Tumors epithelial cells. Medical search. Frequent questions

Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an important step in the progression of primary tumors toward metastasis. (jci.org)
We also determined that the percentage of human lung tumor tissues positive for Brachyury expression increased with the stage of the tumor, indicating a potential association between Brachyury and tumor progression. (jci.org)
The selective expression of Brachyury in tumor cells and its role in EMT and cancer progression suggest that Brachyury may be an attractive target for antitumor therapies. (jci.org)
These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
Our data proved that the high concentration of IL15 in tumor microenvironment , which was mainly secreted by GCMSCs, may contribute to tumor cell metastasis and offer a new opportunity to develop effective therapeutics for intercepting tumor progression. (bvsalud.org)
In a number of human malignancies, tumor-associated macrophages (TAMs) are closely involved in tumor progression. (biomedcentral.com)
Macrophages that infiltrate tumor tissues are referred to as tumor-associated macrophages (TAMs) and are closely involved in tumor progression by inducing angiogenesis, immunosuppression, and invasion [ 1 ]. (biomedcentral.com)
The current results indicated that B[a]P seems to induce EMT in lung cancer cells, and it also may drive disease progression in patients with lung cancer. (nih.gov)
Given that ROS accumulation and necrotic cell death enhance inflammation followed by compensatory proliferation of tumor cells, selective suppression of caspase-dependent ROS accumulation will be an alternative strategy to protect cells from ROS-dependent DNA damage and compensatory tumor progression. (nature.com)
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. (nature.com)
For SCLC patients, the risk factors affecting the prognosis of patients with progression-free survival include newly diagnosed TC, TG levels, and tumor stage. (hindawi.com)
The remaining urine will be stored to evaluate biomarkers for the detection of tumor presence or progression using protein-based analyses. (centerwatch.com)
Cancer stem-like cells (CSCs) are associated with cancer progression, metastasis, and recurrence, and may also represent a subset of circulating tumor cells (CTCs). (biorxiv.org)
Further, in cell lines, CD117 activation by SCF promotes faster proliferation and invasiveness, while blocking CD117 activation with tyrosine kinase inhibitors (TKIs) decreased progression in a context-dependent manner. (biorxiv.org)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)

Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
Approximately 90% of malignant tumors arising in the bladder are of epithelial origin, the majority being transitional cell carcinomas. (centerwatch.com)
The incidence of malignant pheochromocytoma was noted as 1 malignant tumor in control animals and 2 malignant tumors in 1100 mg/m3 male rats. (europa.eu)

Furthermore, we found Brachyury to be overexpressed in various human tumor tissues and tumor cell lines compared with normal tissues. (jci.org)
Brachyury expression in human lung tumor tissues. (jci.org)
SCCs arise from epithelial tissues that can be classified as stratified squamous epithelium (which includes epithelia of skin, oesophagus and oral cavity) and non-squamous epithelia (which include airway epithelium). (hospiceofqueenannes.com)
On the other hand, dendritic cells (DCs) that infiltrate tumor tissues are involved in tumor suppression. (biomedcentral.com)
We examined 69 samples of surgically resected thymic epithelial tumors, namely, 16 thymic carcinomas and 53 thymomas, in which we immunohistochemically evaluated the presence of TAMs using CD68 and CD163 as markers and DCs using S100 as the marker in tumor tissue samples in comparison with normal thymic tissues. (biomedcentral.com)
Here, we immunohistochemically examined tumor tissue samples to characterize TAMs and DCs in thymoma and thymic carcinoma by comparing them with those in normal thymic tissues. (biomedcentral.com)
In this work, pathways governing mucus cell differentiation were investigated in lung tissues from patients with IPF and other chronic pulmonary disorders. (bmj.com)
They are detectable in tissues and blood, including plasma and/or serum, are stable and often tumor specific. (spandidos-publications.com)
The recurrent tumor was about a third of the size of the original, and involved only soft tissues. (medpagetoday.com)
Dendritic cells and macrophages found in large quantities at the corticomedullary junction arise from mesodermal tissues (bone marrow). (medscape.com)
The epithelial cells and these other stromal tissues of the thymus influence the selection and maturation of the T lymphocytes. (medscape.com)
Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. (medlineplus.gov)
Tissues and Cells. (lu.se)
The microenvironment within tumors differs from that of healthy tissues, especially oxygen delivery is poor leading to hypoxia. (lu.se)

