Tumour cell apoptosis. Medical search. Frequent questions

Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
Due to the pleiotropic effect of bortezomibenhanced TRAIL DISC formation upon TRAIL triggering, down-regulation of cFLIP L and activation of the intrinsic apoptosis pathway seem to cooperatively contribute to the antitumor effect of bortezomib/TRAIL cotreatment. (aacrjournals.org)
Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)
Signaling within the cell initiates a pathway that turns on a protein called nuclear factor kappa B that triggers inflammation and leads to the production of immune system proteins called cytokines. (medlineplus.gov)
It is unclear if disruption of the apoptosis pathway plays a role in the signs and symptoms of TRAPS. (medlineplus.gov)
Binding of the trimeric TRAIL to its receptors TRAIL-R1 and TRAIL-R2 induces caspase activation and apoptosis [ 4 ], either through the extrinsic pathway alone or recruiting the intrinsic apoptotic pathway [ 5 ]. (biomedcentral.com)
The aim of this study was to determine the functional link between the c-Met/AKT signaling pathway and death receptor 5 (DR5) in a large cohort of PTC in a tissue microarray format followed by functional studies using PTC cell lines and nude mice. (aku.edu)
Treatment of PTC cell lines with PHA665752, an inhibitor of c-Met tyrosine kinase, inhibited cell proliferation and induced apoptosis via the mitochondrial pathway in PTC cell lines. (aku.edu)
Overexpression of XAF1 impairs tumor progression whereas knockdown of XAF1 promotes tumor growth, suggesting that XAF1 may be a candidate tumor suppressor in neuroblastoma and its associated pathway may be important for developing future interventions. (nus.edu.sg)
The present study explored the effect of NAC on LPS‑induced apoptosis of HUVECs and determined the participation of the p38 mitogen‑activated protein kinase (MAPK) pathway in the process of apoptosis. (spandidos-publications.com)
The death receptor pathway plays an important role in cell apoptosis ( 12 ). (spandidos-publications.com)
The mitochondrial pathway is also referred to as the endogenous apoptosis pathway ( 15 ). (spandidos-publications.com)

Further, oral administration of 50 mg/kg or 100 mg/kg Triphala in PBS, 5 days/week significantly suppressed the growth of Capan-2 pancreatic tumor-xenograft. (biomedcentral.com)
A mouse xenograft model of MCL demonstrated that MLN8237 (10 or 30 mg/kg) or docetaxel (10 mg/kg) alone had modest anti-tumor activity. (elsevierpure.com)
Finally, we show that siRNA- or inhibitor-mediated blockade of integrin α6β4-Src-AKT signaling switches the post-irradiation fate from senescence to apoptosis, under p53 activated condition, in both cancer cells and tumor tissues of xenograft mice. (korea.ac.kr)
In summary, our study revealed that DA is an effective treatment against B16F10 melanoma cells and xenograft mice model. (bvsalud.org)
Finally, cotreatment with PHA665752 and TRAIL caused more pronounced effects on PTC xenograft tumor growth in nude mice. (aku.edu)
Growth of an A549 tumor cell xenograft was markedly inhibited without significant side effects. (ntnu.edu.tw)
Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
In the mouse xenograft model of colon cancer, we were able to observe a reduced tumor growth in response to CysLT1R antagonist treatment. (lu.se)

Single-chain antibodies (scFv) take an important role in the field, because they are less immunogenic than whole antibodies, their smaller size allows faster and deeper penetration into solid tumors, and are by definition recombinant proteins, therefore easier to produce and modify. (biomedcentral.com)
Correlation between RICTOR overexpression and amplification in advanced solid tumors. (nih.gov)
Disruption of the centrosome is common in many solid tumors including lung cancer. (cdc.gov)
Efficient systemic pharmacological treatment of solid tumors is hampered by inadequate tumor concentration of cytostatics necessitating development of smart local drug delivery systems. (lu.se)

Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Boswellia sacra essential oil hydrodistilled at 100 o C was more potent than the essential oil prepared at 78 o C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression. (biomedcentral.com)
We also noticed a systematic upregulation of important markers for progression of G1 cell phase such as CDK-2 (p cyclin D1 (p cyclin E (p treatment . (bvsalud.org)
Rictor promotes tumor progression of rapamycin-insensitive triple-negative breast cancer cells. (nih.gov)
Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
The resulting aneuploidy is a key event in the progression of cancer and is correlated with tumor stage. (cdc.gov)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
However, the mechanism of tumor progression in FAP/sporadic colorectal cancer and in colitis-associated colorectal cancer might differ as indicated by reduced tumor expression of COX-2 and reduced serum levels of PGE2 in the female double mutant (CysLT1R−/− ApcMin/+) mice, whereas AOM/DSS-treated female single mutant (CysLT1R−/−) mice demonstrated increased serum levels of PGE2. (lu.se)

