Twins monozygotic. Medical search. Frequent questions

Among numerous causes, premature ovarian failure (POF) frequently has a genetic aetiology and normal menopausal age is strongly heritable judging by the greater concordance between monozygotic (MZ) than dizygotic twins (Snieder et al. (infertile.com)
By integrating data on the immune profiles of healthy monozygotic and dizygotic twin pairs, we estimated the variance in CD25 expression by helper T cells displaying a naive phenotype to be largely driven by genetic and shared early environmental influences. (nature.com)

Whole-exome sequencing was performed for the twin pair that had discordance of aortic valve and aortic aneurysm. (elsevierpure.com)
Sexual discordance in monozygotic twins. (nih.gov)
The twins' varied life histories suggest that environmental risk factors may contribute to apparent discordance for DAT and possible delay in disease onset for the currently nondemented twin. (jamanetwork.com)
Discordance for skeletal and cardiac defect in monozygotic twins. (thejcdp.com)

OBJECTIVE: To analyze genetic differences between 2 pairs of monozygotic twins that had discordant aortic valve morphology, with 1 twin in each pair having a BAV and the other having a trileaflet aortic valve. (elsevierpure.com)
MAIN OUTCOMES AND MEASURES: Genetic coding variations between monozygotic twins using whole-exome sequencing and targeted gene sequencing. (elsevierpure.com)
Genetic sequencing methods identified no pathogenic sequence changes between the twins in each pair. (elsevierpure.com)
3 Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK. (nih.gov)
Twin studies report genetic and individual-level environmental underpinnings in the aetiology of both depression and HRQL, but there is limited twin research exploring this association further. (plos.org)
A novel study of twins who have significant intrapair differences in body mass index (BMI) shows that in the majority of cases, the twin with the higher BMI is the one that veers from their genetic predisposition, based on a polygenic risk score (PRS) for BMI. (medscape.com)
While previous studies have evaluated curious cases of differences in weight between twins, the study is unique in investigating whether the higher or lower weighted twin deviates from their genetic predisposition. (medscape.com)
Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs discordant for MS to dissect the influence of genetic predisposition and environmental factors. (nature.com)
Nonetheless, the expanding helper T cells of twins with MS, which were also elevated in non-twin patients with MS, emerged independent of the individual genetic makeup. (nature.com)
Here we conducted an in-depth pairwise analysis of the systemic immune compartment of 61 monozygotic twin pairs discordant for MS, in which both siblings carry the same genetic and early-life environmental risk for the disease, yet only one is affected by MS. This approach thus eliminated the majority of bias attributed to variable genetic and early environmental influences in a heterogenous population 17 , 18 . (nature.com)
M any scientists once believed that physical similarities between identical twins are genetic, while their personalities, intelligence and other differences between them are an effect of their environment. (youdao.com)
You look at identical twins , monozygotic twins who share the same genetic profile. (youdao.com)
The study was a heritability analysis of 192 pairs of twins, which attributed 37 percent of the variation in risk of autism to genetic factors and 55 percent to shared environmental factors . (cdc.gov)

Method: Four dermatoglyphic markers of prenatal growth were obtained by established procedures from 26 monozygotic twin pairs discordant for schizophrenia, 13 monozygotic twin pairs concordant for schizophrenia, and several normal monozygotic twin samples. (missouristate.edu)
Nongenetic pathologic developments of brain-wave patterns in monozygotic twins discordant and concordant for schizophrenia. (uni-heidelberg.de)
Yet our investigations into mz twins discordant and concordant for schizophrenia yielded a significantly reduced within-pair EEG concordance for both, the pairs discordant for schizophrenia and the pairs concordant for schizophrenia (with concordance for schizophrenia assessed through a syndrome-oriented approach). (uni-heidelberg.de)
Consequently, EEG anomalies associated with schizophrenia and manifested differently in the mz co-twins concordant for schizophrenia are likely the effect of nongenetic, pathologic processes that evolved independently in the co-twins' genetically identical brains once the illness began to progress. (uni-heidelberg.de)

