Tumors via transdifferentiation. Medical search. Frequent questions

Thus, the APJ system in fibroblasts in the tumor microenvironment may be a promising therapeutic target. (spandidos-publications.com)
The tumor microenvironment consists of various cell types and fibroblasts in the tumor tissue, called cancer-associated fibroblasts (CAFs), which play pivotal role in tumor progression ( 7 , 8 ). (spandidos-publications.com)
The mutational inactivation of the TP53 gene in tumor cells has been reported to affect not only tumor cells but also the surrounding cells in the tumor microenvironment and to promote tumor-stromal activation and subsequent tumor growth ( 11 , 12 ). (spandidos-publications.com)
Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)
A main challenge in this development is the concomitant targeting of alterations to PCa cells (e.g. neuroendocrine trans-differentiation) and the accumulation of myeloid-derived suppressor cells (MDSC) in the tumor microenvironment. (cityofhope.org)
While inflammatory injury drives both fibrogenesis and carcinogenesis, the tolerogenic microenvironment of the liver conveys immunosuppressive effects that encourage tumor growth. (mdpi.com)
It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. (scienceopen.com)
What are the influences of specific genomic aberrations and interactions with the tumor microenvironment? (fredhutch.org)
Consequently, tumor vasculature is inefficient in carrying blood flow, resulting in a hypoxic tumor microenvironment, although the intra-tumoral microvessel density is commonly increased in contrast to the non-cancerous counterpart tissue. (biomedcentral.com)
The tumor microenvironment is diverse and involves multiple cells, several cytokines, and the extracellular matrix (ECM). (researchsquare.com)
Carcinoma-associated fibroblasts (CAF) are the most important cells in tumor microenvironment. (researchsquare.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
A tumor cell carrying characteristic genomic alteration(s) exists within its host's microenvironment. (encyclopedia.pub)
The tempero-spatial interaction of tumor cells with its microenvironment is the deterministic factor for tumor growth, progression, resistance to therapy, and its outcome in clinics. (encyclopedia.pub)
Cancer-associated fibroblasts (CAFs) in solid tumors can be defined as a dynamically plastic host mesenchymal fibroblastic component of TME (tumor microenvironment) immediately surrounding the tumor cells. (encyclopedia.pub)

TP53 is a significant tumor suppressor gene, and its somatic mutations are one of the most frequent alterations in ~50% of all human cancers, including colorectal cancer ( 10 ). (spandidos-publications.com)
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
and (ii) therapeutic oligonucleotides, which concomitantly reduce the tumorigenic potential of PCa cells and enhance anti-tumor immunity through specific targeting of the expression of signaling regulators in tumor- and myeloid-derived suppressor cells. (cityofhope.org)
Here we found tumor suppressor RNAs tended to decay fast in normal cell types when compared with other RNAs. (bvsalud.org)
Consistent with a negative effect of m6A modification on RNA stability, we observed preferential deposition of m6A on tumor suppressor RNAs. (bvsalud.org)
Moreover, abundant m6A and fast decay of tumor suppressor RNAs both tended to be further enhanced in prostate cancer cells relative to normal prostate epithelial cells. (bvsalud.org)
Further, knockdown of m6A methyltransferase METTL3 and reader YTHDF2 in prostate cancer cells both posed stronger effect on tumor suppressor RNAs than on other RNAs. (bvsalud.org)
These results indicated a strong post transcriptional expression regulatability mediated by abundant m6A modification on tumor suppressor RNAs. (bvsalud.org)
These studies have identified subcategories of prostate cancer partitioned by tumor suppressor loss (TP53/RB1), mismatch DNA repair deficiency (MSH2/6), homology-directed repair deficiency (BRCA1/2), tandem duplications (CDK12), as well as phenotypes that include amphicrine tumors. (fredhutch.org)
2008) Tumour suppressor menin is essential for development of the pancreatic endocrine cells J Endocrinol. (who.int)
Using 6 biphasic clear cell renal cell carcinoma cases we show that sarcomatoid clear cell renal cell carcinoma shares characteristic markers associated with loss of von Hippel-Lindau tumor suppressor with conventional clear cell renal cell carcinoma and also exhibits a markedly higher proliferative index. (lu.se)

