developing vitamin B12 deficiency. (greenmedinfo.com)
Metformin and sulfonylurea drugs are associated with adverse side effects such as lactic acidosis and hypoglycemia, including fatal incidences. (greenmedinfo.com)
Metformin reduces insulin doses in type 1 diabetes, but does not reduce the rate of glycated hemoglobin (HbA 1c), nor is it clear whether the benefit is sustained beyone 1 year or has any benefit to cardiovascular or other key clinical outcomes. (greenmedinfo.com)
Glipizide and metformin hydrochloride tablets USP contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes, glipizide and metformin hydrochloride. (nih.gov)
Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes. (nih.gov)
Glipizide and metformin hydrochloride tablets combine glipizide and metformin hydrochloride, 2 antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with type 2 diabetes. (nih.gov)
Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. (nih.gov)
For example, metformin carries a potential increased risk for lactic acidosis and should not be used in patients with renal insufficiency. (medscape.com)

A single intravenous dose of DCA rapidly improved lactic acidosis in African children with severe malaria, suggesting that DCA may be a useful adjunct in the initial treatment of these patients, and may increase their chance of survival by improving a major complication of their illness. (ox.ac.uk)

Type B lactic acidosis secondary to hematologic malignancy is important to recognize. (bvsalud.org)

Lactic acidosis frequently complicates severe malaria in African children, and is a strong independent predictor of mortality. (ox.ac.uk)

We report a clinically heterogeneous, multigenerational pedigree with the syndrome of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) associated with a mutation at nucleotide 3243 in the mitochondrial DNA tRNA(Leu)(UUR) gene. (nih.gov)
The eventual development of status epilepticus, associated with a T(1) hypointense as well as T(2), fluid-attenuated inversion recovery, and diffusion-weighted hyperintense brain lesion led to pathologic and genetic testing that identified a A3243G mitochondrial DNA point mutation associated with mitochondrial, encephalomyopathy, lactic acidosis, and strokelike episodes. (nih.gov)
This case emphasizes that occipital epileptic seizures can be the only presenting and long-lasting sign in patients with mitochondrial, encephalomyopathy, lactic acidosis, and strokelike episodes. (nih.gov)
Lactic acidosis typically occurs when lactic acid production exceeds clearance, often in the setting of impaired tissue oxygenation and defective mitochondrial oxygenation. (logicalimages.com)
mitochondrial encephalopathy , lactic acidosis, and stroke-like episodes (MELAS), a rare form of dementia . (medicinenet.com)

With a persistent oxygen debt and overwhelming of the body's buffering abilities (whether from long-term dysfunction or excessive production), hyperlacticaemia and metabolic acidosis ensue, commonly referred to as lactic acidosis. (medscape.com)
Lactic acidosis can occur due to the liver and kidneys' inability to filter lactic acid from the blood and break it down into glucose, the body's main energy source. (healthnews.com)
Also, lactic acid filtered by the kidneys and liver is converted into glucose, the body's energy source. (healthnews.com)
The most common cause of lactic acidosis is severe medical illness in which blood pressure is low and too little oxygen is reaching the body's tissues. (mountsinai.org)
Type 2 diabetes interferes with the body's natural system of responding to insulin as the body becomes less sensitive to its own insulin. (liquid-nutrition-vitamins.com)

A third type, D-lactic acidosis (D-lactate encephalopathy) is an unusual form of lactic acidosis. (msdmanuals.com)
Arg82*) in COX16 with hypertrophic cardiomyopathy, encephalopathy and severe fatal lactic acidosis, and isolated complex IV deficiency. (amsterdamumc.org)

Lactic acidosis may not necessarily produce acidemia in a patient. (medscape.com)
Thus, hyperlactatemia or lactic acidosis may be associated with acidemia, a normal pH, or alkalemia. (medscape.com)
Lactate exits the hepatocyte, causing clinically significant lactic acidemia in proportion to the degree of stimulus for glycogen breakdown. (medscape.com)

