• Since miR-192 was shown to regulate extracellular matrix proteins Collagen, type I, α1 and α2 (Col1α1 and 2) that accumulate during diabetic nephropathy, miR-192 may play a role in kidney diseases as well. (wikipedia.org)
  • A correlation between elevated Notch signaling pathway gene expression, which is important for cell to cell communication, and diabetic nephropathy has also been shown. (wikipedia.org)
  • Diabetes mellitus (DM) is associated with macrovascular and microvascular complications (coronary artery disease, ischemic stroke, peripheral arterial disease, nephropathy, and retinopathy) [ 1 , 2 ]. (hindawi.com)
  • Diabetic nephropathy (DN) is one of the most serious complications of DM. (biomedcentral.com)
  • Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
  • Epigenetics may play a role in a wide array of vascular complications and in diabetes. (wikipedia.org)
  • Prevention of vascular disorders in diabetic patients using dietary supplements ART LIFE. (rv.ua)
  • In DM risk of death from myocardial infarction or other vascular accident is 4-5 times higher than that in the absence of diabetes. (rv.ua)
  • Frequent and serious complication of diabetes are also oklyuzionnye vascular limbs, which usually leads to the development of gangrene and amputation, which in turn causes the growth of early disability of patients and deaths. (rv.ua)
  • When there are two types of diabetes vascular lesion: large - macroangiopathy and small - microangiopathy. (rv.ua)
  • 2. Schmidt AM, Crandall J , Hori O, Cao R and Lakatta E. Elevated plasma levels of vascular cell adhesion molecule-1 (VCAM-1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease. (einsteinmed.edu)
  • The role of chronic administration of antiplatelet drugs in primary prevention of arterial vascular events is known to be less clear than in secondary prevention, and, also in diabetic patients, the decision to give primary prophylaxis should be taken on an individual-patient basis, after a careful evaluation of the balance between the expected benefits and the risk of major bleedings. (hindawi.com)
  • Although, currently, treatment has proven useful in reducing vascular events, diabetic patients continue to have a higher risk of adverse cardiovascular events compared with those in nondiabetic patients. (hindawi.com)
  • This paper reviews the role of currently available antiplatelet drugs in primary and secondary prevention of vascular events in diabetic patients and the limitations of these drugs, and it discusses the role of novel and more potent antiplatelets and of new agents currently under clinical development. (hindawi.com)
  • See Clinical Findings in Diabetes Mellitus, a Critical Images slideshow, to help identify various cutaneous, ophthalmologic, vascular, and neurologic manifestations of DM. (medscape.com)
  • It can also be assumed that the worsening of arterial stiffness in the group of patients with AG+SН is more pronounced, given the significantly higher vascular age in this group of patients, associated with an increase in the number of comorbid pathology, compared with the AН group. (orscience.ru)
  • The most pronounced deterioration of diurnal arterial stiffness indicators in the group of comorbid patients with EAH and SН, as well as the excess of vascular age over chronological and reliable correlation with the comorbidity index, revealed during the study, suggests an assessment of these indicators in patients with cardioendocrine pathology to assess the true risk cardiovascular complications and the selection of adequate therapy. (orscience.ru)
  • Superoxide anion can modulate vascular smooth muscle tone and is potentially involved in diabetic vascular complications. (diabetesjournals.org)
  • The present study was undertaken to characterize both vascular production and the enzymatic source of superoxide anion in type 2 diabetic rats. (diabetesjournals.org)
  • Vascular complications are responsible for the excess mortality associated with diabetes ( 1 ), and impaired endothelium-dependent vasodilation has been described in humans and in animal models of the disease ( 2 - 6 ). (diabetesjournals.org)
  • ABSTRACT Chronic diseases such as diabetes and vascular disease are a major public health problem in Lebanon, where primary care is not well developed. (who.int)
  • Yet the rising was to highlight the major burden of reason) for surgery according to the incidence of diabetes and vascular dis- amputation and to set standards for patient's hospital record. (who.int)
  • A large clinical study found that peripheral vascular disease (PAD) in patients with T2DM is a serious complication. (biomedcentral.com)
  • The aim of this study was to develop a method to evaluate IS in peripheral lymphocytes to identify altered intracellular molecules in patients with MetS to use as risk biomarkers of vascular thrombosis. (biomedcentral.com)
  • Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes : Beyond Hyperglycemia. (ejournals.ca)
  • Diabetes mellitus (referred to as diabetes below) is a chronic progressive disease characterized by uncontrolled hyperglycemia and a series of metabolic disorders. (biomedcentral.com)
  • Diabetes is a methabolic disease characterized by hyperglycemia, with high morbidity and mortility worldwide. (scialert.net)
  • Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
  • Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
  • Subcategory levels first specify the type of complication by system, such as diabetes with kidney complications, ophthalmic complications, neurological complications, and circulatory complications. (medicalbillingcodings.org)
  • CONCLUSION: Tight blood pressure control in patients with hypertension and type 2 diabetes achieves a clinically important reduction in the risk of deaths related to diabetes, complications related to diabetes, progression of diabetic retinopathy, and deterioration in visual acuity. (ox.ac.uk)
  • Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
  • To identify the features of the daily dynamics of arterial stiffness in patients with essential arterial hypertension (EАH) and subclinical hypothyroidism (SH). (orscience.ru)
  • Retina is as a rule damaged in case of the following diseases: hypertension, diabetes mellitus, renal insufficiency etc. (suaway.com)
  • 4. Analysis of polymorphism of the D11S2008 locus of the catalase gene in patients with hypertension and ischemic heart disease in non-insulin-dependent diabetes mellitus in the Muscovite population. (klinika-tverskaya.ru)
  • Hypertension and cerebral amyloid angiopathy (CAA) are the most common causes of primary ICH, but the mechanism of hemorrhage in both conditions is unclear. (nature.com)
  • In primary ICH, hypertension is thought to be the underlying cause in 65% of cases, followed by cerebral amyloid angiopathy (CAA). (nature.com)
  • Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya. (cdc.gov)
  • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. (ox.ac.uk)
  • OBJECTIVE: To determine whether tight control of blood pressure prevents macrovascular and microvascular complications in patients with type 2 diabetes. (ox.ac.uk)
  • Diabetes mellitus (DM) is associated with macrovascular and microvascular complications. (hindawi.com)
  • 2 being neuropathy. (who.int)
  • A combination of host factors, including neuropathy, angiopathy, and immunopathy, combine to make the diabetic foot infection the most severe infection commonly seen by podiatrists. (japmaonline.org)
  • A type of neuropathy resulting in pain, weakness and/or wasting in the muscles. (diabetes.org)
  • CAN was defined as the presence of at least two abnormal tests or an autonomic neuropathy points ≥2. (e-enm.org)
  • Cardiac autonomic neuropathy (CAN) is one of the most common complications of diabetes, and represents a significant cause of morbidity and mortality in diabetic patients. (e-enm.org)
  • Peripheral neuropathy is a common complication of diabetes which affects one of every three patients with type II diabetes. (orangenl.com)
  • During the last three decades, there were no advances in the field of diabetic neuropathy and microangiopathy. (orangenl.com)
  • Diabetic neuropathy and microangiopathy are reversible and curable then diabetic ulcers would be easily treatable and preventable by topical application of NeuroCore. (orangenl.com)
  • MAIN OUTCOME MEASURES: Predefined clinical end points, fatal and non-fatal, related to diabetes, deaths related to diabetes, and all cause mortality. (ox.ac.uk)
  • The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) code for type 1 diabetes without complications is E10.9. (medscape.com)
  • The most severe clinical manifestations of diabetes develops in the presence of microangiopathy in the retina and kidney. (rv.ua)
  • Dr. Crandall is Professor of Medicine at Albert Einstein College of Medicine, where she is director of the Diabetes Clinical Trials Unit and a principal investigator for several NIH sponsored clinical trials, including the Diabetes Prevention Program Outcome Study (for which she holds several national leadership positions, including Executive Committee membership) and the Glycemia Reduction Approaches in Diabetes (GRADE) study. (einsteinmed.edu)
  • The role of novel and more potent antiplatelet strategies, currently under clinical development, seems attractive in diabetic patients. (hindawi.com)
  • Large clinical trials have shown that antiplatelet agents are effective in the prevention of recurrent cardiovascular events in diabetes. (hindawi.com)
  • Bristol Myers Squibb thanks the patients and investigators involved in the CheckMate -67T clinical trial. (businesswire.com)
