• The global outbreak of the new disease (COVID-19) caused by the novel severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) has reached pandemic status in March 2020 [ 1 , 2 ]. (beds.ac.uk)
  • Further Mendelian randomization analysis identified that the amplified risk could be attributed to increased susceptibility (up to 7%) to insulin resistance compared with women. (frontiersin.org)
  • Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic ß-cell function. (vitamindwiki.com)
  • Role of vitamin D in the development of insulin resistance and type 2 diabetes . (vitamindwiki.com)
  • Patients with RA have an increased risk of insulin resistance (IR) and diabetes (DM) secondary to genetic, inflammatory components or to comorbidities and treatment. (springer.com)
  • An association between SLE and insulin resistance and DM type II is described. (springer.com)
  • Metabolic Syndrome (MS) is the denomination proposed by the World Health Organization (WHO) 42 , which designates a set of risk factors for cardiovascular diseases (CVDs), such as visceral obesity, dyslipidemia, high hypertension, glucose intolerance and insulin resistance 32 , which frequently are presented together. (bvsalud.org)
  • In the Japanese population, more than 20% of the population shows insulin resistance and in the adult population with diabetes mellitus type 2 the prevalence of metabolic syndrome ranges from 38 to 53%, depending on the gender and the criterion used 16 . (bvsalud.org)
  • Insulin resistance (IR), i.e., whole-body decreased glucose uptake in response to physiological insulin levels, determines impaired glucose homeostasis and it is recognized as cardinal trigger of T2D and cardiovascular disease in both adults and children. (e-apem.org)
  • Insulin resistance (IR) has been identified as a cardinal trigger of impaired glucose metabolism, T2D, and cardiovascular diseases [ 3 , 4 ]. (e-apem.org)
  • Insulin resistance, glucose intolerance, hyperinsulinemia and dyslipidemia in patients with angiographically demonstrated coronary artery disease. (nhri.edu.tw)
  • Both environmental (lack of physical activity, excess nutritional intake, sedentary lifestyle) and genetic factors contribute to this global epidemic. (e-apem.org)
  • However, genetic susceptibility, sedentary lifestyle, and excessive fat storage in the body can also cause obesity. (biomedres.info)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention and the National Institutes of Health performed a population-based observational study of diabetes in youth also demonstrating an increasing prevalence of T2D in United States between 2001 and 2009. (e-apem.org)
  • Automatic classification of takeaway food outlet cuisine type using machine (deep) learning " (2021) Machine Learning with Applications , 100106. (cam.ac.uk)
  • Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression " (2021) Genome Med 13, 39. (cam.ac.uk)
  • Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (Gip) Levels and Cardiovascular Disease Risk are Driven by Distinct Causal Variants in the Gipr Region " (2021) Diabetes . (cam.ac.uk)
  • Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory " (2021) Int J Obes (Lond) . (cam.ac.uk)
  • 2021 Jan;60(1):142-151.e2. (ppshp.fi)
  • RA patients are more likely to have thyroid-related antibodies, and some studies indicate an increased prevalence of thyroid diseases in RA. (springer.com)
  • Pregnant SLE patients are more prone to develop thyroid diseases and pospartum thyroitidis, and in case they suffer from thyroid disease, they have an increased prevalence of preterm delivery. (springer.com)
  • The most frequent coexisting disease is autoimmune thyroid disease (AITD) which may be partially explained by the higher prevalence of thyroid dysfunction in middle-aged women rather than a true association. (springer.com)
  • The prevalence of people with type 2 diabetes (T2DM) in the general population is reaching epidemic proportions in many countries, with the total number of people with T2DM projected to rise to 366 million in 2030 worldwide [ 1 ]. (biomedcentral.com)
  • Obesity has become a real concern worldwide due to its increasing prevalence and associated cluster of diseases that reduce life quality and expectancy. (oatext.com)
  • Our objective was to examine the pattern of lifestyle factors associated with cardiovascular disease (CVD) in Grenada and to determine whether the prevalence of CVD risk factors differs by subgroups. (cdc.gov)
  • concurrently, these countries' populations often experience changes in diet and reductions in physical activity that lead to higher prevalence of cardiovascular disease (CVD) and CVD risk factors (3). (cdc.gov)
  • Low- and moderate-income nations account for approximately 78% of the world's deaths from noncommunicable disease and 85% of noncommunicable disease prevalence (3). (cdc.gov)
