• Many transcription factor genes regulate their own promoters and when a gene duplicates during evolution then cross-regulation often occurs. (wikipedia.org)
  • Sp1-Sp4 proteins regulate expression of multiple genes in normal tissues and tumours. (houstonmethodist.org)
  • There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor. (houstonmethodist.org)
  • To this effect our laboratory has focused on specificity protein (Sp) transcription factors (TFs) since Sp1 and additional Sp TFs regulate manifestation of multiple genes that are important for malignancy cell growth and survival and Sp TFs can be efficiently targeted by numerous anti-cancer providers. (tam-receptor.com)
  • Ethyl 2-((2 3 bis(nitrooxy)propyl)disulfanyl)benzoate (GT-094) a novel nitro-NSAID induced ROS and decreased mitochondrial membrane potential (MMP) in SW480 and RKO colon cancer cells and treatment with antioxidants GSH and DTT inhibited ROS generation prevented the loss of MMP and reversed the effects on downregulation of Sp1 Sp3 and Sp4 proteins and Sp dependent genes [42]. (tam-receptor.com)
  • Understanding of the transcriptional regulation of tumor/metastasis suppressor genes constitutes a potent approach to the molecular basis of malignant transformation. (korea.ac.kr)
  • Several mammalian genes are controlled by Sp protein often in assistance with additional transcription elements and Sp protein play important jobs in a number of physiological procedures including cell routine rules and development control hormonal activation apoptosis and angiogenesis.5 6 Sp1 generally activates gene transcription whereas Sp3 has both transcriptional repressor and activating properties. (healthanddietblog.info)
  • The transcriptional activation from CACNA1F the p21 gene by these inhibitors is normally marketed by chromatin redecorating pursuing acetylation of histones H3 and H4 in the p21 promoter area (32 54 This activation of p21 takes place within a p53-unbiased fashion and for that reason HDAC inhibitors are appealing realtors for cancers therapy being that they are operative in cells with mutated p53 genes a hallmark of several tumors. (bio2009.org)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • Moreover, transcription factors and their target genes form vast interacting gene regulatory networks which can be exquisitely stable. (amegroups.org)
  • transcription factor (activator) for various hematopoietic-specific genes. (atlasgeneticsoncology.org)
  • Antitumor antibiotic that inhibits RNA synthesis, especially in solid tumors. (fermentek.com)
  • The abnormal reactivation of human Telomerase Reverse Transcriptase (TERT) is a common hallmark of human solid tumors. (biomedcentral.com)
  • We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
  • Chlorambucil-conjugated PI-polyamides (Chb-M'), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation. (atlasgeneticsoncology.org)
  • Lnc408 can recruit transcript factor SP3 to CBY1 promoter to serve as an inhibitor in CBY1 transcription in BCSCs. (nature.com)
  • Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members of a family of transcription factors which bind GC/GT-rich promoter elements through three C 2 H 2 -type zinc fingers that are present at their C-terminal domains. (houstonmethodist.org)
  • 2008. Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. . (oregonstate.edu)
  • The promoter from the individual p21 gene harbors six conserved GC containers binding sites for the transcription aspect Sp1. (bio2009.org)
  • Helicobacter pylori activates the histidine decarboxylase promoter through a mitogen-activated protein kinase pathway independent of pathogenicity island-encoded virulence factors. (mpg.de)
  • Further, the hypomethylated CpG site at the promoter region of PLA2G7 was identified as cg11874627, demethylation of which led to increased binding of Sp3 and expression of Lp-PLA 2 through bisulfate sequencing, chromatin immunoprecipitation assay and enzyme-linked immunosorbent assay. (biomedcentral.com)
  • In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. (wikipedia.org)
  • This family has been expanded to also include the Sp transcription factor and related proteins, forming the Sp/KLF family. (wikipedia.org)
  • KLFs share the similar function of transcription regulation via the recruitment of regulatory proteins. (wikipedia.org)
