Tumors epidermal growth receptor erbb 2. Medical search. Frequent questions

In TGF-beta-treated MCF10A mammary epithelial cells overexpressing HER2 and by chromatin immunoprecipitation, we identified novel Smad targets including protein tyrosine phosphatase receptor type kappa (PTPRK). (nih.gov)
Endogenous RPTPkappa associated with EGF receptor and HER2, resulting in suppression of basal and ErbB ligand-induced proliferation and receptor phosphorylation. (nih.gov)
The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named HER2 in humans and neu in rodents ErbB-3, also named HER3 ErbB-4, also named HER4 v-ErbBs are homologous to EGFR, but lack sequences within the ligand binding ectodomain. (wikipedia.org)
With the addition of trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), improvements in overall survival have been observed among patients with advanced HER2-positive disease. (carcinogenesis.com)
We also review the data the efficacy and safety of anthracycline-based and nonanthracycline-based adjuvant chemotherapy regimens combined with trastuzumab, and optimum chemotherapy regimens in small HER2-positive tumors. (carcinogenesis.com)
One type of breast cancer is identified by the human epidermal growth factor receptor 2 (HER2) gene amplification. (carcinogenesis.com)
HER2 is a member of the cErbB family of receptor tyrosine kinases, and is responsible for HER2-mediated signal transduction in the cytoplasm. (carcinogenesis.com)
Dr. Tahover and her colleagues' review in this issue of "Harefuah" presents the pivotal trials that have brought a change of practice in the adjuvant treatment of patients with breast cancer and HER2 positive tumors. (tau.ac.il)
HER2 gene encodes a cell-surface glycoprotein tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor. (biovisi.com)
HER2 is amplified in about 30% of primary human breast malignancies and overexpression of HER2 is associated with the most aggressive tumors that show uncontrolled proliferation, resistance to apoptosis and increased motility. (biovisi.com)
The HER Alosetron family is comprised of four unique receptors: EGFR (also known as HER1 or ErbB-1) HER2 (ErbB-2 Neu) HER3 (ErbB-3) and HER4 (ErbB-4). (ecolowood.com)
HER2 does not have any identified ligand an undeniable fact explained from the structure from the extracellular area from the receptor which is already in an activated conformation and does not allow ligand docking. (ecolowood.com)
ERBB2 is a protein that is also known as HER2 (human epidermal growth factor receptor 2). (antibodyguide.com)
One such target of these novel therapies has been the human epidermal growth factor receptor 2 ( HER2 ) gene. (degruyter.com)
The human epidermal growth factor receptor 2 (HER2) status is important in the medical management of patients with various human cancers. (ijmpo.org)
HER2 positive breast cancer is identified by the overexpression of human epidermal growth factor receptor-2 (HER2) protein in tumor tissue and results in an increased rate of cell proliferation. (her2support.org)
1 The human epidermal growth factor receptor 2 (HER2 or ErbB2) is a tyrosine kinase receptor that belongs to the EGFR (ErbB) family and is sometimes implicated in breast, lung, and other cancers. (mdforlives.com)
An estimated 2-6% of NSCLC cases have a mutation in the HER2 oncogene, and others have overexpression or amplification of HER2. (mdforlives.com)
Human epidermal growth factor receptor 2 (HER2) bound to a targeted therapeutic agent. (mdforlives.com)
Antibody-drug conjugates are finding success in Phase 2 clinical trials for the treatment of NSCLC that involves HER2 overexpression or HER2 mutation. (mdforlives.com)
MammaPrint/BluePrint subtyping classified patients into four molecular subgroups: Luminal A, Luminal B, HER2 (human epidermal growth factor receptor 2), and Basal type. (nih.gov)
It is a member of the ErbB receptor family, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). (promab.com)
In one study, about 1 in 5 people with stomach cancer had tumors that were HER2-positive (or HER2+). (opiatalk.com)
