Tumors carcinosarcoma. Medical search. Frequent questions

My diagnosis was uterine carcinosarcoma, stage 1b, grade 3. (cancer.org)
Uterine carcinosarcoma, also known as malignant mixed Mullerian tumor (MMMT), is a rare and aggressive form of corpus uteri tumor. (cytojournal.com)
The role of adjuvant radiotherapy in the setting of uterine carcinosarcoma has not been clearly established. (nih.gov)
Carcinosarcoma comprises less than 5% of malignant neoplasms of the uterine corpus. (medscape.com)
Most patients with uterine carcinosarcoma present with abnormal vaginal bleeding. (medscape.com)
This aggressive tumour represents only a small fraction of all uterine cancers but is responsible for a significant number of deaths due to its tendency to spread early and recur after treatment. (withoutaribbon.org)
Malignant mixed Mullerian tumour of the Uterus represents about 3-5% of all uterine cancers. (withoutaribbon.org)
Molecular alterations of PIK3CA in uterine carcinosarcoma, clear cell, and serous tumors. (cdc.gov)
Genetic Investigation of Uterine Carcinosarcoma: Case Report and Cohort Analysis. (cdc.gov)
Integrated Molecular Characterization of Uterine Carcinosarcoma. (cdc.gov)
Assessing inter-component heterogeneity of biphasic uterine carcinosarcomas. (cdc.gov)
Mutational landscape implicates epithelial-mesenchymal transition gene TGF-?2 mutations for uterine carcinosarcoma after adjuvant tamoxifen therapy for breast carcinoma. (cdc.gov)
Genetic characterisation of adult primary pleomorphic uterine rhabdomyosarcoma and comparison with uterine carcinosarcoma. (cdc.gov)
This tumor, which occupies a small uterine cavity, grows primarily as a firm polypoid mass. (medscape.com)
Uterine cancers were classified by histologic type (endometrioid carcinoma, other carcinoma, carcinosarcoma, and sarcoma). (cdc.gov)

While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
This definition excludes other tumors that may affect the thymus, such as lymphoma and germ cell tumors. (medscape.com)

A 35 cm right ovarian mass submitted for intraoperative consultation was a multicystic mucinous tumor with an 8 cm area of hemorrhagic lesion between cystic locules. (hindawi.com)
A macroscopic hemorrhagic area in an ovarian mucinous tumor should be evaluated with care, and the possibility of angiosarcoma should be borne in mind. (hindawi.com)
Mucinous tumor is a common type of ovarian epithelial tumors. (hindawi.com)
The findings in this case may be useful for pathologists in the recognition of this uncommon type of ovarian tumors. (hindawi.com)
8321 epithelial ovarian tumors were evaluated by Caris Life Sciences from 2009 to 2016 by multiplaform profiling, which included protein expression (IHC), NextGen sequencing (SEQ), and /or in-situ hybridization. (carislifesciences.com)
and mixed, 1)), to assess treatment strategies and useful biomarkers for malignant ovarian tumors. (elsevierpure.com)
05). Our study shows that targeted agents can be detected in approximately 40% of malignant ovarian tumors via multigene panel testing, and copy number alteration count can be a useful marker to help assess risks in malignant ovarian tumor patients. (elsevierpure.com)
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors. (cdc.gov)
A total of 153 patients (1.9%) were diagnosed with appendiceal tumors, of which 57 (37.3%) were Appendiceal Neuroendocrine Neoplasm (ANEN), 35 (22.9%) were mucinous cystadenoma and 34 (22.2%) ovarian cancer metastases. (bvsalud.org)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)

according to my CT scan everything is clear I have a dime-sized tumor in the uterus. (cancer.org)
A retrospective review of 60 patients receiving definitive therapy for carcinosarcoma of the uterus was undertaken at a single institution. (nih.gov)
Carcinosarcoma of the uterus is a biphasic neoplasm composed of malignant epithelial and mesenchymal elements. (medscape.com)
Gynecological Carcinosarcoma (GCS) is a rare and aggressive cancer found primarily in the ovaries and uterus and can also originate in the fallopian tubes and vagina. (gcsproject.org)
A malignant mixed Mullerian tumour of the uterus, also known as carcinosarcoma, is a rare type of cancer that contains both carcinoma (cancer of the epithelium) and sarcoma (cancer of the connective tissue) components. (withoutaribbon.org)
The exact cause of the malignant mixed Mullerian tumour of the uterus is unknown, but it is likely to involve genetic mutations that lead to uncontrolled cell growth and division. (withoutaribbon.org)
Risk factors that may increase the likelihood of developing a malignant mixed Mullerian tumour of the uterus include obesity, use of tamoxifen (a drug used in the treatment of breast cancer), and a history of pelvic radiation therapy. (withoutaribbon.org)
What Support can we Give for Malignant Mixed Mullerian Tumour of the Uterus? (withoutaribbon.org)
Malignant Mixed Mullerian Tumour of the Uterus is rare cancer, meaning it is not as well known as other forms of cancer. (withoutaribbon.org)
If you suffer from rare cancer such as Malignant Mixed Mullerian Tumour of the Uterus, we can help and support you through your journey thanks to the generous donations we receive. (withoutaribbon.org)
The remaining sarcomas are made up of heterologous tumors-tumors that contain histologic components foreign to the uterus, such as rhabdomyosarcomas , osteosarcomas , and chondrosarcomas . (medscape.com)

