• We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
  • Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
  • We studied tumour lymphangiogenesis and lymphatic invasion using D2-40 endothelial marker in 35 breast cancer patients treated by primary surgery and correlated it with various clinico-pathological prognostic parameters. (scirp.org)
  • M. A. Ansari, V. Pandey, V. Srivastava, M. Kumar, R. Mishra and A. Kumar, "Lymphangiogenesis as a Prognostic Marker in Breast Cancer Using D2-40 as Lymphatic Endothelial Marker-A Preliminary Study," Journal of Cancer Therapy , Vol. 3 No. 5A, 2012, pp. 814-821. (scirp.org)
  • Suppression of Tumour Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling," Journal of the National Cancer Institute, Vol. 94, No. 11, 2002, pp. 819-825. (scirp.org)
  • Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium," American Journal of Pathology, Vol. 154, 1999, pp. 385-394. (scirp.org)
  • Furthermore, our previous work demonstrated that vascular endothelial growth factor C (VEGFC)-driven lymphangiogenesis in the context of murine melanoma drove increased leukocyte infiltration but associated with poor CD8+ T cell priming in draining lymph nodes (4). (aacrjournals.org)
  • SEMA3F may inhibit angiogenesis and lymphangiogenesis by a novel mechanism, which is the repulsion of vascular and lymphatic endothelial cells (EC) expressing NRP2 similar to the way SEMA3F repels neurons. (harvard.edu)
  • LYVE1, also known as lymphatic vessel endothelial receptor 1 or lymphatic vessel endothelial hyaluronic acid receptor 1, is a member of the link protein family, which has the capability to bind with hyaluronic acid. (prospecbio.com)
  • A CD44 homolog, which is located primarily in lymphatic endothelial cells, LYVE 1 has a number of known functions, but research is ongoing and more could be established in the future. (prospecbio.com)
  • LYVE1 has also been found to play a role in HA localisation to the surface of the endothelial cells that line the lymphatic tissue. (prospecbio.com)
  • Tumour growth and metastasis are associated with angiogenesis and lymphangiogenesis through the production of vascular endothelial growth factor (VEGF) or VEGF-C in tumours, and the phosphorylation of VEGF receptor (VEGFR)-2 or VEGFR-3 in vascular endothelial cells or lymphatic endothelial cells (LECs). (complementaryoncology.com)
  • Wogonin had no effect on VEGF-C production in LM8 cells, or VEGFR-3 expression in human lymphatic endothelial cells (HLECs), however, it inhibited VEGF-C-induced VEGFR-3 phosphorylation in HLECs. (complementaryoncology.com)
  • Lymphatic vessel formation starts after the circulatory system has been established by specification of lymphatic endothelial cells from preexisting embryonic veins. (oncotarget.com)
  • Recently, it has been shown that phosphorylation regulates Foxc2-mediated transcription in lymphatic endothelial cells [ 11 ]. (oncotarget.com)
  • Vascular endothelial growth factor-C (VEGF-C) is a secreted growth factor essential for lymphangiogenesis. (elsevierpure.com)
  • Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from the vasculature of normal tissue and from highly metastatic T-241/vascular endothelial growth factor (VEGF)-C fibrosarcomas implanted in C57BL/6 mice. (ox.ac.uk)
  • The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (nih.gov)
  • e lymphatic blood vascular endothelial cells are activated by several in�ammatory mediators (e.g., vascular endothelial growth capillariestakeupthisprotein-rich�uid,therebymaintaining factor- (VEGF-)A, tumor necrosis factor (TNF-) , inter- not only tissue �uid homeostasis but also exerting immune leukin (IL)-6, and IL-1), leading to the typical signs of surveillance. (sagepub.com)
  • ICAM-)1, vascular cell adhesion molecule- (VCAM-)1, elargestcollectinglymphaticvessel,thethoracicduct,con- and E-selectin on activated blood vascular endothelial cells, nects the lymphatic system with the cardiovascular system. (sagepub.com)
  • Vascular endothelial growth factor receptor 3 (VEGFR-3) supports tumor lymphangiogenesis. (oncotarget.com)
  • It was originally identified as a lymphangiogenic factor expressed in lymphatic endothelial cells. (oncotarget.com)
  • Unfortunately, loss of Stabilin-2 expression in the peri-tumorous environment was the least likely to occur of all the SEC markers tested and may be a significant factor for endothelial-tumor cell adhesion and invasion [ 6 ] . (encyclopedia.pub)
  • NO increases and/or maintains tumor blood flow, decreases leukocyte-endothelial interactions, and increases vascular permeability and thus, may facilitate tumor growth. (harvard.edu)
