Tumour antigens in malignant disease tumor antigen. Medical search. Frequent questions

A pair of studies presented at the AACR Annual Meeting 2019 demonstrated encouraging clinical outcomes with two different chimeric antigen receptor (CAR) T-cell therapies for patients with advanced solid tumors. (aacr.org)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
The basic principles of chimeric antigen receptor design. (msdmanuals.com)

Given the success of CAR T-cell therapies for blood cancers, the most anticipated next step in the field is the development of this type of immunotherapy for solid tumors. (aacr.org)
Developing CAR T-cell therapies for solid tumors, however, has been challenging, and researchers in the field have had several failed attempts. (aacr.org)
This recent review article summarizes the challenges with developing CAR T-cell therapy for solid tumors and strategies to overcome the hurdles, and lists some of the ongoing clinical trials in which CAR T cells that target tumor antigens, including GD2, CEA, and EGFR, are being currently tested against a variety of solid tumors. (aacr.org)
Data presented here at the conference have demonstrated that it is possible to develop CAR T-cell therapies for solid tumors that are not only safe but also yield clinical benefit for patients. (aacr.org)
If this approach is successful, 2 million patients with mesothelin-expressing solid tumors per year in the United States will be eligible for this treatment," said Prasad S. Adusumilli, MD , who presented the study. (aacr.org)
This article in Cancer Discovery reviews the types of solid tumors that express mesothelin, and the potential of mesothelin-directed CAR T-cell therapy to treat such malignancies. (aacr.org)
Dendritic cell-based vaccines were tested in many early phase clinical trials in patients with solid tumors, including malignant melanoma. (pbkom.eu)
Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors. (msdmanuals.com)

In this situation, residual tumor is frequently nonviable. (medscape.com)

Vac- cination with dendritic cells previously exposed to tumor antigens seems to be one of the most attrac- tive approaches of immunotherapy. (pbkom.eu)
Cancer immunotherapy is not a standard in clinical treatment of tumors, while first attempts were made several years ago. (pbkom.eu)
Use of the drug in immunotherapy of malignant tumors originated from connective, epithelial and glandular tissues mainly in combination with surgical treatments (T1-T2). (anticancer.net)
Passive cellular immunotherapy references A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)

Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)

Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
The main components of the vaccine are glycoproteins which imitate particular fragments of tumor antigens . (anticancer.net)

In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)

Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
Due to the presence of specific receptors dendritic cells (DCs) are able to respond to both intra- and extracellular antigens. (pbkom.eu)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)

Natural killer (NK) cells are cytotoxic lymphocytes which constitute a significant element of innate immune responses against tumours and cells infected with viruses or parasites. (pbkom.eu)
The drug stimulates the formation of antitumoral lymphocytes and synthesis of cytokines, which augments the specific anti-tumor responses. (anticancer.net)
Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
In general, two distinct forms are recognized-an epitheliotropic form (in which there is infiltration by malignant lymphocytes into the epidermis and adnexa) and a nodular, nonepitheliotropic form. (merckvetmanual.com)

The FR is an emerging therapeutic target for diagnosis and treatment of cancer and chronic inflammatory diseases. (wikipedia.org)
Non-mucinous ovarian cancer (the majority of ovarian cancers) was the first tumor type to be associated with FR "over-expression", and it was later shown that this antigen was identical to that found on KB tumor cells and in placental tissue. (wikipedia.org)
Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. (wjgnet.com)
In a phase I clinical trial , a team of researchers from Memorial Sloan Kettering Cancer Center tested whether mesothelin-directed CAR T cells that they developed would be safe and effective in patients with malignant pleural disease from mesothelioma and lung and breast cancer. (aacr.org)
Using an interventional radiology procedure, the investigators injected IcasM28z CAR T cells directly into the pleural cavity in 21 patients with malignant pleural disease (19 with malignant pleural mesothelioma, one with metastatic lung cancer, and one with metastatic breast cancer). (aacr.org)
Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Bcr/abl, or tumor associated antigens (TAA) in cancer cells may be used theoreticaly in cancer therapy. (pbkom.eu)
This processes change intracellular signaling roads regulating cell proliferation and/or apoptosis of cancer cells and effect the tumor growth progression. (pbkom.eu)
Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
Carcinoembryonic antigen is used to detect relapse of colorectal cancer, and CA 19-9 may be helpful in establishing the nature of pancreatic masses. (aafp.org)
Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
This article presents a study on the unique effect of qigong in helping patients survive some difficult diseases, especially a study over the anti-tumor mechanism of qigong on the basis of a selection of 104 cases of different cancer patients, e.g. esophagus cancer, stomach cancer, rectum cancer, lung cancer, adenocarcinoma of breast, etc. (qigonginstitute.org)
Concerning cancer etiology, it is widely held that the antigen structure of the tumor cells is the place where carcinogen works. (qigonginstitute.org)
The most widely recognized malignant growths in 2016 are anticipated to be bosom disease, lung and bronchus cancer growth, prostate cancer , colon and rectum cancer, bladder cancer . (cancersummit.org)
A biomarker might be a molecule secreted by a tumour or a specific response of the body to the presence of cancer. (cancersummit.org)
Recent clinical evidence suggests that high serum levels of the tumor‑produced mucin 16 (MUC16) and cancer antigen 125 (CA125) have a negative impact on the effectiveness of RTX clinical activity in up to 40% of patients with follicular lymphoma. (spandidos-publications.com)