While metastases re-epithelialize over time, we found that early metastases are remarkably mesenchymal, discarding the requirement for a mesenchymal-to-epithelial transition for early stages of metastatic growth. (whiterose.ac.uk)
Metastatic tumors involving colon are rare, accounting for only 0.338% of all colorectal malignancies in a large multi-institutional study, when lymphoproliferative diseases, direct invasion, and mesenteric and peritoneal spreading are excluded [ 1 ]. (hindawi.com)
Here, we report a case of ACC metastatic to the colon 19 years after resection of the primary tumor, to broaden the differential diagnosis of colorectal malignancies and to better understand the clinical, histological, and molecular features of ACC. (hindawi.com)
Immunohistochemically, the tumor demonstrated epithelial-myoepithelial dual lineage differentiation, which confirmed the diagnosis of metastatic ACC. (hindawi.com)
Clinically, superficial bladder tumors (stages Ta, Tis and T1) account for 75-80% of bladder neoplasms, while the remaining 15-20% are invasive (T2, T3, T4) or metastatic lesions at the time of presentation. (centerwatch.com)
At 5-year follow-up, she was alive, without recurrent or metastatic tumor. (medscape.com)
No metastatic tumor was noted in axillary lymph node. (medscape.com)
These are widely suspected to be incipient metastatic tumors, as well as triggers for the blood clots that often kill advanced cancer patients. (scripps.edu)
Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)

Carcinomas, malignancies of epithelial tissue, account for 80 to 90 percent of all cancer cases. (hospiceofqueenannes.com)
About 2 out of 10 skin cancers are squamous cell carcinomas (also called squamous cell cancers). (hospiceofqueenannes.com)
Like other types of cancer, carcinomas are abnormal cells that divide without control . (hospiceofqueenannes.com)
Most (95% to 98%) of squamous cell carcinomas can be cured if they are treated early. (hospiceofqueenannes.com)
In the stromal cells a decline in Androgen Receptor expression was also noted but this decline was more pronounced and statistically significant correlation of Androgen Receptor expression was noted between well differentiated carcinomas and moderately and poorly differentiated prostatic carcinomas. (journalcra.com)
subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)
Squamous cell carcinomas, adenocarcinomas, and small cell carcinomas of the urinary bladder are rare and account for less than 5, 2, and 0.5% of all bladder carcinomas, respectively. (cytojournal.com)
There are three types of ovarian cancers: epithelial ovarian carcinomas, germ cell tumors, and stromal cell tumors. (medlineplus.gov)
Renal cell carcinomas (RCCs) are derived from the epithelial cells of the nephron. (lu.se)

Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. (whiterose.ac.uk)
Disappearance of Cav1 enables cells to undergo epithelial-mesenchymal transition (EMT). (cipsm.de)
The effects of IL15 secreted by GCMSCs on GC development were evaluated by detecting the stemness, epithelial-mesenchymal transition (EMT), and migration abilities of GC cell lines . (bvsalud.org)
In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)

A germ is had by them cell cluster that's encircled with a somatic epithelium called the follicle cells. (brain-tumor-cancer-information.com)
Ovarian germ cell tumors (OGCTs) are heterogeneous tumors that are derived from the primitive germ cells of the embryonic gonad, which accounts for about 2.6% of all ovarian malignancies. (wikipedia.org)
Dygerminomas are Malignant germ cell tumor of ovary and particularly prominent in patients diagnosed with gonadal dysgenesis. (wikipedia.org)
OGCT is caused mainly due to the formation of malignant cancer cells in the primordial germ cells of the ovary. (wikipedia.org)
Teratoma are most common germ cell tumor of ovary. (wikipedia.org)
Germ cell tumors- start in the ovarian cells that form eggs. (mountsinai.org)
Germ cell tumors tend to occur in young women or are in their reproductive years. (mountsinai.org)
Diagnosed at an early stage, germ cell tumors are curable. (mountsinai.org)
This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)
Some other rarer types of ovarian cancer are malignant germ cell tumors and stromal tumors. (medlineplus.gov)
Ninety percent of patients with germ cell tumors survive five years after diagnosis. (medlineplus.gov)

Targeting α5β1 integrins might not only prevent metastasis of HNSCC but also delay the development of the primary tumor by reducing tumor cell viability. (cipsm.de)
Several studies show that mesenchymal stem cells (MSCs) homing to tumors not only provide the microenvironment for tumor cells but also promote tumor growth and metastasis . (bvsalud.org)
Based on molecular studies, some mucinous borderline tumors of the ovary may actually represent metastasis from the appendix. (medscape.com)
Adenoid cystic carcinoma (ACC) is a tumor characterized by slow growth and late distant metastasis. (hindawi.com)
Colonic metastasis of such a tumor is rare, with few case reports available. (hindawi.com)
BC is a highly heterogeneous disease that has been classified according to a variety of characteristics, such as histology, anatomical features (Tumor-Node-Metastasis staging system) ( 4 ), tumor grade and molecular traits. (spandidos-publications.com)
Then, can it repress the cancer cells' metastasis potential? (scielo.br)
Thus, we conclude that As2O3 can reduce metastasis potential of NPC cells, involving inhibition of MMP-9 expression. (scielo.br)
Combined, these data indicate that CD117 expression potentially promotes tumor initiation and metastasis. (biorxiv.org)

Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)

