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Thromboxane A2Receptors, ThromboxaneReceptors, Thromboxane A2, Prostaglandin H2Thromboxane-A SynthaseProtein BiosynthesisHydrazinesThromboxane B2ThromboxanesProtein Synthesis InhibitorsKineticsRNA, MessengerStereoisomerismProstaglandin Endoperoxides, SyntheticCells, CulturedMolecular StructureProstaglandins HMolecular Sequence DataDNAEscherichia coliCycloheximideProstaglandin H2Receptors, ProstaglandinDNA ReplicationCyclizationCell LineTranexamic AcidBase SequenceTritiumMutationBicyclo CompoundsLeucineEpoprostenolTranscription, GeneticCarbon IsotopesRNALiverProstaglandinsDactinomycinTime FactorsPlatelet AggregationCell-Free SystemBacterial ProteinsChemistry Techniques, SyntheticAmino Acid SequenceAntifibrinolytic AgentsBlood PlateletsPuromycinThymidine6-Ketoprostaglandin F1 alphaPeptide BiosynthesisCell DivisionAmino AcidsChloramphenicolChemistry, OrganicDose-Response Relationship, DrugMagnetic Resonance SpectroscopyUridineRabbitsCarbon RadioisotopesProstaglandin-Endoperoxide SynthasesStructure-Activity RelationshipEnzyme InhibitorsArachidonic AcidCatalysisDinoprostoneRNA, ViralGene Expression RegulationProstaglandin EndoperoxidesSolid-Phase Synthesis TechniquesIndomethacinIndicators and ReagentsSignal TransductionViral ProteinsTemperatureRats, Inbred StrainsElectrophoresis, Polyacrylamide GelRNA, BacterialCollagenFibroblastsMethioninePolyribosomesCulture MediaCyclooxygenase 1Cyclooxygenase InhibitorsCloning, MolecularAutoradiographyRats, Sprague-DawleyMolecular WeightProstaglandin AntagonistsBenzoxepinsGlucoseAcetatesTemplates, GeneticVasoconstrictor AgentsFatty AcidsVirus ReplicationNitric OxideAdenosine TriphosphateCricetinaePhenylalanine
Platelet aggregationProstaglandinAspirinPGI2 and TXA2ProstaglandinsPromotes plateletPGE2PGF2InhibitVascularPlateletsProstacyclin synthesisProstaglandin synthesisCyclooxygenasePlatelet activationSecretionInhibitionEicosanoidDeficiencyAggregationCholesterolSubstratesPolyunsaturated fattyTXB2ProductionRoleImportantStepEarly
Platelet aggregation2
Prostaglandin7
  • Cyclooxygenase is required for prostaglandin and thromboxane synthesis. (wikipedia.org)
  • The levels of prostaglandin E2 (PGE2), PGF2 alpha, PGI2, thromboxane A2 (TXA2), and leukotriene B4 (LTB4), which represent the cyclooxygenase and 5-lipoxygenase pathways, were determined in 21 pairs of surgically excised human colon cancer and histologically normal mucosa samples 5 to 10 cm away from the tumor. (nih.gov)
  • Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. (drugbank.com)
  • Prostanoids are made by the sequential activities of cyclooxygenase (COX) and particular prostanoid synthases to produce prostaglandin PGD2, PGE2, PGF2, prostacyclin (PGI2), and thromboxane A2 (TXA2) (Fig. 1). (mdm2-inhibitors.com)
  • Because cyclooxygenase-2 (COX-2) dependent prostaglandin synthesis is implicated in preterm birth, we evaluated effects of mono-2-ethylhexyl phthalate (MEHP), the active metabolite of DEHP, on prostaglandin E2 (PGE2) synthesis and COX expression in human placental macrophages (PM). In addition, responses in PM were compared to those in a human macrophage-like cell line, THP-1. (biomedcentral.com)
  • The findings from this study are the first to demonstrate phthalate-stimulated PGE2 synthesis in PM and warrant future studies into COX-2-dependent prostaglandin synthesis as a mechanism of toxicant-associated preterm birth. (biomedcentral.com)
  • Recent data collected by our laboratory suggest that MEHP stimulates expression in human trophoblast cells of PTGS2, the gene for COX-2 [ 18 ], an enzyme that is critical for synthesis of uterotonic prostaglandins, prostaglandin E 2 (PGE 2 ) and prostaglandin F 2α (PGF 2α ). (biomedcentral.com)
Aspirin5
  • Eicosanoids may participate in colon carcinogenesis, as evidenced from work in animal tumor models showing prevention of colon cancer by inhibitors of their synthesis and epidemiologic studies demonstrating reduced risk of colon cancer in long-term users of aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs). (nih.gov)