Cancer‑associated fibroblasts (CAFs) are pivotal in tumor progression. (spandidos-publications.com)
The present study aimed to elucidate the oncogenic role of the apelin‑APJ system in tumor fibroblasts. (spandidos-publications.com)
In addition, xenografts of HCT116 cells with APJ‑suppressed fibroblasts showed accelerated tumor growth. (spandidos-publications.com)
Accelerates down regulation of fibroblast genes in transdifferentiation of human fibroblasts into functional cardiomyocytes, within 9C cocktail. (rndsystems.com)
Firstly, we could confirm that transforming growth factor β1 (TGFβ1) secreted from breast tumor cells is a paracrine mediator of tumor-stroma interaction leading to the activation of autophagy in the stroma component fibroblasts. (nature.com)
Through proof of concept experiments using TGFβ1 as a model factor, we could demonstrate real time monitoring of autophagy induction in fibroblasts by single tumor cells. (nature.com)
In this study, MDA-MB-231 (MDA) triple-negative breast carcinoma cells were used as a tumor cell model and mouse fibroblasts expressing an autophagy marker protein called GFP-LC3, were used as a stroma model. (nature.com)
A recent study demonstrated the transdifferentiation of T helper type 2 cell (Th2)-like regulatory T cells (Tregs) in SSc lesional skin through interleukin (IL)-33 produced by fibroblasts. (biomedcentral.com)
Fli1 haploinsufficiency increases the proportions of Th2- and Th17-like Tregs in bleomycin-induced profibrotic skin conditions, in which IL-33-producing dermal fibroblasts contribute to Th2-like Treg transdifferentiation, suggesting a critical role of Fli1 deficiency in the interaction of dermal fibroblasts with immune cells in pathological skin fibrosis. (biomedcentral.com)
However, a recent study has demonstrated that activated fibroblasts regulate tissue-localized transdifferentiation of regulatory T cells (Tregs) into T helper type 2 cell (Th2)-like cells through IL-33 in SSc lesional skin [ 2 ], suggesting that activated dermal fibroblasts amplify an aberrant immune response characteristic of SSc. (biomedcentral.com)
Scholars@Duke publication: Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle. (duke.edu)
Here we used MYOD1 to establish its capacity to induce skeletal muscle transdifferentiation of human dermal fibroblasts under baseline conditions. (duke.edu)
Breast tumor mass is not only harboring cancer cells but also several types of stromal cells, including fibroblasts. (iyte.edu.tr)
While all of these stromal cells may have a calamitous effect on cancer progression, fibroblasts which make up nearly 80% of tumor mass present unique characteristics such as extensive extracellular matrix (ECM) production. (iyte.edu.tr)
In the context of tumors, the activated cells are referred to as cancer-associated fibroblasts (CAF), expressing several markers such as αSMA, FSP1, FAP, vimentin, and PDGFRβ. (iyte.edu.tr)
However, an in-depth understanding of the transdifferentiation of fibroblasts to CAFs is lacking. (iyte.edu.tr)
CAFs are resident fibroblasts and other mesenchymal components of the host, which are transformed/activated by the tumor cell. (encyclopedia.pub)

Such non-mutational processes are largely driven by tumor cell plasticity, which renders tumor cells insusceptible to the drug-targeted pathway, thereby facilitating the tumor cell survival and growth. (scienceopen.com)
The concept of tumor cell plasticity highlights the significance of re-activation of developmental programs that are closely correlated with epithelial-mesenchymal transition, acquisition properties of cancer stem cells, and trans-differentiation potential during drug exposure. (scienceopen.com)
This expanded knowledge of tumor cell plasticity contributes to developing novel therapeutic strategies or combination therapy regimens using available anticancer drugs, which are likely to improve patient outcomes in clinical practice. (scienceopen.com)
Tumor plasticity is an emerging property of tumor cells which allows them to change their phenotype in dependence on the e. (cn1699.cn)
Pancreatic acinar cells have the intrinsic ability and plasticity to undergo transdifferentiation to a progenitor-like cell type with ductal characteristics, a process termed as acinar-to-ductal metaplasia, occurring during pancreatitis and may represent an initial step towards pancreatic ductal adenocarcinoma (5,6). (scienza-under-18.org)
Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors. (ox.ac.uk)