  • For example,, the blockade of vascular endothelial growth factor signaling can transiently normalize tumor vasculature and potentiate anti-tumor cytotoxic therapies. (harvard.edu)
  • The elevated expression of several angiogenic factors, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF) and interleukin-8, has been detected in primary cutaneous melanomas, and the importance of these mediators in promoting melanoma angiogenesis and metastasis has been confirmed in tumor xenotransplant models. (dermatologytimes.com)
  • Says Prof. Tanaka, "Long-term feeding of SFA and TFA diets to HCVcpTg mice increased the expressions of vascular endothelial cell indicators like CD31 and TEK receptor tyrosine kinase, in addition to lymphatic vessel endothelial hyaluronan receptor 1. (toppersonalhealth.com)
  • Despite the fact that it is well-known that Vascular Endothelial Growth Factor (VEGF) binds to its receptor VEGFR and initiates endothelial cell proliferation, almost nothing is known about their involvement and mechanisms in the process of MTC metastasis.Interestingly, RET (RET/PTC) gene rearrangement, present in papillary thyroid carciomas, modulates the expression of many genes that could be involved on tumor growth and angiogenesis, such as CXCL12 and CXCR4. (fapesp.br)
  • In the past, there were no reliable markers to distinguish blood vessel endothelial cells and lymphatic endothelial cells. (listarfish.it)
  • PROX-1 is expressed in a subpopulation of endothelial cells which by budding and sprouting, give rise to the lymphatic system. (listarfish.it)
  • Our anti-PROX-1 provide a highly specifi c marker of lymphatic endothelial cells. (listarfish.it)
  • Lymphatic capillaries consist of overlapping endothelial cells , and lack pericytes and smooth muscle cells. (turkupetcentre.net)
  • Endothelial junctions in lymphatic capillaries serve as a microvalve which allows the interstitial fluid and small particles (≤25 nm) to flow into the lumen, but reduces the leakage from lumen back into the interstitium. (turkupetcentre.net)
  • Lymphatic endothelial cells express chemokines and adhesion molecules, and can direct the leukocytes into lymphatics or into interstitial space. (turkupetcentre.net)
  • Consistently, TCGA analysis of human cutaneous metastatic melanoma identified positive correlations between LEC gene expression and immune genes, including a T cell-inflamed signature, indicating a relationship between lymphatic vessel remodeling and local immunity. (aacrjournals.org)
  • Furthermore, others have recently demonstrated that lymphatic vessel density (LVD) in combination with intratumoral T cell function stratified best overall survival in nonmetastatic and metastatic colorectal cancer (2). (aacrjournals.org)
  • Yoshiyuki Kimura & Maho Sumiyoshi examined the effects of wogonin isolated from Scutellaria baicalensis roots on tumour growth and metastasis using a highly metastatic model in osteosarcoma LM8-bearing mice. (complementaryoncology.com)
  • The anti-tumour and anti-metastatic actions of wogonin may be associated with the inhibition of VEGF-C-induced lymphangiogenesis through a reduction in VEGF-C-induced VEGFR-3 phosphorylation by the inhibition of COX-2 expression and IL-1? (complementaryoncology.com)
  • Metastatic tumor cells often contain distinctive surface markers for enabling them to escape their indigenous tissue to travel and thrive at a distal site. (encyclopedia.pub)
  • The lymph node itself highly expresses Stabilin-2 and acts as one of the entrapping receptors for metastatic tumor cells. (encyclopedia.pub)
  • Our recent data indicate that stromal cells in the primary tumor travel with tumor cells and facilitate survival and growth of metastatic tumors. (harvard.edu)
  • Currently, tumor thickness is the main factor considered when determining prognosis, but a considerable number of patients with thin melanomas also go on to develop metastatic disease. (dermatologytimes.com)
  • Dr. Detmar postulates that metastatic melanomas can therefore be characterized by increased lymphangiogenesis, as compared to non-metastatic tumors, and that the degree of tumor lymphangiogenesis can serve as a novel predictor of lymph node metastasis and overall patient survival, independent of tumor thickness. (dermatologytimes.com)
  • As a result, blockade of TGF- signaling may decrease tumor cell viability and migratory potential and represents a testable healing strategy against metastatic carcinomas. (conferencedequebec.org)
