Txnip gene. Medical search. Frequent questions

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene. (wikipedia.org)
Thioredoxin-interacting protein (Txnip) is a regulator of metabolism and an inhibitor of the antioxidant thioredoxins, but little is known about its roles in the myocardium. (jci.org)
This was found to be dependent on the reactive oxygen species (ROS)/p38 MAPK/forkhead box O1 (FOXO1)/thioredoxin interacting protein (TXNIP) signaling pathway. (spandidos-publications.com)
This is a follow-up study to the authors' previous report about the roles of an alpha-arrestin called protein thioredoxin interacting protein (Txnip) in cone photoreceptors and in the retinal pigment epithelium. (elifesciences.org)
Thioredoxin‑interacting protein (TXNIP) competes with c‑Myc to reduce glucose consumption in tumor cells to restrain cell proliferation. (spandidos-publications.com)
Analysis of our recent genome-wide screen reveals that Gm15441, a thioredoxin-interacting protein (Txnip) antisense lncRNA, is the most robustly induced lncRNA in the fasting mouse liver. (nau.edu)
Additionally, miR-23a knockdown or CXCR4 overexpression in naïve mice could increase the thioredoxin-interacting protein (TXNIP), which was associated with induction of NOD-like receptor protein 3 (NLRP3) inflammasome. (biomedcentral.com)
Thioredoxin Interacting protein (TXNIP), controlled by an exquisitely glucose sensitive gene, is increasingly recognized for its role in diabetes. (bvsalud.org)
A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis. (ox.ac.uk)
Global gene expression analysis identified thioredoxin-interacting protein (Txnip) as the only significantly upregulated gene (by 46%) under these conditions (P = 0.036), subsequently verified independently at mRNA and protein levels. (ox.ac.uk)

These oxLDL‑mediated effects under HG conditions were also demonstrated to be dependent on this ROS/p38 MAPK/FOXO1/TXNIP signaling pathway. (spandidos-publications.com)
Furthermore, since Txnip is related to multiple intracellular signaling pathway, this study is of value for research in the mechanism of secondary cone dystrophy as well. (elifesciences.org)
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Gene chip were used to analyze the expression levels of genes in the signaling pathway. (silverchair.com)
Our data highlight that the Gal-3 plays a vital role in regulating the severity of neuroinflammation of SCI by enhancing the activation of ROS/TXNIP/NLRP3 signaling pathway. (silverchair.com)

The team then showed that giving the mice gene therapies that reduced oxidative stress and inflammation, along with Txnip gene therapy, provided additional protection for the cells. (azolifesciences.com)
Protects endothelial cells against free fatty acid-induced inflammation by suppressing oxidative stress, reducing expression of TXNIP and inhibiting activation of the NLRP3 inflammasome which inhibits expression of pro-inflammatory cytokines IL1B and IL18 (PubMed:32923762). (cansar.ai)
Distinct from the effects of thapsigargin, SW016789 did not affect beta cell viability or apoptosis, potentially due to a rapid induction of adaptive genes, weak signaling through the eIF2α kinase PERK, and lack of oxidative stress gene Txnip induction. (indianabiosciences.org)

Shalev's study, "Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action," published in Cell Metabolism, researched new therapies for diabetes. (uab.edu)
Using adenovirus-mediated liver-specific overexpression, we determined whether Gm15441 regulates Txnip in the mouse liver and modulates key aspects of liver metabolism. (nau.edu)
miR-23a, by directly targeting CXCR4, regulates neuropathic pain via TXNIP/NLRP3 inflammasome axis in spinal glial cells. (biomedcentral.com)
A mitochondrial thioredoxin-sensitive mechanism regulates TGF-β-mediated gene expression associated with epithelial-mesenchymal transition. (nih.gov)

The present results suggested that 3‑BrPA promoted TXNIP protein expression and reduced HK2 expression in TNBC cells by downregulating c‑Myc expression, inhibiting glycolysis including suppressing lactate generation, intracellular ATP generation and HK activity, inducing mitochondrial‑mediated apoptosis and eventually suppressing TNBC cell proliferation. (spandidos-publications.com)