In 1929, Taylor first described a subset of epithelial ovarian tumors that he termed semimalignant. (medscape.com)
Borderline tumors, as with other ovarian tumors, are difficult to detect clinically until they are advanced in size or stage. (medscape.com)
If benign lesions are included, epithelial tumors account for 60% of all ovarian tumors. (medscape.com)
In the United States, borderline tumors make up approximately 15% of all epithelial ovarian tumors. (medscape.com)
Comprehensive staging of borderline ovarian tumors is of significant prognostic value and is performed surgically. (medscape.com)
Guillaume and Pirrello reported that 75% of patients with borderline ovarian tumors are at an early FIGO stage at the time of diagnosis. (medscape.com)
Borderline ovarian tumors are staged according to the FIGO classification of ovarian cancer. (medscape.com)
Borderline ovarian tumors represent 10-20% of epithelial ovarian neoplasm's [ 5 ] with an incidence of 1.8-4.8 out of 100.000 women per year [ 6 ] and typically have an excellent prognosis. (intechopen.com)

D: Microscopy showing mononuclear intermediate trophoblastic cells, increased mitotic activity, and destructive invasion of the left ovary, 2020. (wjgnet.com)
It begins in the cells that cover the ovary. (medlineplus.gov)
About 85% to 90% of these cancers start in the cells that cover the outer surface of the ovary. (medlineplus.gov)

Using xenograft limiting dilution assays and serial tumor initiation assays, we show that CD117+ cells represent a CSC population. (biorxiv.org)

Epithelial cell tumors- the most common type of ovarian cancer tumor. (mountsinai.org)

Real-time PCR was performed for Brachyury on lung tumor tissue cDNA from 80 lung cancer patients of the indicated stages of disease. (jci.org)
Epithelial tissue is found throughout the body. (hospiceofqueenannes.com)
Does squamous cell carcinoma affect epithelial tissue? (hospiceofqueenannes.com)
Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. (hospiceofqueenannes.com)
It begins in the epithelial tissue of the skin, or in the tissue that lines internal organs, such as the liver or kidneys. (hospiceofqueenannes.com)
T47-D cell lysate, colon cancer lysate, Human breast carcinoma tissue, Human normal breast tissue. (abcam.com)
Mammary fibroadenoma: A fibrous, benign, epithelial tumor in which cells are derived from glandular tissue. (ratguide.com)
Tumors can arise anywhere that mammary tissue type is present but is most often seen at the pit of the arm, abdomen, and groin of female rats. (ratguide.com)
An evolving paradigm expanding the genetic basis of cancer suggests that developmental programs indelibly imprint restricted repertoires of homeostasis, forming the substrate for lineage-dependent tumor induction by deregulation of tissue-specific survival pathways. (jefferson.edu)
Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
A ) Tumor growth significantly increased in ETP + -tumor tissue allograft into WT mice. (jci.org)
Inhibition of this enzyme reduces cancer risk and it is highly elevated in tumour tissue. (lu.se)

16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
Shimizu T, Shimizu S: Azithromycin inhibits mucus hypersecretion from airway epithelial cells. (karger.com)
Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)
Conclusion Expression of SOX2 and MUC5B and lack of SPDEF in atypically differentiated cells of bronchiolised distal airspaces are consistent with abnormal programming of airway epithelial cells in IPF. (bmj.com)

Cell viability was estimated by cell counting kit-8 and cell apoptosis by flow cytometry. (karger.com)
In LPS-induced ARDS cell model, astragaloside IV up-regulated cell viability, SOD activity and ZO-1 and LC3B I expressions but down-regulated cell apoptosis, TNF-α, IL-6, LC3B II, Beclin-1 and atg5 expressions and LDH and MDA levels. (karger.com)
Astragaloside IV might suppress autophagy initiation directly or indirectly through suppressing the oxidative stress and inflammatory response, which further enhances the cell viability and tight junction and reduces apoptosis in LPS-stimulated pulmonary endothelial ARDS cell model, thus exerting its therapeutic function in ARDS. (karger.com)
thus, those cells that fail to receive a signal (ie, do not recognize self) die by apoptosis or become inactive. (medscape.com)
Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients. (mpg.de)
Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
Indeed, in colons of mice carrying mutations in Apc (ApcMin/+) or exposed to the carcinogen azoxymethane, elimination of GCC increased tumor initiation by corrupting genomic integrity in the context of disabled compensatory apoptosis. (jefferson.edu)
Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
GSK2606414 treatment inhibited RPE cell proliferation in a dose‑dependent manner, however it did not induce apoptosis. (spandidos-publications.com)
Disruption of PERK activity has been demonstrated to reduce hydroquinone-induced apoptosis and hypoxia-induced VEGF expression in human RPE cells in vitro ( 5 , 21 ). (spandidos-publications.com)
Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)

