Type 2 angiotensin ii receptor. Medical search. Frequent questions

Emerging evidence suggests that blockers of the renin-angiotensin system (RAS) prevent new onset diabetes and improve insulin resistance. (uky.edu)
Objective To determine the effect of combinations of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors in the secondary prevention of all cause mortality in patients with ischaemic heart disease. (bmj.com)
Exposure was current use of different combinations of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors before death in cases, or the equivalent date in controls. (bmj.com)
Treatments associated with the smallest reduction in all cause mortality were β blockers alone (19% reduction, 37% reduction to 4% increase), angiotensin converting enzyme inhibitors alone (20% reduction, 1% to 35%), and combined statins and angiotensin converting enzyme inhibitors (31% reduction, 57% reduction to 12% increase). (bmj.com)
Conclusions Combinations of statins, aspirins, and β blockers improve survival in high risk patients with cardiovascular disease, although the addition of an angiotensin converting enzyme inhibitor conferred no additional benefit despite the analysis being adjusted for congestive cardiac failure. (bmj.com)
1 - 5 Although combinations of drugs (as proposed in the Polypill) 6 have been received with enthusiasm, we found no direct evidence evaluating the effects of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors in combination. (bmj.com)
Drugs segment is further segmented into angiotensin-ii receptor blockers, ace inhibitors, beta-blockers, calcium channel blockers, and erythropoiesis-stimulating agents. (medgadget.com)
Treatment targeted a systolic blood pressure ≤ 135 mm Hg and a diastolic blood pressure ≤ 85 mm Hg by using drugs other than angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers, and calcium channel blockers, if necessary. (bmj.com)
Dapagliflozin became the first agent in a new drug class approved for treating people with isolated CKD since angiotensin-converting enzyme inhibitors and angiotensin receptor blockers became mainstays more than two decades ago. (medscape.com)

We investigated the effects of the angiotensin II (Ang II) type 1 receptor (AT 1 ) antagonist KRH-594 on levels of the mRNAs for AT 1A , AT 1B , platelet-derived growth factor-receptor β (PDGF-Rβ), and extracellular matrix (ECM)-related genes using the competitive reverse transcription-polymerase chain reaction (RT-PCR) method and on neointimal formation in the balloon-injured rat carotid artery. (aspetjournals.org)
Aim 2 will define efficacy of losartan, an AT1R antagonist, on glucose tolerance in obese mice lacking pancreatic AT1aR. (uky.edu)
Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. (ox.ac.uk)
BACKGROUND: The clinical efficacy of the Angiotensin II (AngII) receptor AT2R antagonist EMA401, a novel peripherally-restricted analgesic, was reported recently in post-herpetic neuralgia. (ox.ac.uk)
These new members will help guide the development of Spinifex's lead program EMA401, a novel angiotensin II type 2 (AT2) receptor antagonist being developed as a potential first-in-class oral treatment for chronic pain without CNS side effects. (salesandmarketingnetwork.com)
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. (bmj.com)
QUESTION: In patients with type 2 diabetes mellitus, diabetic nephropathy, and hypertension, what effect does the angiotensin II receptor antagonist (ARA) irbesartan and the calcium channel blocker amlodipine have on renal disease? (bmj.com)
It is a receptor for ANGIOTENSIN 1-7 and acts as an antagonist of ANGIOTENSIN-2 TYPE 1 RECEPTOR. (bvsalud.org)

This receptor functions to mediate signaling in lung fibrosis and regulate nitric oxide synthase expression in pulmonary endothelium. (wikipedia.org)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and COX-2 inhibitors: Increased risk of renal impairment. (nih.gov)
In humans, angiotensin-converting enzyme inhibitors, a potent class of antihypertensive agents, lower blood pressure at least partially by favoring enhanced kinin accumulation in plasma and target tissues. (nature.com)
The effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blocker AT-1 (ARBs) in reducing the systemic hypertension (SH) is widely known. (intechopen.com)
Considering that ACE inhibitors or ARBs are the first-line drugs for antihypertensive treatment in patients with type 2 diabetes (T2D) and have potential "nonclassical" RAS-mediated benefits, it is meaningful to measure the change in the plasma levels of "nonclassical" RAS components after drug treatment. (biomedcentral.com)
Strippoli Giovanni FM, Bonifati Carmen, Craig Maria E, Navaneethan Sankar D, Craig Jonathan C. Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease. (bvs.br)

