Tumour tumor markers biological. Medical search. Frequent questions

Tumor markers can be used to detect relapse with a high degree of sensitivity in patients with central nervous system nongerminomatous germ cell tumors (CNS-NGGCTs), according to a pooled analysis of cooperative group trials. (medscape.com)
This pooled analysis represents the largest prospective cohort to date of relapsed intracranial germ cell tumors, Dr. Fonseca said. (medscape.com)
Recent Children's Oncology Group data showed that 98% of patients with extracranial germ cell tumors who relapsed were detectable by tumor markers alone, and this led to a change in surveillance guidelines for those patients. (medscape.com)
2004). "Testicular tumor markers: Corner-stones in the management of malignant germ cell tumors" (PDF). (wikipedia.org)
10. Significance of primary tumor size and preorchiectomy serum tumor marker level in predicting pathologic stage at retroperitoneal lymph node dissection in clinical Stage A nonseminomatous germ cell tumors. (nih.gov)
18. Tumor markers in patients with non-seminomatous germ cell tumors of the testis. (nih.gov)
Newswise - PHILADELPHIA-A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT) - a 40 percent increase in the number of regions known to be associated with the cancer. (newswise.com)
Germ cell tumors account for 95 percent of testicular cancer cases. (newswise.com)
Nathanson and TECAC teams have used the method to find locations on chromosomes - called loci - that contain variants associated with an increased risk of germ cell tumors. (newswise.com)

[ 47 ] Tumor markers such as CA-125 are not good discriminators of benign lesions from malignant lesions in premenopausal women but have better accuracy in postmenopausal women. (medscape.com)
We evaluated the clinicopathological characteristics of a cohort of 246 Chinese patients in relation to the expression of epithelial-to-mesenchymal (EMT) markers in benign, borderline and malignant tumors and the prognostic value of different surgical regimens. (oncotarget.com)
Expression of E-cadherin, Snail, Slug and Twist were higher in epithelial cells from borderline and malignant tumors than those in benign tumors, whereas the expression of N-cadherin was opposite. (oncotarget.com)
Expression of mesenchymal stem cell markers contributed to the inherent heterogeneity in the malignant tumors. (oncotarget.com)
More than half a century later, the term ''cystosarcoma phyllodes'' was replaced by ''phyllodes tumor'' to distinguish it from purely mesenchymal malignant tumors. (oncotarget.com)
All the TS1 tumors (from 13 to 20 mm) showed higher SUVs in FDG-PET with dual time point evaluation in the delayed phase compared with the early phase, which suggested the lesions were malignant. (wjgnet.com)
Upon receiving dominant proangiogenic stimuli from malignant cells or the tumor microenvironment through several effectors, such as vascular endothelial growth factors (VEGFs), platelet-derived growth factor (PDGF), placenta-derived growth factor (PlGF), hypoxia-inducible factor-1 (HIF-1 α ), angiopoietin-2, transforming growth factor β (TGF- β ), or interleukin-8, ECs from preexisting vessels become activated. (hindawi.com)
In tumor vessels, the basement membrane has defects in its structure and composition and can provide a productive environment for metastatic malignant epithelial cells and proliferating ECs [ 10 ]. (hindawi.com)
In some cases, it may be necessary to test more than one tumor marker for certain types of cancer, especially when diagnosing malignant lymphoma or other solid tumor diseases. (odemshop.hr)
Glioblastoma is a malignant tumor of the central nervous system (brain or spinal cord) and one of the deadliest types of cancer. (fapesp.br)

CXCL10 is an ELR-negative CXC chemokine that attenuates angiogenesis and has anti-tumor actions ( 21 - 23 ). (spandidos-publications.com)
We show that the loss of TEM8 in cancer cells results in inhibition of cancer progression, reduction in tumor angiogenesis and reduced metastatic burden in breast cancer mouse models. (oncotarget.com)
Angiogenesis, an essential component of tumor growth and survival, is regulated by complex interactions between several cell types and soluble mediators. (hindawi.com)
Although the application of angiogenesis inhibitors in some types of cancers has shown clinical benefits, predictive markers to assess treatment effects have yet to be established. (hindawi.com)
Early studies in this field have revealed that a tumor mass cannot exceed 1 mm 3 without angiogenesis [ 3 ]. (hindawi.com)

ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)
There were 86 patients with tumor marker assessments at diagnosis, and 83 had tumor marker elevations in serum, cerebrospinal fluid (CSF), or both. (medscape.com)
The sensitivity of tumor markers at diagnosis was 94% for serum, 83% for CSF, and 97% for either serum or CSF. (medscape.com)
The sensitivity of tumor markers was 82% in serum, 85% in CSF, and 88% in either. (medscape.com)
To better understand if tumor markers can be used for surveillance, the researchers analyzed data from patients who had either serum or CSF tumor marker levels available at both diagnosis and relapse. (medscape.com)
Current surveillance strategies use a combination of brain and spine MRI and serum tumor markers with declining frequency over time. (medscape.com)
1. [Significance of serum ferritin level in testicular tumors]. (nih.gov)
6. [Human placental alkaline phosphatase (hPLAP) is the most frequently elevated serum marker in testicular cancer]. (nih.gov)
15. Serum alpha-fetoprotein and human chorionic gonadotropin in the management of testicular tumors. (nih.gov)
20. [Evaluation of serum AFP, HCG, and CEA in testicular tumor]. (nih.gov)
Background: High serum immunoglobulins and circulating immune complexes (IgG, IgM, IgA and CIC) values in patients with cancer have been used as tumor markers. (amrita.edu)
Samples were selected at random and subjected for sequential analysis of serum biochemical markers (IgG, IgA, IgM and CIC-circulating immune complexes levels) in the pre- and post-treatment period. (amrita.edu)
CEA, CA125, and ProGRP are commonly used serum tumor markers for lung cancer. (geneticsmr.com)

Furthermore, associations of gene expression with blood and urinary measures of biomarkers of exposure, early phenotypic effects, and tumor markers were investigated. (nih.gov)
Biological variation and reference change value as decision criteria in clinical use of tumor biomarkers. (degruyter.com)
Metabolomics has recently emerged as a promising field for developing novel tumor biomarkers. (medsci.org)

As Bert Gold, PhD, FACMG, a staff scientist with the National Cancer Institute's Center for Cancer Research, explained, "Circulating tumor cells are cells of origin from a usually solid tumor that have gone into the general circulation and can be viewed in peripheral blood. (aacc.org)

A promising target for blocking tumor progression, without causing severe side effects [ 2 ], is Tumor Endothelial Marker 8 (TEM8), an integrin-like cell surface protein expressed predominantly in the tumor endothelium and in cancer cells [ 3 , 4 ]. (oncotarget.com)
These observations indicate that MSCs and derived cell types create a cancer stem cell niche to enable tumor progression via release of PGE 2 and cytokines. (aacrjournals.org)
abstract = "Substantial advances have been made in understanding critical molecular and cellular mechanisms driving tumor initiation, maintenance, and progression in non-small-cell lung cancer (NSCLC). (tmu.edu.tw)
Other markers help physicians track the progression of a disease as well as assess the effectiveness of treatment. (odemshop.hr)
Genes are used as tumor markers to monitor the presence, progression and response of a tumor to treatments. (odemshop.hr)

Consequently, there is an urgent need to expand research on understanding the biologic implications of how different types, doses, and dose rates of ionizing radiation - whether administered locally, or systemically by radiopharmaceuticals - affect the tumor and surrounding tissues, with the goal of improving the therapeutic ratio and providing clinical benefit to patients. (nih.gov)
In the case of cancer, prostate tissues contain almost 10 times as many of these markers as healthy tissues of the prostate gland. (bionity.com)
Non-functional pituitary adenoma (NFPA) is a common tumor that occurs in the pituitary gland, and generally without any symptoms at its early stage and without clinical elevation of hormones, which is commonly diagnosed when it grows up to compress its surrounding tissues and organs. (frontiersin.org)
Therefore, independent investigation of mRCC and pRCC tumor tissues is essential to comprehend the intratumoral landscape within a patient and ultimately to achieve sustainable therapeutic benefit through a rational drug combination design. (biomedcentral.com)