We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of TRAIL-induced apoptosis induction, long-term tumor cell survival, caspase, and caspase target cleavage. (aacrjournals.org)
Present results show that the higher sensitivity to PS-3-PDT in glioma cells arise on account of a higher level of apoptosis and suggest that induction of apoptosis is an important determinant of photodynamic sensitivity in certain cell types. (elsevierpure.com)
Triphala-mediated reduced cell survival correlated with induction of apoptosis, which was associated with reactive oxygen species (ROS) generation. (biomedcentral.com)
GzB may also contribute to apoptosis induction through the cleavage of other cellular substrates including nuclear lamin B, poly (ADP-ribose) polymerase (PARP), and inhibitor of caspase-activated DNase (ICAD) [ 2 ]. (biomedcentral.com)
TRAIL-R1 and TRAIL-R2 have distinct crosslinking requirements for apoptosis induction [ 6 ]. (biomedcentral.com)
Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis. (bvsalud.org)
is required for NGF withdrawal-dependent apoptosis, mediated by the induction of XIAP-associated Factor 1 (XAF1). (nus.edu.sg)
An increased expression of Bcl-2 was observed and induction of apoptosis confirmed in presence of AHCC. (researchgate.net)
More than 15 years ago, cholesterol decrement was first shown to inhibit tumor cell growth, metastasis of tumor cells, and induction of apoptosis (7). (cdc.gov)

Cell biology of tumour development including apoptosis, oncogenes and tumour suppressor genes. (bath.ac.uk)
tumor suppressor genes. (upstate.edu)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Overexpression of sNEDD4 increased the invasive ability of SK cells through upregulation of matrix metalloproteinase 9 and inhibited serum deprivation-induced apoptosis via upregulation of myeloid cell leukemia 1. (oncotarget.com)
In occasional cells, this crossing over may lead to increased 12p copy number and overexpression of cyclin D2. (medscape.com)
Aberrant NOTCH3 signaling and overexpression is oncogenic, related with most cancers stem cells and drug resistance, but therapeutic concentrating on stays elusive. (kashbiotech.com)
miR-381-3p overexpression remarkably represses malignant behaviors of papillary thyroid carcinoma cells [ 9 ]. (hindawi.com)
When primed by inhibition of their antiapoptotic proteins using genetic (BCL-2 or BCL-XL deletion or BAD overexpression) or pharmacologic (navitoclax) means, apoptosis resulted upon p53 restoration in vitro and in vivo. (nih.gov)

In addition, SK228 inhibits cancer cell invasion via FAK/Paxillin disruption at noncytotoxic doses. (ntnu.edu.tw)
Open up in another window Shape 2 Leucine deprivation inhibits breasts tumor cell proliferation(A) MDA-MB-231 or CORIN MCF-7 cells had been seeded in 12-well plates and incubated in charge (+leu) or leucine-deficient (?leu) moderate. (racetab.org)
In normal cells, RBM4 inhibits alternative splicing," Wang says. (sciencedaily.com)

After that, to determine whether basal appearance of the anti-apoptotic reviews proteins would influence the effect of BCL6 inhibitors, we uncovered a panel of 22 DLBCL cell lines to RI-BPI. (nonamimaho.com)
Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation. (biomedcentral.com)
These misfolded proteins are trapped within the cell and are not able to get to the cell surface to interact with TNF. (medlineplus.gov)
Inside the cell, these proteins clump together and are thought to trigger alternative pathways that initiate inflammation. (medlineplus.gov)
Western blot analysis was performed to test the expression of activated KIT, its downstream proteins, and apoptosis associated proteins. (biomedcentral.com)
A series of caspases proteins have been shown to be activated by the death induced signal complex [a form of death ligand that binds to the corresponding death receptor on the cell surface ( 13 )], which in turn induces apoptosis. (spandidos-publications.com)
In separate work, my team identified a set of secreted proteins overexpressed in the tumor microenvironment, and developed antibodies to block their cognate receptors for therapeutic gain. (gene.com)
The UPR normally helps secretory cells to resolve issues with 3D shaping of newly synthesized proteins. (gene.com)
Historically, scientists haven't targeted the proteins in cancer cells that are involved in gene splicing," said Zefeng Wang, PhD, associate professor in the department of pharmacology and senior author of the Cancer Cell paper. (sciencedaily.com)
Then his team conducted further experiments to pinpoint changes in the activity of these proteins in various kinds of human cancer cells and in mouse models. (sciencedaily.com)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)
Because of their surface charge, asbestos fibers can adsorb to cellular macromolecules (proteins, DNA, RNA) and cell surface proteins. (cdc.gov)
We have shown that LTD4 via its receptor CysLT1 induces expression of proteins associated with colorectal cancer and promotes proliferation, survival and migration in intestinal epithelial cells. (lu.se)