HER2 is a growth-promoting protein on the outside of all breast cells. (opiatalk.com)
In the international, double-blind, placebo-controlled study, 612 patients with unresectable locally advanced or metastatic HER2-positive breast cancer who were previously treated with trastuzumab, pertuzumab, and T-DM1were randomized 2:1 to receive trastuzumab and capecitabine combined with either tucatinib (n = 410) or placebo (n = 202). (onclive.com)
Human epidermal growth factor receptor-2 (HER2/ErbB-2) is a receptor tyrosine kinase involved in cell growth and differentiation and over-expressed in about 15-30% of breast cancers. (scitechnol.com)
Introduction Epidermal development element receptor (EGFR) was the 1st discovered from the ErbB category of receptor tyrosine kinases with a total of four users: Erbb1/EGFR, ErbB2/Her2, ErbB3 and ErbB4. (bio-biz-navi.com)
It regulates HLA class I and induces apoptosis in HER2/neu beneficial tumor cell lines. (mirnamimics.com)
Amplification of the human epidermal growth factor receptor 2 ( HER2 ) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. (wjgnet.com)
The objective of this study was to determine the conversion rate of human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER) and progesterone receptor (PR) between primary tumors and metastatic lesions in advanced breast cancer. (springer.com)
There was substantial agreement regarding the expression of HER2 in primary tumors and metastases, and ER at metastases, between local and central laboratories. (springer.com)
The status of human epidermal growth factor receptor 2 (HER2) and the hormone receptors (HR), including estrogen receptor (ER) and progesterone receptor (PR), are the most relevant biomarkers for clinical practice, predicting response to anti-HER2 and endocrine therapies, respectively. (springer.com)
Recently, the 12th St Gallen International Breast Cancer Conference Expert Panel recommends that the subtype classification of breast cancer, namely 'HR positive' (including 'luminal A' and 'luminal B' tumors), 'HER2 amplified' and 'triple negative,' should guide the treatment plan for breast cancer patients. (springer.com)
Being aware of the benefits that the correct systemic therapy provides to patients with advanced breast cancer, the Spanish Breast Cancer Research Group (GEICAM) performed a prospective, observational study to determine the conversion rate of receptor status (ER, PR and HER2) between the primary tumor and the recurrent lesion. (springer.com)
In particular, HER2 and HER3 are over-expressed in 23277-43-2 IC50 a number of tumors, and their expression levels are associated with abnormal growth and poor clinical prognosis. (researchhunt.com)
While this has led to the development of a range of therapeutics targeting the HER2 receptor [15], the use of these drugs can often lead to resistance through a diverse set of mechanisms [16]. (researchhunt.com)
It is used for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 (ErbB2). (hmdb.ca)
HER2-positive (HER2+) breast cancers are defined as those that have an excess number of HER2 genes or over-produce the protein product of the HER2 gene, the HER2 cell surface receptor. (cancer.gov)
HER2 is a member of the epidermal growth factor receptor ( ErbB ) family of genes, which encode proteins that are cell surface-bound tyrosine kinase proteins. (cancer.gov)
These tumors tend to grow faster and are generally more likely to recur than tumors that do not overproduce HER2. (cancer.gov)
The ALTTO clinical trial was unique in that, for all of patients, there was central pathology review of the primary tumor, including re-evaluation of the cancer's estrogen receptor (ER), progesterone receptor (PR), and HER2 status, before patients were randomly assigned to one of the trial's four treatment groups. (cancer.gov)
About 15 percent to 20 percent of breast cancers are HER2-positive and about half of the HER-2 positive cancers also express ER and/or PR. (cancer.gov)