Patients who utilize either an ACE inhibitor (ACEI) or angiotensin receptor blocker (ARB) may experience a decreased incidence of new-onset type 2 diabetes. (thaiendocrine.org)

There was a significant interaction (p = 0.033) between genotypes of ACE and angiotensin II type 1 receptor (AGTR1). (bmj.com)
The AGTR1 gene provides instructions for making a protein called the angiotensin II receptor type 1 (AT1 receptor). (medlineplus.gov)
The AGTR1 gene mutations that cause this disorder likely change or block the AT1 receptor's ability to stimulate signaling, which results in a nonfunctional renin-angiotensin system. (medlineplus.gov)

The well-known components of "classical" RAS include angiotensinogen, angiotensin I, angiotensin II (AngII), renin, and angiotensin-converting enzyme (ACE). (biomedcentral.com)
All components of the RAS (angiotensinogen, angiotensin converting enzyme, angiotensin receptors) are expressed in many types of tumours, including endometrial cancer ( 2 , 4 ). (spandidos-publications.com)
Renin converts angiotensinogen, a proenzyme synthesized in the liver, into the decapeptide angiotensin I, which is then converted in the lungs into the octapeptide angiotensin II by angiotensin-converting enzyme (ACE). (medscape.com)

Recent studies have advanced our understanding of the molecular mechanisms underlying receptor activation and signal transduction of AT 1 and AT 2 receptor in the cardiovascular system. (current-pharmaceutical-design.com)

To determine whether dysregulation of TGFβ/Klf11/Cyp3a signaling affected endometriotic progression, we treated wild-type control and Klf11-/- mice with a Tgfβ type 1 receptor inhibitor (TGFβR1I) that inhibits Tgfβ signaling upstream of the canonical Smad proteins or a combination of TGFβR1I and a histone acetyltransferase inhibitor that additionally inhibits Klf11 signaling. (endometriosi.it)
In April 2021, dapagliflozin (Farxiga) received a new indication from the US Food and Drug Administration (FDA) for slowing progression of chronic kidney disease (CKD) in people without any other disorder - type 2 diabetes or heart failure - that qualified them for treatment with a sodium-glucose cotransporter 2 (SGLT2) inhibitor, the class that includes dapagliflozin. (medscape.com)
In this study, somewhat more than half of the 6609 randomized participants did not have type 2 diabetes, and again the efficacy of SGLT2 inhibitor treatment significantly surpassed that of placebo in both those with and those without diabetes. (medscape.com)
We recommend treating adults with CKD and heart failure or eGFR ≥20 mL/min/1.73m 2 with a urine albumin-to-creatinine ratio ≥200 mg/g with an SGLT2 inhibitor (1A). (medscape.com)

These results indicate that up-regulation of AT 1A , PDGF-Rβ, and ECM-related genes in the balloon-injured carotid artery is in part an AT 1 -mediated phenomenon and that prevention of receptor up-regulation may contribute to the attenuating effects of AT 1 antagonists on neointimal formation after injury. (aspetjournals.org)
The Company also intends to conduct further pre-clinical research on AT2 receptor antagonists in pain, including the company's follow on candidate program. (salesandmarketingnetwork.com)

Angiotensin II receptor type 2, also known as the AT2 receptor is a protein that in humans is encoded by the AGTR2 gene. (wikipedia.org)
Angiotensin II receptor type 2 (AGTR2) gene is a protein coding gene responsible for encoding AGTR2, the integral membrane protein that binds to two different G-protein coupled receptors. (wikipedia.org)
Genetically modified mouse studies determined that absence of the AGTR2 gene normalized pulmonary function indicators in two independent CF mouse models. (wikipedia.org)
To test the hypothesis that gene-gene interaction of the renin-angiotensin system is associated with an effect on the extent of coronary atherosclerosis. (bmj.com)
Patients carrying the D allele of the angiotensin I converting enzyme (ACE) gene had greater coronary extent scores (defined as the number of coronary segments with 5% to 75% stenosis) than those not carrying this allele (p = 0.006 in non-parametric analysis and p = 0.019 in parametric analysis). (bmj.com)
b) investigation of whether a positive or negative correlation exists between angiotensin II receptor gene polymorphisms and human lung cancer in lung cancer patients and corresponding normal control subjects. (k-state.edu)
Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes. (medlineplus.gov)