The overall goal of this phase of the TCGA initiative is to provide genome-wide catalogs of genomic alterations in 20-25 different types of human cancer that could be used to identify and accelerate the development of new diagnostic and prognostic markers, new targets for pharmaceutical interventions, and new cancer prevention and treatment strategies. (nih.gov)
proposed a grading system for lung squamous cell carcinoma in which the scores for two independent prognostic markers, including tumor budding and tumor-cell nest size, are summed ( 14 ). (iiarjournals.org)

Recent technology advances in multiplex genotyping and high-throughput genomic profiling by next-generation sequencing technologies now offer the possibility of rapidly and comprehensively interrogating the cancer genome of individual patients from small tumor biopsies. (tmu.edu.tw)

Although the 2015 World Health Organization (WHO) Classification of lung tumors reported that histological grading may be helpful for lung cancer management ( 7 ), a widely accepted histological grading system with clearly defined criteria and demonstrable clinical significance has not yet been developed for lung cancer, and more evidence than presented in the WHO report is needed ( 8 ). (iiarjournals.org)
The means of the diagnosis of lung cancer include laboratory tumor markers, imaging examination and histopathologic analysis of biopsy [ 4 ]. (medsci.org)
Parathyroid hormone-related protein (PTHrP) are very high in patients with lung cancer, but there are no specific markers for tumors in other organs. (odemshop.hr)
The role of Tumor-infiltrating lymphocytes (TILs) in the prognosis of patients with lung cancer is still controversial. (karger.com)
Specificity and sensitivity of single as well as combination markers in lung cancer diagnosis were determined. (geneticsmr.com)
In this study, we assessed the feasibility of using traditional plasma tumor markers together with IL-6, IL-10, and MCP-1 in the screening and diagnosis of lung cancer. (geneticsmr.com)

CNS-NGGCTs are rare and heterogeneous tumors that respond best when treated using multimodal approaches, including surgical resection, chemotherapy, and radiation, according to Dr. Fonseca. (medscape.com)
Patients may also receive systemic chemotherapy depending on severity and recurrence of the tumors. (medscape.com)
Neoadjuvant chemotherapy may be considered for select patients with UTUC (eg, higher stage, grade tumor). (medscape.com)
If the chromosome 1p19q is showing deletion from an oligodendroglioma it means that the tumour is more responsive to chemotherapy. (brainstrust.org.uk)
The researchers identified a set of such molecular markers in which higher levels of methylation were associated with a greater risk of fiver-year recurrence of TNBC as recorded in patients' medical records following local/regional treatment without chemotherapy. (hopkinsmedicine.org)
The standard treatment is surgical removal of the tumor, followed by chemotherapy with temozolomide, radiation therapy, and then nitrosoureas (such as lomustine). (fapesp.br)

A particularly promising method is liquid biopsy, which exploits the presence of tumor cells in the bloodstream. (aacc.org)

1. van Rossum, HH, Meng, QH, Ramanathan, LV, Holdenrieder, S. A word of caution on using tumor biomarker reference change values to guide medical decisions and the need for alternatives. (degruyter.com)
Already, the standard of care for patients with advanced-stage NSCLC is shifting from selecting therapy empirically based on a patient's clinicopathologic features to using biomarker-driven treatment algorithms based on the molecular profile of a patient's tumor. (tmu.edu.tw)

Pituitary adenoma is an intracranial tumor, which is clinically classified as functional pituitary adenomas (FPAs) with the elevation of the corresponding hormone in blood and non-functional pituitary adenomas (NFPAs) without clinical elevation of hormones in the blood. (frontiersin.org)

