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  • growth
  • Given the growth-inhibiting effects of cannabinoids on gliomas and the wide tissue distribution of the two subtypes of cannabinoid receptors (CB1 and CB2), we studied the potential utility of these compounds in anti-skin tumor therapy. (420magazine.com)
  • This was accompanied by impairment of tumor vascularization, as determined by altered blood vessel morphology and decreased expression of proangiogenic factors (VEGF, placental growth factor, and angiopoietin 2). (420magazine.com)
  • These tumors are believed to arise mainly from stem cells of hair follicles (3), and their growth and development seems to rely on an early burst of neovascularization (4) in which VEGF (5-7) and EGF-R (8, 9) are essential components. (420magazine.com)
  • The epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR-2), as potent targets for cancer therapy, have been proved to be crucial in signal transduction pathways involved in tumor cell proliferation, differentiation, migration and angiogenesis [ 1 , 2 , 3 , 4 ]. (mdpi.com)
  • However other studies find that stem cells actually promote tumor growth by inducing infiltration of new blood vessels. (medindia.net)
  • For both the subcutaneous and lung tumors, injection of MSC reduced cell division, consequently slowing the rate of tumor growth. (medindia.net)
  • Commenting on this study Celia Gomes, from the University of Coimbra, said, "One of the interesting questions this study raises is when MSC promote tumor growth and when they restrict it. (medindia.net)
  • The answer seems to be timing - this study looks at already established tumors, while others, which find that MSC increase growth, tend to be investigating new tumors. (medindia.net)
  • Furthermore, we demonstrated in a mouse xenograft model that both curcumin and AKBA treatments suppressed tumor growth, which corresponded with alterations in the expression of miR-34a and miR-27a, consistent with our in vitro findings. (aacrjournals.org)
  • In vitro , RAD001 inhibited the proliferation of VEGF-stimulated and fibroblast growth factor-stimulated human endothelial cells but not dermal fibroblasts and impaired VEGF release from both sensitive and insensitive tumor cells but did not inhibit migration of human endothelial cells. (aacrjournals.org)
  • The main objective of this article was to present the modification of the CAM assay in order to evaluate tumor growth from two feline fibrosarcoma cell lines (FFS1, FFS3) and describe their morphological and histopathological features. (biomedcentral.com)
  • Targeting oncogenic BRAF with PLX4720 or PLX4032 resulted in inhibition of growth and invasion of three-dimensional melanoma spheroids into a collagen matrix and caused tumor regression of melanoma xenografts without evidence of toxicity [ 6 , 7 ]. (mdpi.com)
  • cell lines
  • Both tumor cell lines were stably transfected with constructs that allow expression of green fluorescent protein (GFP), which serves as a tumor-specific marker. (frontiersin.org)
  • We found that the expression of MALAT1 was elevated in human MCL tumors and cell lines as compared to normal controls, and the elevated levels of MALAT1 correlated with higher MCL international prognostic index (MIPI) and reduced overall survival. (biomedcentral.com)
  • vasculature
  • Claire Rome who led this study explained, "We found that MSC altered vasculature inside the tumor - although new blood vessels were generated, overall they were longer and fewer than in untreated tumors. (medindia.net)
  • RAD001 did not affect blood vessel leakiness in normal vasculature acutely exposed to VEGF nor did it affect tumor vascular permeability ( K trans ) as measured by dynamic contrast-enhanced magnetic resonance imaging. (aacrjournals.org)
  • invasion
  • Matrix metalloproteinases (MMPs) have been implicated in tumour invasion as well as various normal processes of tissue remodelling, such as embryonic development, wound healing, trophoblast implantation, and organ morphogenesis. (bmj.com)
  • 4 5 MMPs are often active during tumour invasion, resulting in an excessive proteolytic degradation of the extracellular matrix. (bmj.com)
  • prostate
  • Here, we assessed the role of MCs in prostate tumor development. (aacrjournals.org)
  • Such a dual source of MMP-9 was confirmed in human tumors, suggesting that MCs could be a good target for early-stage prostate cancer. (aacrjournals.org)
