• Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral nasopharynx or pharyngeal recess (fossa of Rosenmüller), accounting for 50% of cases. (wikipedia.org)
  • The association between Epstein-Barr virus and nasopharyngeal carcinoma is unequivocal in World Health Organization (WHO) types II and III tumors but less well-established for WHO type I (WHO-I) NPC, where preliminary evaluation has suggested that human papillomavirus (HPV) may be associated. (wikipedia.org)
  • Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. (nih.gov)
  • Nasopharyngeal carcinoma (NPC) is a rare disease and one of the most common types of malignancies that appear in the nasopharynx, which is the narrow tube passage behind the nasal cavity and one of the malignancies associated with the Epstein-Barr virus (EBV) and is considered one of the malignant and rare tumors in most parts of the world and is distinguished by distribution geographical and ethnic [ 1 ]. (intechopen.com)
  • They are morphologically similar to nasopharyngeal carcinoma (the undifferentiated, nonkeratinizing subtype), but occur outside of the nasopharynx. (ucdavis.edu)
  • According to the WHO (2005) Pathology of Head and Neck Tumors, lymphoepithelial carcinoma is a malignant epithelial tumor of the nasal cavity and paranasal sinuses that can be defined as "a poorly differentiated squamous cell carcinoma or histologically undifferentiated carcinoma accompanied by a prominent reactive lymphoplasmacytic infiltrate, morphologically similar to nasopharyngeal carcinoma"². (ucdavis.edu)
  • Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. (sncrf.org)
  • Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. (sncrf.org)
  • Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. (sncrf.org)
  • Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract. (sncrf.org)
  • Oropharyngeal Carcinoma (with Comments on Nasopharynx and Hypopharynx) -- 14. (nshealth.ca)
  • Second primary tumors (SPTs) have a significantly worse prognosis on patients with head and neck squamous cell carcinoma (HNSCC) (1). (bvsalud.org)
  • Nasopharyngeal carcinoma is an uncommon tumour in Nigeria but the burden of the disease in terms of morbidity and mortality is very high. (bvsalud.org)
  • Inflammatory myofibroblastic tumor (IMT), as a mesenchymal tumor, is common in the lung and abdomen but rare in the paranasal sinus and nasopharynx. (hindawi.com)
  • This study aimed to summarize the clinical characteristics of IMT in the paranasal sinus and nasopharynx and analyze the relationship between the treatment and the overall survival (OS). (hindawi.com)
  • The clinical features, treatment, and follow-up data of patients diagnosed with IMT of the paranasal sinus or nasopharynx from 2006 to 2017 were retrospectively analyzed, and the previous literature was reviewed. (hindawi.com)
  • IMTs of the paranasal sinus and nasopharynx are rare, and most studies were case reports. (hindawi.com)
  • The medical records of 13 patients diagnosed pathologically with IMT, inflammatory pseudotumor, or plasma cell granuloma of the paranasal sinus and nasopharynx in the Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital from 2006 to 2017 were reviewed. (hindawi.com)
  • The records of 13 patients with IMT of paranasal sinus or nasopharynx diagnosed in the hospital were reviewed. (hindawi.com)
  • Non-Epithelial Tumors of the Nasal Cavity, Paranasal Sinuses and Nasopharynx. (scirp.org)
  • 1 A recent literature review found only 22 cases of benign leiomyogenic tumours arising in the nose and paranasal sinuses. (bmj.com)
  • It's my pleasure to be with you today and to discuss with you some advanced cases of tumors within the paranasal sinuses. (brainlab.com)
  • Tumors or cancer of the PARANASAL SINUSES . (lookformedical.com)
  • This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. (sncrf.org)
  • Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: [email protected]] (closed to accrual 03/15/2019) 34. (sncrf.org)
  • The information in this article contains billing, coding or other guidelines that complement the Local Coverage Determination (LCD) for MolDX: Next Generation Sequencing for Solid Tumors L38045. (cms.gov)
  • By combining all our TCRs with our PD1-41BB or CD40L-CD28 costimulatory switch proteins, we remain convinced that our approach will consistently deliver best-in-class TCR-T therapies leading to improved outcomes for patients suffering from difficult-to-treat solid tumors. (nwahomepage.com)
  • The company's pipeline product candidates include zanzalintinib, XB002 and XL102 for the treatment of advanced or metastatic solid tumors and CBX-12 for advanced metastatic refractory solid tumors. (pharmaceutical-technology.com)