  • Moreover, in this common female patient population, there is markedly high prevalence of multiple cardio-metabolic conditions, such as type 2 diabetes, obesity, and hypertension, which may significantly increase the risk for adverse COVID-19-related outcomes. (beds.ac.uk)
  • There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)
  • However, animal or mainly attributed to the accumulation ing prevalence of uncontrolled weight genetic studies, studies not relevant of intra-abdominal (visceral) fat ( 13 ). (who.int)
  • Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
  • Diabetes is increasingly becoming a major chronic disease burden all over the world. (biomedcentral.com)
  • Type 2 diabetes is increasingly becoming a major chronic disease health burden in Africa. (biomedcentral.com)
  • Periodontal disease (PD) is a chronic infection that produces a local and systemic inflammatory response. (bvsalud.org)
  • Periodontitis is a chronic infectious disease affecting the world adult population, characterized by the loss of gingival insertion and bone resorption as a result of the infect ion by periodontal pathogens, such as Porphyiromonas gingivalis (Pg), Prevotella intermedia (Pi), Tannerella forsythia (Tf) and Aggregatibacter (Actinobacillus) actinomycetemcomintans (Aa) 13 . (bvsalud.org)
  • Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. (frontiersin.org)
  • Major factors causative towards 'diabesity' include chronic overconsumption of energy-dense food, lifestyle, genetic makeup and environment play important roles in adipose tissue function or dysfunction. (oatext.com)
  • Abnormal deposition of fat in the adipose tissue due to chronic over nutrition or reduced physical activity or hereditary reasons is called as obesity [1]. (oatext.com)
  • Chronic kidney disease - identification, evaluatio. (blogspot.com)
  • www.cdc.gov/pcd/issues/2022/21_0231.htm Preventing Chronic Disease. (cdc.gov)
  • The epidemiologic transition has made chronic disease a major health threat in the Caribbean and throughout the world. (cdc.gov)
  • We used a population-wide, community-based approach by adapting the World Health Organization's STEPwise Approach to the Surveillance of Chronic Disease survey for a local context. (cdc.gov)
  • 3- Screening of Chronic Disease in Saudi Arabia. (biochemistry4all.com)
  • Most patients with diabetes and chronic kidney disease have symptoms involving the digestive system. (xiahepublishing.com)
  • Increased creatinine production and reduced renal clearance in patients with chronic kidney disease (CKD) are likely to lead to accumulation of inflammatory factors in the body. (xiahepublishing.com)
  • 1 More than 50% of patients with Type 2 diabetes mellitus (T2DM) and 30% of those with Type 1 diabetes mellitus (T1DM) develop kidney disease, and a considerable number of cases can progress to end-stage renal disease (ESRD). (emjreviews.com)
  • Family history is a known risk factor for type 2 diabetes (T2DM), and more so in the presence of overweight. (biomedcentral.com)
  • Worldwide obesity is showing no signs of lessening and is fueling an angry outburst in numbers of Type 2 Diabetes Mellitus (T2DM). (oatext.com)
  • Obesity and T2DM form part of the metabolic syndrome, which combined with hypertension and Dyslipidaemia result in impulsive mortality from cardiovascular disease in millions of people each year. (oatext.com)
  • We investigated the contribution of gestational diabetes mellitus (GDM) to the historic epidemic of type 2 diabetes mellitus (T2DM) in Saskatchewan. (aphapublications.org)
  • The rise of the global epidemic of type 2 diabetes mellitus (T2DM) has been particularly rapid and acute among disadvantaged and indigenous populations. (aphapublications.org)
  • 2 Although research has pointed to the influence of rapid environmental and behavioral changes, 2 as well as possible genetic contributors, 3 recent attention has also been directed at the possible role of diabetic pregnancies (gestational diabetes mellitus [GDM] and pre-existing maternal T2DM) in this epidemic. (aphapublications.org)
  • Type 2 diabetes (T2DM) is associated with cognitive deficits. (oncotarget.com)
  • The BDNF Val66Met polymorphism may not contribute directly to the susceptibility to T2DM. (oncotarget.com)
  • Type 2 diabetes (T2DM) is often accompanied with cognitive dysfunction, and has an increased rate for developing dementia [ 1 ] and Alzheimer's disease (AD) [ 2 - 4 ]. (oncotarget.com)
  • It is divided into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), which account for 5-10% and 90-95% of DM cases resepectively. (xiahepublishing.com)
  • The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) code for type 1 diabetes without complications is E10.9. (medscape.com)
