• Intraductal papillary neoplasms of the bile duct (IPNB) are a tumor derived from bile duct epithelium that tends to spread laterally and non-invasively. (bvsalud.org)
  • For resection specimens, new concepts are introduced such as adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) for small solitary adenocarcinomas with either pure lepidic growth (AIS) or predominant lepidic growth with ≤ 5 mm invasion (MIA) to define patients who, if they undergo complete resection, will have 100% or near 100% disease-specific survival, respectively. (qxmd.com)
  • All 8 EBV-GCLSs occurred in male patients and invaded deep submucosa (SM2) without lymph node metastasis (LNM), four (50%) of which had synchronous non-gastric malignant tumors (3 gastric gastrointestinal stromal tumors and 1 primary clear cell renal cell carcinoma), and four (50%) arose in the proximal stomach. (biomedcentral.com)
  • Adenocarcinoma is the most common histologic type of lung cancer. (qxmd.com)
  • micropapillary is added as a new histologic subtype. (qxmd.com)
  • The pathophysiology of adenocarcinoma is complicated, but generally follows a histologic progression from cells found in healthy lungs to distinctly dysmorphic, or irregular cells. (wikipedia.org)
  • Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)
  • In the present study, we aimed to analyze the clinicopathology and prognosis of EBV-GCLS and to compare them with those of invasion-depth stratified conventional early gastric carcinomas without lymphoid stroma or micropapillary components. (biomedcentral.com)
  • These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis. (nature.com)
  • Smoking is the major cause of lung adenocarcinoma but, as smoking rates decrease, proportionally more cases occur in never-smokers (defined as less than 100 cigarettes in a lifetime). (nature.com)
  • Our efforts focused on comprehensive, multiplatform analysis of lung adenocarcinoma, with attention towards pathobiology and clinically actionable events. (nature.com)
  • We analysed tumour and matched normal material from 230 previously untreated lung adenocarcinoma patients who provided informed consent ( Supplementary Table 1 ). (nature.com)
  • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. (qxmd.com)
  • To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society. (qxmd.com)
  • This new classification strategy is based on a multidisciplinary approach to diagnosis of lung adenocarcinoma that incorporates clinical, molecular, radiologic, and surgical issues, but it is primarily based on histology. (qxmd.com)
  • Lung adenocarcinoma is further classified into several subtypes and variants. (wikipedia.org)
  • The recent identification of prognostic biomarker s in lung cancer , particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. (zju.edu.cn)
  • Recent research has also revealed clinical, radiologic, and pathologic correlates, leading to greater knowledge in molecular profiling and targeted therapeutics, as well as an emphasis on the rising incidence of adenocarcinoma histology. (scienceopen.com)
  • Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. (nshealth.ca)
  • Distended duct with intact basement membrane and central tumor necrosis. (medscape.com)
  • Characterized byvtche presence of tumor necrosis, cytologic atypia and mitotic activity. (brainscape.com)
  • Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
  • However, most lung adenocarcinomas either lack an identifiable driver oncogene, or harbour mutations in KRAS and are therefore still treated with conventional chemotherapy. (nature.com)
  • Scores for tumor size, surgical margin, and pathologic classification are added to produce a total VNPI score of 3 to 9, with increasing scores representing a progressively worse prognosis. (medscape.com)
  • Tumor spread through air spaces (STAS) has been shown to adversely affect the prognosis of lung cancer. (biomedcentral.com)
  • Tumor STAS was associated with several invasive clinicopathological features. (biomedcentral.com)
  • STAS consists of micropapillary clusters, solid nests, or single cells beyond the edge of the tumor into air spaces in the surrounding lung parenchyma. (biomedcentral.com)
  • The terms BAC and mixed subtype adenocarcinoma are no longer used. (qxmd.com)
  • Treatment of this lung cancer is based upon the specific subtype and the extent of spread from the primary tumor. (wikipedia.org)
  • It was difficult to determine the extent of superficial tumor extension with modalities such as contrast-enhanced computed tomography, magnetic resonance imaging, and endoscopic ultrasonography but the detailed evaluation was possible using POCS with red dichromatic imaging 3. (bvsalud.org)