  • I. To evaluate the Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 overall response rate (ORR) in subsets of patients with advanced rare cancers treated with ipilimumab plus nivolumab combination immunotherapy. (clinicaltrialsgps.com)
  • Benign tumors of the skull base include true neoplasms, inflammatory masses, cysts, and developmental anomalies occurring at the osseous interface between the brain and the underlying structures of the head and neck. (medscape.com)
  • Abnormal Low Intensity on T2-Weighted MR Images in Head and Neck Tumors and Tumorlike Conditions," The 25th International Congress of Radiology, Marrakesh, 5-8 June 2008, p. 171. (scirp.org)
  • Lipomas are common benign soft tissue tumors, with 15 to 20% of the cases affecting the head and neck region and 1 to 4% involving the oral cavity. (academicjournals.org)
  • Most patients had undergone primary RT using a two-dimensional technique with two lateral opposing faciocervical fields in the first treatment phase, followed by two lateral opposing fields in the second phase to cover the nasopharynx, matched with a single anterior cervical field to cover the neck. (hindawi.com)
  • The National Head and Neck Cancer Audit focuses on cancer sites within the head and neck (excluding tumours of the brain and thyroid cancers). (data.gov.uk)
  • A team of multi-disciplinary Japanese researchers found that a weakened version of herpes simplex virus (HSV) effectively eradicated neck and flank tumors in mice. (news-medical.net)
  • Report of 7 Cases," otolaryngologist - head and neck surgeons sought to determine if Flutamide, a tumor reducing drug used to treat prostrate cancer, would be helpful in reducing juvenile angiofibroma. (news-medical.net)
  • At Duke, our experienced nasopharyngeal cancer team includes cancer specialists, skull base tumor experts, ENT (ear, nose, and throat) doctors, head and neck surgeons, speech therapists, and others who work together to provide you or your child with complete care. (dukehealth.org)
  • NPC is a malignant tumor that occurs in the nasopharyngeal mucosal epithelium and is one of the most common head and neck cancers in China. (itbusinessnet.com)
  • He has been the local leader of the brachytherapy program for head and neck tumors. (mdanderson.org)
  • Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. (sncrf.org)
  • The department of Otorhinolaryngology surgery and head and neck surgery provides diagnosis and treatment for problems of the ear ,nose and throat & tumors of the head & neck area. (edu.in)
  • The introduction of HPV vaccines has also drawn more attention to the fact that HPV is associated not only with cervical cancer and genital warts but also with other tumors, such as head neck and anogenital cancers ( 3 ). (cdc.gov)
  • It is also being investigated as to whether or not chronic sinusitis could be a potential cause of cancer of the nasopharynx. (wikipedia.org)
  • Perform staging of the tumor according to the American Joint Committee on Cancer staging protocol because this is of critical importance to the patient's prognosis. (medscape.com)
  • Specific treatment of palate cancer depends on the location of the tumor (hard vs soft palate), stage of the tumor, and pathologic type of the cancer. (medscape.com)
  • The American Joint Committee on Cancer (AJCC) tumor/node/metastasis (TNM) classifications and prognostic stage groups for nasopharyngeal cancers are provided below. (medscape.com)
  • External beam radiation therapy focuses high-energy X-ray beams on tumors to kill or stop the growth of cancer cells. (dukehealth.org)
  • Our surgeons are experts at treating rare skull base tumors like nasopharyngeal cancer. (dukehealth.org)
  • Association of Pretreatment Circulating Tumor Tissue-Modified Viral HPV DNA With Clinicopathologic Factors in HPV-Positive Oropharyngeal Cancer. (dana-farber.org)
  • Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (sncrf.org)
  • Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. (sncrf.org)
  • Tumors or cancer of the NOSE . (lookformedical.com)
  • This study estimated the relative frequencies of oral and pharyngeal cancers among Yemeni cancer patients registered in 2007 and 2008 and determined patients' demographic and tumour characteristics. (who.int)
  • RÉSUMÉ Des études en milieu hospitalier ont révélé des fréquences relatives très élevées du cancer oropharyngé au Yémen. (who.int)
  • La présente étude a estimé les fréquences relatives du cancer de la cavité buccale et du pharynx chez des patients yéménites atteints de cancers enregistrés en 2007 et 2008. (who.int)