  • The rheumatic manifestations may result from a direct effect of the hormones, the occurrence of several autoimmune phenomena in the same person (due to genetic or environmental influences), secondary to endocrine disease complications or effects of advanced glycation end products in the case of diabetes. (springer.com)
  • In addition, diabetic patients with ESRD are more likely to develop adverse macrovascular complications such as hypertension, atherosclerosis, and peripheral and cerebrovascular disease leading to an increased mortality rate. (emjreviews.com)
  • It is correlated with several metabolic and cardiovascular complications in both adults and children [ 1 , 2 ]. (e-apem.org)
  • 1 Diabetic nephropathy (DN) is one of the most common microvascular complications associated with DM, and 25-40% of DM patients may be at risk for DN. (xiahepublishing.com)
  • Hypoglycemia remains the major factor limiting the use of the intensified insulin therapy shown to prevent or delay the long-term complications in type 1 diabetes (T1DM). (grantome.com)
  • There are single-nucleotide polymorphisms (rs11651755) in the hepatocyte nuclear factor-1-beta ( HNF1B ) gene, which is highly expressed in ovarian CCC [ 14 ] [ 15 ] . (encyclopedia.pub)
  • To investigate the relationship among alcohol dehydrogenase-2 (ADH2) and aldehyde dehydrogenase-2 (ALDH2) genetic polymorphisms, alcohol consumption, and the susceptibility of stomach cancer in Chinese males. (blogspot.com)
  • Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity. (ox.ac.uk)
  • The aim of this study was to investigate whether the INS VNTR region is a Type 1 diabetes-specific locus or acting as a general autoimmunity gene. (ox.ac.uk)
  • CONCLUSIONS: These data suggest that the INS-IGF2 VNTR is acting as a Type 1 diabetes-specific susceptibility gene rather than as an influence on general autoimmunity. (ox.ac.uk)
  • These processes influence gene expression patterns or cellular phenotypes and disease states with no underlying change in DNA sequence. (emjreviews.com)
  • The hormone plays a role in the suppression of the metabolic derangements that may result in type 2 diabetes, obesity, atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and an independent risk factor for metabolic syndrome. (wikipedia.org)
  • This review provides an update on the characteristics of nonalcoholic fatty liver disease (NAFLD), with a focus on the effects of age, sex, and body mass index. (gutnliver.org)
  • These children, who carry specific human leukocyte antigen (HLA)-DQ genotypes conferring increased susceptibility to type 1 diabetes, were observed from birth for the appearance of diabetes-associated antibodies and viral infections. (cdc.gov)
  • Hypothyroidism contributes to the increased risk for cardiovascular diseases and metabolic syndrome in RA patients and may be correlated with RA disease activity and response to treatment. (springer.com)
  • Introduction: Metabolic syndrome (MS) is a complex pathology that combines several risk factors for cardiovascular disease. (bvsalud.org)
  • Objective: The aim of this study was to review the literature about the possible association between periodontal disease and metabolic syndrome and to identify the components of this syndrome that may contribute to this association. (bvsalud.org)
  • Vitamin D deficiency and obesity are associated with cardiovascular disease, metabolic syndrome, type 2 diabetes, and other diseases. (biomedres.info)
  • Pathogenesis of type 2 diabetes mellitus. (vitamindwiki.com)
  • Combined keyword search on PUBMED identified 1037 articles of which 962 were excluded because studies were conducted outside the region of interest, described diabetes pathogenesis, included genetic or microbiological research, reviewed another disease, used data based on the analysis of patients records, or were case reports (see Additional file 1 for a description of the review and Additional file 2 for the flow-chart). (biomedcentral.com)
  • Although poly-autoimmunity is frequently described in SLE, the association with type 1 DM is uncommon. (springer.com)
  • The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-related diabetes (CFRD), type 2 diabetes (T2D), gestational diabetes, islet autoantibody positivity (AAb+), and without diabetes. (nature.com)
  • Wang Z, Lu Y, Fornage M, Jiao L, Shen J, Li Donghui , Wei P . Identification of novel susceptibility methylation loci for pancreatic cancer in a two-phase epigenome-wide association study. (mdanderson.org)
  • Anwer, T. et al: Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats. (natur-wiki.de)
  • AIMS: The Type 1 diabetes susceptibility locus, IDDM2, has been mapped to a variable number of tandem repeats (VNTR) region 5' upstream of the insulin (INS) and insulin-like growth factor (IGF2) genes on chromosome 11p15. (ox.ac.uk)