  • RNA interference (RNAi) studies carried out in pancreatic malignancy cells shows that Sp1 Sp3 and Sp4 proteins are involved in VEGF VEGFR1 and VEGFR2 manifestation and knockdown of Sp1 Sp3 and Sp4 by RNAi also affected pancreatic malignancy cell growth and cell cycle progression with a decreased percentage of cells in G2/M and S and improved percentage of cells in G0/G1 phase. (tam-receptor.com)
  • Id proteins belong to the helix-loop-helix (HLH) family of transcriptional regulators, acting as dominant negative repressors of basic-HLH (bHLH) transcription factors [ 11 - 13 ]. (oncotarget.com)
  • Mechanistically, Id proteins dimerize with bHLH factors to repress their functions. (oncotarget.com)
  • Specificity protein 1 (Sp1) one of the first eukaryotic transactivators to be identified is now known to be a member of the large multigene family of Sp/Kruppel-like factor (KLF) transcription factors (at least 20 in mammals).5 6 These proteins share a conserved DNA binding domain highly. (healthanddietblog.info)
  • Sp/KLF proteins are at the mercy of several posttranslational adjustments including phosphorylation glycosylation and acetylation allowing fine tuning from CGP60474 the rules of gene transcription. (healthanddietblog.info)
  • proteins known to be aberrant in tumor cells are italicized. (healthanddietblog.info)
  • HDACs form a family of enzymes that catalyze 67346-49-0 the removal of acetyl moieties from acetylated proteins including histones structural proteins or transcription factors (25 31 Together with their counterparts the histone acetyltransferases HDACs regulate the reversible acetylation of core histones and additional proteins. (bio2009.org)
  • In addition acetylation of transcription factors offers been shown elsewhere to impact the stability and intracellular localization of proteins or to modulate the affinity for DNA or additional proteins (34). (bio2009.org)
  • Similarly ascorbic acid (vitamin C) which induced hydrogen peroxide decreased SW480 and RKO colon cancer cell proliferation and induced apoptosis and necrosis and this was accompanied by downregulation of Sp1 Sp3 and Sp4. (tam-receptor.com)
  • In addition, Cd exposure upregulated the mRNA and protein levels of dynamin-related protein 1 (DRP1), receptor-interacting protein kinase 3 (RIP3), mixed lineage kinase domain-like protein (MLKL), and increased tumor necrosis factor-α (TNFα), interferon-γ (IFNγ), interleukin-2 (IL-2), interleukin-4 (IL-4), cyclooxygenase 2 (COX-2) protein levels, and the damage degree of three kinds of lymph nodes was similar after Cd exposure. (bvsalud.org)
  • Proteoglycan degradation contributing to the pathogenesis of intervertebral disc (IVD) degeneration is induced by inflammatory cytokines, such as tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β). (spandidos-publications.com)
  • Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are highly expressed in degenerative IVDs and contribute to a degenerative IVD phenotype by inhibiting the production of ECM ( 3 , 4 ). (spandidos-publications.com)
  • Id1 is a member of the helix-loop-helix (HLH) family of transcriptional repressors that act as dominant-negative inhibitors of basic-HLH factors. (oncotarget.com)
  • The tumor suppressor p53 directly interacts with Sp1 and may compete with the transcriptional repressor HDAC1 for binding to the C terminus of Sp1 leading to histone acetylation and concomitant manifestation of p21. (bio2009.org)
  • A leading contributing factor to metastasis and treatment resistance is the heterogeneity and plasticity of the cells within tumors 6 . (nature.com)
  • Evidence from studies carried out in this laboratory and others show that Sp transcription factors are overexpressed in several tumor cell lines including colon bladder pancreatic prostate breast thyroid and esophageal malignancy cell lines and play a crucial part in tumor growth development and metastasis Semagacestat [48-53]. (tam-receptor.com)
  • KLF/Sps are a family of transcription factors that contain three carboxyl-terminal (C-terminal) C2H2-type zinc finger structural motifs that bind to the GC-rich regions in DNA and regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. (wikipedia.org)
  • Elevated COX-2 is associated with increased angiogenesis, tumor invasion and promotion of tumor cell resistance to apoptosis [ 5 - 8 ]. (oncotarget.com)
  • tumor suppressor p53 may induce cell cycle arrest or apoptosis in response to a variety of stress signals such as DNA damage oncogenic stimuli or hypoxia (reviewed in reference 49). (bio2009.org)
  • This was accompanied by increased manifestation of cyclin-dependent kinase inhibitor p27 with Sp3 knockdown [54-56]. (tam-receptor.com)