  • C. Aspirin can reduce unwanted platelet adhesion by inhibiting TXA2 synthesis. (nursingessay24x7.com)
  • The usage of aspirin to diminish TXA2 synthesis shows little advantage in preeclampsia, whereas indomethacin and ibuprofen are utilized successfully to close PDA in the early newborn. (mdm2-inhibitors.com)
  • Further investigations by Smith concluded that aspirin and indomethacin inhibited synthesis by specifically blocking oxygenation of arachidonic acid. (medscape.com)
  • U73343 had a greater effect than aspirin on the action of collagen, indicating an action on the TxA2-independent component of the signal, via PLC gamma-U73343 lowered TxA2 production by inhibiting the activation of cPLA2, probably at a tyrosine phosphorylation step. (medkoo.com)
PGI2 and TXA22
  • PGI2 and TXA2 go through rapid non-enzymatic hydrolysis towards the steady and biologically inactive 6-keto-PGF1 and TXB2, respectively. (mdm2-inhibitors.com)
  • observations concerning COX-2 inhibitors, which might clearly impact the vascular program not merely by limiting the formation of PGI2 and TXA2. (thetechnoant.info)
Prostaglandins2
  • Much of this is believed to be due to decreased production of prostaglandins and TXA2. (wikipedia.org)
  • NSAIDs are a group of drugs which have anti-inflammatory and analgesic effects via their inhibitory action upon cyclooxygenase (COX) which is involved in the synthesis of prostaglandins. (ozemedicine.com)
Promotes platelet1
PGE21
  • Western blot analysis revealed a significant increase in COX-2 expression in PM and THP-1 cells treated with 180 micromolar MEHP, and no changes in COX-1 expression, supporting the role of COX-2 in MEHP-stimulated PGE2 synthesis. (biomedcentral.com)
PGF21
  • The differences in the levels of PGF2 alpha, TXA2, and LTB4 between normal and malignant tissue were not statistically significant. (nih.gov)
Inhibit1
  • U73343 seems to inhibit only the tyrosine kinases involved in the activation of PLC gamma and the generation of TxA2. (medkoo.com)
Vascular2
  • The PGI2/TXA2 stability is particularly important in the legislation of maternal and fetal vascular function during being pregnant and in the newborn. (mdm2-inhibitors.com)
  • Actually, PAF and TXA2 have already been implicated in ET-1 -induced mobilization of intracellular Ca2+ in cultured vascular even muscles cells (Takayasu TK receptors, seemed to amplify the ET-1 induced potentiation of EFS-induced contractions. (conferencedequebec.org)
Platelets4
  • It has been thought that the cardiovascular unwanted effects of COXIBs may possibly in massive measure be explained because of COX two inhibition in endothelial cells, leading to a disturbance on the stability concerning prostacyclin synthesis inside the endothelial cells and thromboxane synthesis inside the platelets. (pkc-inhibitors.com)
  • The triggered platelets aggregate towards the hurt sites in PA vessels and launch vasoactve chemicals (5-HT, TXA2), mitogenic and development elements (PDGF, TGF-, VEGF), and inflammatory cytokines (TNF, IL-1, IL-1). (ap26113.com)
  • Collagen + thrombin Prostaglandins synthesis Thromboxan A₂ Lowers platelet cAMP Starts release reaction Vascular endothelial cells Release of prostocyclin Increased level of cAMP Inhibition of the release reaction and aggregation of platelets. (slideshare.net)
  • Cyclooxygenase metabolizes AA to the cycloendoperoxide prostaglandin H2 (PGH2), which is then converted to either PGD2, PGE2, PGF2α, PGI2 (prostacyclin) or TXA2 (thromboxane) by appropriate enzymes (i.e., thromboxane synthase in platelets, prostacyclin synthase in endothelial cells). (theunitutor.com)
Prostacyclin synthesis2
  • Enzymes and substrates associated with thromoboxane and prostacyclin synthesis. (wikimili.com)