However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
Over the last few decades, the treatment of hematological malignancies has gained tremendous headway, but these diseases still have high morbidity and mortality [ 1 - 3 ]. (hindawi.com)
With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
Monoclonal antibodies are used to detect serum antigens associated with specific malignancies. (aafp.org)

Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. (wjgnet.com)

This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
They will drop off from the cell membrane, as a kind of dissolvable antigen, to be dissolved into the serum, being of sugar protein and mucoglobulin in nature. (qigonginstitute.org)
Previous studies have established CA125 as a tumor-microenvironment factor that can be detected and found elevated (above normal 35 U/ml levels) in the serum of up to 40% of FL patients and other NHL patients. (spandidos-publications.com)
High serum level of CA125 is used as an indicator of tumor abdominal involvement, advanced staging, relapse rates and survival in NHL patients ( 8 - 12 ). (spandidos-publications.com)

Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
In the treatment of the malignant tumors it is most effective as an antimetastatic drug, when used in combination with surgical resection of a primary tumor which, depending on the stage of the cancers, results in to a complete destruction of tumor in 30-90% of cases. (anticancer.net)
however, despite its prevalence in FL and other cancers, the role of CA125 in tumor biology and immunity has been only recently elucidated. (spandidos-publications.com)

They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)

The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
Many new tumor markers have been discovered since the development of monoclonal antibodies, and most tumor markers are now detected with them. (medscape.com)
This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
These tumor markers are most useful for monitoring response to therapy and detecting early relapse. (aafp.org)
With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
This article describes the use of common tumor markers in primary care practice. (aafp.org)
Nevertheless, tumor markers can play a crucial role in detecting disease and assessing response to therapy in selected groups of patients. (aafp.org)
Each clinicopathologic subtype can be further classified with respect to morphology, immunophenotype, and antigen markers. (medscape.com)

The FR is also a recognized tumor antigen/biomarker. (wikipedia.org)

In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
Testing for the beta subunit of human chorionic gonadotropin (β-hCG) is an integral part of the diagnosis and management of gestational trophoblastic disease. (aafp.org)

In recent years there has been a shift in perception of DCs not only as inducers of immune reactivity but also as crucial regulators of immunity, which include ability to induce and maintain tolerance and also as effector cells, which are capable to kill tumor cells (NKDCs). (pbkom.eu)
In those cases when thus formed antitumor immunity could achieve a complete destruction of the tumors, relapses do not occur, due to the formation of the immunological memory. (anticancer.net)
On the other hand, human immunity against tumor is mainly performed by the cell immune function in the body. (qigonginstitute.org)

Challenges include finding the right target to direct the T cells, the ability to expand in an often-immunosuppressive tumor microenvironment, yielding an effective antitumor response, and avoiding adverse side effects. (aacr.org)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
These changes are thought to lead to tumor-microenvironment interactions via factors secreted by stromal or epithelial cells in response to lymphoma cell-produced cytokines ( 7 ). (spandidos-publications.com)

Use of the drug for the treatment of benign tumors , with general volume of 10-70 cm 3 , containing fibrotic (fibroma, fibroadenoma, fibromyoma) and glandular (adenoma, adenomatous polyps) tissues, as well as to prevent malignancy of benign tumors. (anticancer.net)
The quantity of new instances of malignancy (disease occurrence) is 454.8 per 100,000 people for each year (in light of 2008-2012 cases). (cancersummit.org)