  • His research interests focus on clinical trials in patients with heart failure. (espacecrm2023.org)
  • The recommendations can be accessed at American Diabetes Association DiabetesPro Professional Resources Online, Clinical Practice Recommendations - 2015. (medscape.com)
  • Updated clinical guidelines "Standards of specialized diabetes care", 9th Edition. (orscience.ru)
  • This clinical study enrolled 163 type 2 diabetes mellitus (T2DM) patients, who were divided into the diabetes with DF (84 cases) group, diabetes with no DF (79 cases) group. (biomedcentral.com)
  • Angle α, k-value and fibrinogen have clinical significance on the risk of occurrence and development of diabetic foot, which can contribute to early diagnosis and early clinical intervention in DF. (biomedcentral.com)
  • A large clinical study found that the prevalence of PAD in patients with T2DM was 23.5% [ 2 ], and diabetic patients with combined PAD are more likely to develop ulceration and gangrene of the limb, significantly increasing the risk of amputation. (biomedcentral.com)
  • The present clinical case is that of a man with the renal complications of scleroderma and the difficulties of the treatment even in the developed countries like France. (scirp.org)
  • Early detection of complications through a minimal clinical examination supplemented with paraclinic tests has proved necessary. (scirp.org)
  • In the clinical 2 practice this preparation turned out to be highly effective in the treatment of the aftereffects of retinal veins thrombosis, glaucoma, haemorrhagic retinopathies, retinal sun and laser burns and many other diseases. (antiaging-peptides.com)
  • However, very little data are available on IS of circulating cells of MetS patients although clinical data show that inhibited mTOR, with specific inhibitors such as Serolimus or Everolimus after kidney transplantation, significantly increase the presence of de novo thrombotic micro-angiopathy with artery lesion characterized by intimal cell proliferation, necrosis and narrowed lumen. (biomedcentral.com)
  • Despite rampant use in Brazil, with thousands of patients seeking injections for cellulite, back rolls, and lower eyelid fat pad herniation, Lipostabil was banned in December 2002 for cosmetic use by ANVISA, the Brazilian equivalent of the FDA, as there were no clinical trials supporting efficacy or safety of the drug. (jcadonline.com)
  • Since Type 2 diabetes is characterized by chronic hyperglycaemia as a result of impaired pancreatic beta cell function and insulin resistance in peripheral tissues, it was thought that the gene might be downregulated in type 2 diabetes patients through DNA methylation. (wikipedia.org)
  • Growth hormone (GH) exerts many of its effects via the synthesis and release of IGF-I. IGF-I has been variably associated with diabetic microvascular disease, and a transient rise in IGF-I has been reported in the early phase of neovascularization of the retina ( 2 ). (diabetesjournals.org)
  • Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, accounting for more than 431,000 new cases and 179,000 deaths worldwide each year. (businesswire.com)
  • Adapted from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (diabetes.org)
  • Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
  • Foot infection is the single most common reason for hospitalization of the diabetic patient. (japmaonline.org)
  • Recent studies have shown that diabetic microangiopathies are associated with macroangiopathies and suggest that microangiopathies may have a prominent role in the pathogenesis of microangiopathy development [ 2 ]. (e-enm.org)
  • Women who suffered from polycystic ovary syndrome (a common condition characterized by irregular menstrual periods, obesity ) increase the risk of diabetes. (deepayurveda.com)
  • DM, primarily type 2 DM (T2DM) is often associated with obesity, hypertriglyceridemia, and high cholesterol and is a risk factor for TB. (ejournals.ca)
  • Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA) Concentrations in Patients with Obesity and the Risk of Obstructive Sleep Apnea (OSA). (cdc.gov)
  • The IGF system has been associated with development and progression of diabetic retinopathy. (diabetesjournals.org)
  • We examined whether a simple measurement of the IGF system (serum total IGF-I) correlated with progression of diabetic retinopathy in pregnancy in type 1 diabetes. (diabetesjournals.org)
  • Pregnancy is a prominent risk factor for the development and progression of retinopathy in women with type 1 diabetes. (diabetesjournals.org)
  • The aim of the present study was to examine the correlation between serum IGF-I and progression of retinopathy in diabetic pregnancy in 103 pregnant women with type 1 diabetes. (diabetesjournals.org)