The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. (wikipedia.org)
GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of epidermal growth factor receptor (EGFR, ErbB-1) and ErbB-2. (rcsb.org)
Surprisingly, we found that GW572016 has a very slow off-rate from the purified intracellular domains of EGFR and ErbB-2 compared with OSI-774 and another EGFR selective inhibitor, ZD-1839 (Iressa). (rcsb.org)
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. (neobiotechnologies.com)
The epidermal growth factor receptor (EGFR) continues to be implicated in head and neck squamous cell carcinoma (HNSCC) carcinogenesis. (ecolowood.com)
If ultimately shown to reduce the risk of oral tumor chemoprevention with EGFR inhibitors may significantly reduce morbidity and possibly mortality from HNSCC. (ecolowood.com)
They may be created as transmembrane precursors and could become subdivided into three organizations according with their affinity for just one or even more HER receptors: the 1st group includes ligands that bind specifically to EGFR (e.g. (ecolowood.com)
Once activated these pathways contribute to the development of a malignant cellular phenotype including resistance to apoptosis increased proliferation invasion metastasis and stimulation of angiogenesis (Figure 1).1 Figure 1 Epidermal growth factor receptor (EGFR) pathway activation during HNSCC carcinogenic process. (ecolowood.com)
Loss of heterozigosity (LOH) EGFR overexpression/amplification and cyclooxygenase-2 (COX2) dysregulation in pre-malignant lesions have been associated with … The EGFR has been implicated in head and neck squamous cell carcinoma (HNSCC) carcinogenesis. (ecolowood.com)
It is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. (antibodyguide.com)
HER-2/neu , also known as c-erbB-2/neu , is an oncogene located in chromosome 17 which encodes HER-2/neu, a transmembrane protein belonging to the EGFR family. (degruyter.com)
Recently, we isolated a novel negative regulator of epidermal growth factor receptor (EGFR), termed EGFR-related protein (ERRP), whose expression attenuates EGFR activation. (aacrjournals.org)
In the current study, we examined the effects of recombinant ERRP on the growth and ligand-induced activation of multiple members of erbB family in three pancreatic cancer cell lines that express varying levels of EGFR and other member(s) of its family, specifically HER-2. (aacrjournals.org)
ERRP also inhibited ligand-induced activation of EGFR, HER-2, and HER-3 (ErbB3). (aacrjournals.org)
In contrast, Erbitux and Herceptin only partially or modestly inhibited activation of EGFR, HER-2, and HER-3. (aacrjournals.org)
Epidermal growth factor receptor ( EGFR , ErbB ) gene mutations are one of the most well-researched targets for lung cancer treatment. (mdforlives.com)
1,2 EGFR tyrosine kinase inhibitors (EGFR TKI) are used as first-line treatments in advanced NSCLC cases where EGFR mutations are present. (mdforlives.com)
1,2 Patritumab deruxtecan (HER3-DXd/U3-1402) is a HER3-targeted antibody-drug conjugate that showed anti-tumor activity and acceptable safety in patients with advanced NSCLC who are on EGFR TKI. (mdforlives.com)
2,13 Monoclonal antibodies against programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) are effective treatment options for a relatively small percentage of patients with NSCLC, but they are not recommended for patients with EGFR-mutated NSCLC. (mdforlives.com)
EGFR (epidermal growth factor receptor) is a transmembrane protein and receptor for members of the epidermal growth factor (EGF) family of extracellular protein ligands. (promab.com)
Defective signaling of EGFR and other receptor tyrosine kinases in humans has been linked to diseases such as Alzheimer's disease, while overexpression has been linked to the development of various tumors. (promab.com)
Disruption of EGFR signaling by blocking the EGFR-binding site on the extracellular domain of the receptor or inhibiting intracellular tyrosine kinase activity prevents the growth of EGFR-expressing tumors and improves patient outcomes. (promab.com)
The anti-EGFR CAR in this product is approximately 56 kD and consists of anti-EGFR scFv (single-chain variable fragment) linked to a second-generation CAR (chimeric antigen receptor) containing the CD8 hinge and transmembrane domain and 4-1BB and CD3ζ signaling domains. (promab.com)
Interestingly reduces tumourigenesis in vivo4 5 These findings have spurred interest in supplementing clinical TH287 Erb1 (also known as epidermal growth factor receptor (EGFR)) inhibition with synergistic targeting of ADAM171. (bioskinrevive.com)
We demonstrate that TH287 PACS-2 controls ADAM17 cell-surface availability shedding of ErbB ligands and EGFR activity in vivo. (bioskinrevive.com)
The epidermal growth factor receptor (EGFR) is among the most well-studied signaling pathways in cancer progression. (bio-biz-navi.com)
General, we help with the hypothesis that fundamental adjustments in EGFR signaling between main and metastatic tumors, an activity we term the EGFR paradox, donate to the medically observed inherent level of resistance to EGFRi. (bio-biz-navi.com)
2 Since its finding, EGFR continues to be characterized like a mediator of a multitude of signal transduction occasions that control cell proliferation, migration and success. (bio-biz-navi.com)
3 Aberrant EGFR activation in tumor cells can derive from improved transcriptional manifestation 202825-46-5 manufacture and/or gene amplification. (bio-biz-navi.com)
Neratinib is an irreversible inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases by targeting a cysteine residue in the ATP-binding site of the receptor. (lclabs.com)
Neratinib inhibits the proliferation of HER-2 overexpressing human breast cancer cell lines and EGFR-dependent cells in vitro. (lclabs.com)
In vivo, neratinib is active against HER-2- and EGFR-dependent tumor xenograft models. (lclabs.com)
Activation of MAPK is initiated by one of the four ErbB receptors (ErbB1/epidermal growth factor receptor (EgfR), ErbB2-4), which leads to signaling through Raf (RAF proto-oncogene serine/threonine-protein kinase), Mek (mitogen-activated protein kinase kinase 1/2) and Erk. (biomedcentral.com)
For NSCLC, much of the work in the last decade has been focussed on mutations of the epidermal growth factor receptor (EGFR) and on the abnormal fusion of the anaplastic lymphoma kinase (ALK) being inhibited successfully with EGFR tyrosine kinase inhibitors (TKI) and crizotinib respectively. (amegroups.org)