  • In addition, nuclear factor κB (NF‑κB), c‑Jun N‑terminal kinase (JNK), extracellular signal‑regulated kinases and p38 mitogen‑activated protein kinase inhibitors and TNF‑α were used to determine the molecular mechanism of autophagy during the inflammatory conditions, and only the NF‑κB and JNK inhibitor were found to enhance the autophagy of rat NP cells. (spandidos-publications.com)
  • Besides, CREB1 knockdown suppressed xenograft tumor growth in the presence of Imidazole Ketone Erastin (IKE), a potent FIN, and this effect was reversed by SCD. (bvsalud.org)
  • Today's work examined MTM-SDK and MTM-SK as applicants for treatment AZD8931 of ovarian cancers using individual tumor xenograft versions in nude mice. (colinsbraincancer.com)
  • RECK encodes a membrane-anchored glycoprotein that suppresses tumor invasion and angiogenesis by regulating matrix-metalloproteinases (MMP-2, MMP-9 and MT1-MMP). (korea.ac.kr)
  • CWR22Rv1 cells, a castrate-resistant prostate cancer cell line, were treated with Zyflamend and the expression of class I and II histone deacetylases, along with their downstream target the tumor suppressor gene p21, was investigated. (biomedcentral.com)
  • Expression of the tumor suppressor gene p21, a known downstream target of histone deacetylases and CBP/p300, was increased by Zyflamend treatment and the effect on p21 was, in part, mediated through Erk1/2. (biomedcentral.com)
  • Tumorigenesis in vivo is also increased in both subcutaneous flank and orthotopic intracranial tumor models. (oncotarget.com)
  • Zhang, X. & Kschischo, M. MFmap: A semi-supervised generative model matching cell lines to tumours and cancer subtypes. (for2800.de)
  • TERT p duplications ( TERT p dup ) mainly affected the binding capacity of two transcription factors' families, i.e. the members of the E-twenty-six and the Specificity Protein/Krüppel-Like Factor groups. (biomedcentral.com)
  • KLF5, like KLF3, is important in adipocytes and KLF6 is an important tumour suppressor gene, that is often mutated in prostate cancers. (wikipedia.org)
  • Sp transcription elements like Sp1 Sp3 and Sp4 have an effect on multiple cellular procedures and also have been involved with development numerous kinds of malignancies including pancreatic breasts gastric and thyroid cancers [7]. (colinsbraincancer.com)
  • COX-2 is overexpressed in many cancers and contributes to tumor development and progression [ 2 - 4 ]. (oncotarget.com)
  • however, restoration of CBY1 expression in tumor cells reduces BCSC and its enrichment, thus lnc408 plays an essential role in maintenance of BCSC stemness. (nature.com)
  • In shortly, these findings highlight that the novel lnc408 functions as an oncogenic factor by recruiting SP3 to inhibit CBY1 expression and β-catenin accumulation in nucleus to maintain stemness properties of BCSCs. (nature.com)
  • In gastric cancer induced by Helicobacter pylori (H. pylori) there is no information regarding what transcription factors induce/upregulate the expression of CLDN6. (bvsalud.org)
  • Previous studies revealed that COX-2 is overexpressed in many gliomas and expression level, in particular, is positively correlated with tumor grade [ 9 , 10 ]. (oncotarget.com)
  • Helicobacter pylori stimulates host vascular endothelial growth factor-A (vegf-A) gene expression via MEK/ERK-dependent activation of Sp1 and Sp3. (mpg.de)
  • Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells. (mpg.de)
  • This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
  • In this review, we highlight the main signals and transcription factors and how they are integrated at the level of chromatin programming and gene expression control. (amegroups.org)
  • Reverse transcription quantitative PCR results demonstrated high expression of an actin-binding Rho-activating protein in the latter stages of virus-infected cells, and molecular docking, cell transfection and coimmunoprecipitation experiments confirmed that it interacted with the ORF55 protein. (biomedcentral.com)
  • Accordingly, the expression of human HMGCS2 is down-regulated in 90% of Myc-dependent colon and rectum tumors. (aacrjournals.org)
  • The factors responsible for the postnatal and starvation-associated induction of HMGCS2 gene expression have been identified and shown to involve changes in circulating hormone and fatty acid levels. (aacrjournals.org)
  • The present study provides new insights into TERT p mutational spectrum occurring in central nervous system tumors, with the identification of new recurrent somatic gain-of-function mutations, occurring in 0.8% of glioblastoma IDH -wildtype. (biomedcentral.com)