The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling. (current-pharmaceutical-design.com)
Angiotensin II (Ang II) is the major octapeptide of the renin-angiotensin system (RAS). (spandidos-publications.com)

AGTR2 belongs to a family 1 of G protein-coupled receptors. (wikipedia.org)
Furthermore, pharmacological antagonism of AGTR2 signaling improved lung function in CF mice to near wild-type levels. (wikipedia.org)
Manipulation of the angiotensin-signaling pathway to reduce AGTR2 signaling may be translatable for the treatment or prevention of CF. Angiotensin II receptor type 2 has been shown to interact with MTUS1. (wikipedia.org)

Angiotensin II (AngII), the primary peptide of the RAS, promotes oxidative stress and reduced insulin secretion from pancreatic beta-cells. (uky.edu)
We will first determine if pancreatic AT1aR deficiency is capable of (1) ameliorating HF diet-induced glucose intolerance and (2) abolishing in vitro effects of AngII to impair GSIS from isolated pancreatic islets. (uky.edu)
We have immunostained AngII, AT2R and the capsaicin receptor TRPV1 in control post-mortem and avulsion injured hDRG, control and injured human nerves, and in cultured hDRG neurons. (ox.ac.uk)
Angiotensin II (AngII) stimulates oxidative stress in VSMC, inducing VSMC proliferation and migration, which is a critical factor in both developments of hypertension and angioplasty-induced arterial restenosis. (hindawi.com)
We found that fisetin could dose-dependently inhibit the effect of AngII via inducing the expression of an antioxidant, paraoxonase-2 (PON2), whose overexpression could inhibit the proliferation and migration of A10 cells and downexpression by siRNA had the opposite effect. (hindawi.com)
Angiotensin II (AngII), as the major effector of the renin-angiotensin-aldosterone system (RAAS), plays an important role in regulating blood pressure and arterial remodeling [ 5 ]. (hindawi.com)
Via AT1a receptor, AngII increased oxidative stress, which is a critical regulator of VSMC proliferation and migration in hypertension and vascular remodeling [ 6 - 8 ]. (hindawi.com)

Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (kegg.jp)

Understanding the cardio-protective actions of the AT2R in females: Shifting gears between AT1 and AT2 receptor balance of function with relaxin. (monash.edu)
Vicore Pharma has received approval from the UK's Medicines and Healthcare products Regulatory Agency for a phase 2 trial of its proprietary compound, VP01, an angiotensin II receptor type 2 (AT2R) agonist, in COVID-19 patients. (centerwatch.com)
As part of the development of new ATRAGs for novel diseases, Vicore is developing a simple method for early dose finding of angiotensin II type 2 receptor (AT2R) stimulation in man. (healthcap.eu)

Recent studies suggest that angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) [Ang-(1-7)] might have beneficial effects on the cardiovascular system. (biomedcentral.com)
For many decades Ang II was mainly perceived as a regulator of the cardiovascular system, an important factor in the pathogenesis of hypertension, atherosclerosis, and angiogenesis. (spandidos-publications.com)

Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. (lookformedical.com)

Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by interleukin-6 (IL-6) production. (kegg.jp)
Type I angiotensin II receptors (AT1R) are somewhat unique in that they are expressed at apical (AP) and basolateral (BL) membranes in proximal tubule cells and both receptor sites undergo endocytosis. (duke.edu)
We analyzed AT1R cytoplasmic (-COOH) tail deletion mutants to determine whether classic AT1R endocytosis motifs functioned similarly in polarized cells and simultaneously altered receptor properties. (duke.edu)
Serially truncating the AT1R tail had little effect on AP/BL AT1R distribution as determined by 125I-angiotensin II binding in LLCPK(Cl4) cells transfected with an AT1R transcript. (duke.edu)

Ang II activates Ang II type 1 (AT 1 ) receptor and type 2 (AT 2 ) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family. (current-pharmaceutical-design.com)
Beta-arrestin-biased ligands at seven-transmembrane receptors. (nih.gov)