  • Once a lesion or tumor is identified with various imaging modalities, such as computed tomography (CT) or X-ray, a biopsy is required to confirm the diagnosis. (wikipedia.org)
  • Background and Aim: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer, partly because its early detection is difficult. (bvsalud.org)
  • Breast cancers usually are epithelial tumors of ductal or lobular origin. (medscape.com)
  • Protruding polypoid masses which are inflammatory in origin, soft, yields to palpation, and have a smooth, glistening surface with underlying cystically dilated spaces filled with mucinous secretion. (brainscape.com)
  • citation needed] Adenocarcinoma, like other forms of lung cancer, is usually advanced or metastatic at time of diagnosis. (wikipedia.org)
  • One patient who had 50-gene panel only also had his metastatic site (esophagus) of his tumor tested with FoundationOne. (cancerindex.org)
  • CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. (novodiax.com)
  • Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. (nature.com)
  • Supplementary Table 3 summarizes molecular estimates of tumour cellularity 16 . (nature.com)
  • This new adenocarcinoma classification is needed to provide uniform terminology and diagnostic criteria, especially for bronchioloalveolar carcinoma (BAC), the overall approach to small nonresection cancer specimens, and for multidisciplinary strategic management of tissue for molecular and immunohistochemical studies. (qxmd.com)
  • With declining smoking rates in developed countries and knowledge gains made through molecular profiling of tumors, the emergence of new risk factors and disease features will lead to changes in the landscape of lung cancer epidemiology. (scienceopen.com)
  • Adenocarcinoma of the lung is the most common type of lung cancer, and like other forms of lung cancer, it is characterized by distinct cellular and molecular features. (wikipedia.org)
  • Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonarry neuroendocrine tumors. (zju.edu.cn)
  • Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development. (nshealth.ca)
  • Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. (nshealth.ca)
  • DCIS is divided into comedo (ie, cribriform, micropapillary, solid) and noncomedo subtypes.This division provides additional prognostic information on the likelihood of progression or local recurrence (see the images below). (medscape.com)
  • The advent of low-dose helical computed tomography (CT) altered the landscape of lung-cancer screening, with studies indicating that low-dose CT detects many tumors at early stages. (scienceopen.com)
  • Less than 1% of patients with adenocarcinoma of the lung will exhibit this finding, but when it does occur, it is a poor prognostic factor. (wikipedia.org)
  • Adenocarcinoma is more common in patients with a history of cigarette smoking, and is the most common form of lung cancer in younger women and Asian populations. (wikipedia.org)
  • The exclusion criteria were as follows: (1) Patients who underwent a needle biopsy of the tumor site before surgery. (biomedcentral.com)
  • Immunologic Markers in the Differential Diagnosis of Small Round Cell Tumors from Lymphocytic Lymphoma and Leukemia. (novodiax.com)
  • It is extremely important to accurately diagnose the extent of lateral tumor extension. (bvsalud.org)
  • Parathyroid hormone-related peptide (PTHrP) is produced by tumor cells and functions similarly to parathyroid hormone (PTH). (wikipedia.org)
  • The most common paraneoplastic syndromes associated with adenocarcinoma of the lung are described below: Hypercalcemia of malignancy is more common in squamous cell carcinoma of the lung, but can occur in adenocarcinoma as well. (wikipedia.org)
  • Although peroral cholangioscopy (POCS) is a potentially useful modality for detecting tumor range with direct observation, poor image quality is a limitation of POCS. (bvsalud.org)
  • Lung cancer is the most common cause of global cancer-related mortality, leading to over a million deaths each year and adenocarcinoma is its most common histological type. (nature.com)
  • A biopsy of the main tumor in the lower common bile duct revealed IPNB. (bvsalud.org)
  • Skálová A., Leivo I., Michal M., Saksela E. Analysis of collagen isotypes in crystalloid structures of salivary gland tumors. (biopticka.cz)
  • Skálová A: Cell proliferation in salivary glands and tumors of salivary gland origin. (biopticka.cz)
  • To evaluate tumor-specific genetic changes using next-generation sequencing (NGS) panels. (cancerindex.org)
  • Adenocarcinoma of the lung is the leading cause of cancer death worldwide. (nature.com)
  • Nkx2-1: a novel tumor biomarker of lung cancer[J]. Journal of Zhejiang University Science B, 2012, 13(11): 855-866. (zju.edu.cn)