Pharmacologic inhibition of glycolytic metabolism completely abolished the protection afforded the heart by Txnip deficiency under hypoxic conditions. (jci.org)
We then found that genetic deletion or non-specific pharmacological inhibition of TXNIP (with the blood pressure drug, verapamil) protected mice from type 1 and type 2 diabetes. (uab.edu)
It is unclear why inhibition enhances the protection of Txnip. (elifesciences.org)
Furthermore, we found that Gm15441 robustly reduced Txnip protein expression in vitro through sequence-specific regulation and translational inhibition. (nau.edu)
Lastly, we confirmed the Txnip inhibition by Gm15441 in vivo (mice) and found that Gm15441 liver-specific overexpression lowered plasma triglyceride and blood glucose levels and elevated plasma ketone body levels. (nau.edu)
In particular, inhibition of TXNIP reversed pain behavior elicited by pSNL, miR-23a knockdown, or CXCR4 overexpression. (biomedcentral.com)
In conclusion, we have identified Txnip as a novel negative regulator of creatine levels in vitro and in vivo, responsible for mediating substrate feedback inhibition and a potential target for modulating creatine homeostasis. (ox.ac.uk)

Silencing of TXNIP gene led to the downregulation of NLRP3 order FK-506 inflammasome activation, and inhibited the manifestation degrees of IL-18 and IL-1 inside a high-glucose environment. (mycareerpeer.com)
Taken collectively, the high-glucose environment could upregulated the level of inflammatory factors by promoting the expression of TXNIP and the activation of NLRP3 inflammasome, consequently participating in DN. (mycareerpeer.com)
The outcomes indicated the fact that high-glucose environment could upregulate the appearance of TXNIP as well as the activation of NLRP3 inflammasomes within a dose-dependent and time-dependent way, respectively, although it promoted the secretion of IL-1 and IL-18 in HK-2 cells also. (mycareerpeer.com)
A previous research has reported a high-glucose focus and lipopolysaccharides considerably induced the mRNA and proteins degrees of TXNIP, NLRP3, procaspase-1 and IL-1 in mesangial cells (31). (mycareerpeer.com)
Another research has also determined the fact that high-glucose circumstances also caused individual retinal microvascular endothelial cell harm via the TXNIP/NLRP3 pathway (32). (mycareerpeer.com)
This recommended the fact that high-glucose environment may work on individual kidney tubular epithelial cells and activate NLRP3 inflammasomes straight, resulting in inflammatory damage, which might be connected with their capability to promote TXNIP appearance levels. (mycareerpeer.com)
To help expand research the function of TXNIP gene in DN as well as the system of regulating NLRP3 inflammasome, RNA disturbance technology was put on silence TXNIP gene, and the result of TXNIP gene silencing on NLRP3 inflammasome in the high-glucose environment was looked into. (mycareerpeer.com)
The outcomes uncovered that TXNIP gene appearance was upregulated in the high-glucose Mouse monoclonal to ERBB3 order FK-506 environment which NLRP3 inflammasome was overactivated. (mycareerpeer.com)
Disturbance with siTXNIP plasmids inhibited the result of high-glucose on TXNIP, aswell simply because decreased the activation of NLRP3 inflammasome as well as the secretion of downstream IL-18 and IL-1. (mycareerpeer.com)
This shows that TXNIP silencing inhibited NLRP3 inflammasome activation-associated protein. (mycareerpeer.com)
To research the system by which TXNIP activates the NLRP3 inflammasome further, the consequences of TXNIP gene silencing in the antioxidant genes and ROS had been looked into in HK-2 cells under a the high-glucose condition. (mycareerpeer.com)
Moreover, miR-23a overexpression or CXCR4 knockdown inhibited the increase of TXNIP and NLRP3 inflammasome in pSNL mice. (biomedcentral.com)

