AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureHealth Care
Subcutaneous Fat, AbdominalSubcutaneous FatAbdomenIntra-Abdominal FatAdipose TissueBody CompositionObesityFat NecrosisBody Fat DistributionDietary FatsTorsoFats, UnsaturatedAbsorptiometry, PhotonFatsSkinfold ThicknessSubcutaneous TissueBody WeightVisceraAbdominal FatEnergy IntakeBody Mass IndexMeatDietary CarbohydratesLipodystrophyDietary ProteinsAdiposityAnthropometryPanniculitisButtocksBody ConstitutionHIV-Associated Lipodystrophy SyndromeInsulin ResistanceLeptinFat BodyLipectomyFatty AcidsOmentumAdipocytesAnimal FeedLipolysisMuscle, SkeletalInsulinWeight GainObesity, AbdominalTomography, X-Ray ComputedBlood GlucoseCattleLipidsAdipokinesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetes MellitusDiabetes ComplicationsDiabetes Mellitus, Experimental
Diabetes MellitusIntra-abdominalInsulin resistanceAdiposityGlycemic controlT2DMHypertensionVisceral fatCarbohydratesCardiovascular diseaseEctopicPrevalenceEtiologyIncreasesMetSDepositionMortalityMetabolicMmolDiabeticTriglyceridePathologicalAssessDiagnosticStudiesInflammationDisorderMaternalLeanHealthcareRiskPancreasBody fatCloselyHormoneDailyApproachBloodIndexPeopleHoursContent
Diabetes Mellitus10
Intra-abdominal2
  • In old age, fat is redistributed from subcutaneous to intra-abdominal visceral depots as well as other ectopic sites, including bone marrow, muscle and the liver. (biomedcentral.com)
  • However, animal or mainly attributed to the accumulation ing prevalence of uncontrolled weight genetic studies, studies not relevant of intra-abdominal (visceral) fat ( 13 ). (who.int)
Insulin resistance11
  • Overconsumption of energy-dense foods results in excessive fat deposition and enhanced insulin resistance. (oatext.com)
  • FFAs spill into systemic circulation result in lipotoxicity of organs such as pancreas, heart and muscles initiate a viscous cycle of fat damage, inflammation, worsening insulin resistance and beta cell insulin secretion, and eventually demonstration of T2DM. (oatext.com)
  • Visceral fat content is an independent predictor of insulin resistance, whilst adipokines such as adiponectin protect against obesity-induced T2DM. (oatext.com)
  • Because insulin resistance can interfere with your ability to burn fat, you may accumulate more body fat, especially in your belly. (sharecare.com)
  • It can produce hormones and substances linked to endocrine and metabolic conditions, such as insulin resistance, prediabetes , and type 2 diabetes . (sharecare.com)
  • Though the diagnostic criteria for MetS has been variably defined in the literature, most definitions now include the presence of at least three of the following: Abdominal obesity, insulin resistance, hypertension, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoprotein levels. (surgicalneurologyint.com)
  • A requirement of insulin resistance and abdominal adiposity as part of the diagnostic criteria depends on the group or agency proposing the definition. (surgicalneurologyint.com)
  • The cause/consequence characteristics of the relationship between insulin resistance, pathological fat deposition and/or mobilsation, elevated and/or poorly-distributed lipid within myocytes and an impaired capacity to use lipid as fuel remains to be clarified as does the role of muscle mitochondria in the metabolic decline. (biomedcentral.com)
  • Prevalence of insulin resistance, obesity and type 2 diabetes in the US adult population. (biomedcentral.com)
  • Recent statistics indicate that number of epidemiological studies standing of the role of excessive fat dep- nearly 50% of the total Arab population from each country, we did not set any osition in promoting insulin resistance, are less than 25 years of age. (who.int)
  • At the end of the study significant reductions in fasting blood sugar (FBS), the homeostasis model assessment insulin resistance (HOMA-IR), triglyceride (TG), alkaline phosphatase (ALP), and Omentin level were found in groups 3 and 4 in comparison with group 2. (researchgate.net)
Adiposity4
  • 26 120 180 ] Body mass index (BMI) has been widely used to indicate the level of obesity, though recent studies have found that abdominal or visceral adiposity (vs subcutaneous), as reflected in the waist-to-hip ratio or waist circumference, is a strong criteria for predicting the risk of developing metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). (surgicalneurologyint.com)
  • This analysis investigated the independent association of BMI versus surrogate measures of central adiposity with all-cause mortality in individuals with type 2 diabetes. (biomedcentral.com)
  • Exposures were BMI and the surrogate measures of central adiposity waist circumference (WC), waist-to-height ratio (WHtR), and A Body Shape Index (ABSI). (biomedcentral.com)
  • The reason for these findings is that BMI does not precisely reflect overall adiposity and does not distinguish visceral fat, which induces the onset of IR. (e-agmr.org)
Glycemic control2
  • Unfortunately, normal aging is associated with a progressive increase in A1C, and there can be a significant discordance between glucose-based and A1C-based diagnosis of diabetes in this age group, a difference that is accentuated by race and gender (2) (see Monitoring Glycemic Control chapter, p. (diabetes.ca)
