Cell AgingCyclin-Dependent Kinase Inhibitor p16Telomerebeta-GalactosidaseTumor Suppressor Protein p53Aging, PrematureCyclin-Dependent Kinase Inhibitor p21TelomeraseCell Line, TumorBiological ProcessesAgingCell ProliferationCells, CulturedTelomere ShorteningFibroblastsSignal TransductionDNA DamageTumor Markers, BiologicalTumor BurdenTumor Necrosis Factor-alphaRetinoblastoma ProteinApoptosisOxidative StressReactive Oxygen SpeciesCell CycleEndothelial CellsCell DivisionTime FactorsMice, Inbred C57BLGenes, Tumor SuppressorTumor Suppressor ProteinsUp-RegulationWilms TumorDown-RegulationCell LineRNA, Small InterferingReverse Transcriptase Polymerase Chain ReactionBlotting, WesternTOR Serine-Threonine KinasesPhenotypeNeoplasms, ExperimentalRNA InterferenceGene Expression RegulationRNA, MessengerCarcinoid TumorGene Expression Regulation, NeoplasticTransfectionFlow CytometryMice, KnockoutStem CellsImmunohistochemistryNeuroendocrine TumorsDNA-Binding ProteinsTumor MicroenvironmentDose-Response Relationship, DrugCell Transformation, NeoplasticBrain NeoplasmsHistonesp38 Mitogen-Activated Protein KinasesEndothelium, VascularCell Cycle ProteinsCell DifferentiationNeoplasmsMammary Neoplasms, ExperimentalPlant LeavesPhosphorylationNeovascularization, PathologicTransplantation, HeterologousNeoplasm MetastasisAdenocarcinomaBiological MarkersMutationEnzyme ActivationXenograft Model Antitumor AssaysAtherosclerosisNeoplasm ProteinsMice, Inbred BALB CGastrointestinal Stromal TumorsTumor Suppressor Protein p14ARFSkin NeoplasmsFibrosarcomaColonic NeoplasmsAntigens, NeoplasmLiver NeoplasmsCell SurvivalGene Expression ProfilingMice, NudeCarcinoma, Ehrlich TumorOvarian NeoplasmsGliomaMice, SCIDKidney NeoplasmsGenes, p53DNA, NeoplasmMolecular Sequence DataNeoplasm StagingDisease ProgressionRhabdoid TumorModels, BiologicalGenes, ras