HTLV-1 is a member of the Retroviridae family, the Orthoretrovirinae subfamily and the Deltaretrovirus genus, which includes bovine leukemia virus (BLV) and T-lymphotropic viruses infecting primates (PTLV). (biomedcentral.com)
Suppressive activity2
The inhibitory effect of CKS-17 is, however, significantly blocked by a protein synthesis inhibitor cycloheximide, indicating that CKS-17 requires de novo protein synthesis to induce the suppressive activity. (duke.edu)
Among these genes we identified was BRCC3, a component of the BRCA1 complex that guards genome integrity and exerts tumor suppressive activity during cancer development. (bvsalud.org)
Squamous cell carc2
Open in a separate window Figure 1 (A) Representative images of LC3B immunohistochemical (IHC) staining (200 and 400 magnification) in tumor sites of oral squamous cell carcinoma (OSCC) tissue samples with or without areca nut usage. (cancercurehere.com)
There is heterogeneity between the behavior and response to treatment of HPV-positive oropharyngeal squamous cell carcinoma that may be linked to the tumor virome. (oncotarget.com)
Mutations4
Small-scale mutations include point mutations, deletions, and insertions, which may occur in the promoter of a gene and affect its expression, or may occur in the gene's coding sequence and alter the function or stability of its protein product. (wikipedia.org)
The main goal of the work was to analyze the characteristics of Tat protein in HIV-1 A6 variant, that is, to identify substitutions characteristic for A6 and A1 variants, as well as to compare the frequency of mutations in functionally significant domains in sub-subtype A6 and subtype B. (crie.ru)
Yet, mutations of YAP/TAZ or of their upstream regulators do not fully account for their activation in cancer, raising the possibility that other upstream regulatory pathways, still to be defined, are altered in tumors. (bvsalud.org)
This may suggest that, in tumors, inactivating mutations of BRCA1 may unleash cell transformation by activating the TAZ oncogene. (bvsalud.org)
We have previously shown that a synthetic peptide (CKS-17) homologous to retroviral envelope protein suppresses the accumulation of superantigen staphylococcal enterotoxin-induced TNF-alpha mRNA in human PBMC and in highly purified human monocytes. (duke.edu)
Taken together, these results suggest that the synthetic retroviral peptide CKS-17 down-regulates TNF-alpha mRNA expression through inhibition of transcriptional activation of the TNF-alpha gene, which requires de novo synthesis of a transcriptional repressor protein(s). (duke.edu)
Retroviral proteins, often glycosylated, coded by the envelope (env) gene. (lookformedical.com)
Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. (lookformedical.com)
Genes3
Tumor suppressor genes are genes that inhibit cell division, survival, or other properties of cancer cells. (wikipedia.org)
Tumor suppressor genes are often disabled by cancer-promoting genetic changes. (wikipedia.org)
The env genes contain a cis-acting RNA target sequence for the rev protein (= GENE PRODUCTS, REV ), termed the rev-responsive element (RRE). (lookformedical.com)
Envelope protein3
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
It serves as a precursor for both the HIV ENVELOPE PROTEIN GP120 and the HIV ENVELOPE PROTEIN GP41 . (lookformedical.com)
Transcriptional2
As a single-strand nucleic acid binding protein it functions in both transcriptional and post-transcriptional regulation, while facilitating multiple stages of RNA metabolism to affect proliferation and control cell fate. (bvsalud.org)
TAZ (WWTR1) is a transcriptional co-activator regulated by Hippo signaling, mechano-transduction, and G-protein couple receptors. (bvsalud.org)
Viruses3
Finally Oncovirinae, viruses that contain an oncogene, are categorized as oncogenic because they trigger the growth of tumorous tissues in the host. (wikipedia.org)
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. (lookformedical.com)
Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)
Stability1
Here we provide an minireview of this important regulatory protein and describe its complex subcellular functions to affect RNA metabolism, stability, miRNA biogenesis and maturation, stress granule function, metastasis, and inflammatory processes. (bvsalud.org)
Primary2
This is referred to as the primary structure of proteins. (lookformedical.com)
The virome findings of primary tumors and neck lymph nodes were correlated with clinical data to determine if specific organisms were associated with clinical outcomes. (oncotarget.com)
Expression1
B) Box plots of the expression level of LC3B in tumor site comparing cisplatin sensitive vs. cisplatin non-sensitive group of advanced OSCC patients. (cancercurehere.com)
Cancer2
K homology-type splicing regulatory protein (KSRP) is emerging as a key player in cancer biology, and immunology. (bvsalud.org)
Oncogenic KRAS-Induced Protein Signature in the Tumor Secretome Identifies Laminin-C2 and Pentraxin-3 as Useful Biomarkers for the Early Diagnosis of Pancreatic Cancer. (lsbio.com)
Human immun1
Tat protein is a major factor of HIV (human immunodeficiency virus) transcription regulation and has other activities. (crie.ru)
Target1
Nonstructural HIV proteins can become a promising target of future therapeutic agents and vaccines [ 1-3 ]. (crie.ru)
Important1
Adenosine monophosate-activated protein kinase (AMPK) plays an important 6-Thioguanine role in energy metabolism, which can also be triggered by oxidative stress [24]. (cancercurehere.com)
Viral2
The two proteins required for reverse transcription of the viral RNA, reverse transcriptase and integrase, are encoded by the pol region. (medscape.com)
Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease in virus-associated tumors. (bvsalud.org)
Oncogenes1
Transforming protein encoded by ras oncogenes. (uams.edu)
Oncovirinae1
Finally Oncovirinae, viruses that contain an oncogene, are categorized as oncogenic because they trigger the growth of tumorous tissues in the host. (wikipedia.org)
Tyrosine2
A well-known example of this is the Philadelphia chromosome, or translocation of chromosomes 9 and 22, which occurs in chronic myelogenous leukemia, and results in production of the BCR-abl fusion protein, an oncogenic tyrosine kinase. (wikipedia.org)
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors. (lookformedical.com)
Capsid1
The proteins assembling the capsid of presumably icosahedral structure are encoded by the gag region as well as the protease. (medscape.com)
Cellular2
Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. (uams.edu)
Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments. (lookformedical.com)
Genetic1
After fusion of the lipid membranes of the virus and host cell, the genetic material of the virus and the pol -encoded proteins are transferred to the cytoplasm. (medscape.com)
Encodes2
env encodes the transcription unit for the envelope protein. (medscape.com)
and env (envelope) encodes the retroviral coat protein (this consists of two subunits: a surface glycoprotein and a transmembrane protein, linked by a disulfide bridge) (Figure 1C). (medscape.com)
Sequences1
RNA sequences that serve as templates for protein synthesis. (lookformedical.com)
Cells1
They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. (reference.md)
Technique2
Here we have developed an array-based high-throughput technique that facilitates gene expression and copy number surveys of very large numbers of tumors. (nih.gov)
Our detection of six gene amplifications as well as p53 and estrogen receptor expression in breast cancer demonstrates the power of this technique for defining new subgroups of tumors. (nih.gov)
Human1
Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumors. (uams.edu)
Single1
As many as 1000 cylindrical tissue biopsies from individual tumors can be distributed in a single tumor tissue microarray. (nih.gov)
Include1
Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
Structure1
This is referred to as the primary structure of proteins . (lookformedical.com)