Cell death caused by PDT (through the generation of reactive oxygen species) can occur either by apoptosis (interphase death or as a secondary event following mitosis) and/or necrosis depending on the cell type, concentration and intracellular localization of the sensitizer, and the light dose. (elsevierpure.com)
Furthermore, PHA665752 treatment upregulated DR5 expression via generation of reactive oxygen species in PTC cell lines, and synergistically potentiated death receptor-induced apoptosis with tumor necrosis factor- related apoptosis-inducing ligand (TRAIL). (aku.edu)
SK228 induced DNA damages mainly by producing reactive oxygen species (ROS) resulting in apoptosis. (ntnu.edu.tw)

Eight genes related to apoptosis and ten genes regulating key points of cell cycle were investigated. (oncotarget.com)
Genes expressed differentially in SKM and SK cells were identified via microarray analyses. (oncotarget.com)
BCL6 chromatin immunoprecipitation (ChIP) for focus on genes BCL2 and BCL-XL and detrimental control in OCI-Ly1 cells transfected with siRNAs. (nonamimaho.com)
Apoptosis refers to the self-regulated and orderly death of cells controlled by genes in order to maintain the stability of internal environment ( 8 ). (spandidos-publications.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)

Malignant gliomas are the most aggressive human brain tumors without any curative treatment. (aacrjournals.org)
2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
Malignant transformation of germ cells is the result of a multistep process of genetic changes. (medscape.com)
Four varieties of tumor cells were examined: malignant melanoma A375, lung caner A549, ovarian carcinoma breast and A2780 cancer MCF-7 and MDA-MB-231 cells. (racetab.org)
Induces apoptosis in human malignant glioma cell lines. (sigmaaldrich.com)
When your vet tests the cells within the lump or lesion, she'll be able to tell you whether an MCT is benign or malignant. (dogsnaturallymagazine.com)
The presence of asbestos fibers in the lungs sets off a variety of responses leading to inflammation, cell, and tissue damage, which can lead to malignant and non-malignant diseases. (cdc.gov)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Cell cycle and apoptosis are key pathways of multicellular homeostasis and deregulation of these pathways is associated with cancerogenesis. (oncotarget.com)
To check whether up-regulation of BCL2 and BCL-XL may cause lymphoma cells to be especially reliant on these pathways for success in the lack of BCL6, we knocked down BCL6 in OCI-Ly1 cells as before and treated using the BCL2 and BCL-XL inhibitor ABT-737 250 nM for 72 h. (nonamimaho.com)
Consistently, the essential oil represses signaling pathways and cell cycle regulators that have been proposed as therapeutic targets for breast cancer. (biomedcentral.com)
Thereafter, the downstream signaling pathways are activated promoting cell proliferation and/or survival. (biomedcentral.com)
The finding offers a new route toward therapies that can thwart the altered genetic pathways that allow cancer cells to proliferate and spread. (sciencedaily.com)
T cells must substantially increase nutrient uptake to mount a proper immune response and failure to obtain sufficient nutrients or engage the appropriate metabolic pathways can alter or prevent effector T cell differentiation and function. (elifesciences.org)
At high concentrations, NSAIDs have anticarcinogenic properties operating through cyclooxygenase-2-dependent and -independent pathways to inhibit cellular proliferation, inhibit angiogenesis, and induce apoptosis. (medscape.com)