These pathways play important roles in cell energy supply, adhesion, and maintenance of the tumor microenvironment. (frontiersin.org)

Heterogeneous tumor vasculature originates from the collective effect of the nature of carcinoma and the complexity of the angiogenic network. (hindawi.com)

Within-subject biological variation in disease: collated data and clinical consequences. (degruyter.com)
3. [Clinical studies of testicular tumor. (nih.gov)
Taken together, our findings may have broad clinical and therapeutic potential for breast and colorectal primary tumor and metastasis treatment by targeting TEM8. (oncotarget.com)

Mesenchymal cells of the tumor-associated stroma are critical determinants of carcinoma cell behavior. (aacrjournals.org)
We focus here on interactions of carcinoma cells with mesenchymal stem cells (MSC), which are recruited to the tumor stroma and, once present, are able to influence the phenotype of the carcinoma cells. (aacrjournals.org)
Here we show that tumor cells are able to elicit a strong induction of the COX-2/microsomal prostaglandin-E synthase-1 (mPGES-1)/PGE 2 axis in MSCs recruited to the tumor-associated stroma by releasing IL-1, which in turn elicits a mesenchymal/stem cell-like phenotype in the carcinoma cells. (aacrjournals.org)

Moreover, considering that single targeting agents may eliminate a certain subpopulation of tumor cells while leaving others unharmed, it is necessary to analyze the tumor transcriptome at high resolution to detect drug-resistant clones that may be concealed within ITH. (biomedcentral.com)

CXCL10 is associated with a variety of human diseases including infectious diseases, chronic inflammation, immune dysfuntion, tumor development, metastasis and dissemination. (spandidos-publications.com)

The three patients without tumor marker elevations at diagnosis had mixed GCT, choriocarcinoma, and yolk sac tumor, which are usually associated with tumor marker elevation, so this will be investigated further, Dr. Fonseca said. (medscape.com)
Of the 74 evaluable patients who had elevated tumor markers at diagnosis, 68 had elevated tumor markers at relapse as well. (medscape.com)
Only six patients had tumor marker-negative relapses, and interestingly, one patient who was tumor marker negative at diagnosis relapsed with tumor markers positive," she added. (medscape.com)
The well-known marker for prostate cancer is PSA (prostate specific antigen), which is already used in medicine for the diagnosis of prostate cancer. (bionity.com)
A surgical procedure to remove a small piece of tumour for examination to make a diagnosis. (brainstrust.org.uk)
Tumor markers are an important part of the diagnosis and treatment of cancer. (odemshop.hr)
Also, certain benign liver diseases, chronic hepatitis B virus infections, and bile duct-related protein tests require the determination of tumor markers in combination with other tests to make an accurate diagnosis and appropriate treatment. (odemshop.hr)
Parathyroid hormone-related protein marker levels are particularly relevant to the diagnosis of parathyroid-related hypercalcemia. (odemshop.hr)
Highest sensitivity (95.2%) in cancer diagnosis was achieved when all six markers were used. (geneticsmr.com)

The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC chemokine family which binds to the CXCR3 receptor to exert its biological effects. (spandidos-publications.com)
Detecting the expression of certain protein characteristics in patient cells is another use for tumor markers. (odemshop.hr)
Circ_0005015, circRNA PWWP domain containing 2A, circRNA zinc finger protein 532, circRNA zinc finger protein 609, circRNA DNA methyltransferase 3β, circRNA collagen type I α2 chain and circHIPK3 widely affect multiple biological processes of diabetic retinopathy. (spandidos-publications.com)
They are so named because they do not express hormone receptors for estrogen and progesterone and do not overexpress the HER2 protein receptor, making these tumors resistant to drug therapies that target these hormones and HER2. (hopkinsmedicine.org)

unfortunately, no tumor marker with optimal sensitivity and specificity is currently available. (medsci.org)