Transforming growth factor beta (TGF-beta) inhibits proliferation and promotes cell migration. (nih.gov)
RNA interference (RNAi) of PTPRK accelerated cell cycle progression, enhanced response to epidermal growth factor (EGF), and abrogated TGF-beta-mediated antimitogenesis. (nih.gov)
The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB-2), 1M6B (ErbB-3) and 2AHX (ErbB-4): The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher-order oligomers upon activation by a subset of potential growth factor ligands. (wikipedia.org)
The ability ('+') or inability ('-') of each growth factor to activate each of the ErbB receptors is shown in the table below: The dimerization occurs after ligand bind to the extracellular domain of the ErbB monomers and monomer-monomer interaction establishes activating the activation loop in a kinase domain, that activates the further process of transphosphorylation of the specific tyrosine kinases in the kinase domain of ErbB's intracellular part. (wikipedia.org)
More than 10,000 patients with tumors that were defined as human epidermal growth factor receptor 2, ErbB-2 positive have been recruited into these trials. (tau.ac.il)
It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. (neobiotechnologies.com)
Lymph node, epidermal growth factor receptor, and estrogen receptor status, tumor size, and histological grade also had prognostic significance but, applying multivariate analysis, only lymph node status was a more important predictor of relapse-free and overall survival than staining for the oncoprotein. (ox.ac.uk)
Positive staining was correlated with negative estrogen receptor status and high histological grade, but there was no association with either lymph node or epidermal growth factor receptor status or tumor size. (ox.ac.uk)
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. (nature.com)
LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation. (nature.com)
The epidermal growth factor receptor (ERBB1) and related family member HER-2/ neu (ERBB2) are often overexpressed in aggressive breast cancers and their overexpression is correlated with poor prognosis. (aacrjournals.org)
The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)
The ligands to HER receptors (also known as epidermal growth factor [EGF] family of growth factors) are characterized by the presence of an EGF-like website (composed of three disulfide-bonded intramolecular organizations which confer binding specificity) and extra structural motifs (such as for example immunoglobulin-like domains heparin-binding sites and glycosilation sites). (ecolowood.com)
The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. (cdc.gov)
Also called c-erbB-2 positive and human epidermal growth factor receptor 2 positive. (opiatalk.com)
Each pool was transfected into quadruplicate wells of HT1080 fibrosarcoma cells stably expressing alkaline phosphatase-tagged pro-heparin-binding EGF-like growth factor (AP-HB-EGF). (bioskinrevive.com)
35 Another well-established change in function in BC is usually that of changing development factor-beta (TGF-) where it features as a robust tumor suppressor in main tumors but drives disease development within the metastatic establishing. (bio-biz-navi.com)
Recently, several novel agents targeting growth factor receptors, angiogenic pathways, adhesion molecules and mediators of intracellular signal transduction have been clinically explored. (docksci.com)
Second-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. (lclabs.com)