Multiple binding sites of FOXO1 (A) and PPARα (B) located on the promoter and/or the gene bodies of Gm15441 and Txnip. (figshare.com)
Methods We examined the response of Gm15441 and Txnip under in vivo metabolic signals such as fasting and refeeding, and in vitro signals such as insulin and key metabolic transcription factors. (nau.edu)
Results We found that the expression levels of Gm15441 and Txnip showed a similar response pattern to metabolic signals in vivo and in vitro, but that their functions were predicted to be opposite. (nau.edu)

A and B ) PMAGE demonstrated transcriptional changes in mitochondrial metabolism-related pathways in Txnip-KO hearts. (jci.org)
We designed codon-optimized biosynthesis pathways based on genes mined from Escherichia coli . (elifesciences.org)
Differentially expressed genes elsewhere in the genome might share pathways with genes in the QTL region and reflect downstream effects of the QTL. (biomedcentral.com)
A number of genes concerned in IFN associated pathways have been upregulated within the head kidney. (esb2017.org)

ECs were treated with oxLDL under HG conditions in the presence or absence of ROS scavengers mitoTEMPO and NAC, p38 inhibitor SB203580, FOXO1 inhibitor AS1842856 or transfected with the TXNIP siRNA, before protein expression levels of intercellular adhesion molecule 1 (ICAM‑1), vascular cell adhesion molecule‑1 (VCAM‑1), phosphorylated vascular endothelial‑cadherin (VE‑cadhedrin), VE‑cadherin and zonula occludens‑1 (ZO‑1) were measured by western blotting. (spandidos-publications.com)
Together, this suggested that a specific TXNIP inhibitor could provide a novel and effective therapeutic approach for type 1 and type 2 diabetes. (uab.edu)
Conclusions Our data demonstrate that Gm15441 is a potent Txnip inhibitor and a critical metabolic regulator in the liver. (nau.edu)

Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs. (utah.edu)
strong course="kwd-title" Subject conditions: Biomarkers, Cardiology, Illnesses Launch Hypertrophic cardiomyopathy (HCM) is among the mostly inherited cardiovascular illnesses due to mutations in genes encoding essential cardiac sarcomeric proteins1. (phytid.org)
USH2A gene mutations in rabbits lead to progressive retinal degeneration and hearing loss. (harvard.edu)
Scientists have developed a few targeted gene therapies to help individuals with certain mutations that affect the photoreceptors, but no treatments are currently available that would be effective for a broad set of families with the disease. (azolifesciences.com)

These findings were relevant to the in vivo heart since creatine-deficient mice showed 39.71% lower levels of Txnip mRNA, whereas mice overexpressing the CrT had 57.6% higher Txnip mRNA levels and 28.7% higher protein expression compared with wild types (mean myocardial creatine concentration 124 and 74 nmol/mg protein, respectively). (ox.ac.uk)