Not recommended for stage TaG1 papillary tumors, unless diagnosed as high risk of tumor recurrence. (medscape.com)
Research led by scientists at the Johns Hopkins Kimmel Cancer Center report they have identified a set of molecular markers linked to a chemical process called methylation that may help predict the risk of cancer recurrence within five years for patients with triple-negative breast cancer. (hopkinsmedicine.org)
In both validation sets, higher levels of methylation at these markers were associated with significantly worse five-year recurrence rates. (hopkinsmedicine.org)
Researchers @hopkinskimmel identify markers that may predict recurrence for triple-negative #breastcancer. (hopkinsmedicine.org)

More importantly, CXCL10 has been identified as a major biological marker mediating disease severity and may be utilized as a prognostic indicator for various diseases. (spandidos-publications.com)
They can help determine the severity of the tumor and monitor the effectiveness of therapy. (odemshop.hr)

Tumor Markers in Testicular Cancers" (PDF). (wikipedia.org)

This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
Markers such as CEA (conventional epithelial antigen) and CA 19-9 are commonly used in diagnosing certain types of cancer. (odemshop.hr)

1% of all mammary tumors and 2-3% of fibro-epithelial neoplasms of the breast. (oncotarget.com)
Biological strategies primarily use antibodies against tumor-specific cell surface antigens such as epithelial cell adhesion molecule (EpCAM) to identify CTCs. (aacc.org)
Molecular assays are also being developed that isolate CTCs based on gene expression, which is analyzed using total CTC RNA and reverse transcription polymerase chain reaction techniques to amplify tumor- and epithelial-specific markers. (aacc.org)

In monitoring environmental cancer risk among human populations, several markers of early biological effects [e.g. (nih.gov)
PLAP is a tumor marker, especially in seminoma and ovarian cancer (e.g., dysgerminoma). (wikipedia.org)
4. Applications of biologic tumor markers in testicular cancer. (nih.gov)
5. Immunochemical determination of human chorionic gonadotropin and alpha-fetoprotein in sera and tumors of patients with testicular cancer. (nih.gov)
17. [Testis cancer markers. (nih.gov)
Hence, the aim of the study was to estimate these immunological markers in pre- and post-treatment phases with a follow-up of 3-24 months and to understand the prognostic significance of the same in patients with oral cancer. (amrita.edu)
However, to ensure the drug selectivity, the scientists need some object which is present only in cancer cells - and not anywhere else: a cancer marker. (bionity.com)
Tumor markers are biological substances that can be detected in the blood or other body fluids that result from cancer. (odemshop.hr)
With the right level of knowledge about tumor markers, it can help doctors to recognize signs of cancer earlier than they otherwise would and thus be able to treat it in time. (odemshop.hr)
They can also help diagnose certain types of cancer by identifying specific genes associated with certain tumors. (odemshop.hr)
Determining tumor markers is an important step in diagnosing a specific cancer, as the results can help better differentiate the type of cancer. (odemshop.hr)
In a bid to identify high risk molecular markers in TNBC, the researchers examined breast cancer tissue from 110 TNBC patients from archival tissue repositories at Johns Hopkins University, University of Iowa, and Duke University to look for the biological footprints of DNA methylation, an epigenetic process that can chemically silence tumor suppressor genes, and has been well-documented across many types of cancer. (hopkinsmedicine.org)
Despite significant evidence that susceptibility to these tumors is hereditary, CHEK2 is the only moderate penetrance gene in which pathogenic variants have been associated with risk of the cancer. (newswise.com)
The project on molecular markers of head and neck cancer was supported by FAPESP and also involved André Vettore, another author of the recently published article. (fapesp.br)

Beyond the statistical significance of the new loci, the study also demonstrated two relevant biological pathways tied to disease susceptibility, male germ cell development and chromosomal segregation during cell division. (newswise.com)

Intratumoral heterogeneity hampers the success of marker-based anticancer treatment because the targeted therapy may eliminate a specific subpopulation of tumor cells while leaving others unharmed. (biomedcentral.com)