  • The specific aims are to: 1) determine if T1DM patients with hypoglycemia unawareness (vs. T1DM and non-diabetic controls) lose the capacity to normally activate both striatal and hypothalamic neurocircuits and deactivate pre-frontal and anterior cingulate cortex (ACC) executive control in response to food cues during mild and moderate hypoglycemia. (grantome.com)
  • Patients with type 2 diabetes are generally obese, and may have acanthosis nigricans and/or hirsutism in conjunction with thick necks and chubby cheeks. (medscape.com)
  • Type 2 diabetes (T2D) is an emerging health risk in obese children and adolescents. (e-apem.org)
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
  • Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease. (who.int)
  • However, coronary artery disease has been found to be positively associated with high molecular weight adiponectin, but not with low molecular weight adiponectin. (wikipedia.org)
  • on behalf of the FinnDiane Study Group, Genetic Risk Score Enhances Coronary Artery Disease Risk Prediction in Individuals With Type 1 Diabetes. (diabetesjournals.org)
  • Individuals with type 1 diabetes are at a high lifetime risk of coronary artery disease (CAD), calling for early interventions. (diabetesjournals.org)
  • Secondary prevention of coronary artery disease. (blogspot.com)
  • Participants were from the ongoing population-based Diabetes Prediction and Prevention (DIPP) study, a prospective survey of the preclinical events preceding type 1 diabetes among genetically susceptible children in Finland ( 18 , 19 ). (cdc.gov)
  • Diabetic nephropathy (DN) is a lethal microvascular complication associated with Type 1 and Type 2 diabetes mellitus, and is the leading single cause of end-stage renal disease. (emjreviews.com)
  • At the same time, it is currently the leading cause of end-stage renal disease. (selcukmedj.org)
  • therefore, subjects with periodontitis would be more prone to CVDs and other systemic diseases. (bvsalud.org)
  • In the UK, approximately 2-2.5% of the diabetic population have a foot ulcer at any one time, representing a significant health burden and costing the NHS approximately £1 billion annually (Kerr et al, 2019). (diabetesonthenet.com)
  • Sci Rep. 2019 ;9(1):5941. (bcm.edu)
  • 2019 ;4(1):30-39. (bcm.edu)
  • New research directions on disparities in obesity and type 2 diabetes. (cdc.gov)
  • ABSTRACT The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. (who.int)
  • Genetic predisposition to risk for or protection from type 1 diabetes (T1D) is highly polygenic, with the total possible set of disease-associated variants yet to be fully defined 1 . (nature.com)
  • Complementary methods for detecting genetic variants associated with T1D. (nature.com)
  • hypertension variants, unfavorable long gold, and change misdemeanor allow FREE Irish location in time analysis of genetic frozen liner: definitions in 183 individuals. (flash-controller.de)
  • Replication studies identify several genetic variants in Arabs with obesity- linked diabetes. (who.int)
  • The State of Microbiome Science at the Intersection of Infectious Diseases and Antimicrobial Resistance. (cdc.gov)
  • The epidemiologic transition (1,2) is the shift in mortality from childhood infectious diseases, nutrient deficiencies, and epidemics at all ages to degenerative and lifestyle-related diseases at a later age. (cdc.gov)
  • METHODS: We genotyped the INS-IGF2 VNTR [using the surrogate INS-23 HphI single nucleotide polymorphism (SNP)] in 823 Graves' disease (GD)/multiple sclerosis (MS) families, 1433 GD/MS patients and 837 healthy control subjects. (ox.ac.uk)
  • It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
  • All patients with type 1 diabetes should learn how to self-monitor and record their blood glucose levels with home analyzers and adjust their insulin doses accordingly. (medscape.com)
  • Patients with type 1 diabetes require lifelong insulin therapy. (medscape.com)
  • Correctly determining whether a patient has type 1 or type 2 diabetes is important because patients with type 1 diabetes require continuous exogenous insulin for survival. (medscape.com)
  • As previously stated, patients with type 2 diabetes mellitus can usually be differentiated from those with type 1 disease on the basis of history and physical examination findings and through simple laboratory tests. (medscape.com)
  • When dealing with patients with known diabetes in the emergency department, distinguishing the type of diabetes can be difficult in 2 groups: (1) patients who are treated with insulin and are young but clinically appear to have type 2 diabetes, and (2) older patients with late-onset of diabetes who nonetheless take insulin and seem to share characteristics of patients with type 1 diabetes. (medscape.com)
  • Some adolescents or young adults, mostly Hispanic or African American patients, who present with classic DKA are subsequently found to have type 2 diabetes. (medscape.com)