These cancers start in the flat cells in the upper (outer) part of the epidermis. (hospiceofqueenannes.com)
Larger squamous cell cancers are harder to treat, and fast-growing cancers have a higher risk of coming back. (hospiceofqueenannes.com)
In rare cases, squamous cell cancers can spread to lymph nodes or distant parts of the body. (hospiceofqueenannes.com)
Approximately 90% of these cancers are tumors of epithelial origin. (medscape.com)
Than histological score was correlated with tumor grade using the Gleason scoring system were the cancers were divided into well differentiated prostatic carcinoma (G1) (Gleason score 2-6), moderately differentiated carcinoma (G2) (Gleason score 7) and poorly differentiated carcinoma (G3) (Gleason score 8-10). (journalcra.com)
Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along with fallopian tube and peritoneal cancers because of shared clinical features. (merckmanuals.com)
Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
Serum amylase and/or lipase levels are elevated in less than half of patients with resectable pancreatic cancers and are elevated in only one quarter of patients with unresectable tumors. (medscape.com)
Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
General references Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)

Overexpression of Brachyury in human carcinoma cells induced changes characteristic of EMT, including upregulation of mesenchymal markers, downregulation of epithelial markers, and an increase in cell migration and invasion. (jci.org)
Conversely, inhibition of Brachyury resulted in downregulation of mesenchymal markers and loss of cell migration and invasion and diminished the ability of human tumor cells to form lung metastases in a xenograft model. (jci.org)
Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
3) Tumour invasion and dissemination. (qub.ac.uk)
Then the survival cells were collected to investigate their potential of colony formation, attachment, invasion, and migration. (scielo.br)
Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution. (lu.se)
Evidence suggests that the protein plays a role in tumor invasion. (bvsalud.org)

Distant metastases arise in 20-30% of patients with squamous cell carcinoma of the head and neck (HNSCC) in the 2 years following treatment. (cipsm.de)
Is squamous cell carcinoma an epithelial tumor? (hospiceofqueenannes.com)
Is carcinoma an epithelial cancer? (hospiceofqueenannes.com)
Carcinoma refers to a malignant neoplasm of epithelial origin or cancer of the internal or external lining of the body. (hospiceofqueenannes.com)
Squamous cell carcinoma. (hospiceofqueenannes.com)
Is squamous cell carcinoma a Tumour? (hospiceofqueenannes.com)
What is epithelial carcinoma? (hospiceofqueenannes.com)
Is squamous cell carcinoma simple or stratified? (hospiceofqueenannes.com)
What is Stage 2 squamous cell carcinoma? (hospiceofqueenannes.com)
Do you need chemo for squamous cell carcinoma? (hospiceofqueenannes.com)
How long can you live with squamous cell carcinoma? (hospiceofqueenannes.com)
Once squamous cell carcinoma has spread beyond the skin, though, less than half of people live five years , even with aggressive treatment. (hospiceofqueenannes.com)
Thymic epithelial tumors are rare mediastinal tumors and can be classified into thymoma and thymic carcinoma. (biomedcentral.com)
As opposed to its true malignant counterpart, epithelial ovarian carcinoma, borderline ovarian cancer is often found at an early stage. (medscape.com)
Cells from the bronchioloalveolar carcinoma cell line A549 were exposed to benzo(a)pyrene (B[a]P) for 24 weeks, and morphology, proliferative activity, and gene expression profiles were analyzed. (nih.gov)
Conclusion: Androgen Receptor expression in stromal cells of prostatic carcinoma shows more pronounced decrease as the tumor dedifferentiates compared to Androgen Receptor expression in epithelial cells of prostatic carcinoma. (journalcra.com)
Foamy gland carcinoma of the prostate features cells with abundant finely vacuolated cytoplasm and pyknotic hyperchromatic nuclei. (medscape.com)
According to the pathological type, it can be divided into non-small-cell lung carcinoma and small-cell lung carcinoma (SCLC) [ 2 ]. (hindawi.com)
When lung carcinoma occurs, the proliferation of tumor cells is abnormally active, and the tumor cells continue to proliferate, and in this process, more energy and cell membrane synthesis are required. (hindawi.com)
The tie-in between the level and the prognosis is to determine whether the blood lipid level during the initial treatment of small cell lung carcinoma affects the prognosis and to provide a theoretical basis for the clinical treatment of SCLC patients. (hindawi.com)
Between the period of 1983 and 2009, there were a total of 25 cases of small cell carcinoma, 20 of squamous carcinoma, and 10 of adenocarcinoma, wherein prediagnosis urine cytology was available. (cytojournal.com)
There were eight cases (12 samples) of small cell carcinoma, four cases (6 samples) of squamous cell carcinoma and four cases (5 samples) of adenocarcinoma. (cytojournal.com)
Of the nine samples of small cell carcinoma, categorized as atypical, suspicious for carcinoma, three (33%) were categorized as suspicious for small cell carcinoma, while the others were not further classified, due to limitations of cellular preservation. (cytojournal.com)
In the squamous cell carcinoma subgroup, the samples with 'atypical, suspicious for carcinoma' diagnoses did not show any keratinization and were interpreted as atypical urothelial cells. (cytojournal.com)
None of the samples of small cell carcinoma had a false negative diagnosis on cytology, while only one case of squamous cell carcinoma was diagnosed as negative. (cytojournal.com)
Erk2 but not Erk1 regulates crosstalk between Met and EGFR in squamous cell carcinoma cell lines. (mpg.de)