  • Par rapport à d'autres pays de la Région, le cancer de la cavité buccale et du nasopharynx représente une charge sanitaire importante pour le Yémen au niveau national. (who.int)
  • major proportion of pharyngeal cancers cancer has been known to be preva- Tumours with other codes (i.e. not epi- (214/239, 89.5%) (Table 1). (who.int)
  • For the included cases, Of the 541 cases of oropharyngeal are believed to reflect different preva- tumour staging was reclassified and cancer 19.2%, 11.8%, 8.7% and 7.8% lences and patterns of risk habits such coded according to the SEER summary were referred from Al-Hodeida, Taiz, as khat chewing and waterpipe smoking staging manual 2000 [16]. (who.int)
  • To address these issues, we retrospectively reviewed male BRCAm carriers with a diagnosis of tumor from our cancer genetics database (SYSUCC cohort, n = 52) and a public database (TCGA cohort, n = 294). (biomedcentral.com)
  • Signs and symptoms related to the primary tumor include trismus, pain, otitis media, nasal regurgitation due to paresis (loss of or impaired movement) of the soft palate, hearing loss and cranial nerve palsy (paralysis). (wikipedia.org)
  • Primary leiomyogenic tumours have been reported in unusual locations where smooth muscle cells are usually absent, such as the sinonasal cavity. (bmj.com)
  • The majority were confirmed by biopsy, and all of them showed histological features similar to the primary tumor. (hindawi.com)
  • Primary tumors were staged according to the 1992 Fuzhou staging system [ 6 ] as they were diagnosed, a system approved and recommended by the Chinese Association of Radiation Oncology in Fuzhou and widely used in mainland China since 1992. (hindawi.com)
  • In HNSCC, 18 F-FDG PET has a clear impact on both primary tumor delineation and cervical lymph node staging ( 5 , 6 ). (snmjournals.org)
  • Some studies in the literature have found that the presence of metastasis or local invasion depends on the location of the primary tumor. (ucdavis.edu)
  • Due to the location of the primary tumor, surgery is rarely an option, and patients with localized disease are treated primarily with chemotherapy and radiotherapy. (itbusinessnet.com)
  • In all patients, the tumor became manifest in symptoms resembling a primary extradural entity, like chronic sinusitis, chordoma or nasal polyposis. (biomedcentral.com)
  • Another threatening element to the patients' survival chances and quality of life is the high risk of developing a second primary tumor (SPT). (bvsalud.org)
  • Adrenal cortical tumors (closed to accrual 06/27/2018) 32. (sncrf.org)
  • A variety of benign tumors occur along the cranial base. (medscape.com)
  • They were also asked to indicate if they routinely used perioperative facial nerve monitoring devices in parotid surgery for benign tumors. (bvsalud.org)
  • Epithelial tumors of major salivary glands (closed to accrual 03/20/2018) 3. (sncrf.org)
  • Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018) 14. (sncrf.org)
  • They use advanced imaging techniques to determine the exact location of the tumor and minimize damage to surrounding tissues. (dukehealth.org)
  • Nasopharyngeal cancers are malignant tumors that develop in the upper part of the throat and behind the nose (doctors call this area the nasopharynx), near the base of the skull. (dukehealth.org)
  • Tests will be done to identify problems, such as tumors, at the base of the skull. (medlineplus.gov)
  • The 5-year cumulative rate of nasopharynx and cervical lymph node recurrence is between 12.0% and 22.0% [ 1 - 5 ]. (hindawi.com)
  • Biochemistry profiles, chest radiography, abdominal ultrasonography, and contrast-enhanced CT or MRI of the nasopharynx and cervical region were routine elements of the assessment. (hindawi.com)
  • 1. Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, part 1. (meduniver.com)
  • For ulcerative lesions, obtaining a biopsy specimen from closer to the edge of the tumor is important to avoid the necrotic central component. (medscape.com)
  • A review of the literature reveals only a few reports of this tumor, and there has been scanty discussion of the imaging findings of posterior pituitary astrocytomas compared with lesions of the anterior pituitary gland. (ajnr.org)
  • In extensive lesions extending into the nasopharynx, middle ear effusion is common. (medscape.com)
  • Carcinomas of the lung, bladder, stomach, and cutaneous melanoma were the frequent tumors demonstrating BRCAm in males, of which the majority were stage II or III diseases with a higher frequency of BRCA2 mutations. (biomedcentral.com)