  • Enhancement of the dietary EPAAA ratio will consequently have an impact on the fee of prostacyclin synthesis from the endothelium much less than it has an effect on the price of thromboxane synthesis while in the plate lets. (pkc-inhibitors.com)
Prostaglandin synthesis2
  • Moderate dose (650mg - 4g/day): Inhibits cyclooxygenase 1, 2 enzymes, prevents prostaglandin synthesis leading to inhibition of thermogenesis processes, enhanced heat loss and decreased sensitivity of sensory nerves to other substances. (vinmec.com)
  • COX-1 and COX-2, also called prostaglandin-endoperoxide synthase 1 and 2 respectively, catalyze the speed limiting ABT-888 stage of prostaglandin synthesis. (careersfromscience.org)
Cyclooxygenase1
  • Cyclooxygenase is required for prostaglandin and thromboxane synthesis. (wikipedia.org)
Platelet activation2
Secretion1
  • The increase in hypothalamic PGE 2 synthesis correlated with the pubertal increase in ovarian estrogen secretion, as measured by the changes in uterine weight that encompass the day of the first LH surge. (elsevierpure.com)
Inhibition1
  • After selective inhibition of endogenous TXB2 generation by imidazole or OKY-158l no correlation was found between platelet aggregation and thromboxane synthesis in platelet rich plasma. (iospress.com)
Eicosanoid1
Deficiency2
  • Follow this link to review classifications for Bleeding diathesis due to thromboxane synthesis deficiency in Orphanet. (nih.gov)
  • The deficiency in pyrimidine synthesis due to deficiency in synthetase functions will cause deficiency in pyrimidine kinases and mutations in thymine kinases and in cytosine pyrimidine kinases. (genesispub.org)
Aggregation1
Cholesterol1
  • As a consequence, statins prevent the synthesis of other important isoprenoid intermediates such as farnesyl pyrophosphate and geranyl pyrophosphate, and reduce intracellular cholesterol synthesis. (e-cmh.org)
Substrates1
  • Omega-3 polyunsaturated fatty acids seem to be the preferred substrates for desaturases, although the synthesis of omega-6 polyunsaturated fatty acids is prevalent due to the high dietary intake of linoleic acid. (tuscany-diet.net)
Polyunsaturated fatty2
  • Nevertheless it functions like a compe titive inhibitor for the oxidation of polyunsaturated fatty acids with 20 carbon atoms inside the platelet cyclooxygen ase response and hence as an inhibitor of your bio synthesis of thromboxane A2. (pkc-inhibitors.com)
  • The elongases and desaturases that catalyze the conversion of linoleic acid to arachidonic acid and beyond, up to 22:5n6, are shared with the pathways leading to the synthesis of omega-3, omega-7 and omega-9 polyunsaturated fatty acids. (tuscany-diet.net)
TXB21
  • TxB2, a stable degradation product of TxA2, plays a role in acute hepatoxicity induced by acetaminophen. (wikimili.com)
Production1
  • Administration of estradiol benzoate to anestrous rats, to evoke a premature LH surge, enhanced hypothalamic synthesis of PGE 2 without affecting the production of the other PGs, thus mimicking the changes observed during normal puberty. (elsevierpure.com)
Role1
  • Thromboxane A synthase 1 (TBXAS1) catalyses the synthesis of thromboxane A2 (TXA2), which plays an important role in the pathogenesis of ischemic stroke. (nih.gov)
Important1
  • It is suggested that this change in PGE 2 synthesis represents an important component of the maturational process by which the hypothalamus acquires the capability of releasing a preovulatory surge of LHRH. (elsevierpure.com)
Step1
  • Its synthesis, which occurs in the endoplasmic reticulum, involves five reactions, of which two desaturation steps and an elongation step. (tuscany-diet.net)
Early1
  • In download Dopamine in the Pathophysiology and Treatment of Schizophrenia: to find the place of here shown early ligands, Rev clusters between the synthesis and storage-inducing resulting body homodimer protein proteins( suggested in Li et al. (evakoch.com)