This case raises our awareness of such tumors as a differential diagnosis of colorectal cancer. (hindawi.com)
Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
A serious concern for IBD patients is the increased risk of developing colorectal cancer and since there seems to be a general connection between inflammation and cancer we hypothesised that LTD4 induced signalling events could be involved in increasing the tumourgenic potential of cells. (lu.se)

In our group we are integrating bioinformatic data from renal malignancies with data describing the more than 20 normal cell types of the normal kidney, to better describe and understand the key perturbations leading to the different subtypes of RCC. (lu.se)

This biopsy is usually performed as part of a surgery to remove the tumor. (mountsinai.org)
A biopsy is done during surgery to remove the tumor. (medlineplus.gov)

He was tumor free until 9 years ago when multiple small nodules in the right lung were identified. (hindawi.com)
Activation of abnormal respiratory epithelial differentiation programs may contribute to the expression of MUC5B and bronchiolisation of the distal lung, a salient feature of IPF. (bmj.com)
Overall, the results presented here indicate that SWCNT or MWCNT induce cytotoxicity in human lung epithelial cells in a time and dose-dependent manner. (cdc.gov)
In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)
Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)

In this study, we examined samples from 69 patients diagnosed and treated for primary thymic epithelial tumors at Showa University Northern Yokohama Hospital, Showa University Hospital, and Showa University Fujigaoka Hospital from August 2003 to June 2014. (biomedcentral.com)
Patients with SCLC are included in the case set, who are initially treated in the tumor center of our hospital from January 2020 to January 2021 and are confirmed by histopathology or cytology as the research subjects. (hindawi.com)
NRG1α was detected in serous cells within normal submucosal glands and in epithelial cells lining honeycombing areas in IPF, and was not detected in other patients. (bmj.com)
Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
Neuregulin1α, which drives mucus cell differentiation in vitro, was expressed in normal airway submucosal glands and in lungs from patients with IPF. (bmj.com)
Over 70% of patients affected with superficial tumors will have one or more recurrences after initial treatment, and about one-third of those patients will progress and eventually succumb to their disease. (centerwatch.com)
We propose to assess the use of a multiple mutation-based assay, using DNA from exfoliated cells in the urine of patients, to establish the sensitivity and specificity in tumor detection compared to cystoscopy and cytology. (centerwatch.com)
All patients harboring tumors and scheduled to have a cystectomy, cystoscopy,or nephroureterectomy will be eligible for this study. (centerwatch.com)
as many as two thirds of patients have a palpable breast tumor. (medscape.com)
Scientists from The Scripps Research Institute, Scripps Health, and collaborating cancer physicians have successfully demonstrated the effectiveness of an advanced blood test for detecting and analyzing circulating tumor cells (CTCs)-breakaway cells from patients' solid tumors-from cancer patients. (scripps.edu)
In the third study, the team used HD-CTC to compare circulating tumor cells from prostate cancer patients with cells from prostate cancer cell lines that researchers often use as convenient models for prostate cancer biology in the lab. (scripps.edu)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)
Even tumor markers can be elevated in patients with chronic pancreatitis. (medscape.com)
in these patients with low or absent titer of CA 19-9, monitoring disease with this tumor marker will not be possible. (medscape.com)
Fewer than 4% of patients with a CA 19-9 level of more than 300 U/mL have been found to have resectable tumors. (medscape.com)

Here we show that expression of the EMT master inducer Snail in primary adult Drosophila intestinal tumors leads to the dissemination of tumor cells and formation of macrometastases. (whiterose.ac.uk)

IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. (nih.gov)

However, there have been very few reports on the distribution profiles of TAMs and DCs in thymic epithelial tumors. (biomedcentral.com)
Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)

Choline kinase (ChoK) is increased in human mammary tumors with high incidence, and this activation is associated with clinical variable indicators of greater malignancy. (aacrjournals.org)
Although mammary tumors can occur at a younger age, they have a higher occurrence after 18 months of age. (ratguide.com)
The development and growth of mammary tumors are primarily dependent on estrogen and prolactin (hormones controlled by the pituitary gland and the hypothalamus) receptor concentrations. (ratguide.com)
Although most mammary tumors in rats are benign, if not treated will continue to grow becoming quite large measuring from several millimeters to several centimeters and encompassing up to half the body weight of the rat. (ratguide.com)