  • In animal models, overexpression of lymphangiogenic factors VEGF-C and VEGF-D in tumor cells enhances metastatic spread of tumors. (listarfish.it)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • This unequivocal requirement for a functional lymphatic vasculature in the priming of cutaneous immunity further supports the prediction that LVD may be a novel biomarker of immune reactivity within tumor parenchyma. (aacrjournals.org)
  • Dysfunction of the lymphatic vasculature results in lymphedema formation and compromises immune function. (oncotarget.com)
  • Therefore, dysregulation of the angiogenic process has been linked to tumour development and progression [ 1 ]. (hindawi.com)
  • Altered expression and activity levels of MMPs have been strongly implicated in the progression and metastasis of many forms of cancer. (wikipedia.org)
  • One of the major implications of MMPs in cancer progression is their role in ECM degradation, which allows cancer cells to migrate out of the primary tumor to form metastases. (wikipedia.org)
  • Lymphatic vessel remodeling and lymphangiogenesis is correlated with melanoma progression and lymph node metastasis. (aacrjournals.org)
  • Our previous studies show that activation of the VEGF-C/VEGFR-3 axis promotes cancer metastasis and is associated with clinical progression in patients with lung cancer, indicating that VEGFR-3 is a potential target for cancer therapy. (oncotarget.com)
  • Therefore, we propose to investigate p.G533C mutation on gene RET associated to inherited MTC genesis modulating different VEGF isoforms, VEGFR, and other mediators involved on the process of angiogenesis and lymphangiogenesis on tumor progression. (fapesp.br)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • VEGF messenger RNA (mRNA) is widely overexpressed in tissues and is associated with metastasis, recurrence, and prognosis [ 2 ]. (hindawi.com)
  • VEGF-C functions in both physiological and pathological lymphangiogenesis, particularly in tumor metastasis, making it an attractive therapeutic target. (elsevierpure.com)
  • Moreover, these peptides abolished VEGF-C-induced drug resistance and tumor initiating cell formation. (oncotarget.com)
  • VEGF-C interactions with VEGF R3 are critical for lymphangiogenesis. (bio-techne.com)
  • Over-expression of VEGF-C in tumor cells induces tumoral lymphatic hyperplasia, neoangiogenesis, and vessel sprouting, resulting in enhanced lymph flow and metastasis to regional lymph nodes. (bio-techne.com)
  • Most significantly, they have found that VEGF-C over-expression leads to lymphangiogenesis, intralymphatic tumor growth and lymph node metastasis in several tumor models. (euroacadti.eu)
  • According to Prof. Tanaka , "We demonstrated for the first time that hepatic angiogenesis and lymphangiogenesis were enhanced by saturated-fat- or trans-fat-rich diets, but not cholesterol-rich diets, mainly through the JNK-HIF1α-VEGF-C axis. (toppersonalhealth.com)
  • It is also known that Tumor-Associated Macrophages (TAM) are attracted by CXCL12 and VEGF, and can promote angiogenesis and tumor metastasis. (fapesp.br)
  • VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. (ox.ac.uk)
  • Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C and -D on VEGFR3. (ox.ac.uk)
  • We re-evaluated the potential role of VEGF-A in lymphangiogenesis using a novel model in which both lymphangiogenesis and hemangiogenesis are induced in the normally avascular cornea. (ox.ac.uk)
  • Furthermore, both lymphangiogenesis and hemangiogenesis were significantly reduced in mice transgenic for VEGF-A(164/164) or VEGF-A(188/188) (each of which expresses only one of the three principle VEGF-A isoforms). (ox.ac.uk)
  • Because VEGF-A is chemotactic for macrophages and we demonstrate here that macrophages in inflamed corneas release lymphangiogenic VEGF-C/VEGF-D, we evaluated the possibility that macrophage recruitment plays a role in VEGF-A-mediated lymphangiogenesis. (ox.ac.uk)
  • We conclude that VEGF-A recruitment of monocytes/macrophages plays a crucial role in inducing inflammatory neovascularization by supplying/amplifying signals essential for pathological hemangiogenesis and lymphangiogenesis. (ox.ac.uk)
  • VEGF is one of most important mediators of neoplastic angiogenesis and lymphangiogenesis (Hirakawa et al . (vin.com)
  • The percentage of VEGF-positive tumor cells was scored at 0 to 4 levels (0: less than de 5% of labeled cells to 4: more than 75% of labeled cells). (vin.com)