Dual blockade of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia. (nih.gov)
Immune checkpoint blockade (ICB) agents such as antibodies blocking programmed death (PD) 1, PD-1 ligand (PD-L) 1, and cytotoxic T lymphocyte-associated antigen (CTLA)-4 have been approved by the U.S. Food and Drug Administration (FDA) to treat several types of cancers. (portlandpress.com)

A cohort of 1162 patients with coronary artery disease were genotyped for genetic polymorphisms in the renin-angiotensin system. (bmj.com)
CONCLUSIONS -ACEIs or ARBs may decrease patients' odds of developing new-onset type 2 diabetes but does not reduce the odds of mortality, cardiovascular, or cerebrovascular outcomes over the study follow-up periods among patients with hypertension. (thaiendocrine.org)
In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)
ME/CFS onset is following an infection in approximately two thirds of patients ( 4 ). (frontiersin.org)
Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
Treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes, an elevated serum creatinine, and proteinuria. (nih.gov)
Nephropathy in type 2 diabetic patients: The most common adverse reactions which were more frequent than placebo were hyperkalemia dizziness, orthostatic dizziness, and orthostatic hypotension. (nih.gov)
It is also indicated for the treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus as part of an antihypertensive medicinal product regimen (see sections 4.3, 4.4, 4.5 and 5.1). (medicines.org.uk)
In hypertensive type 2 diabetic patients, therapy should be initiated at 150 mg irbesartan once daily and titrated up to 300 mg once daily as the preferred maintenance dose for treatment of renal disease. (medicines.org.uk)
The demonstration of renal benefit of Irbesartan Zentiva in hypertensive type 2 diabetic patients is based on studies where irbesartan was used in addition to other antihypertensive agents, as needed, to reach target blood pressure (see sections 4.3, 4.4, 4.5 and 5.1). (medicines.org.uk)
there is an increased risk of severe hypotension and renal insufficiency when patients with bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated with medicinal products that affect the renin-angiotensin-aldosterone system. (medicines.org.uk)
Hypertensive patients undergoing angioplasty of percutaneous coronary intervention (PCI) are highly predisposed to vascular restenosis [ 1 , 2 ]. (hindawi.com)
1715 patients between 30 and 70 years of age (mean age 59 y, 66% men) who had type 2 diabetes, hypertension, proteinuria defined as a urinary protein excretion rate ≥ 900 mg/24 hours, and serum creatinine concentrations between 88 and 265 μmol/l in women and between 106 and 265 μmol/l in men. (bmj.com)
In patients with type 2 diabetes, nephropathy, and hypertension, irbesartan was more effective in reducing progression of nephropathy independent of the effect on blood pressure than was amlodipine or placebo. (bmj.com)
Once end stage renal disease (ESRD) has developed, the median survival of patients with type 2 diabetes is 2 years, and most of these deaths are from cardiovascular disease. (bmj.com)
The daily mean values of serum CRP were significantly higher in patients with a surgical complication starting at the second postoperative day (POD 2, p = 0.004). (endometriosi.it)
0.05) on POD 2 and 3 in patients with a surgical complication. (endometriosi.it)
Although ICB agents have shown outstanding clinical success, and their application has continued to expand to additional tumor types in the past decade, immune-related adverse events (irAEs) have been observed in a wide range of patients who receive ICB treatment. (portlandpress.com)
The first cohort of patients has already been dosed in a separate phase 1/2 trial being conducted in Germany in collaboration with BioNTech. (centerwatch.com)
The effect of pentoxifylline on Klotho levels in patients with type 2 diabetes mellitus with chronic kidney disease (CKD) was assessed in a post hoc analysis of the Pentoxifylline for Renoprotection in Diabetic Nephropathy (PREDIAN) trial. (diabetesjournals.org)
A longitudinal observation study followed an unselected population of 451 patients diagnosed with type 1 diabetes during 1983-1987 before the age of 35 years in a region of Southeast Sweden. (diabetesjournals.org)
We investigated the effects of olmesartan on the changes in serum ACE2 and Ang-(1-7) levels as well as kidney and vascular function in patients with type 2 diabetes and hypertension. (biomedcentral.com)
On the other hand, a significant number of patients with early-stage disease develop both localised recurrence and distant metastases ( 2 ). (spandidos-publications.com)
Patients with type 2 diabetes from the Fremantle Diabetes Study Phase II and on stable renin-angiotensin system blocking therapy were divided into those remaining untreated with a PPI (group 1, n = 686), on PPI therapy throughout (group 2, n = 174), and commencing (group 3, n = 109) or discontinuing regular PPI therapy (group 4, n = 67) during the 2 years between assessments. (medscape.com)
[ 9 ] It can be hypothesized, therefore, that patients with type 2 diabetes initiating PPI therapy will manifest a subsequent increase in urinary albumin excretion that will persist after withdrawal of treatment. (medscape.com)
Iranian population of patients with type 2 diabetes mellitus. (who.int)
The high prevalence of CVD in Iranian patients with type 2 diabetes underscores the importance of better detection and treatment of metabolic risk factors of CVD in these patients. (who.int)
RÉSUMÉ La présente étude visait à déterminer la prévalence et les facteurs de risque des maladies cardio- vasculaires dans une population iranienne de patients atteints de diabète de type 2 entre 2006 et 2008. (who.int)
Les antécédents et les examens cliniques de 752 patients consultant dans un centre de recherche sur l'endocrinologie et le métabolisme ont été consignés et des analyses en laboratoire ont été réalisées. (who.int)
La prévalence élevée des maladies cardio-vasculaires chez les patients iraniens souffrant de diabète de type 2 souligne l'importance d'un meilleur dépistage des facteurs de risque métaboliques de ces maladies chez les patients diabétiques et d'un meilleur traitement. (who.int)