Objective: This co-twin study investigated monozygotic twins who were discordant for schizophrenia for evidence of prenatal growth differences between the affected and well co-twins. (missouristate.edu)
Results: The a-b ridge count differences between the affected and well co-twins were greater than those found for concordant and normal monozygotic pairs. (missouristate.edu)
In contrast, no significant differences were found between the affected twins and their well co-twins on markers associated with fetal development before 13 or after 15 weeks estimated gestational age. (missouristate.edu)
The main differences were the lower pressure pain threshold and higher hyperalgesia locally presented by TMD- Twin . (bvsalud.org)
The aim was to evaluate differences of salivary protein expression in the CFS patient in respect to his healthy twin. (biomedcentral.com)
Cite this: Differences in Twins Suggest Obesity Veers From Genetics - Medscape - Nov 21, 2023. (medscape.com)
Brain structural differences in monozygotic twins discordant for body mass index. (mpg.de)

In particular, the within-pair EEG concordance of monozygotic (mz) twins was found to be typically as high as r = 0.81 across channels and frequency bands, thus being comparable to that between repeated assessments on the same individual with typically r = 0.83. (uni-heidelberg.de)

A series of monozygotic (MZ) twin pairs discordant for premature ovarian failure presented an unusual opportunity to study ovarian transplantation . (infertile.com)
The aim of this study was to investigate the relationship between poor motor ability and anxious and depressive symptomatology in child and adolescent monozygotic twins. (edu.au)
METHOD: Thirty healthy, never-depressed monozygotic (MZ) twins with a co-twin history of depression (high risk group: n = 13) or without co-twin history of depression (low-risk group: n = 17) were enrolled in a functional magnetic resonance imaging (fMRI) study. (ox.ac.uk)
Our study considered whether children who do not reach their potential birthweight, as indexed by the weight of their heavier twin, also do not attain their potential IQ. (uel.ac.uk)
We had quite a few when we initially pulled the articles on this kind of topic, but we determined studies to be eligible if they used this co-twin control design, and that's where you have a pair of twins participate in a study, and for our review, we were specifically looking at twins that were discordant for autism, clinical symptoms, or traits. (acamh.org)
The aim of this study is to report a clinical case of monozygotic twins discordant for pain -related temporomandibular joint disorder (TMD) from a cognitive-behavioral-emotional phenotypic analysis , from the comparison of clinical variables of pain , history of exposure to painful procedures in early childhood, and coping with pain . (bvsalud.org)
In the present study, we used a proteomic approach to evaluate the global changes in the salivary profile in a couple of monozygotic twins who were discordant for CFS. (biomedcentral.com)
This study shows the presence of differentially expressed proteins in the saliva of the couple of monozygotic twins discordant for CFS, probably related to the disease. (biomedcentral.com)
note = "Funding Information: The authors gratefully acknowledge the ongoing contribution of the{\^A} participants{\^A} in the Twins Early Development Study (TEDS){\^A} and their families. (psu.edu)
The study of monozgotic twins can elucidate possible environmental causes for a disease in genetically identical subjects. (jamanetwork.com)
Data for 3,948 participants came from the Colombo Twin and Singleton Follow-up Study (CoTaSS-2). (plos.org)
The Colombo Twin and Singleton study was funded in whole, or in part, by the Wellcome Trust [Grant number 093206/Z/10/Z], https://wellcome.org . (plos.org)
The study included 3227 twin pairs of the same gender from the Older Finnish Twin Cohort, consisting of twins born before 1958 and alive in 1974 in Finland. (medscape.com)
Conversely, a registry-based study investigated the familial recurrence rate of MS and revealed that monozygotic twin pairs displayed the highest familial risk (17% age-adjusted risk for the unaffected twin) of developing MS, indicating a strong heritable effect 8 . (nature.com)
A monozygotic co-twin control study in men. (erowid.org)
The obese brain as a heritable phenotype: A combined morphometry and twin study. (mpg.de)
The first study asks if health and educational attainment are related within monozygotic twin (MZ) pairs. (lu.se)

Among the twin pairs, the twin with the higher BMI of the two more frequently deviated from their genetically predicted BMI (approximately two thirds) compared with the lower-weight twin, while those who were the lower weight of the two deviated from their predicted BMI approximately a third of the time. (medscape.com)
Together, our matched-pair analysis of the extended twin approach allowed us to discern genetically and environmentally determined features of an MS-associated immune signature. (nature.com)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)