Notably, the ErbB1 and ErbB4 are the two most studied and intact among the family of ErbB proteins, Which forms functional intracellular tyrosine kinases. (wikipedia.org)
Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
ERBB1 and ERBB2 inhibition rapidly (within 3 h) inhibits both tumor cell motility and intravasation. (aacrjournals.org)
Using gefitinib, ERBB1 inhibition rapidly inhibits tumor cell motility and invasion but not intravasation, whereas ERBB2 inhibition by AG825 rapidly blocks intravasation. (aacrjournals.org)
ERBB1 and ERBB2 inhibition can rapidly block tumor cell invasive properties. (aacrjournals.org)
In addition, we differentiate for the first time the contributions of ERBB1 and ERBB2 to the key metastatic properties of in vivo tumor cell invasion and intravasation. (aacrjournals.org)

ErbB2 belongs to the ErbB family of receptor tyrosine kinases, which has been implicated in a variety of human cancers , including cancers of the breast. (her2support.org)

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). (neobiotechnologies.com)
As ErbB-family ligands and receptors are highly expressed within the stem-cell niche 7 , we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. (nature.com)
Its structure consists of an extracellular ligand-binding website a Alosetron single transmembrane hydrophobic helix and a cytoplasmic carboxy-terminal website to which tyrosine kinase activity is definitely limited.1 HER receptors are usually located in the basolateral membrane of the epithelial cells where they can interact with their ligands present in the stroma thus mediating signaling between the epithelium and the extra-cellular matrix. (ecolowood.com)
The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface a key step underlying epithelial development growth and tumour progression. (bioskinrevive.com)

The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene. (wikipedia.org)
Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors. (cdc.gov)
Many other genetic targets are under active research in lung cancer, including Kirsten rat sarcoma viral oncogene homolog (KRAS), c-mesenchymal-epithelial transition receptor (c-Met), anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and neurotrophic tyrosine receptor kinase (NTRK). (mdforlives.com)
erbB 2 antisense oligonucleotides inhibit proliferation of breast cancer cells with erbB oncogene amplification rkungsfaktorsteuerung second Br J Cancer. (mirnamimics.com)
Sequencing of the human genome has permitted more efficient identification of epigenetic mutations, tumour-suppressor-gene inactivation as well as oncogene driver mutations that are potential targets for therapy ( 3 - 8 ). (amegroups.org)

The intracellular/cytoplasmic region of the ErbB receptor consists mainly of three subdomains: A juxtamembrane with approximately 40 residues, a kinase domain containing approximately 260 residues and a C-terminal domain of 220-350 amino acid residues that become activated via phosphorylation of its tyrosine residues that mediates interactions of other ErbB proteins and downstream signaling molecules. (wikipedia.org)
Treatment of tumor cells with these inhibitors results in down-regulation of receptor tyrosine phosphorylation. (rcsb.org)
We evaluated the duration of the drug effect after washing away free compound and found that the rate of recovery of receptor phosphorylation in the tumor cells reflected the inhibitor off-rate from the purified intracellular domain. (rcsb.org)
The slow off-rate of GW572016 correlates with a prolonged down-regulation of receptor tyrosine phosphorylation in tumor cells. (rcsb.org)
Following dimerization there is increased intracellular kinase activity of the receptor through a proximity effect resulting in phosphorylation of critical tyrosine residues on the cytoplasmic domain which then triggers the signal transduction cascade. (ecolowood.com)
Downstream signaling from these receptors proceeds TSPAN10 via tyrosine phosphorylation. (bio-biz-navi.com)
Binding of Sema4D to plexin-B1 stimulates the intrinsic tyrosine kinase activity of ErbB-2, resulting in the phosphorylation of both plexin-B1 and ErbB-2. (rupress.org)
Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2-mediated phosphorylation of plexin-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse. (rupress.org)

10% and seems to be related to overexpression in tissue as well as to the most important prognostic factors: tumor size and nodal involvement. (degruyter.com)
Serial HER-2/neu determinations after surgery seem to be useful in the early diagnosis of recurrence, mainly in patients with HER-2/neu overexpression in tissue, but additional studies are necessary to confirm these results. (degruyter.com)
HER-2/neu sensitivity (proportion of patients with abnormal values) in patients with metastasis is around 40%-45%, with a clear relationship to tissue overexpression and to site (higher in visceral metastases) and number of metastases. (degruyter.com)
Given the importance of erbB-2 in human breast cancer, the finding of erbB-2 overexpression in canine OSA may be important in further understanding the pathogenesis and possible therapies of OSA. (cdc.gov)

The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. (neobiotechnologies.com)
Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). (neobiotechnologies.com)
Its effect on the function of other proteins in the ErbB family of proteins that may also fuel cancer cell growth is being studied. (cancer.gov)
In addition to plexins, various other proteins have been implicated either as receptors for semaphorins or as components of the semaphorin receptor complex ( Pasterkamp and Kolodkin, 2003 ). (rupress.org)

It is a complex process due to the domain specificity and nature of the members of ErbB family. (wikipedia.org)

Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. (aacrjournals.org)
Our studies were designed to evaluate the effect of ERBB inhibition on tumor cell motility and intravasation in vivo using clinically relevant small-molecule inhibitors. (aacrjournals.org)
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. (lclabs.com)
Translational research advances now allow such mutations to be inhibited by either receptor monoclonal antibodies (mAb) or small molecule tyrosine kinase inhibitors (TKI). (amegroups.org)