  • It should be noted that studies of lymphatic vessel growth utilizing protein reagents or transgenic technology alone, in a tissue/cell culture environment, during tumor metastasis, in a lymphatic disease paradigm, or during tissue repair, have shown that various growth factors, such as platelet-derived growth factor BB (1), hepatocyte growth factor (2), fibroblast growth factor (3), and VEGF-A (4) appear to play a role. (arizona.edu)
  • Lymphangiogenesis is regulated by VEGF-C and VEGF-D, and indirectly by NO. MMP-9 participates in lymphatic regeneration. (turkupetcentre.net)
  • Herein, we comprehensively analysed the correlation of NRP expression with prognosis and tumour microenvironment landscape in 33 cancer types. (hindawi.com)
  • Our findings reveal that NRPs may be a potential prognostic marker associated with immune infiltration, tumour mutations, and tumour microenvironment, particularly in bladder urothelial carcinoma (BLCA). (hindawi.com)
  • Using genetically engineered mouse and tumor models as well as in vivo imaging techniques, we found for the first time that nontransformed stromal cells -including activated fibroblasts, bone marrow derived cells - are a major inducer of tumor angiogenesis and mediate the formation of abnormal microenvironment. (harvard.edu)
  • We have been studying the tumor microenvironment and transport properties using nano-probes. (harvard.edu)
  • These findings led us to develop multistage nanotherapeutics that shrink upon the entry to the tumor microenvironment in order to facilitate interstitial transport. (harvard.edu)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • A multidimensional bioinformatics analysis was performed to examine the relationship between NRP genes and prognostic and pathological features, tumour mutational burden (TMB), microsatellite instability (MSI), and immunological features based on public databases and find the potential prognostic value of NRPs in pancancer. (hindawi.com)
  • Both the ligand and receptor are usually co-expressed at sites of lymphatic vessel sprouting, in the embryo, and in various pathological conditions. (bio-techne.com)
  • Recent research efforts in studying lymphangiogenesis have suggested the existence of a relationship between lymphatic vessel density and patient survival. (ox.ac.uk)
  • BACKGROUND: High dose unilobar radioembolization (also termed 'radiation lobectomy')-the transarterial unilobar infusion of radioactive microspheres as a means of controlling tumour growth while concomitantly inducing future liver remnant hypertrophy-has recently gained interest as induction strategy for surgical resection. (bvsalud.org)
  • Prognostic Value of Lymphatic and Blood Vessel Invasion in Neuroendocrine Tumours of the Lung," The American Journal of Surgical Pathology, Vol. 29, 2005, pp. 324-328. (scirp.org)
  • Cancer cell invasion, ECM degradation, and metastasis are highly linked with the presence of invadopodia, protrusive and adhesive structures on cancer cells. (wikipedia.org)
  • In vitro, SEMA3F inhibits tumor cell adhesion to fibronectin by inhibiting beta 1 integrin levels, inhibits tumor cell motility, and inhibits tumor cell invasion through matrigel. (harvard.edu)
  • criteria are the absence of extrahepatic metastasis and vascular invasion identifiable with preoperative images, a solitary tumor of 5 cm or less, or if there are multiple tumors, three or fewer tumors measuring 3 cm or less in diameter at a maximum (Milan criteria) (LF005401 level 2a). (hormonessignaling.com)
  • These findings reveal a remarkable degree of phenotypic plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis. (ox.ac.uk)
  • Aim: To determine correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarify the prognostic impact of lymphatic invasion. (iiarjournals.org)
  • Lymphatic invasion was calculated as an average and the degree was also determined (Ly0-3). (iiarjournals.org)
  • Clinicopathological factors including lymphatic invasion were assessed by uni- and multivariate analyses to determine factors affecting survival. (iiarjournals.org)
  • Survival was compared between different degrees of lymphatic invasion and lymph node metastasis. (iiarjournals.org)
  • Conclusion: Lymphatic invasion in colorectal cancer correlates well with the status of lymph node metastasis and disease stage, representing an independent prognostic factor after curative resection. (iiarjournals.org)
  • Lymphatic invasion can be used for evaluating tumor aggressiveness and estimating patient survival, irrespective of the actual number of positive lymph nodes found. (iiarjournals.org)
  • It is well-known that not only the presence or absence of lymph node metastasis, but also the degree of presence, is an important prognostic factor, along with depth of tumor invasion, and is useful in determining the adjuvant chemotherapy and surveillance program ( 3 , 4 ). (iiarjournals.org)