  • Research suggests that fibrinogen (Fib) concentrations are used to assess the occurrence and severity of diabetic foot (DF) and to monitor the progression of diabetic foot in patients. (biomedcentral.com)
  • Therefore, finding indicators that predict the risk of occurrence and progression of diabetic foot and early intervention can help improve the quality of life. (biomedcentral.com)
  • There is a lack of uniform quantitative standards for biomarkers that predict the risk of diabetic foot occurrence and progression. (biomedcentral.com)
  • Diabetic retinopathy (DR), one of the leading causes of blindness and vision impairment, is suggested to exhibit functional and structural changes in retinal neurons as the earliest manifestation, which could be used to predict the progression of related angiopathy. (biomedcentral.com)
  • OPDIVO is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) with progression on or after platinum-based chemotherapy. (opdivohcp.com)
  • Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving OPDIVO. (opdivohcp.com)
  • Diabetic angiopathy is one of the most common complications that arise from chronic diabetes. (bauerfeind.ca)
  • Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
  • During chronic diabetes and tends to progress, but we know that good diabetes compensation in light of its forms is possible to achieve long-term remission, while moderate forms can be transformed into light and heavy forms - a moderate. (rv.ua)
  • Ayurvedic Treatment of Diabetes - Diabetes disease is described as a severe and chronic metabolic disorder characterized by elevated levels of blood glucose or blood sugar, which leads over time to serious damage to the blood vessels, eyes, heart, kidneys , and nerves . (deepayurveda.com)
  • It is not clear whether microangiopathies are associated with subclinical atherosclerosis in type 2 diabetes mellitus (T2DM). (e-enm.org)
  • Although the precise underlying mechanisms linking the diabetic microangiopathies and macroangiopathies are unclear, some evidence suggests that the effects of microangiopathies may be linked to subclinical atherosclerosis [ 3 - 5 ]. (e-enm.org)
  • Carotid atherosclerosis as estimated by carotid intima-media thickness (CIMT) and plaques is considered to reflect an early stage of atherosclerotic disease and is therefore used as a surrogate marker for diabetic macroangiopathies [ 6 - 8 ]. (e-enm.org)
  • So far, studies on the relationship between diabetic microangiopathies and carotid atherosclerosis have yielded inconsistent results. (e-enm.org)
  • Aassociations between carotid atherosclerosis and both urine albumin excretion (UAE) and glomerular filtration rate (GFR) in diabetic patients have been investigated, but these studies showed only inconsistent results [ 5 , 13 , 14 ]. (e-enm.org)
  • The most well-known of these early agents was Lipostabil Endovena® (Aventis Pharma, Germany), an intravenous agent for the treatment of hyperlipidemia, fat emboli, diabetic angiopathy, atherosclerosis, and other intravascular lipid abnormalities. (jcadonline.com)
  • [ 5 ] Benefits of tight glycemic control include not only continued reductions in the rates of microvascular complications but also significant differences in cardiovascular events and overall mortality. (medscape.com)
  • Real-time continuous monitoring of glucose-using continuous glucose monitors (CGMs)-can help patients improve glycemic control. (medscape.com)
  • Survey data (response rate 86.2%) and administrative databases were used to assess diabetes severity, glycemic control, quality of life, microvascular and macrovascular risks and complications, preventive care, utilization, and perceptions of diabetes. (healthpartners.com)
  • RESULTS: Compared to those aged 45-64 years (N = 627), those 65 and older (N = 482) had better glycemic control, better health-related behaviors, and perceived less adverse impacts of diabetes on their quality of life despite longer duration of diabetes and a prevalence of cardiovascular disease twice that of younger patients. (healthpartners.com)
  • A close relationship between poor glycemic control and increased platelet activity (estimated by measuring mean platelet volume-MPV-as part of whole blood count) in patients with type 2 DM has been suggested [ 4 ]. (hindawi.com)
  • Long term diabetes and poor glycemic control are the most important risk factors for DN development ( DCCT Research Group, 1993 ). (scialert.net)
  • To evaluate fitness of Contour® TS glucometer (Contour® TS, Bayer/Ascensia*) - a system for blood glycemia level control, and its characteristics in everyday use for Russian patients with insulin dependent diabetes mellitus (DM) types 1 and 2 and endocrinologists. (orscience.ru)
  • In diabetes mellitus in first place on the frequency of lesions is the cardiovascular system. (rv.ua)