  • p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-I kappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection. (mpg.de)
  • Nuclear factor-kappa B activation and innate immune response in microbial pathogen infection. (mpg.de)
  • In cultured keratinocytes, CWO stimulated calcium signaling, resulting in calcineurin-dependent activation of nuclear factor of activated T cells (NFAT). (biorxiv.org)
  • Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. (zju.edu.cn)
  • The use of herbs, botanicals and their bioactive components have been shown to be effective in many tumor cell lines in vitro and in vivo by inhibiting cell and tumor growth. (biomedcentral.com)
  • A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity. (open.ac.uk)
  • Although some mechanism-based medicines show some promise their beneficial restorative efficacy has been limited due to the complex labyrinth-like signaling pathways and regulatory networks that allow tumor cells to grow and survive. (tam-receptor.com)
  • A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8. (ucsf.edu)
  • Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)
  • The induction of CD11b + Gr-1 + myeloid-derived suppressor cells (MDSCs) is an important immune-evading mechanism used by tumors. (ashpublications.org)
  • The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells. (mpg.de)
  • The RECK gene is widely expressed in normal human tissues but is downregulated in tumor cell lines and oncogenically transformed fibroblasts. (korea.ac.kr)
  • Tumor initiation, development, and relapse may be closely associated with cancer stem cells (CSCs). (nature.com)
  • Hence there is a need for restorative focuses on that can simultaneously target multiple pathways in malignancy cells and tumors. (tam-receptor.com)
  • Interestingly, real-time PCR and translation inhibition studies revealed that survivin was over-expressed partially through the up-regulation of protein translation instead of gene transcription in A549 cancer cells. (biomedcentral.com)
  • This factor has been shown to be regulated by COX-2 in breast carcinoma cells and recent studies suggest that Id1 may also be involved in the genesis/progression of gliomas. (oncotarget.com)
  • Finally, GBM cells with COX-2 or Id1 overexpression show greater migration/invasive potential and tumors that arise from these cells also display increased microvessel density, results in line with the increased malignant potential seen in these cells. (oncotarget.com)
  • Proof is shown for the idea that Sp transcription elements may act in collaboration with Akt to modify the abnormal rate of metabolism of tumor cells. (healthanddietblog.info)
  • Sp1 and Sp3 are expressed whereas Sp4 is expressed primarily in neural cells ubiquitously. (healthanddietblog.info)
  • How the metabolic requirements of proliferating cancer cells are fulfilled by glycolysis has been reviewed recently.9 Since normal mitochondrial respiration cannot occur without oxygen tumor hypoxia will cause a shift to glycolysis. (healthanddietblog.info)
  • Tumor cells however carry out aerobic glycolysis and indeed switch to glycolysis before hypoxia develops. (healthanddietblog.info)
  • Aldolase glyceraldehyde-3-phosphate dehydrogenase phosphoglycerate … Hexokinase From the 4 mammalian hexokinases type II (HKII) which will the external mitochondrial membrane is generally expressed at amounts a lot more than 100-collapse higher in quickly developing tumors than in nontransformed cells.10 11 HKII is usually the main isoform is and overexpressed necessary to maintain high degrees of glycolysis. (healthanddietblog.info)
  • Using rat hepatoma cells cultured in moderate including a serum health supplement and glucose to simulate conditions in a well-vascularized tumor or within the peritoneal cavity Lee and Pedersen 10 using. (healthanddietblog.info)
  • This report is the first thee of a system of interconnecting vesicles and vacuoles termed vesiculo-vacuolar organelles (VVOs) that are prominent in both tumor-associated and con- trol vessel endothelial cells and provide the primary pathway for macro- molecular optioons. (banglaforexacademy.com)
  • In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
  • Part of ROS in Drug Mediated KT3 tag antibody Dowregulation of Sp Transcription Factors Studies with this laboratory have shown that several anti-cancer compounds mediate their effects via induction of oxidative stress and generation of ROS which is necessary for decreased manifestation of Sp TFs. (tam-receptor.com)