  • In 1995, we demonstrated the prognostic importance of lymphatic invasion in rectal cancer and advocated the subdivision of stage III (Dukes' C) tumors according to lymphatic invasion ( 12 ). (iiarjournals.org)
  • The present study examined correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarified the prognostic impact of lymphatic invasion, based on a large series and long-term follow-up of patients with colorectal cancer curatively treated. (iiarjournals.org)
  • Age and sex of patients, site, gross type, size (maximum tumor diameter), preoperative serum level of carcinoembryonic antigen (CEA), depth of wall invasion, status of lymph node metastasis, histopathological differentiation, degree of lymphatic and venous invasion, and presence or absence of postoperative adjuvant chemotherapy were extracted from operation records and pathology reports. (iiarjournals.org)
  • The number of FFPE blocks investigated was significantly correlated with the size of the tumour (lymph vessel invasion Lymph vessel invasion was more frequent than BVI. (bioinbrief.com)
  • Both intra- and peritumourally, vascular invasion assessed on HE was associated with LVI (demonstrated lymphatic invasion in 44% of LN negative and 86% of LN positive (overall 66%) BC patients (Kahn and Marks, 2002). (bioinbrief.com)
  • Furthermore, our data demonstrate that most (lympho)vascular invasion in BC is LVI and that lymph vessel tumour emboli are larger than blood vessel tumour emboli. (bioinbrief.com)
  • Talimogene laherparepvec is an investigational oncolytic immunotherapy designed to selectively replicate in tumor tissue. (amgen.com)
  • Talimogene laherparepvec is injected directly into tumor tissue and then replicates until the membrane of the cancer cells rupture, thereby destroying the cells, in a process known as cell lysis. (amgen.com)
  • The virus that was contained in these cells is then released locally in the tumor tissue along with potential tumor antigens and GM-CSF, a white blood cell growth factor that the virus is engineered to express. (amgen.com)
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (wikipedia.org)
  • MMP production in many cancers may be upregulated in surrounding stromal tissue rather than simply in the tumor lesion. (wikipedia.org)
  • A number of studies have also flagged LYVE1 as a marker for lymphoid tissue and lymphangiogenesis. (prospecbio.com)
  • The lymphatic system is essential for the maintenance of tissue fluid homeostasis, enables the uptake of dietary lipids and regulates the immune response by serving as a trafficking route for immune cells [ 1 ]. (oncotarget.com)
  • esides the increased in�amma- tory cell in�ltration into the in�amed tissue, it has become In vertebrates, there are two vascular systems: the cardio- clearintherecentyearsthatacuteandchronicin�ammatory vascular and the lymphatic system. (sagepub.com)
  • In conclusion, local implantation of ADRCs promotes angiogenesis in response to tissue ischemia in the hind limb without promoting remote tumor growth and related angio/lymphangiogenesis. (nagoya-u.ac.jp)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • Lymphatics function to drain tissue fluid and traffic immune cells, but are also utilised by tumours to metastasise to lymph nodes and secondary sites in cancer. (edu.au)
  • An ideal inhibitor may be one that is anti-angiogenic as well as anti-lymphangiogenic, thereby suppressing both routes of metastasis. (harvard.edu)
  • Tumours may release lymphangiogenic factors. (turkupetcentre.net)
  • Although the process is enhanced by tumor lymphangiogenesis, it is unclear whether this is a consequence of increased lymphatic vessel number, altered lymphatic vessel properties, or both. (ox.ac.uk)
  • Recently we have demonstrated that one member of the class 3 semaphorins, Semaphorin 3F (SEMA3F), can inhibit human melanoma metastasis. (harvard.edu)
  • Melanoma is the most lethal skin cancer with most deaths occurring from distant metastases. (harvard.edu)
  • Melanoma researchers have therefore been concentrating their efforts on learning more about angiogenesis, lymphangiogenesis and the nature of metastasis in order to better understand which types of melanomas have a tendency to metastasize. (dermatologytimes.com)
  • Dr. Detmar set out to investigate whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes. (dermatologytimes.com)