  • Moreover, the concomitant presence of multiple "classical" cardiovascular risk factors in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
  • Cardiovascular (CV) diseases are the leading cause of morbidity and mortality in diabetic patients. (hindawi.com)
  • The leading cause of death in type 2 diabetes mellitus (T2DM) is cardiovascular disease (CVD) [ 1 ]. (e-enm.org)
  • Patients with metabolic syndrome (MetS) have an increased risk of cardiovascular disease. (biomedcentral.com)
  • and five patients experienced temporary renal impairment. (who.int)
  • CheckMate -67T is a Phase 3 randomized, open-label trial evaluating subcutaneous administration of Opdivo co-formulated with Halozyme's proprietary recombinant human hyaluronidase, rHuPH20, or subcutaneous nivolumab (nivolumab and hyaluronidase) compared to intravenous (IV) Opdivo , in patients with advanced or metastatic clear cell renal cell carcinoma (ccRCC) who have received prior systemic therapy. (businesswire.com)
  • He was admitted to the surgical intensive care unit of the CHRU La Cavale Blanche of Brest on 12 September, 2015 for decompensated diabetic ketoacidosis, acute renal failure and hemolytic anemia. (scirp.org)
  • OPDIVO ® (nivolumab), in combination with YERVOY ® (ipilimumab), is indicated for the first-line treatment of adult patients with intermediate or poor risk advanced renal cell carcinoma (RCC). (opdivohcp.com)
  • OPDIVO is indicated for the treatment of adult patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy. (opdivohcp.com)
  • After nine years of follow up the group assigned to tight blood pressure control also had a 34% reduction in risk in the proportion of patients with deterioration of retinopathy by two steps (99% confidence interval 11% to 50%) (P=0.0004) and a 47% reduced risk (7% to 70%) (P=0.004) of deterioration in visual acuity by three lines of the early treatment of diabetic retinopathy study (ETDRS) chart. (ox.ac.uk)
  • The women were scheduled for ophthalmologic examination, including visual acuity testing and fundus photography, before pregnancy, once in each trimester, and 4 months after birth, according to the principles defined in the Early Treatment for Diabetic Retinopathy Study ( 6 ). (diabetesjournals.org)
  • For the treatment of patients with diabetes secondary to severe disease herbs can be used as aids to the calculation of the possible lower dosages of medicines, providing a more long-term remission, prevention of complications. (rv.ua)
  • Tomsk and Voronezh have been studied biologically active food additives (BAA) MEMORY RISE (production company ARTLIFE ) for the prevention and treatment of diabetic angiopathies, including diabetic foot. (rv.ua)
  • The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. (einsteinmed.edu)
  • Adherence to preventive medication: predictors and outcomes in the Diabetes Prevention Program. (einsteinmed.edu)
  • Diabetes prevention, detection and management should be prioritized in any attempt to reduce the current incidence of amputation in Lebanon. (who.int)
  • In Lebanon, the preva- could be achieved in order to support main indication was recorded for each lence of type 2 diabetes was 13.1% for the development of programmes for patient from either trauma, diabetes, those aged 30+ years in 1994-95 [2] amputation prevention and care. (who.int)
  • Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
  • ABSTRACT The effect of different antibiotics on the outcome of surgical care in the management of diabetic foot was investigated. (who.int)
  • Follow-up results will be featured in an oral presentation (Abstract #OA14.03) and have been selected for the official press program at the IASLC 2023 World Conference on Lung Cancer (#WCLC23) hosted by the International Association for the Study of Lung Cancer on September 11, 2023, from 2:32 a.m. to 2:42 a.m. (advfn.com)
  • The rapidly increasing prevalence of diabetes and its related complications do not only affect the morbidity and mortality of patients, but also bring huge medical and economic burdens to society worldwide. (biomedcentral.com)
  • Diabetes mellitus (DM) could be classified as type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM) and others according to etiology and pathology. (biomedcentral.com)
  • Since Mycobacterium tuberculosis (Mtb) relies on host nutrients, lipids, and cholesterol to survive, more knowledge about the nutritional status and lipid profile of T2DM, TB, and TB-T2DM patients is needed in order to establish novel TB management strategies for TB-T2DM patients. (ejournals.ca)
  • Cross-sectional study was conducted to compare the nutritional status and lipid profile of TB-T2DM, TB, and T2DM only patients using data collected from several Primary Health Cares in Bandung, Indonesia. (ejournals.ca)