  • B) At histological examination, the tumour consisted of a proliferation of spindle shaped, pleomorphic cells with eosinophilic cytoplasm in a prominent myxoid background. (bmj.com)
  • therefore, in this study, we aimed to analyze the clinicopathological correlations between these tumors using immunostaining and to develop new treatments based on histological subtypes. (bvsalud.org)
  • These differences in tumor site and histological subtypes shown in this study will lead to the establishment of treatment based on histological and immunohistological classification. (bvsalud.org)
  • Note 1:** Involvement of the pharyngeal space (code 300) is defined as posterolateral infiltration from the nasopharynx beyond the buccopharyngeal fascia into the triangular space lateral to the pharynx. (cancer.gov)
  • Note 2:** Parapharyngeal involvement denotes posterolateral infiltration of tumor beyond the pharyngobasilar fascia. (cancer.gov)
  • Have active tumor bleeding or a high risk of bleeding (examples include but are not limited to radiographic evidence of major blood vessel invasion/infiltration or tumor demonstrates >90 degree abutment or encasement of a major vessel [carotid, jugular, bronchial artery] and/or exhibits other high-risk features such as arteriovenous fistula). (who.int)
  • Because of the complexities of the anatomic region and the relatively low incidence, patients with skull base tumors are best managed by an experienced multidisciplinary team. (medscape.com)
  • Almost half of patients present with extension of the tumor beyond the soft palate. (medscape.com)
  • Similar incidences of BRCAm (6.0 vs. 6.6%) and age at diagnosis of tumor (median, 65 vs. 60 years) were observed in male and female patients. (biomedcentral.com)
  • These findings provide an overview of the distinct characteristics and clinical outcomes of male patients with BRCA-associated tumors, suggesting the importance of further genetic BRCA testing in males. (biomedcentral.com)
  • Frequently, patients who develop SPTs are relatively young, presented a first tumor diagnosed in early stages at sites favourable to treatment, factors which, at the same time, increase the chance both of survival and SPT development (2). (bvsalud.org)
  • Patients usually do not seek counseling until the tumors are large because small tumors cause little distress and may not be noticed by the patient. (cdc.gov)
  • and in obese patients with large tumors. (bvsalud.org)
  • the retrograde approach was the technique of choice by most of them (47) in case of parotidectomy in obese patients with large tumors. (bvsalud.org)
  • La langue était le site le plus souvent touché de la cavité buccale (53,6 %) alors que le nasopharynx était impliqué dans 89,5 % des cancers du pharynx. (who.int)
  • Whether IMT is reactive or neoplastic in nature has been controversial, but recently it is considered as a true tumor because of the identification of anaplastic lymphoma kinase (ALK) gene rearrangement [ 2 ]. (hindawi.com)
  • Summary: Astrocytoma, or pituicytoma, of the posterior pituitary is a relatively rare entity consisting of poorly characterized glial tumor cells. (ajnr.org)
  • Although the anterior lobe completely loses its connections with the primitive nasopharynx, the posterior lobe maintains its relationship with the hypothalamus throughout life. (ajnr.org)
  • However, in tumors with posterior soft palate extension, retropharyngeal nodes may be involved. (medscape.com)
  • Ovarian Tumours (with Comments on Fallopian Tube) -- 24. (nshealth.ca)
  • The tongue was the most affected oral site (53.6%) while the nasopharynx comprised 89.5% of pharyngeal cancers. (who.int)
  • Computed tomography (CT) scanning and magnetic resonance imaging (MRI) are complementary modalities in diagnosis and delineation of tumor extension. (medscape.com)
  • The tumors are under 6cm but they've been growing over the last month or so as I've been going through the process of diagnosis and preparing for treatment. (cancer.org)
  • The three described cases demonstrate, that preoperative MRI and CT imaging is important for differential diagnosis to exclude intracranial connections of the tumors. (biomedcentral.com)
  • Provides a tumor tissue sample obtained at the time of or after the initial diagnosis of R/M HNSCC. (who.int)
  • The treatment of choice for the vast majority of benign skull base tumors is surgical excision. (medscape.com)
  • As a whole, tumors of the skull base are uncommon entities, and the majority of them are malignant. (medscape.com)
  • Benign skull base tumors can be classified into the pathogenetic and histologic groups listed below. (medscape.com)