Diversity index of tumor molecular heterogeneity within and between individuals. (fredhutch.org)
And understanding the importance of specific gene faults in the initiation of FLC could in the future also help to better understand tumor heterogeneity and response between patients. (sciencemission.com)

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses" presented b. (virginia.edu)
This accumulation inhibits Tcell responses and decreases anti-tumor immunity. (cityofhope.org)
Although a variety of anti-tumor agents that target angiogenesis have demonstrated transient benefits for patients, they often fail to restrict tumor growth, which underscores the need for additional therapeutic tools. (oncotarget.com)
We review (1) the characteristics of CAF, (2) their evolution from being anti-tumor to pro-tumor, (3) their involvement in regulating growth and several metastasis-associated phenotypes of tumor cells, (4) their participation in perturbing immune defense and evading immune surveillance, and (5) their role in mediating drug resistance via tumor-CAF cross-talk with particular reference to endometrial cancers. (encyclopedia.pub)

AXL significantly promotes tumour cell migration, invasion and metastasis, as well as angiogenesis. (cancerindex.org)
To evaluate the mechanisms underlying the role of AXL signalling in tumour metastasis, we screened a phage display library to generate a novel human monoclonal antibody, named DAXL-88, that recognizes both human and murine AXL. (cancerindex.org)
In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. (scienceopen.com)
Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. (biomedcentral.com)
The exploration of the underlying mechanisms of these alternative angiogenic approaches would not only widen our knowledge of tumor angiogenesis but also provide novel therapeutic targets for better controlling cancer growth and metastasis. (biomedcentral.com)

The molecular biology underlying renal cell carcinoma (RCC) development and progression has been a key milestone in the management of this type of tumor. (cancerindex.org)
Recent data have expanded the concept that inflammation is a critical component of tumour progression. (scienceopen.com)
GEMMs are particularly useful for the availability of genetically-defined tumor tissue, the ability to longitudinally investigate various stages of prostate cancer progression, and the ease of manipulating the hormone environment. (nih.gov)

A second effort addresses the genetic and epigenetic mechanisms of CRPC dedifferentiation and neuroendocrine transdifferentiation that occurs in response to androgen deprivation. (nih.gov)
Most tumors progress to castration-resistant prostate cancer (CRPC) and develop the neuroendocrine (NE) phenotype under androgen deprivation therapy (ADT). (tmu.edu.tw)
Though highly effective, AR antagonism can produce tumors that bypass a functional requirement for AR, often through neuroendocrine (NE) transdifferentiation. (nyu.edu)
Only a small percentage (1C2%) of all pancreatic cancers correspond to slower-growing pancreatic neuroendocrine tumors (PanNETs), previously known as islet cell tumors, which have a slow, indolent growth and are asymptomatic (7). (scienza-under-18.org)

Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase. (cancerindex.org)
Malignant glioblastomas (GBM) are highly malignant brain tumors that have extensive and aberrant tumor vasculature, including multiple types of vessels. (oncotarget.com)

Conversely, the formation of tumor-associated tertiary-lymphoid-like structures (TA-TLLSs), which are the local site of humoral and cellular immune responses against cancers, is associated with good prognosis, and they have recently been detected in immune checkpoint blockade (ICB)-responding patients. (utu.fi)
PanNETs, which are much less common than pancreatic exocrine tumors, have a better prognosis than PDAC, with an overall median survival from diagnosis of 4.1 years, which is considerably longer than the 6-month median for PDAC (8). (scienza-under-18.org)

Hendriks says, "When reconstructing this mutation in the organoids, we saw that it indeed is able to mirror multiple features of the tumors we see in patients with FLC. (medicalxpress.com)
Mutation of FOXL2 in granulosa-cell tumors of the ovary.N Engl J Med. (neobiotechnologies.com)
PDAC is the most lethal of all common cancers, with the highest mortality-to-incidence ratio (gene, and none of the most commonly mutated genes in PDAC [(encoding p16), and mutation is normally absent in PanNETs, which show 60% fewer genes mutated per tumor than in PADCs. (scienza-under-18.org)
Their advantage lies in the ability to perceive tumors with a low mutation load, thus establishing the first line of defense against pathogens. (explorationpub.com)