Monozygotic twin girls are reported, one of whom has the typical clinical features of Duchenne muscular dystrophy despite a normal female karyotype. (bmj.com)
This segregation was followed by, and may even have resulted in, twinning into a female pair, one normal and one with the full clinical features of the disease. (bmj.com)
In each pair, the twin with a BAV underwent surgical aortic valve replacement for clinical indications. (elsevierpure.com)
Discordant Clinical Outcomes in a Monozygotic Dichorionic-Diamniotic Twin Pregnancy with Early Zika Virus Exposure. (cdc.gov)

A pair of monozygotic male twins discordant for ectopia vesicae urinariae is described. (bmj.com)
We take a microgenetic approach to investigate the issue, illustrated by the analysis of an episode between a pair of male twin children and their grandpa. (bvsalud.org)
We report on a pair of male monozygotic twins, one unaffected and the other affected with gonadotropin-releasing hormone (GnRH)-dependent precocious puberty, and discuss the role of treatment with a GnRH analog in the attainment of full height potential in GnRH-dependent precocious puberty. (elsevierpure.com)
A monozygotic co-twin control design was used to compare the health of former heavy marijuana using male monozygotic twins to that of their co-twins who never used marijuana significantly. (erowid.org)

We performed an intrapair comparison in 27 monozygotic twin pairs, one of whom was taking third-generation OC, whereas the other was not using OC. (maastrichtuniversity.nl)

Results indicated significantly higher levels of anxious and depressive symptomatology in twins with a motor disorder in discordant pairs compared to their co-twins without a motor disorder, and controls. (edu.au)
In comparison with their well co-twins, the affected twins, in discordant pairs, had developed fewer epidermal ridges in the a-b interdigital area of their right palms. (missouristate.edu)

It was remarkable, therefore, to identify a MZ twin pair in which one sister had undergone menopause for unexplained reasons at age 14 years, whereas the other, aged 24, was still fertile with three naturally conceived children, as well as normal ovulatory cycles and ovarian reserve (Silber et al. (infertile.com)
Crossed cerebral lateralization for verbal and visuo-spatial function in a pair of handedness discordant monozygotic twins: MRI and fMRI brain imaging. (ox.ac.uk)
To examine the nature of hemispheric lateralization for neural processes underlying verbal fluency and visuo-spatial attention, we investigated a single pair of handedness discordant monozygotic (MzHd) twins. (ox.ac.uk)
To this end, we studied a pair of monozygotic female twins appearing discordant for dementia of the Alzheimer type (DAT). (jamanetwork.com)
An 81-year-old female monozygotic twin pair. (jamanetwork.com)
Fifty-six marijuana use discordant monozygotic twin pair members of the Vietnam Era Twin (VET) Registry. (erowid.org)

For example, I have used data on monozygotic (or 'identical') twins to analyze if the extent to which mothers read to children affect children's academic performance. (ku.dk)

DESIGN, SETTING, AND PARTICIPANTS: Two pairs of twins that were objectively determined to be monozygotic were examined at a tertiary care medical center associated with an academic medical center. (elsevierpure.com)

Using self-report measures of depressive symptoms and HRQL, we conducted univariate and bivariate sex-limitation twin analyses. (plos.org)
Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients. (mpg.de)

Both monozygotic twins presented a chronic pain phenotype , although they were discordant with the TMD-related pain . (bvsalud.org)

Control- Twin did not show TMD, however she presented other chronic pains . (bvsalud.org)

Many times, the results of this test are the first indication that this is a twin pregnancy. (twinslist.org)
Here we present a case of conjoined twins in a triplet pregnancy diagnosed at 13 of weeks gestation. (hindawi.com)
This case represents to our knowledge the only MRI images of conjoined twins in a triplet pregnancy and demonstrates how 3D imaging can be used to better counsel patients about management options. (hindawi.com)
Conjoined twins within a triplet pregnancy are very rare and a recent review suggested the incidence is less than one in a million deliveries [ 3 ]. (hindawi.com)
The purpose of this report is to describe the presentation and management of a dichorionic triplet pregnancy complicated by conjoined twins. (hindawi.com)
MRI images of conjoined twins in a triplet pregnancy. (hindawi.com)
The parents were counseled and options discussed included (1) continue the pregnancy understanding that the shared heart meant the conjoined twins could not be separated should they survive to delivery, (2) terminate the entire pregnancy or, (3) selective feticide of the conjoined twins. (hindawi.com)
A review published in 2003 reported thirteen cases of conjoined twins within a triplet pregnancy [ 2 ]. (hindawi.com)