By the turn of the 20th century, many physicians recognized that patients who are critically ill could exhibit metabolic acidosis unaccompanied by elevation of ketones or other measurable anions. (medscape.com)
D-lactic acidosis - Occurs in patients with short gut syndrome or malabsorption due to bacterial fermentation of large amounts of glucose and starch to organic acids, including D-lactic acid. (logicalimages.com)
Patients present with episodic metabolic acidosis as well as altered mental status, ataxia, loss of memory, or slurred speech. (logicalimages.com)
In a double blind randomized clinical trial, we investigated 200 type 2 diabetic patients after coronary artery bypass surgery in the open heart ICU of the Mazandaran Heart Center, and randomly assigned them to equal intervention and control groups. (touchcardio.com)
Many patients with type 2 diabetes will eventually need to take insulin by injection. (rxlist.com)
Oral diabetes medications are used to improve blood sugar (glucose) control in patients with type 2 diabetes . (medicinenet.com)
Acute decompensation in thiamine-deficient patients may manifest as neurologic or cardiovascular changes, with severe lactic acidosis as the presenting symptom. (thieme-connect.de)
In patients with jejunoileal bypass or intestinal resection and resultant short bowel syndrome, excess D-lactic acid is produced and is systemically absorbed. (msdmanuals.com)
Metabolic acidosis is among the most common abnormalities seen in patients suffering from critical illness. (biomedcentral.com)
Type B lactic acidosis is rare among patients with malignant diseases. (elsevierpure.com)
Although type B lactic acidosis may more commonly occur in patients with leukemia or lymphoma, it may rarely present in patients with rapidly progressive and refractory MM. (elsevierpure.com)
A popular drug type, proton pump inhibitors (PPIs), that is used to treat heartburn and stomach ulcers has been found to improve blood sugar control in patients with diabetes when used in addition to their usual treatment. (diabetesnews.com)
This specific etiology of lactic acidosis occurs without organ hypoperfusion and has been most commonly described in patients with hematologic malignancies but also in patients with solid tumors. (bvsalud.org)
Without treating the underlying malignancy, the prognosis for patients diagnosed with malignancy-related type B lactic acidosis is extremely poor. (bvsalud.org)

Numerous etiologies may be responsible for the presence of lactic acidosis, most commonly circulatory failure and hypoxia. (medscape.com)
Insulin resistance is a condition that is commonly seen in type 2 diabetes, where it becomes difficult for the body to use the insulin that is produced. (rxlist.com)
Lactic acidosis is commonly seen in people over 40. (healthnews.com)

Shah, S & Wald, E 2015, ' Type B lactic acidosis secondary to thiamine deficiency in a child with malignancy ', Pediatrics , vol. 135, no. 1, pp. e221-e224. (northwestern.edu)
1 Svahn J, Schiaffino MC, Caruso U, Calvillo M, Minniti G, Dufour C. Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy. (thieme-connect.de)

Kombiglyze XR is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus . (drugs.com)
Lactic acidosis may also occur in association with a number of pathophysiologic conditions, including diabetes mellitus, and whenever there is significant tissue hypoperfusion and hypoxemia or significant renal dysfunction. (pdr.net)
Type II - Non insulin Dependent Diabetes Mellitus (NIDDM) or maturity onset diabetes. (mydr.com.au)
Do you have type 1 diabetes mellitus that is well controlled by insulin alone? (mydr.com.au)
Type 2 diabetes mellitus, which occurs in up to 95% of persons with diabetes, is typically managed with lifestyle modifications (e.g., diet, exercise) and medication (e.g., oral drugs). (aafp.org)
Type 2 diabetes mellitus (DM2) is a prevalent chronic disease worldwide. (biomedcentral.com)
This drug is used to treat type 2 diabetes and is also known as non-insulin-dependent diabetes mellitus. (wdxcyber.com)

It also occurs as a result on markedly increased transient metabolic demand (eg, postseizure lactic acidosis). (medscape.com)
However, it typically occurs when the body produces excessive amounts of lactic acid, than desired. (healthnews.com)
Type A lactic acidosis, the most serious form, occurs when lactic acid is overproduced in ischemic tissue-as a byproduct of anaerobic generation of ATP ( adenosine triphosphate) during oxygen deficit. (msdmanuals.com)
Type B lactic acidosis occurs in states of normal global tissue perfusion (and hence ATP production) and is less ominous. (msdmanuals.com)

Several decades later, Huckabee's seminal work firmly established that lactic acidosis frequently accompanies severe illnesses and that tissue hypoperfusion underlies the pathogenesis. (medscape.com)
Type A lactic acidosis - Associated with tissue hypoperfusion caused by circulatory failure from shock, which can be due to many things including sepsis, heart failure, hypovolemia, neurologic compromise, or respiratory failure. (logicalimages.com)

Dysphagia, Lactic Acidosis, Hyperbilirubinemia, Renal Failure in Cirrhosis He was discharged with gastroenterology follow-up and ultimately underwent esophagogastroduodenoscopy which demonstrated narrowing of the distal esophagus suggestive of a peptic stricture. (illnesshacker.com)