The in vivo neointimal hyperplasia model was established 2 weeks after the carotid artery balloon injury in SHR rats. (hindawi.com)

Spinifex is planning a further Phase 2 study with EMA401 in PHN, and investigating it in neuropathic and inflammatory pain conditions such as osteoarthritis, chemotherapy induced neuropathy and peripheral diabetic neuropathy. (salesandmarketingnetwork.com)
Ding W, Wang F, Fang Q, Zhang M, Chen J, Gu Y. Association between two genetic polymorphisms of the renin-angiotensin-aldosterone system and diabetic nephropathy: a meta-analysis. (medlineplus.gov)
Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. (bvs.br)

It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. (wikipedia.org)
The principal regulators of aldosterone synthesis and secretion are the renin-angiotensin system and the potassium ion concentration. (medscape.com)
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (nih.gov)
This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. (medlineplus.gov)
Through a series of steps, the renin-angiotensin system produces a molecule called angiotensin II, which attaches (binds) to the AT1 receptor, stimulating chemical signaling. (medlineplus.gov)
Renal tubular dysgenesis can be caused by mutations in both copies of any of the genes involved in the renin-angiotensin system. (medlineplus.gov)
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. (medlineplus.gov)
Physiologic regulation of the renin-angiotensin-aldosterone axis. (medscape.com)
The synthesis of prorenin, its conversion to renin, and its systemic secretion are stimulated by blood volume contraction detected by stretch receptors, beta-adrenergic stimulation of the sympathetic nervous system, and prostaglandins I 2 and E 2 . (medscape.com)

SARS-CoV-2 infects alveolar epithelial cells [mainly alveolar epithelial type 2 (AEC2) cells] through the angiotensin-converting enzyme 2 (ACE2) receptor. (kegg.jp)
There are "nonclassical" RAS pathways, which include ACE2, its product angiotensin-(1-7) [Ang-(1-7)], and Mas receptor [ 4 ]. (biomedcentral.com)

After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)

Eighty participants with type 2 diabetes and hypertension were randomized to receive 20 mg of olmesartan (N = 40) or 5 mg of amlodipine (N = 40) once daily. (biomedcentral.com)

The synthesis and secretion of prostaglandins I 2 and E 2 and the normal function of the stretch receptors are dependent on the intracellular ionized calcium concentration. (medscape.com)

Type 2 diabetes mellitus causes microvascular and macrovascular complications that pose public health concerns worldwide. (bmj.com)
Type 2 diabetes mellitus and COVID-19: a narrative review. (medline.ru)

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. (wikipedia.org)
Angiotensin II is both a stimulator of aldosterone secretion and a potent vasopressor. (medscape.com)

Analyses were stratified by antihypertensive class, beneficiaries' state and county of residence, type of prescription drug plan, and treatment and demographic characteristics. (cdc.gov)