PJS is autosomal-dominant condition caused by mutations of STK11, characterized by gastrointestinal polyposis, mucocutaneous pigmentation, and predisposition to a range of epithelial cancers: including colorectal, gastric, pancreatic, breast, ovarian cancers and sex cord tumors with annular tubules). (cancerindex.org)
Kong B, Michalski CW, Kleeff J. Tumor initiating cells in pancreatic cancer: A critical view. (wjgnet.com)

Nonetheless, recent studies in other cancers partially support the CSC hypothesis by demonstrating a link between epithelial-to-mesenchymal transdifferentiation/transition (EMT) and CSC properties. (wjgnet.com)
Many cancers re-emerge after treatment, despite the sensitivity of the bulk of tumor cells to treatments. (mdpi.com)
The purpose of the review is to present a new vision and initiate a thought process which recognizes the importance of CAF in a tumor, thereby resulting in a novel approach to the design and management of the disease in endometrial cancers. (encyclopedia.pub)

This allowed the researchers to better understand the different biological consequences of different mutations found in FLC and to study the biology of the tumors. (medicalxpress.com)
Hendriks says "These findings open the possibility to look for other factors to occur together with PKA mutations in FLC tumors. (medicalxpress.com)

When the concept of tumor vasculature normalization was first introduced, it was believed that along with the pruning of the immature and undifferentiated vessels in a solid tumor, the remaining vasculature would also undergo shrinkage and be eventually unable to support tumor growth. (biomedcentral.com)

We also showed that TGFB1 polarized M2-Tumor Associated Macrophages foster immune evasion and that TGFB1 expression correlates with reduced survival probability. (nih.gov)

Due to its rarity there is not many tumor tissue available for research. (medicalxpress.com)
Epithelial mesenchymal transdifferentiation (EMT) has been shown to contribute to renal disease and tissue fibrosis and is known to be mediated by transforming growth factor-β (TGF-β). (cardiff.ac.uk)
Skeletal muscle holds significant regenerative potential but is incapable of restoring tissue loss caused by severe injury, congenital defects or tumour ablation. (duke.edu)
Vessels co-option, a procedure of hijacking the blood vessels in surrounding normal tissue along with the invasion of a solid tumor, has been recognized as an important approach to establish tumor vasculature, especially in more aggressive tumors [ 2 , 15 ]. (biomedcentral.com)

Although the inflammasomes participate in tumorigenesis, their role as an oncogenic booster or a tumor suppresser is still controversial. (thno.org)

The TME is the deterministic and dynamic context of a solid tumor [ 10 ] . (encyclopedia.pub)

In turn, tumor HEVs boost intratumoral lymphocyte influx and foster permissive lymphocyte niches for PD1 − and PD1 + TCF1 + CD8 T cell progenitors that differentiate into GrzB + PD1 + CD8 T effector cells. (utu.fi)

Our results demonstrated the existence of a complex circular ecosystem in which, within a strong asbestos-driven inflammatory environment, MPM and immune cells affect each other to support S-transdifferentiation. (nih.gov)
Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. (scienceopen.com)
By employing single-cell transcriptomics, endothelial fate mapping, and functional multiplex immune profiling, we demonstrate that antiangiogenic immune-modulating therapies evoke transdifferentiation of postcapillary venules into inflamed high-endothelial venules (HEVs) via lymphotoxin/lymphotoxin beta receptor (LT/LTβR) signaling. (utu.fi)
Tumor-HEVs require continuous CD8 and NK cell-derived signals revealing that tumor HEV maintenance is actively sculpted by the adaptive immune system through a feed-forward loop. (utu.fi)
I performed my PhD thesis under the supervision of Professor Thomas Blankenstein by investigating the antitumor immune responses in transgenic mouse models with spontaneous tumor development. (ox.ac.uk)
TME is the niche that provides metabolic support, immune surveillance, angiocrine, and inflammatory milieu to the tumor cells in a host's body. (encyclopedia.pub)

