MiceGlandCarcinomasCarcinomaIncidenceGLANDSMurine mammaryTesticularHypoxiaMultiplicityBenignMetastasis in animal modelsGenesRatsSolid tumorsMacrophagesIncreased tumor growthPrimary tumorsSpontaneousProliferationCells2020InvasiveCancerBreastVitroHumansDMBAPathologicHormone-DependentGrowthAngiogenesisProgressionCancersBlood vesselLymph nodeOvarianLeukemiaCanineTumoursLesionsAnimalsVascularAnimal
Mice15
- Tumour infiltrating macrophages (TIMs) isolated from primary mammary carcinomas of C3H/Avy mice were cultured on bone slices to assess their ability to resorb bone. (ox.ac.uk)
- Experimental studies had indicated that 1,3-butadiene induced a carcinogenic response in rats and mice at multiple sites. (cdc.gov)
- We report the first obser- vation of PrPres in spontaneous lymphoreticular tumors of Lymphoreticular mice with vCJD. (cdc.gov)
- Experimental studies in mice were approved by the Creutzfeldt-Jakob institutional animal care and use committee of the American Red Cross Holland Laboratory. (cdc.gov)
- We report protease-resistant prion protein (PrPres) in ic saline, while 4 control animals received physiologic spontaneous lymphoreticular tumors of mice infected with saline only. (cdc.gov)
- ble tumors developed in the neck areas of 5 mice, 4 with PrPres may accumulate in lymphoreticular system tumors of vCJD and 1 control. (cdc.gov)
- estimates of vCJD prevalence might be increased by The remaining mice in the vCJD group, including 2 other expanding screening to include samples of lymphoreticular neoplasms. (cdc.gov)
- In 4 mice with tumors, PrPres agent ( 5 ). (cdc.gov)
- In mice, bromochloroacetic acid caused a significantly increased incidence of hepatocellular adenoma (a rare, benign liver tumor) and hepatocellular carcinoma (liver cancer) in males and females, and of hepatoblastoma (uncommon malignant liver cancer) in males. (epicwaterfilters.com)
- Early animal experiments involving mice did demonstrate mammary tumors and urogenital changes in males which were found in initial testing prior to NutraSweet approval. (aspartaam.nl)
- The aim of this study was to analyze the effect of indole-3-carbinol on a SCID mice xenograft model of canine inflammatory mammary cancer, using equivalent human oral dose as a preventive therapy in humans for 3 weeks. (biomedcentral.com)
- Indeed, in colons of mice carrying mutations in Apc (ApcMin/+) or exposed to the carcinogen azoxymethane, elimination of GCC increased tumor initiation by corrupting genomic integrity in the context of disabled compensatory apoptosis. (jefferson.edu)
- Several methods exist for generating metastasis models in mice canonical to human cancer: tumor transplantation, genetic modification, and the amplification of specific promoters. (openwetware.org)
- This method also allows for the development of multiple different models depending on the desired tissue of study, with one additional example being that "C3(1)-SV40 T-antigen transgenic mice develop invasive mammary carcinomas," making the technique malleable to a variety of purposes. (openwetware.org)
- The aim of this work was to determine the kinetics of porphyrin generation in tissues after topical application of ALA delivered in different vehicles on the skin overlying the tumour and normal skin of mice. (uba.ar)
Gland24
- Tumors or cancer of the MAMMARY GLAND in animals ( MAMMARY GLANDS, ANIMAL ). (nih.gov)
- It also increased the multiplicity of fibroadenomas of the mammary gland in females. (epicwaterfilters.com)
- Sorenmo KU, Worley DR, Zappulli V. Tumors of the Mammary Gland. (scielo.br)
- Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%-60% of these neoplasms. (bvsalud.org)
- CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximately 3%-6% of all salivary gland tumors. (bvsalud.org)
- OBJECTIVE: Salivary gland tumors (SGT) are a diverse group of uncommon neoplasms that are rare in pediatric patients. (bvsalud.org)
- Advances in the understanding of may be more susceptible at a par- sembled for IARC Group 1 carcino- host susceptibility in tandem with the ticular site (i.e. the mammary gland gens contains information on mecha- evolution of the knowledge on the in females). (who.int)
- DMBA-induced mammary tumors was achived using DMBA dissolved in 1ml of vehicle (0.5 ml of DMSO plus 0.5 ml of saline) and injected by subcutaneous injection beneath the mammary gland on either side. (ivsajournals.com)
- Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
- Some common salivary gland neoplasms are listed in the image below. (medscape.com)
- Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
- [ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 1.5 cases per 100,000 individuals in the United States. (medscape.com)
- An estimated 700 deaths (0.4 per 100,000 for males and 0.2 per 100,000 for females) related to salivary gland tumors occur annually. (medscape.com)
- Salivary gland neoplasms most commonly appear in the sixth decade of life. (medscape.com)