By the segment of indication, the chronic kidney disease market has included Type 1 or Type 2 diabetes, polycystic kidney disease, high blood pressure, and others. (medgadget.com)
In addition, angiotensin II may play a more direct role in kidney development, perhaps by affecting growth factors involved in the development of kidney structures. (medlineplus.gov)
Some people with type 2 diabetes develop kidney disease. (healthline.com)

The efficacy of preventing asymptomatic infection was about two thirds. (medpagetoday.com)
In this study, one third of the randomized 4094 participants did not have type 2 diabetes, and the superior efficacy of dapagliflozin compared with placebo was similar in both the diabetes and nondiabetes subgroups. (medscape.com)

Role of angiotensin II receptor subtypes in porcine basilar artery: functional, radioligand binding, and cell culture studies. (uchicago.edu)

Mechanisms for beta-cell failure in the progression of type 2 diabetes are unknown. (uky.edu)
Moreover, both angiotensin receptors (AT1 and AT2) are overexpressed in different types of cancers, which confirms the role of local RAS in cancer development and progression ( 3 , 5 - 8 ). (spandidos-publications.com)

RESEARCH DESIGN AND METHODS -Three reviewers conducted a systematic literature search of Medline, EMBASE, CINAHL, and the Cochrane Library (1966 to present) to extract a consensus of trial data involving an ACEI or ARB with an end point of new-onset type 2 diabetes. (thaiendocrine.org)
The influence of either an ACEI (six trials) or an ARB (five trials) alone on new-onset type 2 diabetes was similar (0.79 [0.71-0.89] and 0.76 [0.70-0.82], respectively). (thaiendocrine.org)

These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
Biased ligands at G-protein-coupled receptors: promise and progress. (nih.gov)

The positive results of Spinifex's Phase 2 clinical trial of EMA401 in postherpetic neuralgia (PHN) were recently published in The Lancet[1]. (salesandmarketingnetwork.com)

Most endometrial cancer cases are diagnosed in the early stages and therefore result in favourable clinical outcomes ( 2 ). (spandidos-publications.com)
Although PPI use was not associated with a sustained adverse effect on uACR, the association between PPI initiation and both worsening nephropathy and increasing 5-year CVD risk has potential clinical implications in type 2 diabetes. (medscape.com)

The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: a systematic review and meta-analysis. (medline.ru)

Pancreatic beta-cells express several components of the RAS, including angiotensin type 1 a receptor (AT1aR). (uky.edu)

HbA 1c may reflect a pathogenic mechanism of glucose metabolism in diabetes complications, as it mirrors glycosylation of proteins ( 2 ). (diabetesjournals.org)

The major factors stimulating aldosterone production and release by the zona glomerulosa are angiotensin II and the serum potassium concentration. (medscape.com)

1].DMisariskequivalentforcoronary coronaryarterybypassgraft,angioplasty, andhigh-densitylipoprotein(HDL) heartdisease(CHD)[2].Silentischae- treatmentforCVD,cerebrovascular cholesterol were measured by the miaandasymptomaticCHDismore accident, transient ischaemic attack, enzymatic method (ParsAzmon). (who.int)

The aim of the present study was to evaluate the influence of angiotensin II (Ang II) on human EC cells. (spandidos-publications.com)

Endocytosis modulates cell responses by removing and recycling receptors from the cell surface. (duke.edu)

Anatomy38

Organisms14

Diseases22

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology2

Phenomena and Processes40

Disciplines and Occupations1

Information Science3

Health Care5

Blockers9

Antagonist8

Signaling in lung1

Inhibitors5

Blocker1

AGTR13

Angiotensinogen3

Signal transduction1

Inhibitor4

Antagonists2

Gene7

Octapeptide2

AGTR23

AngII7

20191

AT2R3

Cardiovascular system2

Agonists1

AT1R4

Seven-transmembrane2

Blockade2

Patients30

Rats1

Diabetic3

Renin9

ACE22

Genes3

Hypertension1

Calcium1

Diabetes mellitus2

Potent2

Antihypertensive1

Kidney3

Efficacy2

Porcine1

Progression2

ACEI2

Protein2

EMA4011

Clinical2

Meta-Analysis1

AT1aR1

Mechanism1

Serum potassium1

Angioplasty1

Study was to evaluate1

Endocytosis1