More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
However, most female Brca1Delta11/Delta11 Trp53+/- mice develop mammary tumors with loss of the remaining Trp53 allele within 6-12 months. (nih.gov)
Upon subcutaneous introduction of sNEDD4-overexpressing SK cells into flanks of nude mice, tumors grew faster than those of the control group. (oncotarget.com)
Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)
Therefore, to search for indole compounds with more efficacy and less side effect for cancer therapy, we developed a novel indole compound SK228 and examined its effects and mechanisms on antitumor growth and invasion inhibition in cell and tumor xenografts in nude mice models. (ntnu.edu.tw)
SK228-induced apoptosis was confirmed by terminal deoxynucleotidyl transferase dUTP nick end labeling assay and immunohistochemistry of cleaved caspase-3 in tumors from treated mice. (ntnu.edu.tw)
Open up in another window Shape 3 Leucine deprivation induces apoptosis of human being breast tumor BAY 293 cell(A and B) MDA-MB-231 or MCF-7 cells had been incubated in charge (+leu) or leucine-deficient (?leu) moderate for 48h, accompanied by dedication of cleaved caspases inside a and annexin-V assay in B. (C and D) Nude mice. (racetab.org)
Tumors that developed in mice deficient in INK4A were enhanced by the topical application of carcinogens and ultraviolet light. (medscape.com)
Also, a decreased nuclear expression of β-catenin within the epithelial tumor compartment was determined for CysLT1R mutant female mice in both models. (lu.se)

Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. (biomedcentral.com)
Our study provides the first evidence that SK228 exhibits cancer cell-specific cytotoxicity by inducing mitochondria-mediated apoptosis. (ntnu.edu.tw)
BAY 293 We looked into the cytotoxicity of leucine deprivation on regular cells further, including major hepatocytes, brownish adipose cells (BAT) and MCF-10A cells. (racetab.org)
NOTCH3-ADCs internalize into receptor and ligand cells impartial of signaling and induce cell dying in each cell sorts representing an atypical mechanism of ADC cytotoxicity. (kashbiotech.com)
significant cytotoxicity was observed in the MWCNT-exposed cells. (cdc.gov)

Apoptosis, 2021 Jun. (nih.gov)

In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
As prooxidants, polyphenols may stimulate apoptosis and inhibit tumour growth [ 8 ]. (hindawi.com)
IM combined with IR can synergistically inhibit the proliferation, apoptosis, clonogenesis, invasion, migration and cell cycle of GIST cells. (researchsquare.com)
Further, inhibitory receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly and through release of extracellular vesicles such as exosomes. (elifesciences.org)
Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)

Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
Background: Neuroendocrine tumors of the lung comprise typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine cancer (LCNEC) and small-cell lung cancer (SCLC). (oncotarget.com)
1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
Boswellia sacra essential oil-mediated cell viability and death were studied in established human breast cancer cell lines (T47D, MCF7, MDA-MB-231) and an immortalized normal human breast cell line (MCF10-2A). (biomedcentral.com)
All three human breast cancer cell lines were sensitive to essential oil treatment with reduced cell viability and elevated cell death, whereas the immortalized normal human breast cell line was more resistant to essential oil treatment. (biomedcentral.com)
Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. (biomedcentral.com)
Similarly, Triphala induced apoptosis in another pancreatic cancer cell line BxPC-3 by activating ERK. (biomedcentral.com)
Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
Prostate cancer cells, either positive or negative for K V 10.1 were treated with the purified construct. (biomedcentral.com)
After sensitization with cytotoxic drugs, scFv62-TRAIL induced apoptosis only in K V 10.1-positive cancer cells, but not in non-tumor cells, nor in tumor cells lacking K V 10.1 expression. (biomedcentral.com)
In co-cultures with K V 10.1-positive cancer cells the fusion protein also induced apoptosis in bystander K V 10.1-negative cancer cells, while normal prostate epithelial cells were not affected when present as bystander. (biomedcentral.com)
Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumor. (medscape.com)
On the basis of our finding that, integrin α6β4 is specifically activated and acts primarily to induce premature senescence in irradiated cancer cells, we propose that this integrin may be a valuable target and biomarker for radiotherapy. (korea.ac.kr)
SK228 significantly inhibited growth of different lung and esophageal cancer cell lines at sub-micromolar range, but not normal lung cells. (ntnu.edu.tw)
Moreover, low-dose SK228 significantly reduced the invasion of cancer cells. (ntnu.edu.tw)
it killed lung, breast and brain cancer cells and left the healthy cells alone. (snopes.com)
In human bodies there is a natural cancer fighting human cell, the mitochondria, but they need to be triggered to be effective. (snopes.com)
Scientists used to think that these mitochondria cells were damaged and thus ineffective against cancer. (snopes.com)
it triggers the mitochondria which in turn fights the cancer cells. (snopes.com)
You see, mitochondria contain an all-too-important self-destruct button that can't be pressed in cancer cells. (snopes.com)
With glycolysis turned off, the body produces less lactic acid, so the bad tissue around cancer cells doesn't break down and seed new tumors. (snopes.com)
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)
Our investigations are ongoing in biomarkers of resistance and potential new targets for therapeutic intervention in colorectal cancer, melanoma and Merkel cell carcinoma. (massgeneral.org)
Our contributions to elucidating the mechanisms of apoptosis led to clinical investigation of a novel class of molecules called Pro-Apoptotic Receptor Agonists, and aided in the advancement of apoptosis-promoting cancer medicines such as venclexta. (gene.com)
We have discovered that the key UPR enzyme IRE1 is hijacked by certain cancer cells to avert apoptosis and resist proteotoxic stress. (gene.com)
Our research further revealed that inhibiting IRE1 activity in cancer-surveilling dendritic cells augments anti-tumor immunity. (gene.com)
We are currently developing strategies that aim to kill cancer cells by directly disrupting their inherent stress-adaptation mechanisms or by augmenting the anti-tumor immune response. (gene.com)
Wang, a member of the UNC Lineberger Comprehensive Cancer Center, studies how alternative splicing happens in normal cells and in cancer cells. (sciencedaily.com)
Wang's group also found that RBM4 played a role in controlling another splicing regulator called SRSF1, which is highly expressed in some cancer cells. (sciencedaily.com)
The TME, however, can be metabolically hostile due to insufficient vascular exchange and cancer cell metabolism that leads to hypoxia, depletion of nutrients, and accumulation of waste products. (elifesciences.org)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)
Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)
[ 17-20 ] In vitro and in vivo research suggests that NSAIDs and selective cyclooxygenase-2 inhibitors hinder growth and survival of bladder cancer cells and nitrosamine-induced tumors. (medscape.com)
many other tumours, so their role is still important role in cancer pathogenesis controversial. (who.int)

The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. (biomedcentral.com)
Granzyme B (GzB) is a serine protease found in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. (biomedcentral.com)
The postulated mechanisms of action of corticosteroids in brain tumors include reduction in vascular permeability, cytotoxic effects on tumors, inhibition of tumor formation, and decreased CSF production. (medscape.com)

Locally delivered DOX via the HA particles had a stronger tumor eradication effect compared to the controls as seen by PET-CT and immunohistochemical staining of proliferation and apoptosis markers. (lu.se)
The inhibition of the tumor growth was accompanied with changes in proliferation and apoptosis as determined by reduced Ki-67 expression, increased expression of p21WAF/Cip1, cleaved caspase 3 and caspase-cleaved keratin 18. (lu.se)

Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
ALK+ ALCL cell lines stably expressing GzB or non-targeting (control) shRNA were generated and apoptosis was examined by anti-PARP western blotting and terminal deoxynucleotidyl transferase dUTP nick end labelling. (biomedcentral.com)

GzB primarily initiates apoptosis either through direct proteolytic processing and activation of initiator (caspase 8) or executioner (caspases 3 and 7) caspases, or through disruption of mitochondrial outer membrane potential via cleavage of the Bid protein [ 2 ]. (biomedcentral.com)
is initiated when the TNFR1 protein, bound to the TNF protein, is brought into the cell and triggers a process known as the caspase cascade. (medlineplus.gov)
High dose of ATRA induced morphologic change in GIST-T1 cells, rounded-up cells, and activated the caspase-3 protein. (biomedcentral.com)
Rictor, an essential component of mTOR complex 2, undergoes caspase-mediated cleavage during apoptosis induced by multiple stimuli. (nih.gov)

Anti-invasive and anti-multicellular tumor properties were evaluated by cellular network and spheroid formation models, respectively. (biomedcentral.com)
According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
Many recent studies have demonstrated that cellular senescence plays a crucial role in the regression of tumors exposed to ionizing radiation (IR), but the underlying mechanism remains unknown. (korea.ac.kr)
To familiarise the student with recent advances in molecular and cellular processes underlying tumour development and its treatment. (bath.ac.uk)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)

