Cell AgingCell CycleCell Line, TumorCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p16Tumor Suppressor Protein p53Cyclin-Dependent Kinase Inhibitor p21TelomereCell ProliferationTumor Cells, Culturedbeta-GalactosidaseCell DivisionApoptosisAging, PrematureTelomeraseCells, CulturedSignal TransductionCell Cycle CheckpointsRetinoblastoma ProteinDNA DamageFibroblastsBiological ProcessesAgingCell LineTumor Markers, BiologicalFlow CytometryTime FactorsTelomere ShorteningG1 PhaseNeoplasms, ExperimentalTumor Suppressor ProteinsGene Expression Regulation, NeoplasticBlotting, WesternNeoplasmsRNA, MessengerTumor BurdenRNA, Small InterferingDown-RegulationReverse Transcriptase Polymerase Chain ReactionTransfectionTumor Necrosis Factor-alphaDNA-Binding ProteinsMitosisPhosphorylationMice, Inbred C57BLUp-RegulationReactive Oxygen SpeciesGene Expression RegulationImmunohistochemistryCyclinsOxidative StressRNA InterferencePhenotypeEndothelial CellsS PhaseCell SurvivalGenes, Tumor SuppressorCell DifferentiationMice, NudeMolecular Sequence DataDose-Response Relationship, DrugMutationAntineoplastic AgentsCell Transformation, NeoplasticNeoplasm ProteinsNeoplasm MetastasisG2 PhaseTOR Serine-Threonine KinasesHistonesNeoplasm TransplantationMammary Neoplasms, ExperimentalCyclin-Dependent Kinase Inhibitor p27Protein-Serine-Threonine KinasesCarcinoma, Ehrlich TumorBrain NeoplasmsMice, KnockoutBreast NeoplasmsAdenocarcinomaXenograft Model Antitumor AssaysWilms TumorModels, BiologicalBase SequenceMice, Inbred BALB CTransplantation, HeterologousTranscription FactorsStem CellsColonic NeoplasmsAntigens, NeoplasmNeovascularization, PathologicG2 Phase Cell Cycle CheckpointsTumor MicroenvironmentFibrosarcomaMenstrual CycleEnzyme ActivationNeoplastic Cells, CirculatingGene Expression ProfilingDNA, NeoplasmCyclin D1Carcinoid TumorCell Nucleus