The well-known vascular endothelial growth factor (VEGF) signaling is crucial for sprouting angiogenesis as well as recruitment of circulating progenitor endothelial cells to tumor vasculature, which has become therapeutic targets in clinical practice. (biomedcentral.com)
In this article, we discuss the most recent findings and understanding on how solid tumors evade VEGF-targeted therapy, with a special focus on vessel co-option, vessel remodeling, and tumor cell-derived vasculature establishment. (biomedcentral.com)
Abnormal tumor vasculature typically lacks hierarchical structure and is composed of immature differentiated and undifferentiated vessels with increased permeability [ 1 , 2 ]. (biomedcentral.com)
In the present article, we discuss the origin of the remaining vessels after vasculature normalization treatment, as well as the alternative cellular origins of tumor vasculature, which are of great interest for improving the efficacy of antiangiogenic therapy. (biomedcentral.com)

B cell-derived tumors arose at high incidence and displayed Ig gene rearrangement with downregulated expression of B cell-associated antigens, which are features of PEL. (jci.org)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

Moreover, siRNA-mediated knockdown of KLF5 blocked the expression of CDX2, MUC2 and villin, but transfection of a KLF5 expression vector into esophageal epithelial cells promoted their transdifferentiation into columnar-like cells, as demonstrated by increased expression of the intestinal markers CDX2, MUC2 and villin. (jcancer.org)
Role of tumour necrosis factor alpha stimulated Gene-6 in the regulation of peri-cellular hyaluronan assembly in renal proximal tubular epithelial cells. (cardiff.ac.uk)
We therefore suggest that sarcomatoid clear cell renal cell carcinoma morphologically and immunohistochemically may represent a completed epithelial-mesenchymal transition and that transforming growth factor β1 could be an important driving force during the sarcomatoid transdifferentiation of clear cell renal cell carcinoma. (lu.se)

This review focuses on recent discoveries that the angiogenic factor YKL-40 (CHI3L1) acts on glioblastoma-stem like cells (GSCs) to drive the formation of two major forms of tumor vascularization: angiogenesis and vasculogenic mimicry (VM). (oncotarget.com)
Vessel co-option may occur in tumors independently of sprouting angiogenesis, and sprouting angiogenesis is not always required for tumor growth. (biomedcentral.com)

CAFs with tumor-promoting effects were usually activated and exhibited myofibroblast-like properties such as the upregulation of alpha-smooth muscle actin (α-SMA) ( 9 ). (spandidos-publications.com)
Yet, CAFs are the least characterized, the least understood, and the most underutilized component of a tumor so far to aid the management of the disease. (encyclopedia.pub)

We used this system to study how tumor cells induced autophagy in the stromal niche. (nature.com)
FOXL2 is mainly expressed in ovary, parathyroid gland and sex cord-stromal tumors. (neobiotechnologies.com)
FOXL2 is generally used for diagnosis of sex cord-stromal tumors with Inhibin, Calretinin and SF-1. (neobiotechnologies.com)
FOXL2 is generally used to diagnose sex cord-stromal tumors with inhibin, calretinin, and SF-1. (zeta-corp.com)

MYOD1, a master gene regulator, induces transdifferentiation of a variety of cell types into skeletal muscle, although inefficiently in human cells. (duke.edu)

Interestingly, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic cell markers. (jci.org)

In this study, we demonstrated that CAF EVs are involved in the EMT of SACC and promote tumor invasion. (researchsquare.com)

Glioblastoma is the most common form of primary brain tumour. (bmj.com)

Understanding the importance of specific gene faults in the initiation of FLC and the original cell could be crucial to understand how the tumor could behave later on. (medicalxpress.com)
HA assembly is influenced by its interaction with hyaladherins and this study investigated the role of tumour necrosis factor-α stimulated gene (TSG)-6, one of the hyaladherins by assessing its interaction with HA, HABP and CD44 in proximal tubular cells (PTC) EMT. (cardiff.ac.uk)

Mechanistically, manipulation of individual signalling pathways modulated the transdifferentiation process via myoblast proliferation, lowering the transdifferentiation threshold and inducing cell fusion. (duke.edu)