Regardless of the tumor heterogeneity, cotreatment with the proteasome inhibitor bortezomib efficiently sensitized all primary glioma samples for TRAIL-induced apoptosis and tremendously reduced their clonogenic survival. (aacrjournals.org)
Exposure of Capan-2 cells to the aqueous extract of Triphala for 24 h resulted in the significant decrease in the survival of cells in a dose-dependent manner with an IC50 of about 50 μg/ml. (biomedcentral.com)
However, MLN8237 plus docetaxel demonstrated a statistically significant tumor growth inhibition and enhanced survival compared to single agent therapy. (elsevierpure.com)
We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low priming would lead to survival and cell cycle arrest. (nih.gov)
Forced BCL-2 or BCL-XL expression reduced priming and resulted in survival and cell cycle arrest. (nih.gov)

Furthermore, sNEDD4-mediated promotion of tumor metastasis was demonstrated in the orthotopic mouse model. (oncotarget.com)
In conclusion, sNEDD4 is a novel metastasis-associated gene, which prevents apoptosis under nutrient restriction conditions. (oncotarget.com)
Furthermore, the scracht assay result suggested that ATRA was a potential reagent to prevent the invasion or metastasis of GIST cells. (biomedcentral.com)

This review will discuss the metabolic changes that drive T cells into different stages of their development and how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes. (elifesciences.org)

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms occurring throughout the entire region of the gastrointestinal tract and are considered to originate from intestitial cells of Cajal, the pacemaker cells of the gut [ 1 ]. (biomedcentral.com)

On the other hand, Triphala failed to induce apoptosis or activate ERK or p53 in normal human pancreatic ductal epithelial (HPDE-6) cells. (biomedcentral.com)

Nevertheless, BCL6 also represses many prominent B-cell oncogenes including and and (BCL-XL)[7]. (nonamimaho.com)

The purpose of BAY 293 our current research would be to investigate the result of leucine deprivation on breast tumor cells and also to elucidate the root mechanisms. (racetab.org)
Blocks estradiol-stimulated VEGF production in breast tumor cells. (sigmaaldrich.com)

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for the design of bifunctional antibodies. (biomedcentral.com)
Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising strategy to set off anti-tumor immune responses. (kashbiotech.com)
Fc-ARMs efficiently interacted with antibodies in vivo and amassed in tumors. (kashbiotech.com)
Moreover, Fc-ARMs recruited antibodies to suppress tumor progress in a mouse mannequin. (kashbiotech.com)

Treatment of DA resulted in growth inhibition and cell cycle arrest at G0/G1 (p immunoblotting . (bvsalud.org)
NAC treatment was able to ameliorate DA-induced apoptosis and cell cycle arrest to support our finding. (bvsalud.org)
Present findings indicate that T44Bf-mediated antiproliferative effects are associated with a reversible chronic mitotic arrest caused by defects in chromosome alignment, followed by induced programmed cell death. (tmu.edu.tw)
Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. (nih.gov)
Using a panel of Kras-driven, p53 restorable cell lines derived from genetically engineered mouse models of lung adenocarcinoma and sarcoma (both of which undergo cell cycle arrest upon p53 restoration), as well as lymphoma (which instead undergo apoptosis), we show that the level of mitochondrial apoptotic priming is a critical determinant of p53 reactivation outcome. (nih.gov)
Cells with low initial priming (e.g., lung adenocarcinoma and sarcoma) survived and proceeded to arrest in the cell cycle. (nih.gov)
Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)

We have previously reported a mouse model in which Brca1 exon 11 is eliminated in mammary epithelial cells through Cre-mediated excision. (nih.gov)
Interleukin (IL)-15, a major cytokine involved in cross-talk between accessory cells (dendritic cells and macrophages) and NK cells, is produced by epithelial renal cells. (nih.gov)
We have previously shown mitotic spindle aberrations in cultured primary and immortalized human airway epithelial cells exposed to single-walled carbon nanotube s (SWCNT). (cdc.gov)
Immortalized and primary respiratory epithelial cells were exposed to 0.024, 0.24, 2.4, and 24 microg/cm2 carbon nanotube s. (cdc.gov)

An impaired tumor angiogenesis was also demonstrated by detection of increased levels of VEGF and reduced vessel size. (lu.se)

Pretreatment of cells with pifithrin-α or U0126, specific inhibitors of p53 or MEK-1/2, significantly attenuated Triphala-induced apoptosis. (biomedcentral.com)