A carcinosarcoma neoplasm is a biphasic tumor in which the carcinomatous component is usually a poorly differentiated adenocarcinoma, an undifferentiated carcinoma, or a squamous cell. (medscape.com)
Sarcomatoid carcinoma or carcinosarcoma (CS) is a rare neoplasm of the urinary bladder that is defined by the World Health Organization as a biphasic tumor consisting of malignant epithelial and mesenchymal components [1]. (pfeiffertheface.com)
Other specified malignant neoplasm (Other specified cancer tumour Other codes are obsolete, ie the entities have been in the previous edition). (who.int)

GCS, is also known as MMMT or Malignant Mixed Mullerian Tumor. (gcsproject.org)
The GCS Project is dedicated to finding a cure for Gynecological Carcinosarcoma (aka MMMT), providing current scientifically valid information, and offering a place for the community impacted by this cancer to share stories and hope. (gcsproject.org)
Have you been diagnosed with gynecologic carcinosarcoma (MMMT) and want to seek expert medical advice? (gcsproject.org)
Malignant mixed müllerian tumor (MMMT) is a rare tumor. (bmj.com)
Peritoneal MMMT are frequently associated with gynecologic tumors. (bmj.com)

The pathology report on the tumor will help your doctor determine your recommended treatment plan. (cancer.org)

Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
Participant must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 criteria (by local Investigator) (Eisenhauer, 2009). (uclahealth.org)
Purpose Treating solid tumors with cancer immunotherapy (CIT) can result in unconventional responses and overall survival (OS) benefits that are not adequately captured by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1. (medscape.com)
Response Evaluation Criteria In Solid Tumors (RECIST) v1.1 end points, originally developed to evaluate the benefit of chemotherapeutic and targeted agents, are accepted measures of clinical efficacy in advanced solid malignancies. (medscape.com)
Immune-related response criteria (irRC) were developed based on experience with ipilimumab (anti-cytotoxic T-cell lymphocyte-4) in melanoma to better capture the response to CIT per changes in tumor biology and the long-termeffects of CITon solid tumors and to enable additional adaptations as the field evolved. (medscape.com)

These preliminary results support the potential utility of the neoadjuvant perioperative treatment with DDAVP in advanced mammary tumors. (vin.com)
They constituted a heterogeneous, but distinct group of murine mammary tumors, with molecular features of the luminal subtype of human breast cancer. (biomedcentral.com)

A biplastic tumor or biphasic tumor has two tissue types. (wikipedia.org)

Druggable hypermutation/ultramutation (tumor mutation burden ≥ 10 SNVs/Mbp) was found in 7.4% of high-grade serous carcinoma, 46.7% of endometrioid carcinoma, 10% of clear cell carcinoma, 0% of mucinous carcinoma, 25% of undifferentiated carcinoma, and 33.3% of the other cancer cases. (elsevierpure.com)

Determine the impact on survival and the antitumor effects of thalidomide in patients with sarcomas or carcinosarcoma (mixed mesodermal tumors) of gynecologic origin. (knowcancer.com)

Due to the rarity of angiosarcoma in the ovary, this tumor can be a diagnostic challenge to surgical pathologists, particularly during an intraoperative consultation. (hindawi.com)
Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018) 14. (sncrf.org)
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (cancercentrum.se)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. (cancercentrum.se)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)

Data describing appendiceal tumor incidence and epidemiology is limited. (bvsalud.org)

Identification of genomic alterations that drive the clinically aggressive serous and clear cell tumors of the endometrium. (researchgate.net)

Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. (sncrf.org)

An estimated 16% of carcinosarcomas have a low-grade stromal component. (medscape.com)
Growing evidence suggests that the interaction between the genomic/epigenomic aberrations in cancer cells and the surrounding microenvironment, composed of immune and stromal cells, contributes to the development of tumor invasion via mechanisms such as the so-called "angiogenic switch,"[3-5] creating multiple opportunities for therapeutic intervention. (cancernetwork.com)
Gastrointestinal stromal tumor (GIST) (closed to accrual 09/26/2018) 38. (sncrf.org)