Once the ligand binds to the extracellular domain the receptor undergoes a conformational change of this region which allows homodimerization or heterodimerization with another activated receptor of the HER family. (ecolowood.com)
Finally, we have presented data indicating that surface HSP90 interacts specifically with the extracellular domain of HER-2 and that this interaction which is necessary for the receptor's activation leading to breast cancer cell invasion, is disrupted by mAb 4C5 [ 14 ]. (biomedcentral.com)

These results indicate that ERBB inhibition should be considered for blocking other tumor cell malignant properties besides growth. (aacrjournals.org)

Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. (nature.com)

These receptors convert signals received from the extracellular environment into cell decisions such as growth and survival C a process termed signal transduction. (researchhunt.com)

Expression of the c-erbB-2 oncoprotein appears to be an important independent indicator of prognosis in human breast cancer. (ox.ac.uk)
While the importance 23277-43-2 IC50 of HER expression levels has been established for clinical prognosis and drug resistance, the mechanistic link between receptor expression, HER activation and downstream consequences is not as clear yet. (researchhunt.com)
Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer. (lu.se)

The differences in the off-rates of these drugs and the ability of GW572016 to inhibit ErbB-2 can be explained by the enzyme-inhibitor structures. (rcsb.org)
Most importantly, ERRP was found to inhibit pancreatic tumor growth in a severe combined immunodeficient mouse xenograft model. (aacrjournals.org)

ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling may be critical factors in the development and malignancy of these tumors. (wikipedia.org)
The erbB family of receptor tyrosine kinases plays critical roles in human cancers, including pancreatic cancer. (aacrjournals.org)
Reasons for these discrepancies may include the possibility that the molecular profile of breast cancers evolves over time and that biomarkers are heterogeneously expressed within the tumor [ 4 ] and technical inconsistencies in both tissue processing and sample evaluation. (springer.com)
Starting with basics: "All cancers arise as a result of the acquisition of a series of fixed DNA sequence abnormalities, mutations, many of which ultimately confer a growth advantage upon the cells in which they have occurred. (anti-agingfirewalls.com)
These include novel therapies for the treatment of primary brain tumors such as glioblastoma multiforme (GBM) and metastatic brain tumors that arise from cancers affecting the breast, lung or skin. (pacificneuroscienceinstitute.org)

HER-2/neu in serum is a specific tumor marker and only slight elevations may be found in the absence of malignancy, mainly in association with liver diseases. (degruyter.com)

Oncologists altered their treatment plans in 31 % of patients whose tumor subtype had changed. (springer.com)
However, they also may have limited effectiveness in some patients whose tumor growth depends on molecules that are not exclusively targeted by the agents or whose cancer mutates to use other growth pathways. (cancer.gov)

Figure 5: Lrig1 controls ErbB activation in vivo . (nature.com)
Preclinical In Vivo Modeling of Cytokine Release Syndrome Induced by ErbB-Retargeted Human T Cells: Identifying a Window of Therapeutic Opportunity? (kcl.ac.uk)
Inhibitory Fc receptors modulate in vivo cytotoxicity t t towards tumor targets. (mirnamimics.com)

Results Genome-wide screen identifies PACS-2 as an ADAM17 regulator To identify genes that regulate ADAM17-mediated shedding we screened a whole-genome human siRNA library (see Supplementary Information for an extensive description of the screen). (bioskinrevive.com)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease, while excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. (wikipedia.org)
Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. (wikipedia.org)
It's hard to believe, but I actually did all of solid tumor oncology and Hodgkin disease for about 10 years. (medscape.com)

Patients with suspected diagnosis of locally recurrent or metastatic breast cancer, either at first relapse or after successive disease progressions, who had an appropriately preserved sample from a primary tumor and were scheduled for a biopsy of the recurrent lesion, were included. (springer.com)

Blinded determinations of receptor status on paired samples were performed by immunohistochemistry and fluorescence in situ hybridization at a central laboratory and compared with those performed locally. (springer.com)

Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. (lclabs.com)

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer. (ox.ac.uk)
Sections of formalin-fixed, paraffin-embedded tissue from 185 primary breast carcinomas were stained immunohistochemically using a polyclonal antibody against the c-erbB-2 oncoprotein. (ox.ac.uk)
The primary antihuman antibody against c-erbB-2 oncoprotein (DAKO Diagnostics) was used for IHC. (ijmpo.org)