- Among salivary gland neoplasms, 80% arise in the parotid glands, 10-15% arise in the submandibular glands, and the remainder arise in the sublingual and minor salivary glands. (medscape.com)
- That is, as the size of the gland decreases, the incidence of malignancy of a tumor in the gland increases in approximately these proportions. (medscape.com)
- The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the image below. (medscape.com)
- Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
- Salivary gland neoplasms are rare in children. (medscape.com)
- In children, 35% of salivary gland neoplasms are malignant. (medscape.com)
- Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
- The etiology of salivary gland neoplasms is not fully understood. (medscape.com)
- In the multicellular theory, each tumor type is associated with a specific differentiated cell of origin within the salivary gland unit. (medscape.com)
- Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)
Carcinomas5
- Labeling indices for Ki67 and proliferating cell nuclear antigen marker in mammary carcinomas of the treated group were 35% and 30% lower, respectively, than those of the corresponding control group. (nih.gov)
- These results indicate that the root extract reduced the number of mammary carcinomas that developed and reduced the rate of cell division in the carcinomas. (nih.gov)
- The Wistar Kyoto (WKy) rat is resistant to mammary carcinomas induced with 7,12-dimethybenz[a]anthracene (DMBA), whereas the Wistar Furth (WF) strain is susceptible. (mcw.edu)
- We also investigated allelic imbalance (AI) in mammary carcinomas from (WKy x WF)F1 rats and Mcs7 heterozygous congenics. (mcw.edu)
- Objective: To analyze differences in the presentation of clinicopathological variables according to GRB7 protein expression in HER2-positive tumors in Colombian patients with invasive ductal breast carcinomas diagnosed between 2013 and 2015 at the Instituto Nacional de Cancerología (Bogotá, Colombia).Methods: A total of 158 breast cancer patients were included with a confirmed diagnosis of invasive ductal carcinoma. (bvsalud.org)
Carcinoma6
- Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-a and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models. (uams.edu)
- Jin L, Sturgis EM , Zhang Y, Huang Z, Song X, Li C, Wei Q, Li G . Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. (viictr.org)
- O carcinoma de células escamosas foi o segundo tumor mais frequente (15% de todos os tumores). (scielo.br)
- With the exception of the situations described below, the margins of the resected specimen must be histologically free of invasive tumor and/or a component of ductal carcinoma in situ (DCIS) as determined by the local pathologist. (who.int)
- Este tumor se originó espontáneamente como carcinoma del pulmón en un ratón C57BL. (bvsalud.org)
- This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. (bvsalud.org)
Incidence3
- It is also the tumor with the highest incidence among Brazilian women in all regions (excluding non-melanoma skin cancers). (bvsalud.org)
- The microbiome may lack statistical power to detect common, tumour site concordances can also play a critical part in host an increase in tumour incidence at among the species studied. (who.int)
- Results- The overall tumor analysis showed that 6 treatment significantly inhibited the breast tumor incidence, tumor multiplicity, and tumor size in the DMBA-initiated rat model. (ivsajournals.com)
GLANDS3
- During the sixth week of development, the mammary glands first develop as solid downgrowths of the epidermis that extend into the mesenchyme from the axilla to the inguinal regions. (medscape.com)
- Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
- Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
Murine mammary2
- Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion. (rochester.edu)
- Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model. (ox.ac.uk)
Testicular2
- All but one of the testicular tumors occurred in the rats from a single supplier. (wikipedia.org)
- NutraSweet has already been shown to induce mammary tumors and testicular changes in experimental animals. (aspartaam.nl)
Hypoxia7
- Scholars@Duke publication: Optical imaging of tumor hypoxia dynamics. (duke.edu)
- The influence of the tumor microenvironment and hypoxia plays a significant role in determining cancer progression, treatment response, and treatment resistance. (duke.edu)
- Finally, a green-fluorescence-protein reporter for hypoxia inducible factor-1 (HIF-1) provides an endpoint for hypoxic stress in the tumor, which is used to demonstrate a significant association between tumor hypoxia dynamics and HIF-1 activity in an in vivo demonstration of the technique. (duke.edu)
- Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia. (uams.edu)