  • Just like other skull base tumors , nasopharyngeal cancers are complex because they grow close to vital nerves and structures like the carotid artery, the main vessel supplying blood to the brain. (dukehealth.org)
  • Gastrointestinal stromal tumor (GIST) (closed to accrual 09/26/2018) 38. (sncrf.org)
  • Thyroid Gland Tumours (With Comments on Parathyroid and Adrenal Gland). (nshealth.ca)
  • Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. (sncrf.org)
  • Gestational Trophoblastic Tumours -- Part VII. (nshealth.ca)
  • Bone and Soft Tissue Sarcomas (With Comments on Retroperitoneum) -- Part X. Ophthalmic Tumours -- 37. (nshealth.ca)
  • The finding of pronounced nuclear pleomorphism associated with prominent myxoid matrix in an otherwise leiomyogenic tumour has not been previously reported at this site and must be distinguished from other neoplasms and non-neoplastic processes. (bmj.com)
  • J. E. Ash, M. R. Beck and J. D. Wilkes, "Tumors of the Upper Respiratory Tract and Ear," In: Atlas of Tumor Pa- thology, Armed Forces Institute of Pathology, Washington DC, 1964, pp. 273-278. (scirp.org)
  • If the ear infection does not present with an upper respiratory tract infection, then an examination should be done on the nasopharynx. (wikipedia.org)
  • A thorough history and physical examination help to assess the extent of tumor. (medscape.com)
  • Histopathological examination showed lobules and fascicles of uniform partly spindle-shaped tumor cells with oval nuclei and intranuclear clear inclusions (Fig. 1 ). (biomedcentral.com)
  • General ENT examination showed a soft tumor in the nasopharynx. (biomedcentral.com)
  • It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g. (lookformedical.com)
  • Recently, in Finland, the United Kingdom, the Netherlands, the United States, and Sweden, incidence of OSCC has increased, and an increase in the proportion of HPV-positive tumors was noted. (cdc.gov)
  • Therefore, the types of ious forms of radiation, carcinogen ifested as a higher incidence of the tumours that occur during childhood ic infectious agents, and chemicals same kinds of tumours that occur in in humans, including various embry and chemical mixtures. (who.int)
  • Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
  • The susceptibility of but a few known transplacental car and reach the fetus, a carcinogenic the fetus relative to that of adult rats cinogens are organic compounds chemical may have no transplacen is measured as the incidence and that act principal y or entirely by a ge tal carcinogenic activity or may only multiplicity of tumours that develop notoxic mode of action. (who.int)
  • Factors that cause a low incidence of tumours in offspring after birth, compared contribute to fetal susceptibility to near the end of gestation, in offspring with the incidence and multiplicity of these agents include maternal, pla that were exposed trans placental y. the same types of tumours in their cental, and fetal metabolism, the im This pattern can be seen in the directly exposed mothers. (who.int)
  • which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)
  • Inflammatory myofibroblastic tumor (IMT) is recognized as an intermediate mesenchymal tumor by the World Health Organization [ 1 ]. (hindawi.com)
  • Biopsies obtained prior to the administration of any systemic therapy administered for the treatment of a participant's tumor (such as neoadjuvant/adjuvant therapy) are not acceptable. (who.int)
  • We present three cases of common intracranial tumors, with purely extracranial extension. (biomedcentral.com)
  • IMT is an intermediate tumor that often mimics malignancy. (hindawi.com)
  • After deploying Medigene's proprietary algorithms for evaluation of the unique characteristics of each of the 3S TCRs, including peptide specificity, tumor cell recognition and off-target toxicity, the Company has prioritized one of the 3S TCRs as the lead to move forward to the pre-clinical stage for Medigene's MDG2011 program. (nwahomepage.com)
  • The clinical characteristics and prognostic implications of BRCA-associated tumors in males are also underdetermined. (biomedcentral.com)
  • Functional imaging, that is, modalities that offer information on factors that influence treatment outcome (e.g., tumor burden, proliferation, and hypoxia), is expected to provide the biologic target volume for such dose painting ( 2 , 3 ). (snmjournals.org)
  • I. To evaluate the association of tumor mutational burden measured by tissue sequencing with durable response (complete response [CR] or partial response [PR] lasting 24 weeks or more). (clinicaltrialsgps.com)