Only two patients presented with isolated tumor marker elevations as the sole evidence of relapse, and the elevations usually preceded the presence of macroscopic disease, Dr. Fonseca said. (medscape.com)
At the time of relapse, 88% of patients (n = 73) had tumor marker elevations. (medscape.com)
CSF tumor markers are not performed during follow-up, and they are usually obtained only at the time of relapse," Dr. Fonseca said. (medscape.com)
We hypothesized that tumor markers alone may be sufficient for relapse detection in children and adolescents treated for CNS-NGGCT, and hence, the frequency and associated risk with serial MRIs could be safely avoided," she said. (medscape.com)
Accurate identification of disease-causing sequence variants and driving pathways is essential to minimize drug resistance or tumor relapse with targeted therapeutics [ 15 ]. (biomedcentral.com)

Sprouting microvessels establish a plexus that keeps all tumor cells within a distance of 100-200 μ m from the blood supply [ 7 ]. (hindawi.com)
The imbalance between tumor cell growth and vascular formation may often cause a collapse of tumor cells and the new vasculature. (hindawi.com)
Although PGE 2 has been implicated time and again in fostering tumorigenesis, its effects on carcinoma cells that contribute specifically to tumor formation are poorly understood. (aacrjournals.org)
However, experimental applications of the analyzed ITH signature to effectively eradicate tumor cells have not been extensively investigated. (biomedcentral.com)
The success of this approach, however, depends on isolation and detection of circulating tumor cells (CTCs), a challenging task given their rarity-about 1 to 10 CTCs per mL of whole blood. (aacc.org)
The researchers conducted in vitro tests to evaluate the biological effects of 12 compounds obtained through total synthesis of apomorphine hydrochloride against glioblastoma cells. (fapesp.br)
They found that two of these compounds - an isoquinoline derivative called A5 and an aporphine derivative called C1 - reduced the viability of glioblastoma cells, suppressed the formation of new tumor stem cells and boosted the effectiveness of temozolomide. (fapesp.br)
More research is needed to glean a better understanding of the action of these compounds on tumor cells and normal cells, but the results so far suggest a potential therapeutic application as novel cytotoxic agents to control glioblastomas," said Dorival Mendes Rodrigues-Junior , first author of the article and a postdoctoral researcher at the University of Uppsala's Department of Medical Biochemistry and Microbiology in Sweden. (fapesp.br)

In the latest study, TECAC researchers analyzed genetic data from 10,156 testicular germ cell tumor cases and 179,683 controls in the largest GWAS of TGCT to date. (newswise.com)

Considering the observed significant differences between gene expression levels in inhabitants of various regions in Flanders and the associations of gene expression with blood or urinary measures of environmental carcinogens, we conclude that gene expression profiling appears promising as a tool for biological monitoring in relation to environmental exposures in humans. (nih.gov)

Now that you have learned more about tumor markers, ask yourself: What are genes used for as tumor markers? (odemshop.hr)
What are genes used for as tumor markers? (odemshop.hr)
For this reason, it is imperative that genes be used as tumor markers to ensure effective treatment of disease. (odemshop.hr)

It has become important to determine whether histological grading should be performed with either one system for all tumor types or a separate system for each histological type ( 8 ). (iiarjournals.org)
Therefore, we assessed the histological grade of NSCLC tumors based on a conventional histological criterion: tumor cell differentiation. (iiarjournals.org)
This study retrospectively reviewed our Institutional experience and analyzed the outcomes of 531 patients who underwent complete resection of NSCLC of all stages, focusing especially on conventional histological grading based on tumor cell differentiation. (iiarjournals.org)

Determination of these markers allows better understanding of disease symptoms and targeting of effective therapies. (odemshop.hr)

Pericytes, which stabilize ECs and mediate EC survival and maturation in normal vasculature both through direct cell contact with ECs and paracrine signaling, are also abnormal in the tumor vasculature [ 9 ]. (hindawi.com)
All of this information can be used to determine what normal levels the tumor markers should have and whether abnormal levels are occurring, which could be possible signs of disease. (odemshop.hr)