  • Dr. Detmar and his team of researchers conducted a study consisting of 45 patients with primary cutaneous melanoma, where the extent of tumor lymphangiogenesis in the excised primary tumors and the presence of metastases in the sentinel lymph node biopsy samples were examined. (dermatologytimes.com)
  • A melanoma is a tumor produced by the malignant transformation of melanocytes. (medscape.com)
  • Melanoma is a tumor that develops as a result of the malignant transformation of melanocytes. (medscape.com)
  • Existing lymphatic networks can be expanded, venous structures can be reprogrammed, or lymphatic progenitor cells are recruited. (turkupetcentre.net)
  • Tumour growth can obstruct lymph flow, causing lymph reflux and lymphatic-venous shunting, which may promote metastasis formation. (turkupetcentre.net)
  • The forkhead transcription factor Foxc2 plays a central role in lymphatic vessel development and lymphatic valve formation [ 4 - 6 ]. (oncotarget.com)
  • Because heavily O-glycosylated mucoproteins were identified recently as counterreceptors for selectins that mediate adhesion of infl ammatory cells, it is possible that podoplanin plays a similar role in lymphatic endothelia. (listarfish.it)
  • In summary, our study elucidates the Cdk5-Foxc2 interaction as a critical regulator of lymphatic vessel development. (oncotarget.com)
  • This is intended to lead to the activation of a systemic immune response to kill tumor cells throughout the body. (amgen.com)
  • EVT801 also has marked activity on the immune system within the tumour and may therefore enhance the activity of immuno-oncology therapies. (checkorphan.org)
  • Following cutaneous vaccinia infection we demonstrate that in the absence of lymphatic vessel transport, both cellular and humoral adaptive immune responses fail to initiate, leading to enhanced cutaneous immunopathology and persistent viral load. (aacrjournals.org)
  • As well as being involved in HA degradation and transportation, studies indicate that HA localisation towards lymphatic surfaces, which is linked to LYVE1, can affect the body's immune responses and tumour metastases. (prospecbio.com)
  • The lymphatic system plays important roles in immune function, homeostasis and tumor metastasis. (listarfish.it)
  • Our recent study elucidates the serine-threonine kinase cyclin dependent kinase 5 (Cdk5) as the missing link in the regulation of Foxc2 in the lymphatic endothelium [ 12 ]. (oncotarget.com)
  • Colorectal cancer remains one of the most common malignant tumors in the world ( 1 , 2 ). (iiarjournals.org)
  • kidney, angiogenesis (CD31-positive cells), lymphangiogenesis (LYVE-1-positive cells), and TAM (F4/80-positive cell) numbers in the tumors of LM8-bearing mice. (complementaryoncology.com)
  • A study in which the investigators injected PC3M-LN4 prostate cancer cells that are known to be rich in pericellular HA in mice, found that when Stabilin-2 was blocked with a blocking antibody prior to tumor injection, the number of lymph node metastases was dramatically reduced [ 7 ] . (encyclopedia.pub)
  • More specifically, prior studies conducted on certain types of transgenic mice have shown that fat-rich diets comprising trans-fatty acid (TFA), saturated fatty acid (SFA), and cholesterol cause non-alcoholic fatty liver disease, which may then promote inflammation and tumor formation in the liver. (toppersonalhealth.com)
  • Using experiments involving transgenic mice, they have successfully shown that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis, leading to the promotion of hepatic tumors. (toppersonalhealth.com)
  • In addition, no distant metastases were detected in any of the mice regardless the group. (nagoya-u.ac.jp)
  • PROX-1-defi cient homozygous mice have unaffected vasculogenesis and angiogenesis, but liver and lymphatics do not develop. (listarfish.it)
  • We characterise molecular mechanisms that control lymphangiogenesis using model organisms (zebrafish and mice). (edu.au)
  • EVT801 is a pre-clinical-stage, orally available, small molecule inhibitor of the lymphatic growth factor receptor VEGFR3, originally developed within Evotec's partnership with Sanofi. (checkorphan.org)
  • Moreover, we show similar induction of ESAM, Endoglin, and leptin receptor within tumor lymphatics in a series of human head and neck and colorectal carcinomas, and uncover a dramatic correlation between ESAM expression and nodal metastasis that identifies this marker as a possible prognostic indicator. (ox.ac.uk)
  • High LYVE-1-Positive Lymphatic Vessel Numbers Are Associated with Poor Outcome in Breast Cancer," Clinical Cancer Research, Vol. 10, No. 21, 2004, pp. 7144-7149. (scirp.org)