Snail drives an EMT in tumor cells, which, although retaining some epithelial markers, subsequently break through the basal lamina of the midgut, undergo a collective migration and seed polyclonal metastases. (whiterose.ac.uk)
Each AdnaTest has a unique combination of tumor associated markers and an optimized combination of antibodies for cell selection. (qiagen.com)
The combination of highly specific immunomagnetic cell selection system (using the optimized antibody combination, see "A CTC captured by three antibodies coupled to magnetic beads ") and highly sensitive RT-PCR technology (using a combination of mRNA tumor markers) provides the highest degrees of analytical specificity and sensitivity. (qiagen.com)
Evaluation usually includes ultrasonography, CT or MRI, and measurement of tumor markers (eg, cancer antigen 125). (merckmanuals.com)

Reverse transcription results in cDNA, which is subsequently used as template for preamplification and tumor cell detection and characterization by qRT-PCR. (qiagen.com)
However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)

In Sweden, the incidence of borderline tumors may be increasing, according to a study. (medscape.com)

[ 4 ] This is especially the case when they occur in seemingly infiltrating nests, cords, or single cells on small biopsy specimens. (medscape.com)
We do this by examining you, understanding your symptoms, and analyzing the cells of your tumor through a biopsy to determine if it is cancerous (malignant) or noncancerous (benign). (mountsinai.org)

Here, we report a case of ACC arising from minor salivary gland that metastasized to the colon 19 years after the primary tumor resection, with literature review of the clinical, histological, and molecular features of ACC. (hindawi.com)
Early stage bladder tumors have been classified into two groups with distinct behaviors and different molecular profiles: Low-grade tumors (always papillary and usually superficial), and high-grade tumors (either papillary or non-papillary and often invasive). (centerwatch.com)

The role of urinary cytology in the preoperative diagnosis of the above-mentioned tumors has rarely been reported. (cytojournal.com)
Although the sample size is small, this study highlights the relevance of urine cytology in the preoperative diagnosis of these rare non-urothelial tumors of the bladder. (cytojournal.com)
Morphological analysis identified odontogenic epithelial islands without dentin or enamel formation, suggesting a diagnosis of primary malignant ameloblastoma. (medpagetoday.com)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)

We found that IL15 derived from GCMSCs enhanced stemness, induced EMT and promoted migration of GC cell lines . (bvsalud.org)
Throughout their migration (arrow), the follicular epithelial cells crawl along the cellar membrane, which continues to be fixed. (brain-tumor-cancer-information.com)
Axelrod and Matis, 2013), whereas the cell migration equipment reaches the basal surface AR-C69931 tyrosianse inhibitor area. (brain-tumor-cancer-information.com)
The egg chamber offers a effective model to research the mechanisms managing epithelial AR-C69931 tyrosianse inhibitor migration (Statistics 1CC1G). (brain-tumor-cancer-information.com)
We demonstrate that CD117+ cells display increased proliferation and migration. (biorxiv.org)
Chemotaxis was set up by following cell migration from DMEM/serum-free to DMEM/2% FBS/PBS or DMEM/2% FBS/ETP protein (1 μg/well). (jci.org)

Development of the prostate gland as well as development of prostatic cancer is closely associated with stromal-epithelial interactions and in the centre of these interactions stands the Androgen Receptor in both stromal and epithelial cells. (journalcra.com)
Other patterns include arrangement of the histiocytes in cords or single cells that percolate between benign prostatic glands. (medscape.com)
If prostate biopsies are performed following hormonal therapy for prostatic adenocarcinoma, the appearance of residual tumor cells can mimic xanthoma cells. (medscape.com)
Tumor cells usually retain prostatic epithelial antigenicity, and immunohistochemical stains can be used for their identification. (medscape.com)
The model will be useful for understanding the mechanisms by which the prostatic stem cell niche controls the tumorigeneis of prostatic cancer stem cells. (jcancer.org)

Female mice displayed increases in liver and uterus tumors however, because the highest neoplasm incidence increase occurred in 25 ppm females, there was not a significant response in the 100 ppm group, and there were no supporting increases in neoplasm multiplicity, it was unclear if the increased neoplasm incidences in females were related to decalin. (europa.eu)
It is well known that caloric intake affects tumor incidence in rats. (ratguide.com)
Rats fed ad libitum (free-fed) have lower survival and a higher incidence of pancreatic, mammary, and pituitary tumors than rats fed a moderate dietary restriction of identical diets (Boorman & Everitt, 2006). (ratguide.com)
In addition to increasing tumor incidence, high caloric intake decreases latency and enhances tumor growth (Keenan et al, 1995). (ratguide.com)

The uniformly positioned cells are separated through the fibrous strands and lymphocytic infiltration is commonly observed. (wikipedia.org)