The usefulness of a tumor marker is in its sensitivity and specificity, as well as its influence on patient management decisions. (medscape.com)
Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)
This process theoretically provides a line of T cells with greater tumor specificity than those obtained from the blood. (msdmanuals.com)
TAAs) with high specificity to tumor cells. (msdmanuals.com)

Although most patients with localized tumors can be cured with surgical therapies, 20-30 % of the patients without any evidence of metastasis will develop relapse and/or metastatic RCC in the future [ 3 ]. (biomedcentral.com)

Expression of the FR is selectively upregulated on certain malignant cells and activated macrophages. (wikipedia.org)
Overexpression of the FR on these types of cells is clinically significant because they designate areas where the physiological symptoms of disease are most extensive. (wikipedia.org)
Folate is attached to polyethylene glycol bound to the phosphate heads of membrane phospholipids, thus directing the liposomes to FRs of tumor cells, by which they are engulfed. (wikipedia.org)
The team also worked to deliver the CAR T cells directly to the tumor site using regional delivery techniques. (aacr.org)
Various biological processes including immunoreaction of infection, tumor prevention, and human aging could cause telomere damage, tumor-related stress responses, and T regulatory (Treg) cells activation, which even trigger T cell senescence showing the distinctive phenotypic and functional alternation [ 9 , 10 ]. (hindawi.com)
Dendritic cells are professional antigen-presenting cells. (pbkom.eu)
Tumor cells in transformation process accumulate products of oncogenes and/or loss the functional products of tumor suppressor genes. (pbkom.eu)
The antigens, which are imitated by the drug, are present in cells of the most common malignant (see the list here) and benign tumors containing fibrotic and glandular tissues. (anticancer.net)
The drug does not render any toxic effect in normal cells of an organism, has no mutagenic and teratogenic effect and does not contain any cells and tissues of tumors. (anticancer.net)
However, it is certain that the antigen related to tumors is composed of cells and the product of cell metabolism, the affected cell membrane contains some antigens that do not possess strictly formulated particular embryos. (qigonginstitute.org)
During the embryonic period, the genes in the chromosomes of cells are very active, producing many types of antigens. (qigonginstitute.org)
3. The anti-tumor mechanism of the human body is mainly performed by the immune function of the cells. (qigonginstitute.org)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
Lymphokine-activated killer (LAK) cells are produced from the patient's T cells which are extracted from the tumor and grown in a cell culture system with the lymphokine interleukin-2 (IL-2). (msdmanuals.com)
However, the progenitor cells consist of T cells isolated from resected tumor tissue. (msdmanuals.com)
Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)
Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)
T-cell engagers are bispecific antibodies that recruit cytotoxic T cells to kill tumor cells. (msdmanuals.com)
CD20 is a B-cell-specific antigen expressed on malignant FL cells. (spandidos-publications.com)

An understanding of the various immune components during HCC becomes necessary so that novel therapeutic strategies can be designed to combat the disease. (wjgnet.com)
As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
RESAN vaccine when used in the complex therapy of inoperable malignant tumor (T3-T4) can give a considerable therapeutic effect. (anticancer.net)

In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)

Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)

The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)

Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
Usage as antimetastatic drug in a combination with surgical resection of a primary tumor - destroys the metastases of size up to 10-50 cm 3 ( depending on the histological structure ). (anticancer.net)

The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)

The vaccine triggers mainly the cellular antitumoral immune responses which enable a complete destruction of different malignant and benign tumors. (anticancer.net)

Screening tests require high sensitivity to detect early-stage disease. (aafp.org)

Targeted drug therapy is advantageous because it deposits the drug at the specific location where it can be most useful in treating the disease. (wikipedia.org)
The appearance of tumor specific antigens (TSA) e.g. (pbkom.eu)
High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
The vaccine possesses a vast and strong antitumoral properties due to a unique combination of telomerase antigen imitators together with more than 40 other tumor specific antigen imitators in its composition. (anticancer.net)
The changes of the specific protein reported in this article indicates that the regulation of sugar protein and mucoglobulin due to the qigong therapy is beneficial to the alleviation of diseases. (qigonginstitute.org)