  • The same heterogeneous histologic features of human prostate cancer can be found in tumors from mouse counterparts, such as the transgenic adenocarcinoma of the mouse prostate (TRAMP), in which SV40 large T antigen oncogene expression, driven by the rat probasin promoter, induces prostate transformation ( 4, 5 ). (aacrjournals.org)
  • several studies on human prostate tumor samples have tried to address this issue ( 9-13 ), but no conclusive data exist about the actual role of MCs in promoting or suppressing cancer at this site. (aacrjournals.org)
  • biology
  • VEGFR and mTOR inhibitors show similar but also distinct effects on tumor vascular biology, which has implications for their clinical activity alone or in combination. (aacrjournals.org)
  • responses
  • The etiopathogenesis is unclear, however, inflammatory responses within the injections site (especially vaccines against rabies and feline leukemia virus - FeLV) may play a role in malignant transformation of the connective tissues cells resulting in sarcoma. (biomedcentral.com)
  • primary
  • This tumor arises from the developing neural crest cells, which possess self-renewal and multipotency characteristics (Huang and Weiss, 2013), and aberrations in normal developmental processes are most likely its primary cause (Takahashi et al. (deepdyve.com)
  • evaluate
  • The results obtained indicate that PCNA may be helpful to evaluate the tumor grade, better than Ki-67, for feline fibrosarcomas. (biomedcentral.com)
  • role
  • The interaction of cancer cells with the tumor microenvironment plays a major role in the function and regulation of cancer cells and is therefore a critical determinant of the response of cancer cells to therapeutic agents [ 9 , 10 ]. (mdpi.com)
  • model
  • At present, the transplanted liver cancer model is commonly used in the laboratory, and the transplanted model can be divided into In situ tumor and Ectopic tumor according to the location of the transplanted tumor. (cloud-clone.us)
  • In addition, Boswellia sacra essential oil Fraction IV exhibited anti-proliferative and pro-apoptotic activities against pancreatic tumors in the heterotopic xenograft mouse model. (biomedcentral.com)
  • important
  • The establishment of tumor animal models is an important method to study the pathogenesis of tumor and to carry out tumor treatment. (cloud-clone.us)
  • Depends on what you are injecting, needles are most important for sq injections, 25 or 27 gauge are the best and then you have Insulin syringes, 1, 3 or 5 cc syringes, and the prepackaged syringes for blood-thinners such as Lovenox (enoxaparin) or arixtra, to name a few. (healthtap.com)
  • treatment
  • Different therapeutic strategies for the treatment of these tumors are currently being investigated. (420magazine.com)
  • These results support a new therapeutic approach for the treatment of skin tumors. (420magazine.com)
  • Different types of strategies are currently being investigated as therapies for the treatment of these tumors, including cryotherapy, topical chemotherapeutic agents such as 5-fluorouracil, and photodynamics, the success of which is hampered by limitations such as the poor penetration of molecules into the skin and the difficulty to gain access to the whole tumor (10-12). (420magazine.com)
  • high
  • The expression of PHF20 in NB was significantly associated with high aggressiveness of the tumor and poor outcomes for NB patients. (deepdyve.com)
  • Alcohol (high content) injected into tumors can cause cancer cell death. (healthtap.com)
  • Potency of essential oil-suppressed tumor cell viability may be associated with the greater abundance of high molecular weight compounds in Fractions III and IV. (biomedcentral.com)
  • single
  • Prostatic carcinoma is often a multifocal disease, in which multiple histologic patterns, reflective of the varied differentiated aptitude of the neoplastic clone, may coexist within a single tumor ( 2 ). (aacrjournals.org)
  • No tumour was induced in rats following either a single intrapleural administration or four intraperitoneal injections of talc, or following administration of talc in the diet. (inchem.org)
  • Although
  • Although chemical component(s) responsible for tumor cell cytotoxicity remains undefined, crude essential oil prepared from hydrodistillation of Boswellia sacra gum resins might be a useful alternative therapeutic agent for treating patients with pancreatic adenocarcinoma, an aggressive cancer with poor prognosis. (biomedcentral.com)