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  • analogs
  • Most work in the field of TXA2 is done instead with synthetic analogs such as U46619 and I-BOP. (wikipedia.org)
  • Synthetic analogs of TXA2 that activate TP but are relatively resistant to spontaneous and metabolic degradation include SQ 26655, AGN192093, and EP 171, all of which have binding and activating potencies for TP similar to I-BOP. (wikipedia.org)
  • contraction
  • Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). (wikipedia.org)
  • primarily
  • Due to its very short half life, TXA2 primarily functions as an autocrine or paracrine mediator in the nearby tissues surrounding its site of production. (wikipedia.org)
  • production
  • In human studies, 11-dehydrothromboxane B2 levels are used to indirectly measure TXA2 production. (wikipedia.org)
  • Effects of nimodipine on the production of thromboxane A2 following total global cerebral ischemia. (curehunter.com)
  • Its abundant production during blood clotting, the presence of cyclooxygenases and to a lesser extent thromboxane synthase in a wide range of cell types and tissue, and its production by other pathways imply that 12-HHT has one or more important bioactivities relevant to clotting and, perhaps, other responses. (wikipedia.org)
  • promotes
  • Thus, platelet-derived TXA2 orchestrates the generation of a favorable intravascular metastatic niche that promotes tumor cell seeding and identifies COX-1/TXA2 signaling as a target for the prevention of metastasis. (jci.org)