Granulosa cell tumor. (neobiotechnologies.com)
Formalin-fixed, paraffin-embedded human adult granulosa cell tumor stained with anti-FOXL2 antibody using peroxidase-conjugate and DAB chromogen. (zeta-corp.com)

This transformation, referred to as transdifferentiation, reduces the cancer cells' ability to form tumors and grow aggressively. (a-star.edu.sg)
This observation has led to the 'cancer stem cell' (CSCs) hypothesis, stating that a subpopulation of cancer cells survive therapy and lead to tumor relapse. (mdpi.com)
Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in adults in Europe and represents approximately 2.5% of cancer deaths. (cancerindex.org)
This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention. (scienceopen.com)
Models of aggressive CRPC in mice have provided insight into poorly differentiated tumors enriched for cancer stem/progenitor cells. (nih.gov)
A total of 9881 patients across 33 tumor types from The Cancer Genome Atlas database were included in this study. (thno.org)
Kumar A. Substantial Interindividual and Limited Intra-individual Genomic Diversity Among Tumors from Men with Metastatic Prostate Cancer. (fredhutch.org)
ZBTB46 is inversely correlated with SPDEF and is increased in higher tumor grades and small-cell NE prostate cancer (SCNC) patients, which are positively associated with PTGS1. (tmu.edu.tw)

We interrogate the functional characteristics of CAF in the light of its dialogue with tumor cells and other components of TME towards developing a CAF-based strategy for precision therapy to supplement tumor-based therapy. (encyclopedia.pub)

Retrieval of individual tumor cells from the microfluidic system and their subsequent genomic analysis was possible, allowing us to determine the nature of the factor mediating tumor-stroma interactions. (nature.com)

however, knockdown of ZBTB46 sensitizes the PTGS1 inhibitor and reduces tumor malignancy. (tmu.edu.tw)

A novel human anti-AXL monoclonal antibody attenuates tumour cell migration. (cancerindex.org)

Therefore, our microfluidic platform might be used as a promising tool for quantitative investigation of tumor-stroma interactions, especially for and high-throughput screening of paracrine factors that are secreted from heterogeneous tumor cell populations. (nature.com)

We propose that targeting YKL-40 may compliment conventional anti-angiogenic therapies to provide a substantial clinical benefit to patients with GBM and several other types of solid tumors. (oncotarget.com)

This new information is needed to understand why the tumors arise, and to identify possible targets for better treatments for the disease. (medicalxpress.com)

Mini organs and the 'molecular scissor' system CRISPR-Cas9, allowed the researchers to better understand tumor biology and biological consequences of different DNA changes. (medicalxpress.com)
The molecular basis for NE transdifferentiation after ADT remains incompletely understood. (tmu.edu.tw)
Parallel, I was working as a Clinical/Postdoctoral Fellow by Professor Frank Rosenbauer from 2014 to 2017 in the Institute of Molecular Tumor Biology, Münster. (ox.ac.uk)

Therefore, we investigated the role of Fli1 deficiency in dermal fibroblast-mediated transdifferentiation of Tregs. (biomedcentral.com)

Inflammasome inhibition reverted the therapeutic failure of ICB in inflammasome-activated tumors. (thno.org)
We found significant transdifferentiation improvement via transforming growth factor-β/activin signalling inhibition, canonical WNT signalling activation, receptor tyrosine kinase binding and collagen type I utilization. (duke.edu)
These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)

Overall, we used transdifferentiation to achieve the robust derivation of human skeletal myotubes and have described the signalling pathways and mechanisms regulating this process. (duke.edu)
Furthermore, I took part in the characterization of a mouse model with biphenotypic leukaemia and transdifferentiation mechanisms. (ox.ac.uk)

The incidence of this tumour is fairly low, with two to three cases per 100 000 people in Europe and North America. (bmj.com)

6,7-Dimethoxy-2,4-dihydroindeno[1,2- c ]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. (rndsystems.com)
This possibly explains the uncontrolled growth of cells during FLC tumor formation. (medicalxpress.com)
second, after normalization, the remaining "normalized" vessels can undergo further remodeling and become more efficient in providing blood flow to support tumor growth. (biomedcentral.com)

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