The first familial cases were reported in twins by Rosen and subsequently in 8 persons from a large 3-generation pedigree reported by Pipkin. (medscape.com)

1984). We have encountered a conjoined stillborn twin fetas. (ivis.org)

METHODS: Ten MZ twin pairs requested ovarian transplantation and eight have undergone transplantation with cryopreservation of spare tissue. (infertile.com)
2005). After the sterile twin received a graft of ovarian tissue from her sibling, she conceived naturally during the second menstrual cycle, and delivered a healthy baby at full-term. (infertile.com)

Shared fetal heart of conjoined twins. (hindawi.com)
A repeat scan was performed four days later again confirming a viable singleton gestation with fetal demise of conjoined twins. (hindawi.com)

There has been no real doubt that human homologous or identical twins come from the division of a single egg. (edu.au)
She couldn't tell the difference between the identical twins. (youdao.com)
N-COUNT Identical twins are twins of the same sex who look exactly the same. (youdao.com)
One of her most famous photographs is called " Identical Twins . (youdao.com)
But what if you are able to find identical twins who were separated at birth, and reared in radically different environments. (youdao.com)
It even distinguished between identical twins--their genes are the same, but their irises aren't. (youdao.com)
The developing embryo starts to split into identical twins within the first two weeks after conception. (youdao.com)
And it is only a predisposition towards having non-identical twins that is passed down through families. (youdao.com)

A thirty-two-year-old gravida 1 para 0 was referred to High Risk Obstetrics with a diagnosis of dichorionic diamniotic twin gestation. (hindawi.com)
An early ultrasound at six weeks gestation was reported as a dichorionic diamniotic twin gestation. (hindawi.com)

This case of discordant twins is not unique, however, and nine other twin pairs have subsequently consulted our center for ovarian transplantation in preference to conventional oocyte donation . (infertile.com)

Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression. (ox.ac.uk)
TMD- Twin was more exposed to painful procedures and emotional events due to congenital heart problems. (bvsalud.org)

Conclusions: Because the a-b ridges are known to complete development between 13 and 15 weeks estimated gestational age, the results provide physical evidence suggesting that the schizophrenia-affected monozygotic twins alone experienced a time-specific and time-limited dysgenesis during this time. (missouristate.edu)

We examined whether sub-optimal intra-uterine growth relates to impaired cognitive outcome by comparing birthweight and cognition in monozygotic (MZ) twins. (uel.ac.uk)

Beside the present case, the only other illustrative specimens among mammals are the normal developmental stages of the Texas armadillo (Newman and Patterson, '10) and Assheton's ('98) single case of a sheep's blastodermic vesicle which bore twin germinal areas. (edu.au)
CASE REPORT TMD- Twin presented a diagnosis of painful (myofascial pain with referral ) and joint (disk displacement with reduction) TMD according to the criteria of the DC/TMD. (bvsalud.org)

Restricting analyses to MZ twins enables the effect of reduced intra-uterine growth on cognition to be examined independently of confounding factors including parental IQ and education, gender, age, genes, and gestation. (uel.ac.uk)

Analysis of an X linked DNA polymorphism in 16 independent somatic cell hybrids made between cells derived from each girl and a mouse line suggest that in one twin only the maternal X chromosome is active, whereas in the other the active X was paternally derived. (bmj.com)
The cultural psychology approach demands a qualitative, systemic analysis of complexities of twin development, considering the dynamics of internalization processes taking place within culture, and across social relations with significant adults. (bvsalud.org)
Phenotypic analysis of discordant monozygotic twins for pain-related temporomandibular joint disorder. (bvsalud.org)
We combined the high-throughput of mass cytometry, facilitating the analysis of 57 twin pairs, with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) of eight selected twin pairs to obtain a comprehensive overview of epitopes, transcriptome and T cell receptor (TCR) clonotypes. (nature.com)

The co-twin control design was used to explore these mental health issues in MZ twins concordant and discordant for a motor disorder, and controls. (edu.au)
The design of research with monozygotic twins discordant for the disease has emerged as a powerful tool for the detection of phenotypic risk factors . (bvsalud.org)

There is a dearth of studies examining monozygotic ASD discordant twins, and Lynnea explains why this group is so important for inclusion in research to advance the science into non-shared environmental effects, and explains the implications of the findings for professionals working in child and adolescent mental health. (acamh.org)