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. (wikipedia.org)
Deletion of Txnip in the myocardium results in mitochondrial dysfunction with decreased expression of transcripts encoding mitochondrial metabolism. (jci.org)
Expression levels of HK2, glucose transporter 1, TXNIP, c‑Myc and mitochondria‑regulated apoptosis pathway proteins were measured through western blotting. (spandidos-publications.com)
3‑BrPA inhibited cell proliferation, downregulated c‑Myc and HK2 expression, and upregulated TXNIP expression in TNBC cells, but it doesn't have the same effect on non‑TNBC cells. (spandidos-publications.com)
Gene expression signatures within memory B cells suggest qualitative differences in the antibody responses in aged patients with severe disease. (medrxiv.org)
Antisense lncRNAs are known to regulate their sense gene expression. (nau.edu)
We investigated the regulation of Txnip expression by Gm15441 and the underlying mechanism in mouse hepatocytes. (nau.edu)
Furthermore, low expression of TXNIP promoted the known degrees of antioxidant genes and decreased the ROS levels. (mycareerpeer.com)
The outcomes demonstrated that this high-glucose environment inhibited the expression of antioxidant genes catalase and MnSOD in HK-2 cells, and increased ROS levels. (mycareerpeer.com)
There was no change in Txnip expression with exposure to 5 mM taurine, confirming a specific response to creatine rather than osmotic stress. (ox.ac.uk)
With the advent of 'omics technologies such as gene expression microarrays, new ways of studying genetic variation through so called 'endo-phenotypes' are becoming increasingly popular. (biomedcentral.com)
The general principle of complementing QTL studies with gene expression data is illustrated in Figure 1A . (biomedcentral.com)
Panel A shows the two areas of comparing gene expression results with QTL results: 1) co-location at the genome level between differentially expressed genes and QTL, 2) significant overlap at the pathway level between genes in the QTL region and differentially expressed genes elsewhere in the genome. (biomedcentral.com)
Objective : To investigate the effect of S1P on signalling and regulation of gene expression in ASM cells from healthy and asthmatic individuals. (le.ac.uk)
Gene expression was analysed using microarray, real-time PCR and western blotting. (le.ac.uk)
Results : S1P potently regulated the expression of more than 80 genes in human ASM cells, including several genes known to be involved in the regulation of cell proliferation and airway remodelling (HBEGF, TGFB3, TXNIP, PLAUR, SERPINE1, RGS4). (le.ac.uk)
S1P acting through S1P[subscript 2] and S1P[subscript 3] receptors activated intracellular calcium mobilisation and extracellular signal-regulated and Rho-associated kinases to regulate gene expression. (le.ac.uk)
The Unit characterizes regulation of gene expression, particularly post-transcriptional regulation that includes regulation by microRNA, and long non-coding RNA and RNA binding proteins. (oist.jp)
Subsequently, to check gene expression between experimental AO-infested ESB tissues and uninfested ESB tissues (gills and head kidney) RNA-seq was adopted. (esb2017.org)
Adjustments within the expression of innate immune genes in gills and head kidney at 2, 3, 5, 7 and 23 dpi have been analysed utilizing real-time PCR. (esb2017.org)

With overexpression of a-arrestin Txnip in RPE, cones and the combined respectively, the authors show a potential gene agnostic treatment that can be applied to retinitis pigmentosa. (elifesciences.org)
The findings suggest that this therapy, whether used alone or in combination with other gene therapies that boost eye health, may offer a new approach to preserving vision in people with retinitis pigmentosa or other conditions that cause vision loss. (azolifesciences.com)
A gene therapy that would preserve photoreceptors in people with retinitis pigmentosa regardless of their specific genetic mutation would help many more patients. (azolifesciences.com)
To find a widely effective gene therapy for the disease, Xue and colleagues screened 20 potential therapies in mouse models with the same genetic deficits as humans with retinitis pigmentosa. (azolifesciences.com)
2021) AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa. (azolifesciences.com)

both methods indicated suppression of genes and proteins participating in mitochondrial metabolism. (jci.org)
Moreover, the study explored the roles of two proteins, HSP90AB1 and Arrdc4, which share similarities or associations with Txnip. (elifesciences.org)
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. (nih.gov)
Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease (PubMed:11371646, PubMed:11717357, PubMed:12860203, PubMed:19386761, PubMed:12787071, PubMed:12154011). (cansar.ai)

Given that Txnip is a critical metabolic regulator of the liver, we aimed to investigate the role of Gm15441 in the regulation of Txnip and liver metabolism. (nau.edu)