For recurrent, invasive tumors, more aggressive attempts at excision or electroporation may be required. (merckvetmanual.com)

Treatment for these tumors targets local control using localized techniques described above. (merckvetmanual.com)

The present study demonstrated that CA125 could bind to RTX and reduce its tumor cell killing activity. (spandidos-publications.com)

This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)

To date, no tumor marker has demonstrated a survival benefit in randomized controlled trials of screening in the general population. (aafp.org)
Nomograms were generated as prediction model for overall survival and disease free survival at 5 and 8 years after nephrectomy. (biomedcentral.com)
The present results show high expression of ST3GAL-1 is associated with reduced overall survival ( p = 0.013) and disease free survival ( p = 0.004). (biomedcentral.com)
In multivariate cox analyses, ST3GAL-1 was defined as an independent prognostic factor for overall survival ( p = 0.006) and disease free survival ( p = 0.001). (biomedcentral.com)
The nomograms revealed better predictive accuracy in predicting 5- and 8- year overall survival and disease free survival than the TNM stage alone. (biomedcentral.com)
For tumors resistant to radiation and for those animals unable to receive radiation therapy, systemic treatment with administration of chemotherapeutic agents, including melphalan, chlorambucil, cyclophosphamide, and glucocorticoids, have been recommended and have yielded long-term survival. (merckvetmanual.com)
Treatment for FL includes successive lines of therapy that unfortunately result in progressively shorter periods of disease-free survival followed by the development of either chemo-refractory disease, large cell transformation or death from treatment-related toxicities ( 2 ). (spandidos-publications.com)

Normalization of tumor marker values may indicate cure despite radiographic evidence of persistent disease. (medscape.com)
Sometimes, tumor marker values may rise after effective treatment (due to cell lysis), but the increase may not portend treatment failure. (medscape.com)
A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
Particular emphasis is given to when these tests should be ordered and to common factors that influence the interpretation of tumor marker levels. (aafp.org)
Following tumor marker response is particularly useful when other evidence of disease is not readily accessible. (aafp.org)

PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
Primary Cutaneous Neuroendocrine Tumors Ceruminous gland tumors are discussed in Tumors of the Ear Canal. (merckvetmanual.com)
Cutaneous lymphosarcoma may occur as a disease in which the skin is the initial and primary site of involvement, or it may be secondary to systemic, internal disease. (merckvetmanual.com)

In case of the inoperable malignant tumors (T3-T4) by using in a complex therapy (combine immuno-, chemo- and hormonotherapy). (anticancer.net)
The decrease of AAT and AAG indicates that the qigong therapy is very significant in the control, alleviation, improvement and rehabilitation of diseases. (qigonginstitute.org)
At the same time, it helps prove that through stimulating the human conscious initiative, the qigong therapy does adjust yin and yang, qi and blood in the body, strengthen the anti-pathogenic qi, dispel pathogenic factors, improve the patient's constitution, and bring the disease under control. (qigonginstitute.org)
When tumors are multiple or when surgical excision is not feasible, radiation therapy appears to be the best secondary treatment. (merckvetmanual.com)

Residual elevation after definitive treatment usually indicates persistent disease. (medscape.com)
The clinical and experimental studies suggest their use in tumor treatment, viral infections and autoimmunological disorders. (pbkom.eu)
Most of these tumors are locally confined, and complete but conservative surgical excision is the treatment of choice. (merckvetmanual.com)

Change in the structure of glycan chains is one of the most shared features of the malignant transformation [ 8 ]. (biomedcentral.com)

Patients diagnosed with GB have a dismal prognosis, and typically succumb to the disease within 3 months if untreated. (frontiersin.org)

This strategy includes the monoclonal anti-CD20 antibody, rituximab (RTX), alone or in combination with chemotherapy for patients who have advanced-stage disease. (spandidos-publications.com)

It may change the metabolism in the body, accelerate cell generation, activate the vital energy in the body, and obtain a cure of the disease. (qigonginstitute.org)
Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)

Anatomy21

Organisms14

Diseases49

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes41

Disciplines and Occupations1

Information Science4

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Chimeric antigen receptor3

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Residual tumor is frequently nonviable1

Immunotherapy4

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Glycoproteins3

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Cancer25

Malignancies6

Progression1

Serum4

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Immunity3

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CA1251

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Typically1

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