Person-specific non-shared environmental influences on intra-individual variability of daily school feelings were estimated using time series data from twenty-one pairs of monozygotic twins (age = 10 years, 16 female pairs) over two consecutive weeks. (psu.edu)

RESULTS: High-risk twins showed increased neural response to happy and fearful faces in dorsal anterior cingulate cortex (ACC), dorsomedial prefrontal cortex (dmPFC), pre-supplementary motor area and occipito-parietal regions compared to low-risk twins. (ox.ac.uk)
The results suggest that the mean advantage for heavier twins relative to their lighter co-twins can be as much as half a SD in VIQ points. (uel.ac.uk)
As the sample is taken from the mother's blood, there's no way to isolate the results for each twin. (twinslist.org)

71 MZ twin pairs participated (7 years 11 months to 17 years 3 months). (uel.ac.uk)
At 1.6 years of age, the affected twin was studied for tall stature (+3.8 SD), and was diagnosed as having GnRH-dependent precocious puberty due to a hypothalamic hamartoma of the tuber cinereum. (elsevierpure.com)
He attained a final height of 171.0 cm at 14.9 years of age (+0.10 SD) and his twin 170.0 cm at 15.3 years of age (-0.10 SD), with their target height being 174.5 ± 9.0 cm. (elsevierpure.com)
A total of 1,240 Finnish twins aged 21-26 years completed a questionnaire containing items on the appraisal of their career goals along five dimensions: importance, progress, effort, strain, and self-efficacy. (cambridge.org)

This scan identified a triplet gestation complicated by a set of conjoined twins. (hindawi.com)

Moreover, review of previous reports of monozygotic twin pairs concordant or discordant for Alzheimer's disease, with adequate family history data, suggest a pattern indicating interactions among age at dementia onset, sex, and familiality. (jamanetwork.com)
Using complementary multimodal high-throughput and high-dimensional single-cell technologies in conjunction with data-driven computational tools, we identified an inflammatory shift in a monocyte cluster of twins with MS, coupled with the emergence of a population of IL-2 hyper-responsive transitional naive helper T cells as MS-related immune alterations. (nature.com)

The internal locus of control indicates greater pain sensitivity , with better coping of the painful experience for the TMD- Twin . (bvsalud.org)

These task-related changes in neural responses in high-risk twins were accompanied by impaired gender discrimination performance during face processing. (ox.ac.uk)
Conjoined twins are a rare complication of monozygotic twinning and are associated with high perinatal mortality. (hindawi.com)

Published reports concerning family incidence and twin reports are reviewed. (bmj.com)

The first of the two new specimens} consisted of a single chorionic sac which contained twin embryos, each 12.3 mm. long (fig. 1). (edu.au)
specimen of human twins demonstrates for the first time their actual origin from a single yolk sac, and hence from a single ovum. (edu.au)
Within the single chorion were twin embryos of 11.5 and 12 mm. (fig. 4). (edu.au)
Conjoined twins occur when division of a single zygote takes place twelve to thirteen days after fertilization [ 1 ]. (hindawi.com)

1,000 fecal samples obtained from the TwinsUK population, including 416 twin pairs. (nih.gov)

There were significantly higher levels of anxious symptomatology in twins with a motor disorder in discordant sets than in sets of twins concordant for a motor disorder. (edu.au)
There were significantly higher levels of anxious symptomatology in concordant twins than in controls. (edu.au)

To the positive list I have there added two new cases of monochorial twins, each unique of its kind. (edu.au)

Anatomy1

Diseases7

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology1

Phenomena and Processes12

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science1

Named Groups7

Health Care3

Geographicals2

Dizygotic2

Discordance4

Genetic13

Concordant for schizophrenia4

Differences7

Concordance1

Study17

Genetically3

Clinical4

Male4

Intrapair1

Discordant pairs2

Pair6

Analyze1

PARTICIPANTS1

MEASURES2

Phenotype1

Chronic1

Pregnancy8

Familial1

19841

Tissue2

Fetal2

Identical twins8

Diamniotic2

Transplantation1

Emotional2

Conclusions1

Cognitive1

Case2

Analyses1

Analysis4

DESIGN2

Research1

Female1

RESULTS3

Years4

Gestation1

Data2

Greater1

High2

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Single4

Samples1

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Unique1