  • All women with pre-existing type 1 or type 2 diabetes should receive preconception care to optimize glycemic control, assess for complications, review medications and begin folic acid supplementation. (diabetes.ca)
T2DM3
  • T2DM is characterized by impaired fat metabolism in adding up to glucotoxicity. (oatext.com)
  • A history of 2-3 years of T2DM does not produce irreversible damages to the beta cells, but as long as the energy overload persists through years, irreversible impairment of the beta cells occurs, and insulin is required in order to control plasma glucose [5]. (oatext.com)
  • T2DM is closely associated with excessive body fat and physical inactivity. (oatext.com)
Hypertension2
  • These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. (mdpi.com)
  • CKD increases the mortality rate and risk of conditions including myocardial infarction, hypertension, and type 2 diabetes in the geriatric population. (e-agmr.org)
Visceral fat3
Carbohydrates1
  • Eat foods and meals high in fiber and lean proteins and low in saturated fats and carbohydrates. (sharecare.com)
Cardiovascular disease3
  • Obesity increases the risk of type 2 diabetes, cardiovascular disease, cancer, and premature death. (oatext.com)
  • The role of inflammation in the increased risk of cardiovascular disease in type 1 diabetes is unclear. (silverchair.com)
  • Individuals with type 1 diabetes are at a dramatically increased risk of cardiovascular disease (CVD) compared with those without diabetes ( 1 ). (silverchair.com)
Ectopic1
  • This has resonance because ectopic fat accumulation appears to represent a central component of disease progression regardless of whether obesity is also part of the equation. (biomedcentral.com)
Prevalence2
  • The increasing global prevalence of diabetes has led several countries to propose or introduce screening programmes for diabetes in the past decade [ 1 , 2 ]. (biomedcentral.com)
  • The objective of this study was to investigate the prevalence and types of cardiovascular complications among patients with SLE in the Aseer region of Saudi Arabia. (bvsalud.org)
Etiology1
  • Although the etiology of type 2 diabetes is complex and cause/consequence characteristics of associated dysfunctions have been debated, it is well established that impaired insulin action plays a critical early role. (biomedcentral.com)
Increases1
  • Poorly controlled diabetes in a pregnant woman with type 1 or type 2 diabetes increases her risk of miscarrying, having a baby born with a malformation and having a stillborn. (diabetes.ca)
MetS3
  • Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) was lower in the general population with metabolic syndrome (MetS). (biomedcentral.com)
  • NT-proBNP level is significantly reduced in elderly persons affected by MetS, and is significantly positively related to age, while negatively related to triglyceride, body fat mass, height in these subjects. (biomedcentral.com)
  • Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O 2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. (surgicalneurologyint.com)
Deposition1
  • Abnormal deposition of fat in the adipose tissue due to chronic over nutrition or reduced physical activity or hereditary reasons is called as obesity [1]. (oatext.com)
Mortality2
  • However, numerous epidemiological surveys have reported an association of increased BMI with decreased mortality in older individuals as well as in patients in acute clinical settings or suffering from several chronic disorders, suggesting that a mild-to-moderate excess of fat might be protective under these conditions [ 4 ]. (biomedcentral.com)
  • The end result is that diabetes was responsible for ~ 12% of deaths in the US in 2010 making it the third leading cause of mortality in the country [ 2 ]. (biomedcentral.com)
Metabolic3
  • [ 1 , 2 ] A study by Stuebe et al found this condition to be associated with persistent metabolic dysfunction in women at 3 years after delivery, separate from other clinical risk factors. (medscape.com)
  • This work investigated cardiovascular and metabolic perturbations in Irish children with obesity as well as the response to exercise in young patients with type 2 diabetes. (universityofgalway.ie)
  • 1][2] The Delta Ratio is a formula that can be used to assess elevated anion gap metabolic acidosis and to evaluate whether mixed acid base disorder (metabolic acidosis) is present. (diabetestalk.net)
Mmol2
  • A diagnosis of GDM is made if one plasma glucose value is abnormal (i.e. fasting ≥5.3 mmol/L, 1 hour ≥10.6 mmol/L, 2 hours ≥9.0 mmol/L). The alternate approach is a 1-step approach of a 75 g oral glucose tolerance test. (diabetes.ca)
  • A diagnosis of GDM is made if one plasma glucose value is abnormal (i.e. fasting ≥5.1 mmol/L, 1 hour ≥10.0 mmol/L, 2 hours ≥8.5 mmol/L). (diabetes.ca)
Diabetic1
  • Rats in group 1 (non-diabetic control) and group 2 (diabetic control) were treated with distilled water, and the rats in the treated groups, group 3 (T250), group 4 (T500), and group 5 (T750) were treated with stevia, gavaged every day at 9 a.m. in doses of 250, 500, and 750 mg/kg, respectively. (researchgate.net)
Triglyceride1