For example, having lactic acidosis due to sepsis means the doctor will take a targeted approach to managing sepsis. (healthnews.com)

Lactic acidosis is caused by elevated levels of lactic acid in the blood due to several factors used to characterize the two types of lactic acidosis: type A and type B. Lactic acidosis type A is a common type resulting from an inadequate supply of oxygen to the blood tissue. (healthnews.com)

Neurologic symptoms, including confusion, ataxia, and slurred speech, occur after a high-carbohydrate ingestion and are characteristic of D-lactic acidosis. (msdmanuals.com)

Lactic acidosis is typically the result of an underlying acute or chronic medical condition, medication, or poisoning. (wikipedia.org)

Lactic acidosis should be suspected in any diabetic patient with metabolic acidosis lacking evidence of ketoacidosis (ketonuria and ketonemia). (pdr.net)
TZDs carry a identified threat of diabetic macular edema (DME), an particularly damaging type of diabetic retinopathy that impacts our keenest imaginative and prescient within the middle of our eyesight. (genkiwellness.com)

lactic acidosis -0.27±0.05. (uzh.ch)

Type B lactic acidosis is an uncommon medical emergency in which acid production overwhelms hepatic clearance. (bvsalud.org)
Because free glucose is the product of the hepatic glucose-6-phosphatase reaction, either type leads to accumulation of liver glycogen, accompanied by fasting hypoglycemia . (medscape.com)

Children with pyruvate carboxylase deficiency type A typically survive only into infancy or early childhood. (medlineplus.gov)

Type 2 diabetes is a condition in which the body does not process insulin properly, resulting in elevated blood sugar ( blood glucose ). (rxlist.com)
Type I - Insulin dependent diabetes or juvenile onset diabetes, when insulin alone is not enough to control blood glucose levels. (mydr.com.au)

We report a new the United States are ST1 and agr allele type 3, but some fatal case of necrotizing pneumonia. (cdc.gov)
Here we report with an agr 1 allele and of a new sequence type 377 was a fatal case of necrotizing pneumonia involving a 59-year- recovered, representing a new, emerging, community- old woman infected by a new clone of PVL-positive CA- acquired methicillin-resistant clone. (cdc.gov)

Type B lactic acidosis as a severe metabolic complication in lymphoma and leukemia: a case series from a single institution and literature review. (thieme-connect.de)

Lactic acid promotes tissue healing by enhancing the physiological processes involved in creating new body tissue. (healthnews.com)
It is contraindicated in persons with decreased tissue perfusion, hemodynamic instability, advanced liver disease, alcohol abuse, acute unstable congestive heart failure, and conditions that can result in lactic acidosis. (aafp.org)

Lactic acidosis is a medical condition characterized by a build-up of lactate (especially L-lactate) in the body, with formation of an excessively low pH in the bloodstream. (wikipedia.org)
It is characterized by excessive amounts of lactic acid in the bloodstream due to oxygen deprivation. (healthnews.com)
Lactic acidosis refers to lactic acid build up in the bloodstream. (mountsinai.org)

The prognosis is better than type A. (gpnotebook.com)

The latest updates about care for type 2 diabetes can be found in the American Diabetes Association's 2023 Standards of Medical Care , which lists treatment guidelines related to diabetes, complications, new technology, and more. (everydayhealth.com)

5% Dextrose and Electrolyte No. 75 Injection (multiple electrolytes and dextrose injection, type 3) is a fluid and electrolyte replenishment and caloric supply used as a source of water, electrolytes and calories or as an alkalinizing agent. (rxlist.com)
Our 5% Dextrose and Electrolyte No. 75 Injection (multiple electrolytes and dextrose injection, type 3) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
5% Dextrose and Electrolyte No. 75 Injection (5% dextrose and electrolyte no. 75 inj) (Multiple Electrolytes and Dextrose Injection, Type 3, USP) is a sterile, nonpyrogenic solution for fluid and electrolyte replenishment and caloric supply in a single dose container for intravenous administration. (rxlist.com)
5% Dextrose and Electrolyte No. 75 Injection (5% dextrose and electrolyte no. 75 inj) (Multiple Electrolytes and Dextrose Injection, Type 3, USP) administered intravenously has value as a source of water, electrolytes, and calories. (rxlist.com)
5% Dextrose and Electrolyte No. 75 Injection (Multiple Electrolytes and Dextrose Injection, Type 3, USP) is indicated as a source of water, electrolytes and calories or as an alkalinizing agent. (rxlist.com)