Renal cell carcinoma primary tumors and lung metastases are infiltrated by activated natural killer (NK) cells. (nih.gov)
We show that renal cell carcinoma cells and normal renal cells express IL-15 mRNA and membrane-bound IL-15 (MbIL-15). (nih.gov)
Silencing of IL-15Ralpha by specific small interfering RNA in renal cell carcinoma had no effect on MbIL-15 production, indicating that the cytokine is not cross-presented by IL-15Ralpha in renal cell carcinoma cells but anchored to the membrane. (nih.gov)
Furthermore, we show that MbIL-15 from renal cell carcinoma cells is functional and involved in rapid nuclear translocation of phosphorylated signal transducers and activators of transcription 3 in IL-2-starved NK cells. (nih.gov)
Since, apoptosis induced by PDT treatment plays an important role in determining the photodynamic efficacy, in the present work we have investigated the role of apoptotic cell death in relation to the observed differences in sensitivity to HpD-PDT between a human glioma cell line (BMG-1) carrying wild-type tumour suppressor gene p53 and a human squamous carcinoma cell line (4451) with mutated p53. (elsevierpure.com)
For example, GzB expression in urothelial carcinoma was implicated in promoting tumour cell invasion, whereas its expression in nasal-type NK/T lymphomas was found to correlate with increased apoptosis. (biomedcentral.com)
To explain the origin of occult carcinoma in situ cells, 2 models have been proposed. (medscape.com)
Low level of miR-381-3p constrains oral squamous cell carcinoma growth [ 10 ]. (hindawi.com)

We could design a strategy that selectively kills tumor cells based on a K V 10.1-specific antibody. (biomedcentral.com)

In this scenario, the identification of molecular biomarkers of response and the use of a multimodal in vivo imaging approach represent unique tools for better understanding tumor features, with the final goal of identifying a cluster of patients that are potential responders to personalized medicine. (mdpi.com)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)

While spontaneous apoptosis was similar in ALK+ ALCL cell lines expressing either GzB or control shRNA, GzB shRNA-expressing cells were less sensitive to staurosporine or doxorubicin-induced apoptosis as evidenced by reduced PARP cleavage and decreased DNA fragmentation. (biomedcentral.com)
During apoptosis, however, proCaspase-3 is activated by cleavage into p20 and p12 subunits, and the p20 subunit is trimmed to yield a p17 subunit. (rndsystems.com)

Lymphoma and ovarian tumors also occur at lower frequencies. (nih.gov)
Chances are the combinatorial aftereffect of multiple simultaneous checkpoint gene reactivations delivers an supreme death indication to lymphoma cells. (nonamimaho.com)
It is likely the combinatorial effect of multiple simultaneous checkpoint gene reactivations delivers an ultimate death signal to lymphoma cells. (nonamimaho.com)
GzB expression is also a hallmark of the non-Hodgkin lymphoma, anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL). (biomedcentral.com)

Relative cell viability was assessed using MTT assays. (wjgnet.com)
Cell viability was assessed using the Cell Counting Kit‑8 (CCK‑8) assay. (spandidos-publications.com)

Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)

The antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gliomas has thus far only been thoroughly established in tumor cell lines. (aacrjournals.org)
Tumor necrosis factor receptor-associated periodic syndrome (commonly known as TRAPS) is a condition characterized by recurrent episodes of fever. (medlineplus.gov)
This gene provides instructions for making a protein called tumor necrosis factor receptor 1 (TNFR1). (medlineplus.gov)
All these ROS induce tumor necrosis factor-alpha (TNF-α). (cdc.gov)

Especially, the potassium channel K V 10.1 (Ether-á-go-go) is attractive as target since this surface protein is virtually not detected in normal tissue outside the central nervous system, but is expressed in approximately 70% of tumors from different origins. (biomedcentral.com)
There is an intense effort invested into the search for innovative therapies that can complement classical chemotherapy, radiation and surgery to overcome the limitations derived from chemo-resistance, toxicity of non-specific drugs and incomplete elimination of tumor tissue. (biomedcentral.com)
With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
[ 15 , 16 ] Although not expressed in normal urothelial tissue, cyclooxygenase-2 has been shown to be overexpressed in both transitional cell and squamous cell urothelial tumor tissue. (medscape.com)

The released DOX then accumulates in the mitochondria causing cell starvation, reduced migration and apoptosis. (lu.se)

Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. (biomedcentral.com)

nHA particles functionalized with DOX get engulfed in the lysosome of osteosarcoma cells where the acidic microenvironment causes a disruption of the binding between DOX and HA. (lu.se)
[ 2 ] Targeted disruption of TP53 in the mouse leads to the development of various tumors (see image below). (medscape.com)