  • In total, 77 TB-T2DM, TB only, and T2DM only patients treated at the Primary Health Care Centers in Bandung, Indonesia, were recruited. (ejournals.ca)
  • All lipid profiles showed a similar pattern with the T2DM without TB having the highest lipid levels, followed by TB-T2DM and TB patients. (ejournals.ca)
  • Three types of diabetes are mentioned: Type 1, Type 2, and Gestational diabetes. (deepayurveda.com)
  • When this condition happens, too little glucose gets into your cells, and too many stays in your blood, resulting in gestational diabetes. (deepayurveda.com)
  • Patients with type 1 diabetes require lifelong insulin therapy. (medscape.com)
  • With this in mind, there is no doubt that, to prevent severe complications of diabetes and stabilization of the disease, patients should receive adequate systemic therapy aimed at improving the microcirculation in the tissues and the stabilization of metabolic processes in them. (rv.ua)
  • Therapeutic measures for diabetes are sufficiently developed and must include diet, hypoglycemic agents (oral or by injection), the means of symptomatic therapy. (rv.ua)
  • Along with medication, phytotherapeutic means having a mild and versatile effect, can be successfully used in conjunction with diet as a base therapy in the treatment of patients with latent or mild form of diabetes. (rv.ua)
  • Here we briefly reviewed the characteristic and etiology of these complications emphasizing on cerebrospinal fluid. (scialert.net)
  • The prevalence of increased urinary albumin excretion (UAE) (micro- and macroalbuminuria) and its association with diabetic retinopathy (DR) (evaluated by fluorescent angiography), coronary heart disease (CHD), and various related risk factors were studied in 320 type 2 diabetic patients. (nih.gov)
  • Despite the high prevalence of diabetes in developed countries, a recent report has indicated that the prevalence of diabetes is currently increasing most markedly in low- and middle-income countries [ 2 ]. (biomedcentral.com)
  • Some people, especially those who are type 2 diabetes, may not experience any symptoms initially, but in type 1 diabetes, symptoms tend to come and may become more severe. (deepayurveda.com)
  • One of the most severe complications of the diabetes mellitus is a diabetic retinopathy, that is a progressive lesion of the retina, requiring laser and surgical intervention. (suaway.com)
  • In pediatric patients under 3 years old without evidence of complete intestinal obstruction or diffuse peritonitis, non-surgical treatment may be considered for appendiceal abscess. (bvsalud.org)
  • Ginsenosides extracted from ginseng, which is derived from the roots and rhizomes of Panax ginseng C. A. Meyer, have been used in China as an adjuvant in the treatment of diabetes mellitus. (frontiersin.org)
  • Rg1, Rg3, Rb1, and compound K demonstrated the most promising therapeutic prospects as potential adjuvant medicines for the treatment of diabetes. (frontiersin.org)
  • Intravenous Opdivo has helped transform the treatment of several solid tumor types over the past decade, but there remains a need for additional administration options to address treatment burden on patients and improve efficiencies in healthcare systems," said Gina Fusaro, Ph.D., vice president, global program lead, Bristol Myers Squibb. (businesswire.com)
  • We believe this new option, given as a single injection administered in less than five minutes, could transform the treatment experience for both patients and physicians. (businesswire.com)
  • But, if a diabetic patient takes Ayurvedic treatment of diabetes, the chances of complications are less and the condition can be reversed naturally. (deepayurveda.com)
  • A set of peptides for the treatment course is designed taking into consideration specificity of the eye ball structure, and depending on the allocation and type of the damage as well as on the general state of the patient it includes peptides of the retina, thymus, pineal gland, cortex, vessels and other. (suaway.com)
  • Diabetes is also associated with poor TB treatment outcomes. (ejournals.ca)
  • Reestablishment of microcirculation is the essence of the successful treatment of diabetic ulcers. (orangenl.com)
  • This publication is dedicated to the application of a complex of peptide bioregulators being highly effective in treatment of different retinal diseases (diabetic retinopathy, pigment retinitis, age-related macular degeneration etc. (antiaging-peptides.com)
  • When the model was used to simulate event history over patients' lifetimes, those treated with a regimen of conventional glucose control could expect 16.35 undiscounted quality-adjusted life years, and those receiving treatment with intensive glucose control could expect 16.62 quality-adjusted life years, a difference of 0.27 (95% CI: -0.48 to 1.03). (ox.ac.uk)