  • Members of the family bind to GC boxes (GGGGCGGGG) GT/CACCC Semagacestat boxes (GGTGTGGGG) and fundamental transcription elements to regulate gene transcription [44-47]. (tam-receptor.com)
  • One of the elements responsible for the Ras-mediated downregulation of mouse RECK gene is the Sp1 site, to which Sp1 and Sp3 factors bind. (korea.ac.kr)
  • Through 3 adjacent C2H2-type zinc fingertips in the C-terminus they bind to GC containers CACCC containers (also known as GT containers) and fundamental transcription components collectively referred to as "'Sp1 sites. (healthanddietblog.info)
  • The activity of these elements is controlled by transcription factors (TFs) which bind to DNA wrapped into chromatin, leading to the modification of the chromatin landscape, and the assembly of the transcription machinery. (amegroups.org)
  • thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. (zju.edu.cn)
  • Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonarry neuroendocrine tumors. (zju.edu.cn)
  • Evaluation of gene regulatory network regulating ovarian AZD8931 cancer development indicates a feasible role from the Sp category of transcription elements within this disease and provides reason for advancement of Sp1 -contending therapeutic strategy. (colinsbraincancer.com)
  • We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)
  • The CyHV-2 gene encoding thymidine kinase (TK) is an important virulence-associated factor. (biomedcentral.com)
  • Overall, our data refine tumor-induced MDSC functions by uncovering mechanistically distinct MDSC subpopulations, potentially relevant for MDSC-targeted therapies. (ashpublications.org)
  • Currently, 17 murine and human KLFs are known to play crucial roles in the regulation of transcription, cell proliferation, cellular differentiation, stem cell maintenance, and tissue and organ pathogenesis. (mdpi.com)
  • Such cross-regulation occurs extensively in transcription factor families. (wikipedia.org)
  • Certainly the hyperactivity of HKII in tumors may be the basis of positron emission tomography that's used for tumor detection.10 The majority of our understanding of the regulation of HKII in cancer has result from research in rat tumors. (healthanddietblog.info)
  • Post-translational modification of histones, in particular the removal or addition of acetyl groups on ϵ-N-acetyl lysine residues, play an important role in epigenetic regulation of transcription. (biomedcentral.com)
  • MTM-SDK and MTM-SK (Amount 1) were attained by targeted inactivation from the ketoreductase in charge of the last stage of MTM biosynthesis [33 35 In biochemical and mobile assays both ELF3 substances acted AZD8931 as powerful repressors of Sp1-governed transcription [35]. (colinsbraincancer.com)
  • The luciferase assay confirmed that TERT p dup behaved as gain-of-function mutations causing a 2,3-2,5 fold increase of TERT transcription. (biomedcentral.com)
  • Objective Increased activity of Sp family of transcription factors is a frequent and essential event in cancer development and progression. (colinsbraincancer.com)
  • Understanding of the mechanisms which control RECK gene transcription may lead to the development of new strategies for cancer prevention and treatment. (korea.ac.kr)
  • as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. (zju.edu.cn)
  • COX-2 is also regulated by epidermal growth factor receptor signaling which is important in the pathogenesis of GBMs. (oncotarget.com)
  • Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
  • SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
  • Safe, S & Abdelrahim, M 2005, ' Sp transcription factor family and its role in cancer ', European Journal of Cancer , vol. 41, no. 16, pp. 2438-2448. (houstonmethodist.org)
  • Sp Transcription Factors Members of the Sp/KLF family have a highly conserved DNA binding website that consists of three contiguously placed C2H2-type zinc fingers that are located in the C-terminal region. (tam-receptor.com)
  • T), are usually heterozygous, mutually exclusive, and produce an identical 11 bp 'CCCCTTCCGGG' sequence, resulting in the creation of de novo consensus binding motifs for E-twenty-six (ETS) transcription family members. (biomedcentral.com)
  • KLF1 is a very important factor in red blood cell biology. (wikipedia.org)
  • However, distinct tumors differentially regulated this inherent MO-MDSC differentiation program, indicating that this phenomenon was tumor driven. (ashpublications.org)