These cells also express IL-15 receptor alpha (IL-15Ralpha). (nih.gov)
As well as, DLL4 ligand binding to the NOTCH3 receptor mediates transendocytosis of NOTCH3-ADCs into ligand-expressing cells. (kashbiotech.com)
We present that Fc-ARM concentrating on folate receptor-α (FR-α) redirects a clinically used antibody combination to FR-α + most cancers cells, leading to most cancers cell lysis by pure killer cells in vitro . (kashbiotech.com)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

In contrast to cell lines, isolated primary tumor cells from all investigated glioma patients were highly TRAIL resistant. (aacrjournals.org)

abstract = "Auroras (A and B) are oncogenic serine/threonine kinases that play key roles in the mitotic phase of the eukaryotic cell cycle. (elsevierpure.com)
abstract = "Anti-mitotic therapies have been considered a hallmark in strategies against abnormally proliferating cells. (tmu.edu.tw)

The intra- and intertumor heterogeneity of cell types and gene mutations as well as the complexity of the microenvironment contribute to limiting the efficacy of the current therapeutic options for high grade glioma. (mdpi.com)
Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1B? (nus.edu.sg)
Neuroblastoma is an aggressive, relapse-prone childhood tumor of the sympathetic nervous system. (nus.edu.sg)
Using 3D tumor organoids and orthotopic PDX models we showed that KSP-inhibition is a powerful treatment strategy against neuroblastoma. (lu.se)

Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
TRAIL is normally present as a membrane protein (memTRAIL) on immune effector cells, like natural killer cells. (biomedcentral.com)
Mast cells are part of your dog's immune defense system. (dogsnaturallymagazine.com)
Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)

H-29 cells were used for in vitro experiments in this study. (wjgnet.com)

RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1. (nih.gov)

This binding sends signals that can trigger the cell either to initiate inflammation or to self-destruct. (medlineplus.gov)
LPS (also referred to as endotoxin) is one of the important virulence factors that is known to mediate inflammation and apoptosis ( 2 ). (spandidos-publications.com)
Other cell-mediated mechanisms (especially inflammation). (cdc.gov)
Other cell-mediated mechanisms (especially inflammation induced by TNF-α). (cdc.gov)

The results of CCK‑8 and flow cytometric analyses showed that pretreatment of HUVECs with NAC or p38MAPK inhibitor (SB203580) attenuated LPS‑induced decrease in cell viability and increase in cell apoptosis. (spandidos-publications.com)

RI-BPI sensitivity did not correlate with C.O.O. classification in.Cell viability was then determined using a fluorometric assay based on the resazurin reduction activity of the cells (Cell Titer Blue, Promega) and confirmed by trypan blue dye-exclusion (Sigma). (nonamimaho.com)
The combination of AHCC with PLD demonstrated a 64.1% reduction in tumor growth compared to the untreated group (p value = 0.03) and a 31.2% improvement in tumor response with combination regimen compared to PLD alone. (researchgate.net)

The cells release those granules into the tissues to destroy the "invader. (dogsnaturallymagazine.com)

Anatomy24

Organisms10

Diseases46

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes51

Disciplines and Occupations1

Information Science3

Health Care1

Pathway13

Xenograft8

Solid tumors4

Progression9

Induction9

Suppressor genes7

Overexpression5

Inhibits3

Proteins13

Reactive oxygen3

Genes6

Malignant7

Pathways8

Mice9

Cytotoxicity8

20211

Inhibit5

Cancer37

Cytotoxic3

Proliferation and apoptosis2

Terminal deoxynucleotidyl tran2

Caspase4

Cellular5

Survival5

Metastasis3

Lymphocytes1

Stromal tumors1

Induce apoptosis1

Oncogenes1

Breast tumor cells2

Antibodies4

Arrest8

Epithelial4

Angiogenesis1

Inhibitors1

Carcinoma8

Selectively1

Vivo2

Cleavage2

Lymphoma4

Viability was assessed2

Pathogenesis1

Necrosis factor4

Tissue4

Migration1

Gastrointestinal strom1

Disruption2

Receptor4

Primary tumor1

Abstract2

Microenvironment2

Neuroblastoma3

Immune5

Vitro1

Promotes1

Inflammation4

Decrease in cell viability1

Reduction2

Tissues1