This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). (uth.edu)
We outline various procedures to localize differentially expressed genes on the pig genome and link this with information on published QTL. (biomedcentral.com)
Different approaches to localize the differentially expressed (DE) genes to the pig genome showed different levels of success and a clear lack of concordance for some genes between the various approaches. (biomedcentral.com)
Also, differentially expressed genes underlying QTL for ACTH response were described. (biomedcentral.com)
Using the latest version of the draft sequence, the differentially expressed genes were mapped to the pig genome. (biomedcentral.com)
The goal is to identify overlap between differentially expressed genes and QTL regions at either the genome or the pathway level. (biomedcentral.com)
Differentially expressed genes in the QTL region are obvious positional candidate genes for the QTL. (biomedcentral.com)
Panel B illustrates the steps to test for co-location between differentially expressed genes and QTL regions in the pig example. (biomedcentral.com)
Panel C illustrates the steps that are required to test for significant enrichment at the pathway level between differentially expressed genes and genes in the QTL region. (biomedcentral.com)
The RNA-seq revealed a number of differentially expressed genes (DEG), particularly 679 upregulated genes and 360 downregulated genes within the gills, and 206 upregulated genes and 170 downregulated genes in head kidney. (esb2017.org)

C and D ) Respiration control ratio was obtained from permeabilized cardiac fibers incubated with indicated substrates in 11 WT and 7 Txnip-KO mice. (jci.org)
The mammal two-hybrid assay revealed the direct interaction between CXCR4 and TXNIP, which was increased in the spinal cord of pSNL mice. (biomedcentral.com)
A gene therapy protects eye cells in mice with a rare disorder that causes vision loss, especially when used in combination with other gene therapies, shows a study published today in eLife . (azolifesciences.com)
The immediate next step is to test Txnip for safety in animals beyond mice, before moving on to a clinical trial in humans,' explains senior author and Howard Hughes Institute Investigator Constance Cepko, the Bullard Professor of Genetics and Neuroscience at Harvard Medical School. (azolifesciences.com)
Description: Analyze the physiological and molecular biological roles of each component of the CCR4-NOT complex using gene-modified mice. (oist.jp)

Small-interfering RNA against Txnip prevented Txnip upregulation in response to high creatine, maintained normal levels of creatine uptake, and prevented downregulation of CrT mRNA. (ox.ac.uk)

We discovered TXNIP almost 20 years ago as the top gene upregulated by glucose in human islets, and subsequently, as a major factor contributing to islet cell death and dysfunction. (uab.edu)

However, the role of TXNIP in modulating diabetes-related endothelial dysfunction remains unclear. (bvsalud.org)

Shalev says, "No oral medications are currently available for type 1 diabetes and none of the approved therapies target the additional problems associated with diabetes, namely the elevation in glucagon (a hormone that leads to even higher blood sugar) and the increase in TXNIP (a detrimental protein that leads to death of insulin-producing pancreatic islet cells). (uab.edu)
Also, currently no oral medications are available for type 1 diabetes and none of the current therapies target the elevated glucagon or the increased TXNIP associated with diabetes. (uab.edu)

This enabled co-location of DE genes and previously studied QTL regions, but the draft genome sequence is still incomplete and will contain many errors. (biomedcentral.com)
A further step to explore links between DE genes and QTL at the pathway level was largely unsuccessful due to the lack of annotation of the pig genome. (biomedcentral.com)

Based on the promising effects in human islets and the increasing evidence of beneficial metabolic effects associated with inhibiting TXNIP signaling in humans, we believe that the chances of this particular work being translatable to humans is high. (uab.edu)

This was achieved by investigating the protection of cone degeneration through the overexpression of five distinct mutated variants of Txnip within the retinal pigment epithelium (RPE). (elifesciences.org)

Gene ontology analysis was performed using the software PANTHER that classified downregulated genes by their molecular functions ( A ) and biological processes ( B ) based on published evidence. (jci.org)

This blog entry reviews research on the beneficial health effects of resveratrol and whether or not it indeed activates the SIRT1 gene. (anti-agingfirewalls.com)

Given the central role that mitochondria play during hypoxia, we hypothesized that Txnip deletion would enhance ischemia-reperfusion damage. (jci.org)