This type develops in cells in the deepest layer of the epithelium, called basal cells. (hospiceofqueenannes.com)
These specific localizations make it improbable that known PCP systems organize specific cell migratory behaviors on the basal surface area. (brain-tumor-cancer-information.com)
The basal epithelial surface area contacts a cellar membrane ECM that ensheaths the egg chamber. (brain-tumor-cancer-information.com)
Coexisting foamy and nonfoamy adenocarcinoma with glandular differentiation devoid of basal cell lining is helpful in clarifying their malignant nature. (medscape.com)
[ 7 ] Knowledge of preceding treatment and the finding of other therapy-related changes, such as glandular atrophy, as well as basal cell hyperplasia, should alert to this differential. (medscape.com)
Se localiza en la membrana basal de la lámina lúcida y funciona uniendo las células epiteliales a las membranas basales. (bvsalud.org)
All these events could be reversed by the addition of LTD4, which even could increase cell survival above basal level. (lu.se)

Not only are there epidemiological differences in BC, there are also differences in tumor biology that affect the prognosis and response to treatment. (spandidos-publications.com)

The concentrations of these hormones are found to be higher in hormone dependent tumors, whereas in hormone independent tumors (as seen in latter stages of mammary adenocarcinoma) they tend to be lower. (ratguide.com)

The rate of occurrence of these tumors is highest in the developed countries, ranking as the sixth most frequent neoplasm. (centerwatch.com)

AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
Moreover, IL15 upregulated Tregs ratio through activation of STAT5 in CD4+ T cells was accompanied by elevated expression of programmed cell death protein -1 (PD-1). (bvsalud.org)
Although no apparent morphologic changes were observed, the B[a]P-exposed A549 cells exhibited enhanced proliferative activity in 1% bovine serum that contained medium, and dramatic changes in expression levels were observed in a large number of genes. (nih.gov)
Studies have been conducted to evaluate androgen receptor expression in cancer cells and most of the studies have concentrated on cancer epithelial cells and not cancer stromal cells. (journalcra.com)
Results: In the epithelial cells Androgen Receptor expression declined as Gleason grade increased but this correlation was statistically not significant. (journalcra.com)
The expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, zonula occludens (ZO)-1, Beclin-1 and autophagy-related (atg) 5 mRNA was evaluated by quantitative PCR, and the expression of ZO-1, microtubule-associated proteins 1A/1B light chain 3B (LC3B) I and, LC3B II protein by Western blot. (karger.com)
LPS effectively inhibited cell viability and LC3B I expression and enhanced LC3B II, Beclin-1 and atg5 expressions in MLE-12 cells. (karger.com)
3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect. (karger.com)
Astragaloside IV suppressed cell viability and ZO-1 expression after the Rap treatment. (karger.com)
The expression patterns of stem cell-specific genes of these DU145 cells were examined. (jcancer.org)
The purified DU145 cells isolated from the tumors with DU145 and stromal cells in PZ had increased ability to migrate and proliferate, and had increased expression of C-Kit. (jcancer.org)
in contrast, the stromal cells in the TZ inhibit it through down-regulating the expression of C-Kit. (jcancer.org)
To determine how CD117 expression and activation by its ligand stem cell factor (SCF, kit ligand, steel factor) alter prostate cancer aggressiveness, we used LNCaP-C4-2 and PC3-mm human prostate cancer cells, which contain a CD117+ subpopulation. (biorxiv.org)
In both 2D and 3D cultures, stemness marker gene expression is higher in CD117+ cells. (biorxiv.org)
For 12 enrichments of tumor cells from whole blood and subsequent detection of prostate cancer-associated gene expression including AR-V7 expression. (qiagen.com)
This allows sensitive analysis of prostate cancer-associated gene expression including AR-V7 detection in immunomagnetically enriched tumor cells by reverse transcription and PCR. (qiagen.com)
In that context, differentiated enterocytes in villi exhibit higher guanylin expression and ligand-dependent cGMP accumulation compared to proliferating progenitor cells in crypts. (jefferson.edu)
In addition, GSK2606414 treatment inhibited eIF2α phosphorylation and reduced CHOP and VEGF mRNA expression levels in RPE cells under TG‑induced ER stress. (spandidos-publications.com)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
We treated non-transformed intestinal epithelial cells with LTD4 and found that this led to increased expression of COX-2. (lu.se)

Serous tumors are presumed to originate from the germinal epithelium. (medscape.com)
In our work we are interested in deciphering the functional consequences of this response in relation to the cell from which these tumors originate. (lu.se)

A promising approach is measuring the presence of biomarkers to detect tumors at various stages and determine their specific characteristics, thus allowing for more personalized treatment. (spandidos-publications.com)

The authors sought to identify mechanisms driving the differentiation of mucus cells during the bronchiolisation process. (bmj.com)
Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. (bmj.com)

The most common mammary tumor found in rats is the mammary fibroadenoma, a benign encapsulated tumor. (ratguide.com)
In addition, benign tumors (fibroadenomas) exhibit growth primarily due to increased influence of circulating prolactin. (ratguide.com)

Breast cancer is still one of the most important tumors among women in industrialized countries. (aacrjournals.org)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases. (mpg.de)
HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells. (lu.se)
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. (lu.se)