Unique in the approach to abolishing function of this gene coded receptor, it was the first target of new monoclonal antibody therapy targeting the extracellular receptor and now also a target of small molecule drugs against the intracellular tyrosine kinase domain. (degruyter.com)

Jensen, K. B. & Watt, F. M. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. (nature.com)
In this study we used real-time reverse transcriptase polymerase chain reaction to evaluate erbB-2 expression in seven canine OSA cell lines and 10 canine OSA tissue samples. (cdc.gov)
The HER/ErbB family of receptor tyrosine kinases drives critical responses in normal physiology and cancer, and the expression levels of the various HER receptors are critical determinants of clinical outcomes. (researchhunt.com)
The model enables us to quantitatively link HER expression levels to receptor dimerization and activation. (researchhunt.com)
The HER receptor expression profile is a critical determinant of cell behavior [6], [7], and outcomes in cancer pathology. (researchhunt.com)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)

Activation of the tyrosine kinase domain leads to the activation of the whole range of downstream signaling pathways like PLCγ, ERK 1/2, p38 MAPK, PI3-K/Akt and more with the cell. (wikipedia.org)
Fig. 1 Genome-wide screen identifies PACS-2 as an ADAM17 regulator Computational algorithms segregated the screen TH287 hits into multiple categories and no enrichment in particular signalling pathways was evident (Supplementary Fig. 1e and Supplementary Data 1). (bioskinrevive.com)
This Part 2 post is concerned with anti-cancer drug and other interventions that simultaneously address multiple growth pathways. (anti-agingfirewalls.com)
In addition, the ErbB receptors integrate a diverse array of signals, both at the cell surface level and through cross-talk with other pathways, such as the phosphoinositide 3-kinase (Pi3k) pathway [ 11 ]. (biomedcentral.com)
These mutations in receptors or protein kinases can stimulate a complex cascade of cross signalling pathways such as the RAS-RAF-MEK-ERK or MAPK, PI3K-AKT-mTOR or JAK-STAT pathways ( Figure 2 ) ( 3 , 4 , 7 , 18 , 20 ). (amegroups.org)

only 2 patients required surgical intervention for local progression or symptoms. (medscape.com)
This has implications for our understanding of ErbB signalling in tissue development and maintenance and the progression of malignant disease. (nature.com)

This drug is currently approved in at least one country for the extended adjuvant treatment of adult patients with early stage HER-2-overexpressed/ampified brest cancer, to follow adjuvant trastuzumab-based therapy. (lclabs.com)
Such examples include trastuzumab for HER-2 over-expressing breast cancer and vemurafenib for BRAF-mutant melanoma ( 9 , 10 ). (amegroups.org)

Administration of T4+ T cells using the i.v. or intratumoral routes achieves partial tumor regression without clinical or histopathologic toxicity. (kcl.ac.uk)
The clinical utility of HER-2/neu in patients with advanced disease is mainly for therapeutic monitoring. (degruyter.com)
Even though tumor size would intuitively be a clinical determinant of pCR, the current analysis showed that the adjusted OR for tumor size was not statistically significant in any of the molecular subgroups. (nih.gov)
To obtain an independent test set, the remaining 11 of the 58 tumors were selected from an ongoing clinical trial and used here as a blinded sion via ER,3 however the details of the estrogen effect on down- test set. (lu.se)

Drug-induced ubiquitination and degradation erbB receptor tyrosine kinases. (mirnamimics.com)
One well-characterized property of invasive tumors is their ability to accelerate the degradation of the extracellular matrix, by matrix metalloproteinases (MMPs) [ 5 ].This degradation provides access to the vasculature and lymphatic system, allowing tumor dissemination. (biomedcentral.com)

Toxicity mediated by T4+ T cells results from target recognition in both tumor and healthy tissues, leading to release of both human (IL-2/IFN-γ) and murine (IL-6) cytokines. (kcl.ac.uk)
Also, inhibited the ACAT activity t in microsomes of human Caco 2 cells Hnlichen IC50 values. (mirnamimics.com)

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. (neobiotechnologies.com)
The antibody can be used for detecting and imaging cancer cells and tumors, and for guided delivery of an active agent to cancer cells and tumors. (creativebiolabs.net)

For example, ErbB-2 and ErbB-4 knockout mice die at midgestation leads to deficient cardiac function associated with a lack of myocardial ventricular trabeculation and display abnormal development of the peripheral nervous system. (wikipedia.org)