  • Bristol Myers Squibb (NYSE: BMY) today announced six-year results from Part 1 of the Phase 3 CheckMate -227 trial, which continues to demonstrate long-term, durable survival benefits of Opdivo (nivolumab) plus Yervoy (ipilimumab) compared to chemotherapy in the first-line treatment of patients with metastatic non-small cell lung cancer (mNSCLC), regardless of PD-L1 expression levels. (advfn.com)
  • Immunotherapy has transformed the treatment of advanced lung cancer, and thankfully, a diagnosis no longer means the same thing as it used to for many patients. (advfn.com)
  • OPDIVO, in combination with platinum-doublet chemotherapy, is indicated as neoadjuvant treatment of adult patients with resectable (tumors ≥4 cm or node positive) non-small cell lung cancer (NSCLC). (opdivohcp.com)
  • Opdualag™ (nivolumab and relatlimab-rmbw) is indicated for the treatment of adult and pediatric patients 12 years of age or older with unresectable or metastatic melanoma. (opdivohcp.com)
  • OPDIVO, in combination with YERVOY ® (ipilimumab), is indicated for the first-line treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors express PD-L1 (≥1%) as determined by an FDA-approved test, with no EGFR or ALK genomic tumor aberrations. (opdivohcp.com)
  • OPDIVO, in combination with YERVOY and 2 cycles of platinum-doublet chemotherapy, is indicated for the first-line treatment of adult patients with metastatic or recurrent non-small cell lung cancer (NSCLC), with no EGFR or ALK genomic tumor aberrations. (opdivohcp.com)
  • OPDIVO ® (nivolumab) is indicated for the adjuvant treatment of completely resected esophageal or gastroesophageal junction cancer with residual pathologic disease in adult patients who have received neoadjuvant chemoradiotherapy (CRT). (opdivohcp.com)
  • OPDIVO is indicated for the treatment of adult patients with unresectable advanced, recurrent or metastatic esophageal squamous cell carcinoma (ESCC) after prior fluoropyrimidine- and platinum-based chemotherapy. (opdivohcp.com)
  • OPDIVO, in combination with fluoropyrimidine- and platinum-containing chemotherapy, is indicated for the first-line treatment of adult patients with unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC). (opdivohcp.com)
  • OPDIVO, in combination with fluoropyrimidine- and platinum-containing chemotherapy, is indicated for the treatment of adult patients with advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma. (opdivohcp.com)
  • OPDIVO ® (nivolumab) is indicated for the adjuvant treatment of adult and pediatric patients 12 years and older with completely resected Stage IIB or Stage IIC melanoma. (opdivohcp.com)
  • We've seen tremendous scientific advancements in the treatment of non-metastatic non-small cell lung cancer in recent years, and remain committed to researching new solutions that may help even more patients achieve better long-term outcomes," said Abderrahim Oukessou, M.D., vice president, thoracic cancers global program lead, Bristol Myers Squibb. (santaclara.com)
  • To date, Opdivo and Opdivo -based combinations have shown improved efficacy in the neoadjuvant, adjuvant or perioperative treatment of four tumor types: lung cancer, bladder cancer, esophageal/gastroesophageal junction cancer and melanoma. (santaclara.com)
  • While many non-metastatic NSCLC patients are cured by surgery, 30% to 55% develop recurrence and die of their disease despite resection, contributing to a need for treatment options administered before surgery (neoadjuvant) and/or after surgery (adjuvant) to improve long-term outcomes. (santaclara.com)
  • Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM. (hindawi.com)
  • PURPOSE: Deregulated metabolism in cancer cells represents a vulnerability that may be therapeutically exploited to benefit patients. (bvsalud.org)
  • Products selected for testing in patients with diabetes due to the possibility of its positive effects on different types of metabolism of the body and improve the trophic tissue. (rv.ua)
  • metabolism, making it appropriate for diabetics, who generally suffer from insufficient circulation. (unaniherbal.org)
  • Our longitudinal data suggest that diabetes-induced functional deterioration and morphological changes were accompanied by reduced mitochondrial function in the retina of db/db mice. (biomedcentral.com)
  • Excludes: endocrine and metabolic disturbances specific to the fetus and newborn (775.0-775.9) Note: All neoplasms, whether functionally active or not, are classified in Chapter 2. (theodora.com)
  • In the structure of endocrine diseases diabetes mellitus (DM) up to 70% of cases. (rv.ua)
  • Analysis of the daily dynamics of arterial stiffness in patients with EAH and the presence of endocrine pathology showed that SН have a negative effect on elastic properties of the arteries, which is confirmed by significantly higher values of PWVao and arterial stiffness index, ASI, including at night, as well as lower PTIN indices compared with patients with isolated EAH. (orscience.ru)