SCLC is a neuroendocrine tumor derived from bronchial mucosal epithelial argentophilic cells. (hindawi.com)
Comparison of carbon nanotube -induced cytotoxicity in A549 and normal human bronchial epithelial (NHBE) cells. (cdc.gov)
Pulmonary bronchial epithelial cells are a potential target for toxicity during respiratory exposure. (cdc.gov)

The primary tumor was 4 cm in size, with multiple positive margins and lingual nerve involvement. (hindawi.com)

Overexpression of Csk-binding protein contributes to renal cell carcinogenesis. (mpg.de)
Although the precise underlying mechanisms of AMD are not fully understood, numerous lines of evidence have indicated that endoplasmic reticulum (ER) stress contributes to the etiology of RPE cell damage and neovascularization formation ( 5 - 7 ). (spandidos-publications.com)

Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)

We found that human intestinal epithelial cells (IECs) triggered IgA(2) class switching in B cells, including IgA(1)-expressing B cells arriving from mucosal follicles, through a CD4(+) T cell-independent pathway involving a proliferation-inducing ligand (APRIL). (nih.gov)

Sex cord-stromal cell tumors- begin in the connective cells that hold the ovaries in place and produce female hormones. (mountsinai.org)
Sex cord-stromal cell tumors tend to occur in women past menopause. (mountsinai.org)

The 2 major histologic tumor subtypes are serous and mucinous, with serous being more common. (medscape.com)
Histologically, most of them are serous or mucinous, but endometrioid, clear cell, Brenner (transitional cell) or mixed histotypes can be also seen. (intechopen.com)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along. (merckmanuals.com)

ECM gel can used with epithelial cells, endothelial cells, muscle cells, nerve cells and tumor cells. (sigmaaldrich.com)
ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)

Mucinous tumors do not have a clearly defined origin. (medscape.com)
Micrograph of a mucinous ovarian tumor. (medlineplus.gov)

The luminal epithelial cells were positive for cytokeratin AE1/AE3, C-kit, and CEA, while the abluminal myoepithelial cells were positive for P63 and SMA (Figure 3 ). (hindawi.com)

We used whole-transcriptome shotgun sequencing (RNA-seq) to compare the S. pneumoniae transcriptome in biofilms, bacteria dispersed from biofilms after exposure to IAV, febrile-range temperature, or ATP, and planktonic cells grown at 37°C. Compared with biofilm bacteria, actively dispersed S. pneumoniae, which were more virulent in invasive disease, upregulated genes involved in carbohydrate metabolism. (lu.se)
The AdnaPanel PrimerMixes allow amplification of four tumor associated antigens and two control genes. (qiagen.com)
The AdnaTest ProstateCancerPanel AR-V7 could demonstrate in this performance evaluation a specificity of 100% for all tumor associated genes (PSA, PSMA, AR-V7) except ARwt where it reached 93% (details in table above). (qiagen.com)

Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator. (mpg.de)
C - L ) Cancer cells were plated in the bottom chamber 1 day prior to seeding MS-1 cells (5 × 10 5 cells/well) and macrophages (1 × 10 5 cells/well) atop the membrane chamber in Transwell and incubated for 18-24 hours ( C ). ( D - K ) Representative images of multiple independent experiments. (jci.org)

Histologically, these tumors are characterized by mixed solid and cystic components. (wikipedia.org)
As with analysis of the patient's earlier masses, the cystic cells show odontogenic epithelial islands, but not dentin or enamel formation. (medpagetoday.com)

Are squamous cells always cancerous? (hospiceofqueenannes.com)
Other parts of the body including the lungs, mucous membranes, and urinary tract also have layers of squamous cells, which may also become cancerous . (hospiceofqueenannes.com)

We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. (jcancer.org)

Anatomy47

Organisms11

Diseases57

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes47

Disciplines and Occupations1

Information Science3

Health Care3

Progression17

Malignant tumors3

Tissues14

Metastatic9

Carcinomas9

Transition5

Germ11

Metastasis9

Microenvironment1

Ovarian tumors8

Ovary3

Limiting dilution assays1

Type of ovarian cancer1

Tissue12

Airway epithelial cells6

Apoptosis13

Cancers11

Invasion7

Carcinoma26

Colorectal cancer3

Malignancies1

Surgery to remove the tumor2

Lung5

Patients17

Intestinal tumors1

Dendritic cells1

Thymic2

Mammary tumors4

Markers4

Characterization2

Borderline tumors1

Biopsy2

Molecular2

Diagnosis4

Increased tumor growth1

Migration6

Prostatic5

Incidence4

Fibrous1

Basal7

Prognosis1

Adenocarcinoma1

Neoplasm1

Expression21

Originate2

Biomarkers1

Differentiation3

Benign2

Breast5

Bronchial3

Primary tumor1

Contributes2

Promotes tumor1

Mucosal1

Stromal cell2

Serous3

Endothelial cells2

Mucinous2

Luminal1

Genes3

Macrophages2

Cystic2

Cancerous2

Differential1