  • Absence of Functional Lymphatics within a Murine Sarcoma: A Molecular and Functional Evaluation," Cancer Research, Vol. 60, No. 16, 2000, pp. 4324-4327. (scirp.org)
  • Finally, MMP-2 and several other MMPs have been shown to proteolytically activate TGF-β, which has been shown to promote epithelial mesenchymal transition (EMT), a key process involved in cancer metastasis. (wikipedia.org)
  • Metastasis is the most common cause of death in cancer patients. (harvard.edu)
  • Our group aims to understand how mitochondria reprogramming in tumors impact cellular behaviors that drive progressive and lethal cancer. (cuanschutz.edu)
  • Deciphering the mechanisms underlying increased risk of brain metastases in young women with triple negative breast cancer. (cuanschutz.edu)
  • Moreover, Foxc2 has been associated with cancer cell metastasis and epithelial-mesenchymal transition [ 9 , 10 ]. (oncotarget.com)
  • The lymphatic system is an important route for cancer dissemination, and lymph node metastasis (LNM) serves as a critical prognostic determinant in cancer patients. (nii.ac.jp)
  • This is especially relevant for the liver sinusoids and lymph nodes which express high levels of Stabilin-2 and also are sites of metastases for a number of cancer types. (encyclopedia.pub)
  • The lymphatic system or "second circulatory system" is a common transportation highway for metastases and tumor lymphangiogenesis and is common among the various types of cancer. (encyclopedia.pub)
  • A follow-up human patient study in the evaluation of tongue cancer supports this finding in which the potential of solid tumor lymph node metastases is positively correlated with Stabilin-2 expression in lymph node [ 8 ] . (encyclopedia.pub)
  • The same year he co-founded the Tumor Immunology Group at the Danish Cancer Society. (euroacadti.eu)
  • Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy, Int J Radiat Biol, 82, 699 (2006). (dergipark.org.tr)
  • Cancer cells can travel via lymphatic system to distant sites. (turkupetcentre.net)
  • Background: The degree of lymph node metastasis represents an important prognostic factor for cancer. (iiarjournals.org)
  • Although the prognostic import of lymph node metastasis is widely accepted in colorectal cancer, 12 nodes or more must be examined to adequately assess the degree of lymph node metastasis ( 5 , 6 ). (iiarjournals.org)
  • Cancer of the supraglottis (supraglottic cancer) is almost exclusively squamous cell carcinoma (SCC), although SCC of the supraglottis is seen less frequently than cancer of the glottis and is treated differently from tumors of the glottis or subglottis. (medscape.com)
  • Together these results indicate that SEMA3F is a potent metastasis inhibitor that targets both tumor and stromal cells and raise the possibility of SEMA3F having therapeutic potential. (harvard.edu)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • The presence of a fibrotic focus is a surrogate marker for hypoxia-driven angiogenesis (Colpaert et al , 2003a) and for lymphangiogenesis in BC (Van der Auwera et al , 2005). (bioinbrief.com)
  • Both the developing embryo and the solid tumor can only continue growing if they manage to establish a circulatory system that supplies them with oxygen and nutrients. (jeltsch.org)
  • The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)
  • In 1889, Dr. Stephen Paget's "seed and soil" theory of metastasis stated that a tumor cell (or seed) will find a home in certain compatible tissues (soil) to continue growing in a suitable environment [ 1 ] . (encyclopedia.pub)
  • We found that relatively large nanoparticles - size of current nanomedicine - can take advantage of enhanced permeability and retention effect for transvascular transport but are unable to penetrate into tumor tissues. (harvard.edu)
  • In contrast, lymphatic vasculogenesis starts after the establishment of the blood circulatory system. (nature.com)
  • HA can bind with CD44 in the presence of LYVE1, and therefore, LYVE1 could act as a substrate for tumour cells or migrating CD44+ leukocytes. (prospecbio.com)
  • Lymphangiogenesis was quantified using lymphatic micro vessel density (LMVD) by counting the immunostained lymphatic microvessels at 200X. (scirp.org)
  • Results showed that prominent 'hot spots' of increased lymphatic vessel density were seen in the primary melanomas of patients whose tumors had metastasized to the sentinel lymph nodes, as compared to nonmetastatic tumors. (dermatologytimes.com)
  • We support this research with a collection of well-validated antibodies against human and mouse lymphatic markers podoplanin, PROX-1 and LYVE-1. (listarfish.it)