- The microenvironment within tumors differs from that of healthy tissues, especially oxygen delivery is poor leading to hypoxia. (lu.se)
- Intra tumor hypoxia leads to poor response to several cancer therapies including anti-estrogens, chemo and radiation. (lu.se)
- In parallel we investigate how the presence of intra-tumor hypoxia correlates to patient outcome. (lu.se)
Multiplicity1
- Tumor multiplicity was significantly higher ( approximately 50%) in DMBA-treated congenics homozygous and heterozygous for the WKy allele at the Mcs7 locus, compared to controls. (mcw.edu)
Benign4
- Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. (lookformedical.com)
- CONCLUSIONS: Benign SGT in pediatric patients are more commonly benign than malignant tumors. (bvsalud.org)
- Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
- Most tumors (65%) are benign, with hemangiomas being the most common, followed by pleomorphic adenomas. (medscape.com)
Metastasis in animal models1
- Although studying tumor metastasis in animal models is a viable option, we argue that moving away from this approach to an in vitro model would prove even more effective. (openwetware.org)
Genes3
- Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. (rochester.edu)
- The service boasts of "more than 100 GFP/RFP expressing tumor models" in which "all types of agents, small molecules, proteins, genes, can be evaluated" [2 ]. (openwetware.org)
- Through the use of a Mouse Mammary Tumor Virus (MMTV), two genes have been identified as primary targets for generating malignant tumors. (openwetware.org)
Rats4
- The reproductive function of rats was studied at the Institute for Experimental Biology at the University of California, Berkeley by Herbert McLean Evans and Joseph A. Long. (wikipedia.org)
- There were even significant variations in the incidences of adrenal medulla tumors among rats from the same source raised in different laboratories. (wikipedia.org)
- The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. (mcw.edu)
- Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. (uams.edu)
Solid tumors2
- Slices with solid tumors are cut somewhat thinner since they won't flatten as much when laid down. (patholines.org)
- We use multi-omic approaches to uncover the genetic landscapes of solid tumors, predominantly glandular tumors. (gu.se)
Macrophages3
- Tumour infiltrating macrophages are capable of bone resorption. (ox.ac.uk)
- Furthermore, imaging of intact lungs revealed that macrophages are required for efficient tumor cell extravasation. (ox.ac.uk)
- CONCLUSION/SIGNIFICANCE: These data indicate a direct enhancement of metastatic growth by macrophages through their effects on tumor cell extravasation, survival and subsequent growth and identifies these cells as a new therapeutic target for treatment of metastatic disease. (ox.ac.uk)
Increased tumor growth1
- Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
Primary tumors2
- Cancer-related pain is defined as chronic pain caused by primary tumors or metastases (chronic cancer pain) or by their treatment (chronic post-cancer treatment pain)(15). (bvsalud.org)
- BACKGROUND: The stromal microenvironment and particularly the macrophage component of primary tumors influence their malignant potential. (ox.ac.uk)
Spontaneous3
- VEGF-DT385 toxin conjugate inhibits mammary adenocarcinoma development in a transgenic mouse model of spontaneous tumorigenesis. (uams.edu)
- Tumours of the large intestine, mesotheliomas and hepatoblastomas are rare spontaneous neoplasms in experimental animals. (epicwaterfilters.com)
- There are no data on the effect of I3C in human inflammatory breast cancer (IBC) or in spontaneous and experimental canine inflammatory mammary cancer (IMC). (biomedcentral.com)
Proliferation7
- STX1040 inhibited E1-stimulated proliferation of T47D cells in vitro and significantly decreased tumor volumes and plasma E2 levels in vivo. (ox.ac.uk)
- Indole-3-carbinol treatment decreased tumor proliferation and increased apoptosis, although tumor embolization and liver metastasis were observed in some animals. (biomedcentral.com)
- Our data reveal for the first time that the ingestion of indole-3-carbinol, as administered, diminishes proliferation and increases apoptosis of tumor cells in an experimental model of inflammatory breast cancer, although this effect could not be enough to avoid the appearance of tumor embolization and metastasis. (biomedcentral.com)
- This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
- Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. (lookformedical.com)
- Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. (novusbio.com)
- Soon after birth, the nipples are raised from the shallow mammary pits by proliferation of the surrounding connective tissue. (medscape.com)
Cells13
- Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells. (uams.edu)
- In a tumour setting, NK T cells activated by alpha-galactosylceramide (alpha-GalCer) execute anti-tumour activity by secreting cytokines. (ox.ac.uk)