  • The impact of diabetes-related complications on healthcare costs: results from the United Kingdom Prospective Diabetes Study (UKPDS Study No. 65). (ox.ac.uk)
  • AIMS: To develop a model for estimating the immediate and long-term healthcare costs associated with seven diabetes-related complications in patients with Type 2 diabetes participating in the UK Prospective Diabetes Study (UKPDS). (ox.ac.uk)
  • METHODS: The costs associated with some major complications were estimated using data on 5102 UKPDS patients (mean age 52.4 years at diagnosis). (ox.ac.uk)
  • In-patient and out-patient costs were estimated using multiple regression analysis based on costs calculated from the length of admission multiplied by the average specialty cost and a survey of 3488 UKPDS patients' healthcare usage conducted in 1996-1997. (ox.ac.uk)
  • A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68). (ox.ac.uk)
  • METHODS: Equations for forecasting the occurrence of seven diabetes-related complications and death were estimated using data on 3642 patients from the United Kingdom Prospective Diabetes Study (UKPDS). (ox.ac.uk)
  • CONCLUSIONS/INTERPRETATIONS: The UKPDS Outcomes Model is able to simulate event histories that closely match observed outcomes in the UKPDS and that can be extrapolated over patients' lifetimes. (ox.ac.uk)
  • Study subjects were a random sample of 1109 adults age 45 and over with an established diagnosis of diabetes using a diabetes identification method with estimated sensitivity 0.91 and positive predictive value 0.94. (healthpartners.com)
  • The International Working Group on the Diabetic Foot has developed guidelines for the diagnosis of the diabetic foot. (biomedcentral.com)
  • Statistical studies show that over 50% of all lower limb amputations due to diabetes. (rv.ua)
  • Among the most frequent retinal diseases there are age-related macular degeneration, hereditary retinal degenerations (including retinitis pigmentosa), complicated myopia, diabetic retinopathy. (suaway.com)
  • While neural function and survival rely on proper mitochondrial function, and a growing body of literature has supported the role of mitochondrial dysfunction in the development of DR, how diabetes affects mitochondrial function in retinal tissue remains elusive. (biomedcentral.com)
  • Importantly, diabetes-induced damage to retinal neural cells and visual function, which may not be revealed by conventional fundus assessments, cannot be readily reversed. (biomedcentral.com)
  • Diabetes & metabolic syndrome 0 13 (2): 1317-1320. (cdc.gov)
  • Bristol Myers Squibb (NYSE: BMY) today announced the Phase 3 CheckMate -77T trial met its primary endpoint of improved event-free survival (EFS) as assessed by Blinded Independent Central Review (BICR) in patients with resectable stage IIA to IIIB non-small cell lung cancer (NSCLC). (santaclara.com)
  • 15 patients ont subi une amputation et cinq patients ont eu une insuffisance rénale passagère. (who.int)
  • RR = 4.56, 95% CI: 2.41-8.64) than patients with trauma-related amputation. (who.int)
  • IC à 95 % : 2,41-8,64) que les patients ayant eu une amputation suite à un traumatisme. (who.int)
  • Number of observations was 23 patients of different age and sex with different forms and severity of diabetes. (rv.ua)
  • AIMS/HYPOTHESIS: The aim of this study was to develop a simulation model for type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health economic outcomes such as quality-adjusted life expectancy. (ox.ac.uk)
  • RÉSUMÉ Nous avons examiné l'effet de différents antibiotiques sur l'issue des soins chirurgicaux dans la prise en charge du pied diabétique. (who.int)
  • La prévention du diabète, son dépistage et sa prise en charge doivent devenir prioritaires afin de tenter de réduire l'incidence actuelle des amputations au Liban. (who.int)
  • L'amélioration du plateau technique et l'accessibilité du bilan immunologique et la sensibilisation paraissent indispensables afin d'améliorer la prise en charge des patients. (bvsalud.org)
  • But type 2 diabetes also increasing among children, younger adults, and adolescents. (deepayurveda.com)
  • Its validity in estimating outcomes in other groups of patients, however, remains to be evaluated. (ox.ac.uk)
  • The model allows simulation of a range of long-term outcomes, which should assist in informing future economic evaluations of interventions in type 2 diabetes. (ox.ac.uk)
  • The long-term efficacy seen with the dual immunotherapy regimen in CheckMate -227 reinforce the importance of nivolumab plus ipilimumab to transform outcomes for appropriate patients with metastatic non-small cell lung cancer. (advfn.com)