A biopsy of the tumor, which provides a definite diagnosis based on the characteristics of tumor tissue seen under a microscope. (sarcomahelp.org)
Reasons for non-evaluability included the inability to perform biopsy ( n = 4) or biopsy results showing normal tissue ( n = 3), benign disease ( n = 3) or a second neoplasia ( n = 2). (springer.com)

Figure 4: Lrig1 controls endogenous signalling through the ErbB pathway. (nature.com)
The Part 1 post was concerned principally with interventions that address the mTOR pathway, a growth pathway also of great interest from the viewpoint of longevity. (anti-agingfirewalls.com)
The mitogen-activated protein kinase (MAPK)/Erk pathway plays a central role in cell communication: it orchestrates signaling from external receptors to internal transcriptional machinery, which leads to changes in phenotype [ 6 , 7 ]. (biomedcentral.com)

abstract = "The ErbB network is dysregulated in many solid tumors. (kcl.ac.uk)

With the technological advances, we are able to characterize molecular subtypes [2] , [3] of breast cancer which has facilitated the development of molecularly targeted therapeutics. (carcinogenesis.com)
We have not yet seen the full potential of this technique, and new implications have been developed for breast tumour localisation with paramagnetic clips and axillary staging after neoadjuvant chemotherapy using paramagnetic clips inserted in lymph node metastases before chemotherapy. (bvsalud.org)
NH 2-terminally truncated HER-2/neu SA: Vergie no partnership with extracellular Ren Ren Cathedral and prognostic components for breast cancer. (mirnamimics.com)
Neratinib is active against HER-2-positive breast cancer in patients. (lclabs.com)
Like sorafenib, lapatinib is a protein kinase inhibitor shown to decrease tumor-causing breast cancer stem cells. (hmdb.ca)

The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases. (nature.com)

This test can rule out 'skip metastases' (spread of the tumor to other areas of the bone). (sarcomahelp.org)

ErbB protein family signaling is important for development. (wikipedia.org)
All four ErbB receptor family members are nearly same in the structure having single-chain of modular glycoproteins. (wikipedia.org)
Discovering a specific agent, which targets multiple members of the erbB family, would be important in pancreatic cancer therapy. (aacrjournals.org)
Neratinib, also known as HKI-272, is considered to be a second-generation inhibitor of the ErbB family of receptor kinases. (lclabs.com)
Author Summary A family of cell surface molecules called the HER receptor family plays important roles in normal physiology and cancer. (researchhunt.com)
Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. (rupress.org)

Incidence rates and tumour localisation vary considerably between geographical regions thus implying genetic and environmental factors in disease pathophysiology. (docksci.com)

Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. (nature.com)
33,34 Furthermore, the acknowledged growth-promoting functions of estrogen in BC are in conjunction with accounts of estrogen-induced apoptosis, termed the estrogen paradox perfectly examined in Jordan and Ford. (bio-biz-navi.com)

3 ] Most meningiomas are benign tumors, but up to 15% are atypical, and 2% malignant according to the World Health Organization histological criteria reported in 2016. (ijmpo.org)
The biopsy will also show whether the tumor is high grade (highly malignant, which is the case for most osteosarcomas) or low grade. (sarcomahelp.org)
Moreover, the squamous stratification Felbamate programme, while essential for pores and skin epidermal development and barrier formation, may, when jeopardized, predispose an individual to pores and skin immunologic deregulations or malignant transformations (once we will discuss later on). (columbiagypsy.net)

Anatomy21

Organisms9

Diseases54

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes50

Disciplines and Occupations1

Information Science4

Health Care7

HER242

EGFR34

Factor19

ErbB16

ErbB21

Ligands4

Oncogene5

Phosphorylation8

Overexpression4

Proteins4

Members of ErbB family1

Inhibitors4

Extracellular domain2

Inhibition1

Proliferation1

Signal Transduction1

Prognosis3

Inhibit2

Cancers5

Malignancy1

Patients whose tumor2

Vivo3

Genes2

Solid tumor3

Metastatic breast1

Immunohistochemistry1

Antitumor activity1

Oncoprotein3

Monoclonal1

Expression6

Pathways5

Progression2

Trastuzumab2

Clinical4

Degradation2

Human2

Antibody2

Peripheral1

Tissue2

Pathway3

Abstract1

Breast5

Negative regulator1

Metastases1

Family6

Localisation1

Apoptosis2

Malignant3