- There was a characteristic subpopulation of lipid-rich cells and increased contents of select steroid hormones in tumor homogenates and serum. (biomedcentral.com)
- The percentage of VEGF-positive tumor cells was scored at 0 to 4 levels (0: less than de 5% of labeled cells to 4: more than 75% of labeled cells). (vin.com)
- Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution. (lu.se)
- An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
- We tested possible down-modulating effects of these monoclonal antibodies on SKBR-3 mammary tumor cells, which express high levels of wild-type human neu protein. (prinsesmaximacentrum.nl)
- Once in the bloodstream, these cells are classified as circulating tumor cells. (openwetware.org)
- Under certain conditions, these circulating cells can extravasate from the blood vessel into a new environment and begin forming a secondary tumor. (openwetware.org)
- More specifically, cancer cells metastasize by degrading local extracellular matrix (ECM) proteins, which allows them to break away from the primary tumor and breach the ECM. (openwetware.org)
- tumor by immunohistochemistry, as assessed locally on a primary disease specimen and defined as ï?³ 1% of tumor cells stained positive according to the ASCO/College of American Pathologists (CAP) guidelines (Allison et al. (who.int)
- Normal and overlying tumour skin tissues showed different kinetic patterns, reflecting histological changes when the latter is invaded by tumour cells. (uba.ar)
- This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)
20201
- In 2020, approximately 2.3 million new cases were estimated, which corresponds to 11.7% of the total number of diagnosed neoplasms(1). (bvsalud.org)
Invasive2
- However, these biomarkers can only be evaluated after the surgical removal of the tumor, and thus are invasive, cumbersome, and undergo prolonged processing. (scielo.br)
- Participants with bilateral synchronous invasive breast cancer are eligible if all histopathologically examined tumors meet pathologic criteria for ER positivity and HER2 negativity. (who.int)
Cancer16
- That the tumor microenvironment is highly heterogeneous with significant intratumor and intertumor variability presents a significant challenge in developing effective cancer therapies. (duke.edu)
- Both E2 production and tumor growth were inhibited by STX1040, suggesting that 17beta-HSD1 inhibitors such as STX1040 may provide a novel treatment for hormone-dependent breast cancer. (ox.ac.uk)
- Practice Guidelines for BRCA1/2 Tumour Testing in Ovarian Cancer. (mun.ca)
- There are no previous studies on its effects in human inflammatory breast cancer or canine inflammatory mammary cancer that is the most aggressive type of breast cancer. (biomedcentral.com)
- The aim of this study was to analyze the hypothetical antitumor effect of I3C administration on a SCID mouse xenograft model of canine inflammatory mammary cancer using an equivalent dose to that used as a preventive anti-cancer agent in humans. (biomedcentral.com)
- The identification of putative prognostic factors in canine mammary neoplasms (CMNs) has been focused on tissue-specific biomarkers, but the serum biomarkers, including cancer antigen 15-3 (CA 15-3), c-reactive protein (CRP), and lactate dehydrogenase (LDH) have been demonstrated to display clinical application in cases of CMNs. (scielo.br)
- Di Gioia D, Blankenburg I, Nagel D, Heinemann V, Stieber P. Tumor markers in the early detection of tumor recurrence in breast cancer patients: CA 125, CYFRA 21-1, HER2 shed antigen, LDH and CRP in combination with CEA and CA 15-3. (scielo.br)
- Shao Y, Sun X, He Y, Liu C, Liu H. Elevated levels of serum tumor markers CEA and CA15-3 are prognostic parameters for different molecular subtypes of breast cancer. (scielo.br)
- Nowadays, the most common neoplasm in the world is breast cancer. (bvsalud.org)
- Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
- An evolving paradigm expanding the genetic basis of cancer suggests that developmental programs indelibly imprint restricted repertoires of homeostasis, forming the substrate for lineage-dependent tumor induction by deregulation of tissue-specific survival pathways. (jefferson.edu)
- Tumors or cancer of the human BREAST. (lookformedical.com)
- Breast cancer was the most common primary tumor location in females, while lung origin was most common in males. (bvsalud.org)
- Like in other tumors including breast cancer, ECM changes play an important role in the PA-CXPA sequence. (bvsalud.org)
- Conclusion and Clinical Relevance-The findings of the present study showed that the 6 treatment was significantly effective in reduction of tumors versus the cancer controls. (ivsajournals.com)