Consistently, Txnip-KO mitochondria were functionally and structurally altered, showing reduced oxygen consumption and ultrastructural derangements. (jci.org)
Thus, although Txnip deletion suppresses mitochondrial function, protection from myocardial ischemia is enhanced as a result of a coordinated shift to enhanced anaerobic metabolism, which provides an energy source outside of mitochondria. (jci.org)
A version of Txnip called C247S worked especially well, as it helped the cone photoreceptors switch to using alternative energy sources and improved mitochondria health in the cells. (azolifesciences.com)

extended their groundbreaking discovery demonstrating the protective effect of Txnip on cone photoreceptor survival. (elifesciences.org)
They found the protection of Txnip in RPE cells and its mechanism is different from its protection in cone cells. (elifesciences.org)
2. Dissect the mechanism of Txnip in RPE vs Cone photoreceptors in retinal degeneration models. (elifesciences.org)
3. Explore the functions of ARrdc4, a protein similar to Txnip and HSP90AB1 in cone degeneration. (elifesciences.org)

A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)
To further validate the results pathway study was performed to identify the involvement of the coding genes in type II diabetes. (researchgate.net)
Our studies now show that a newly designed, orally available small molecule, lowered TXNIP and glucagon and showed strong anti-diabetic effects in mouse models of type 1 and type 2 diabetes. (uab.edu)

Down-regulating the content of TXNIP decreased the effect of Gal-3 on neuroinflammation in in vitro model. (silverchair.com)

The study of genes at the pathway level is also important to identify positional candidate genes in the QTL region that are not represented on the microarray. (biomedcentral.com)

However, the actions system of TXNIP in DN continued to be unclear. (mycareerpeer.com)

Surprisingly, Txnip-KO hearts had greater recovery of cardiac function after an ischemia-reperfusion insult. (jci.org)

The scientists introduced four new genes into harvested gallbladder cells which reprogrammed the cells to act more like the insulin-producing beta cells that the body had destroyed. (diabetesresearchconnection.org)

On the molecular level, circRNAs control gene appearance on the posttranscriptional and transcriptional stage and so are involved with multi-facetted natural procedures, adding to many illnesses10 certainly,11. (phytid.org)

Mouse over or click genes or lines for details. (ucsc.edu)
Their experiments showed that using a virus carrier to deliver a gene called Txnip was the most effective approach in treating the condition across three different mouse models. (azolifesciences.com)

Gene-nutrient interactions may help explain this variability in response to food that is associated with IBD. (mdpi.com)

Microarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection of candidate genes. (biomedcentral.com)

For a focused analysis on 12 genes, overlapping QTL from the public domain were presented. (biomedcentral.com)
Mutation Evaluation In all examples with raised plasma cholestane-3,5,6-triol focus, as well such as cases with solid scientific suspicion of NP-C but regular oxysterols, confirmatory molecular hereditary analysis from the and genes was performed. (bioshockinfinitereleasedate.com)

It identifies gene-nutrient interactions associated with the nutritional deficiencies that people with IBD commonly experience, and the role of the Western diet in influencing these. (mdpi.com)

This finding stemmed from more than two decades of her basic research into a gene in pancreatic islets called TXNIP. (sciencedaily.com)

Anatomy15

Organisms6

Diseases10

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Psychiatry and Psychology1

Phenomena and Processes39

Information Science2

Thioredoxin interac10

Signaling pathway4

Oxidative stress3

Regulates4

Promoted TXNIP protein expression1

Inhibition7

NLRP312

Gm15441 and Txnip3

Pathways4

Inhibitor3

Mutations4

Protein expression1

Expression20

Retinitis pigmentosa5

Proteins4

Regulator1

Differentially10

Mice5

MRNA1

Subsequently1

Endothelial1

Associated with diabetes2

Genome2

Metabolic1

Overexpression1

Ontology1

Activates1

Hypoxia1

Mitochondria3

Cone4

Diabetes3

Vitro1

Positional1

Unclear1

Cardiac1

Cells1

Transcriptional1

Mouse2

Response1

Microarray1

Analysis2

Role1

Research1