These tumors are typically resistant to existing drugs and often grow back after surgery. (fapesp.br)

CircHIPK3 is the most well‑studied circRNA in the field of diabetic complications and is most likely to become a biological marker and therapeutic target for diabetic complications. (spandidos-publications.com)

It is indicated for prophylaxis of primary or recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR). (medscape.com)
Tumour primary site was adrenal in 33 patients, abdominal nonadrenal in 18, thoracic in 5, cervical in 2. (biomedcentral.com)

These markers can be made up of different components: humoral tumor markers, molecular diagnostics, cellular and folicular tumor markers. (odemshop.hr)

A major underlying genetic alteration in ccRCC is the von Hippel-Lindau ( VHL ) tumor-suppressor gene, whose deregulation stimulates an oncologic metabolic shift [ 2 ]. (biomedcentral.com)
Results from our investigation provide further understanding of the genetic architecture of TGCT, enhance comprehension of the biology of male germ cell development, and highlight biological pathways specifically important to TGCT," the authors wrote. (newswise.com)

Based on Cox models, surgical management emerged as an independent predictor for disease-free survival, whereas a history of recent growth and tumor grade were independent predictors for overall survival. (oncotarget.com)
These findings show that expression of EMT markers, the mode of surgical management, and a history of recent tumor growth had prognostic potential for patients with phyllodes tumors of the breast. (oncotarget.com)
During tumor growth, the tumor vasculature develops as the angiogenic switch is intermittently turned on and off [ 12 ]. (hindawi.com)
Initially, the scientists check the substance on cell culture -- this gives them a chance to prove that the above substance can actually slow or stop tumor growth. (bionity.com)
This can be used to model the growth of a brain tumour. (brainstrust.org.uk)
Komorowski, J., Jankewicz, J., Stepien, H., Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and soluble interleukin-2 receptor (sIL-2R) concentrations in peripheral blood as markers of pituitary tumours (2000) Cytobios, 101, pp. 151-9. (uba.ar)

ECs in the tumor vasculature are dependent on cell survival factors (e.g. (hindawi.com)
This complexity contrasts with the simple mechanical role that these proteins are believed to perform and suggests a still uncharacterized participation to important biological functions, such as the control of cell proliferation. (biomedcentral.com)

12. [Two cases of testicular tumors with high alpha-fetoprotein levels: a case report]. (nih.gov)

The findings suggest a role for the routine use of tumor markers for surveillance in CNS-NGGCT patients, said Adriana Fonseca, MD , a pediatric neuro-oncology fellow at the Hospital for Sick Children in Toronto. (medscape.com)

Personalized reference intervals in laboratory medicine: a new model based on within-subject biological variation. (degruyter.com)

Levels of the EMT markers Snail and Slug in the stromal compartment increased with the advancing tumor grade. (oncotarget.com)
Results: We observed significant elevated levels of all the immunological markers ( P (amrita.edu)
Elevated levels of tumor markers indicate a possible tumor. (odemshop.hr)
We confirmed these data by comparing tumour and constitutional DNA: most NB samples with diminished levels of NC2β mRNA had also genomic deletions at the corresponding locus. (biomedcentral.com)

Given the importance and urgency of identifying novel therapeutic substances that can be used to treat glioblastoma, we evaluated the same panel as in the previous study but now for this other type of tumor," Rodrigues-Junior said. (fapesp.br)

Schechter, J., Ultrastructural changes in the capillary bed of human pituitary tumors (1972) Am J Pathol, 67, pp. 109-26. (uba.ar)

Curie discovered radium in 1898 the first brachytherapy treatments, involving implantation of radium tubes directly into tumors, emerged. (nih.gov)

In this review, we focus on tumor vessel maturity as a potential marker for evaluating treatment response. (hindawi.com)

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