- Participants who have multicentric (the presence of two of more tumor foci within different quadrants of the same breast) and/or multifocal (the presence of two or more tumor foci within a single quadrant of the breast) breast cancer are also eligible if all examined tumors meet pathologic criteria for ER positivity and HER2 negativity â? (who.int)
Breast2
- Here we demonstrate that it is 17beta-HSD1 which is important for E2 production and report the inhibition of E1-stimulated breast tumor growth by STX1040, a non-oestrogenic selective inhibitor of 17beta-HSD1, using a novel murine model. (ox.ac.uk)
- Participants must have undergone definitive surgery of the primary breast tumor(s). (who.int)
Vitro1
- Novel research is being conducted with the goal of developing a quality in-vitro device capable of modelling tumor metastasis in a simulated microenvironment, with focus specifically on the phenomena of tropism, cancer's predisposition to colonize particular tissue. (openwetware.org)
Humans1
- Based upon the weight of evidence of carcinogenicity in experimental animals, dichloromethane is classified as "probably carcinogenic to humans", i.e., as a substance for which there is believed to be some chance of adverse health effect at any level of exposure. (canada.ca)
DMBA3
- Tumor yield and size were stabilized after 90 days with the initiation of DMBA. (ivsajournals.com)
- In group DMBA, the tumor was induced by DMBA. (ivsajournals.com)
- In group DMBA/7d the animals with tumor received 100 µL 6 dissolved in DMSO (0.25 µM) solution intraperitoneally for one week. (ivsajournals.com)
Pathologic1
- If pathologic examination demonstrates tumor at the line of resection, additional excisions may be performed to obtain clear margins. (who.int)
Hormone-Dependent2
- Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. (lookformedical.com)
- A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. (lookformedical.com)
Growth1
- The statistical power of anized on day 199 because of rapid tumor growth (Table). (cdc.gov)
Angiogenesis1
- 2005). Angiogenesis is an integral component of the viability of all tumor types, reflecting the inviolable demand of a growing tumor for sufficient levels of nutrients and oxygen exchange (Korkolopoulou et al . (vin.com)
Progression1
- Although the pathogenesis of the PA-CXPA transition remains unclear, CXPA development requires the participation of cellular components and the tumor microenvironment for its progression. (bvsalud.org)
Cancers1
- This finding has been confirmed numerous times and the DNA-protein-cross-links are believed to cause cancers in experimental animals. (aspartaam.nl)
Blood vessel1
- This occurs when a primary malignant neoplasm invades a local blood vessel and gets carried by convection to a different location in the body (Figure 1). (openwetware.org)
Lymph node1
- 2005). Lymphangiogenesis is also important for tumors expansion, especially the for lymph node metastasis (Kadowaki et al . (vin.com)
Ovarian1
- Remove the ovary and ovarian tumor intact. (medscape.com)
Leukemia1
Canine2
Tumours2
- There are several stage, lifestyle, sex, and the impact late-developing tumours, or studies other tumour sites with fewer, or less of co-exposures. (who.int)
- There are various limitations in susceptibility, how host susceptibility ies may focus only on specific tumour epidemiological studies (e.g. statis- factors may modulate the impact of outcomes or may not be designed to tical power, exposure assessment, mechanistic events leading to tumour detect some types of tumours). (who.int)
Lesions1
- Ongoing - Erivwo P , Salama S, Gai L. Mrkonjic M. Armstrong S. Turashvili G. Point-Based Weighted Diagnostic Scale for Histopathologic Assessment of Mammary Cellular Fibroepithelial Lesions. (mun.ca)
Animals4
- Variant Creutzfeldt-Jakob disease (vCJD) is thought to In the control group, the animal with tumors was euth- be caused by exposure to bovine products contami- anized on day 321, and the 3 other animals without tumors nated with the bovine spongiform encephalopathy agent. (cdc.gov)
- 1984. Experimental atrazine toxicity: Relation between morphofunctional indexes and the presence of residues in the parenchymal tissue of treated animals. (cdc.gov)
- Local effects in the upper respiratory tract were induced after repeated inhalation exposure in experimental animals. (europa.eu)
- The overall NOAEC for local effects in experimental animals is 1 ppm (1.2 mg/m³). (europa.eu)
Vascular1
- Microbeam radiation therapy alters vascular architecture and tumor oxygenation and is enhanced by a galectin-1 targeted anti-angiogenic peptide. (uams.edu)
Animal2
- Because animal models are complex, it can be difficult to develop experimental procedures that isolate variables of interest. (openwetware.org)
- lymphoid tissue, and digestive tract), which the animal model captures the It can be difficult to parse out concordance has often been ob- range of potential human response reasons for lack of tumour site con- served among different species after to the particular agent tested. (who.int)