  • The TyG index was calculated as ln [triglyceride concentration (mg/dL)×fasting plasma glucose concentration (mg/dL)]/2. (e-agmr.org)
Pathological1
  • In this narrative review, we consider a number of explanations that have been forwarded regarding the pathological progression to type 2 diabetes both with and without the concurrent influence of overweight/obesity. (biomedcentral.com)
Assess1
  • In-utero hyperglycemia exposure influences later cardiometabolic risk, although few studies include women with pre-existing type 2 diabetes (T2D) or assess maternal body mass index (BMI) as a potential confounder. (nature.com)
Diagnostic1
  • S10, glycated hemoglobin (A1C) can be used as a diagnostic test for type 2 diabetes in adults. (diabetes.ca)
Studies2
  • Insufficient hepatic O 2 in animal and human studies has been shown to elicit a hepatorenal reflex in response to increased hepatic adenosine, resulting in the stimulation of renal as well as muscle sympathetic nerve activity and activating the renin angiotensin system. (surgicalneurologyint.com)
  • Triglycerides increase the pro- creased dramatically during the last 2 studies were excluded (Figure 1). (who.int)
Inflammation3
  • We examined the association of inflammation and progression of coronary artery calcification (CAC)-a marker of subclinical atherosclerosis-in adults with and without type 1 diabetes. (silverchair.com)
  • Measures of inflammation were associated with progression of CAC in a population of adults with and without type 1 diabetes. (silverchair.com)
  • Inflammation is a factor in the pathogenesis of atherosclerosis ( 2 ) and is elevated in type 1 diabetes ( 3 , 4 ), but the role it may play in the increased risk of CVD in type 1 diabetes is unclear. (silverchair.com)
Disorder1
  • The vast majority possess type 2 diabetes (T2D), a disorder that is linked with the 'American obesity epidemic. (biomedcentral.com)
Maternal1
  • Care by an interprofessional diabetes health-care team composed of a diabetes nurse educator, dietitian, obstetrician and endocrinologist/internist with expertise in diabetes, both prior to conception and during pregnancy, has been shown to minimize maternal and fetal risks in women with pre-existing type 1 and type 2 diabetes. (diabetes.ca)
Lean2
  • Although Jane has a body weight within the normal range (identified by being near the 100% mark), her body composition is defined by having more fat mass and less lean body mass and skeletal muscle than Sarah. (inbody.com)
  • The person below has a lower body fat percentage and more Lean Body Mass - which is why when looking at this person, you'd describe them as "lean. (inbody.com)
Healthcare1
  • Talk with your healthcare provider (HCP) or registered dietitian nutritionist (RDN) to figure out how many daily carbs, fats, proteins, and calories would best meet your health needs, body size, and activity level. (sharecare.com)
Risk3
  • Screening programmes for type 2 diabetes inevitably find more individuals at high risk for diabetes than people with undiagnosed prevalent disease. (biomedcentral.com)
  • The first two components of the PCA were modestly (odds ratio 1.38 [95% CI 1.08-1.77] and 1.27 [1.02-1.59], respectively) associated with CAC progression after adjustment for other risk factors. (silverchair.com)
  • Women should be screened for diabetes between 6 weeks and 6 months postpartum, with a 75 g oral glucose tolerance test and be given ongoing education regarding strategies to reduce the risk of developing type 2 diabetes. (diabetes.ca)
Pancreas1
  • Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
Body fat3
  • Weight gain and the increase in body fat are likely due to multiple factors that usually start to take effect as you approach and enter the transition period before menopause called perimenopause . (sharecare.com)
  • And compared to other body fat, belly fat can be harder on your body. (sharecare.com)
  • Before trying these strategies or making significant changes to your diet, have a thorough discussion with your HCP about your weight goals and options for losing weight and body fat. (sharecare.com)
Closely1
  • 8 , 9 ) reported that high fat and low muscle mass are more closely related to CKD than BMI-based obesity evaluation. (e-agmr.org)
Hormone1
  • Other hormone shifts, including rising levels of the adrenal stress hormone cortisol, send fat to your belly for storage. (sharecare.com)
Daily1
Approach1
  • [ 4 , 5 ] The recommendation does not specify whether the 1-step or 2-step screening approach would be preferable. (medscape.com)
Blood1
  • Patients were excluded if they had any acute infection (n = 2), acute myocardial infarction (n = 1), heart failure (n = 5), serum creatinine ≥ 1.2 mg/dl at the time of blood sampling (n = 7) or if they refused to provide informed consent for the study (n = 1). (biomedcentral.com)
Index1
People1
  • There are many people with type 2 diabetes who are over the age of 70 who are otherwise well, functionally independent/not frail and have at least a decade of healthy life expectancy. (diabetes.ca)
Hours1
Content1
  • This led to a three-year MRC-funded Career Development Fellowship there, where he led the first trial to show that aerobic exercise reduces liver fat content in humans. (universityofgalway.ie)