Type B lactic acidosis is an underrecognized clinical entity that must be distinguished from type A (hypoxic) lactic acidosis. (northwestern.edu)
No clinical features are unique to lactic acidosis. (healthnews.com)
In the critically ill, metabolic acidosis is a common observation and, in clinical practice, the cause of this derangement is often multi-factorial. (biomedcentral.com)
Thirdly, alternative classifications that consider phenotypic attributes, such as being vector-borne (e.g., 'arboviruses'), infecting a certain type of host (e.g., 'mycoviruses,' 'bacteriophages') or displaying specific pathogenicity (e.g., 'human immunodeficiency viruses'), may serve important clinical and regulatory purposes but often create polyphyletic categories that do not reflect evolutionary relationships. (cdc.gov)

Here, we present a case of a 66-year-old male who was diagnosed with type B lactic acidosis secondary to mantle cell lymphoma. (bvsalud.org)

Despite the frequency with which non-bicarbonate-losing forms of metabolic acidosis such as lactic acidosis occ. (biomedcentral.com)
When should sodium bicarbonate be given, and what are the recommendations on administration of fluid types? (ebmedicine.net)
Bicarbonate drip was started to correct the lactic acidosis. (bvsalud.org)

Pyruvate carboxylase deficiency is an inherited disorder that causes lactic acid and other potentially toxic compounds to accumulate in the blood. (medlineplus.gov)
Researchers have identified at least three types of pyruvate carboxylase deficiency, which are distinguished by the severity of their signs and symptoms. (medlineplus.gov)
Pyruvate carboxylase deficiency type B has life-threatening signs and symptoms that become apparent shortly after birth. (medlineplus.gov)
A milder form of pyruvate carboxylase deficiency, sometimes called type C, has also been described. (medlineplus.gov)

Changes or mutations that occur in the DNA sequence of a single gene cause this type of inheritance. (medicinenet.com)

People who have uncontrolled diabetes, or liver, kidney, or heart diseases are at a higher risk of developing lactic acidosis than those without these comorbidities. (healthnews.com)
This is caused by a buildup of lactic acid in the blood and it happens most often with people who have kidney problems. (wdxcyber.com)

In 1925, Clausen identified the accumulation of lactic acid in blood as a cause of acid-base disorder. (medscape.com)
This type of genetic disorder is caused by mutations in the non-nuclear DNA of mitochondria. (medicinenet.com)
Helping the body to utilize its own insulin is of the utmost importance in treating type 2 diabetes, as this disorder is caused by insulin resistance. (liquid-nutrition-vitamins.com)
Symptoms and signs of lactic acidosis are dominated by those of the underlying disorder (eg, shock in Type A, toxin ingestion in Type B). (msdmanuals.com)

In some cases, episodes of lactic acidosis are triggered by an illness or periods without food (fasting). (medlineplus.gov)

Symptoms in humans include all those of typical metabolic acidosis (nausea, vomiting, generalized muscle weakness, and laboured and deep breathing). (wikipedia.org)
Type A, which has been identified mostly in people from North America, has severe symptoms that begin in infancy. (medlineplus.gov)
This type is characterized by slightly increased levels of lactic acid in the blood and minimal signs and symptoms affecting the nervous system. (medlineplus.gov)
The onset of lactic acidosis often is subtle, and accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress. (pdr.net)

Characteristic features include developmental delay and a buildup of lactic acid in the blood (lactic acidosis). (medlineplus.gov)

In 1929, von Gierke provided the initial description of glycogen-storage disease type I (GSD I) from autopsy reports of 2 children whose large livers contained excessive glycogen. (medscape.com)

Diseases5

Chemicals and Drugs2

Higher risk of lactic acidosis1

Causes of lactic acidosis2

Anion gap5

Management of lactic acidosis2

Development of lactic acidosis2

Metabolism15

Dichloroacetate2

Diagnosis4

Metformin27

Children with severe malaria1

Hematologic malignancy1

Severe malaria1

Mitochondrial5

Body's5

Encephalopathy2

Acidemia3

Patients14

Commonly3

Thiamine Deficiency2

Diabetes Mellitus7

Occurs4

Hypoperfusion2

Renal failure1

Sepsis1

Caused by elevated1

Ataxia1

Chronic1

Diabetic2

0.051

Hepatic2

Typically1

Glucose2

Fatal2

Complication1

Tissue2

Bloodstream3

Prognosis1

20231

Electrolyte5

Clinical4

Secondary1

Bicarbonate3

Deficiency4

Occur1

Kidney2

Disorder4

Episodes1

Symptoms4

Characteristic1

Excessive1