  • Moreover, the role of vitamin D supplementation in the prevention of both types of diabetes is analysed together with its role in improving glycemic control in diabetic patients. (vitamindwiki.com)
  • Rheumatoid arthritis is the most common coexisting autoimmune disorder in patients with Grave's disease and Hashimoto thyroiditis. (springer.com)
  • In most studies, thyroid diseases (mainly hypothyroidism) are more common in SLE patients. (springer.com)
  • 1 This scientific evidence is still less than optimal for determining the therapeutic options most appropriate for individual patients, necessitating educated guesswork and trial and error during the clinical decision-making process. (medpagetoday.com)
  • Precision medicine suggests that, with the identification of individual variability, clinical and molecular signatures can be composed, with the goal of stratifying patients according to disease subtypes in far greater detail than ever before. (medpagetoday.com)
  • The clinical management of patients has been hindered to a great extent by the complex heterogeneity of many diseases, including type 2 diabetes (T2D). (medpagetoday.com)
  • This conglomeration and dissecting of information can identify clinical and molecular signatures, with the goal of stratifying patients according to disease subtypes in far greater detail than ever before, making therapeutic decisions and disease management more precise and tailored. (medpagetoday.com)
  • La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
  • Two of the main risk factors for diabetic nephropathy are hyperglycemia and arterial hypertension, but the genetic susceptibility in both type 1 and type 2 diabetes is of great importance. (selcukmedj.org)
  • Although onset frequently occurs in childhood, the disease can also develop in adults. (medscape.com)
  • Screening for Type 2 Diabetes Mellitus in Adults. (medscape.com)
  • The Joint Public Health Impact of Family History of Diabetes and Cardiovascular Disease among Adults in the United States: A Population-Based Study. (cdc.gov)
  • Genetic Variations in the Vitamin D Receptor Predict Type 2 diabetes and Myocardial Infarction in a Community-Based Population: The Tromsø Study. (vitamindwiki.com)
  • A lean patient who has had diabetes since childhood, who has always been dependent on insulin, or who has a history of diabetic ketoacidosis (DKA) almost certainly has type 1 diabetes. (medscape.com)
  • The current therapeutic methods to treat DN are limited to slowing disease progression without repair and regeneration of the damaged nephrons. (emjreviews.com)
  • Key transcription factors involved in DN that can be targeted to halt disease progression are also described. (emjreviews.com)
  • Individuals with the same diagnosis may actually have considerable variability in disease pathology, symptom presentation, clinical progression, and response to treatment. (medpagetoday.com)
  • Screening for type 1 diabetes in asymptomatic low-risk individuals is not recommended. (medscape.com)
  • Obesity increases the risk of type 2 diabetes, cardiovascular disease, cancer, and premature death. (oatext.com)
  • This practice depletes the soil, increases the susceptibility of the banana crop to infections and allows easy spread of disease. (cyclingplantbasedgranny.com)
  • Obesity can cause impaired glucose tolerance, which can lead to increased susceptibility to diabetes manifestation. (biomedcentral.com)
  • RESULTS: We found no evidence of excess transmission of the allele associated with Type 1 diabetes to individuals affected by GD or MS within the families. (ox.ac.uk)
  • In 2011, about 14 million individuals were estimated to have diabetes in Africa, and this is expected to rise to 28 million by 2030 [ 1 ]. (biomedcentral.com)
  • [ 6 , 7 ] CGMs contain subcutaneous sensors that measure interstitial glucose levels every 1-5 minutes, providing alarms when glucose levels are too high or too low or are rapidly rising or falling. (medscape.com)
  • Circumventing the PCR-related problems of prolonged or recurrent positivity and disclosing the association of HBoV1 infection with disease require a more reliable diagnosis that uses serum for PCR and antibody detection ( 12 - 16 ). (cdc.gov)
  • The International Diabetes Federation (IDF) conducted a consensus conference on MS definition, in which the ethnic differences were included in the criteria of diagnosis 1 , and it emphasized the focus on the visceral obesity as the main component. (bvsalud.org)
  • Given the increasing health burden from excessive calorie intake and absence of physical inactivity, MetS is a pandemic disease that affects greater than 25% of the global population and has caused comprehensive concerns worldwide ( Grundy, 2008 , 2016 ). (frontiersin.org)
  • In developed countries, this rapid increase in obesity without unchanged genetic background is caused by excessive energy intake and reduced physical activity. (biomedres.info)