These tumors are currently thought to be monoclonal carcinomas with sarcomatous differentiation. (medscape.com)
Type II tumors are usually high-grade and include grade 3 endometrioid carcinomas and tumors with nonendometrioid histology (eg, serous, clear cell, mixed cell, undifferentiated, carcinosarcoma). (msdmanuals.com)
To evaluate their relationship to clinical tumors, we determined phenotypic relationships among these carcinomas, other murine models of breast cancer, and features of luminal tumors in women. (biomedcentral.com)
Our studies demonstrate that prolactin can promote diverse carcinomas in mice, many of which resemble luminal breast cancers, providing a novel experimental model to examine the pathogenesis, progression and treatment responsiveness of this tumor subtype. (biomedcentral.com)

Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin and cytokeratin 18) and up-regulation of mesenchymal markers (vimentin and α-smooth muscle actin) with concomitant transforming growth factor-β1 (TGF-β1) expression at the invasive margin compared with the central tumor. (aacrjournals.org)
The tumor is composed of two cellular components: Epithelial and mesenchymal. (cytojournal.com)
The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
Carcinosarcomas comprise an admixture of histologically malignant epithelial and mesenchymal components, as depicted below. (medscape.com)
Both epithelial and mesenchymal components of carcinosarcoma show high-grade malignant cells. (medscape.com)

Although carcinosarcoma is the preferred term for this group of tumors, according to the International Society of Gynecological Pathologists (ISGyP)/World Health Organization (WHO) classification, it is also referred to as malignant müllerian mixed tumor. (medscape.com)

Carcinosarcoma of the salivary glands was first described by Kirklin et al in 1951. (medscape.com)
[ 1 ] The term true malignant mixed tumor in the salivary glands was first used by King in 1967 in a study that helped to renew interest in this tumor group. (medscape.com)
[ 3 ] It accounts for only 0.04-0.16% of all salivary gland tumors. (medscape.com)
In the major salivary glands, most reported cases of carcinosarcoma (65%) occurred in the parotid gland. (medscape.com)
True malignant mixed tumor (carcinosarcoma) of tonsillar minor salivary gland origin: diagnostic imaging and endovascular therapeutic embolization. (ajnr.org)
We report a case of carcinosarcoma of the minor salivary glands of the left palatine tonsil, an especially rare location. (ajnr.org)
For example, benign pleomorphic salivary gland tumors may have some tumors cells that form pseudocartilage. (wikipedia.org)
Epithelial tumors of major salivary glands (closed to accrual 03/20/2018) 3. (sncrf.org)
Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. (sncrf.org)

The tumor was a huge lesion occupying the inside of the lumen, and histopathological findings revealed that the tumor, the main part of which lay beneath the mucous membrane, had a transitional image composed of both spindle-shaped atypical cells and sarcomatoid shape. (karger.com)
In many cases, the epithelial and the sarcomatoid cells exist in separate areas of the tumor or even in separate areas of the body. (jeffreysglassman.com)
But because epithelial and sarcomatoid cells tend to grow in different locations of the same tumor, doctors may only see one or the other. (jeffreysglassman.com)

Changes on the short (p) arm of chromosome 11 are also associated with developing Wilms tumor. (medlineplus.gov)

Two schools of thought exist as to the origin of carcinosarcomas. (medscape.com)
Although a monoclonal origin of carcinosarcomas has generally been proposed, heterologous differentiation from a single clone might lead to the production of G-CSF only in the epithelial element in the present case. (nih.gov)

In the images below, the sarcomatous (spindle cell sarcoma) component of the tumor is dominant, with the smaller portion being poorly differentiated adenocarcinoma. (medscape.com)
As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a very dense and highly organized tumor microenvironment (TME) consisting of extracellular matrix (ECM) proteins, cancer-associated fibroblasts (CAFs), pancreatic stellate cells (PSCs), and immune cells. (mdpi.com)
Invasive mucinous adenocarcinoma is uncommon and usually arises in the background of benign or borderline tumors. (hindawi.com)
The frozen section diagnosis was at least mucinous borderline tumor, pending adequate tissue sampling for permanent sections to rule out mucinous adenocarcinoma. (hindawi.com)
Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. (sncrf.org)
Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. (sncrf.org)

Previously, we demonstrated that perioperative administration of DDAVP dramatically reduced lymph node involvement and lung metastasis in a mouse model of mammary tumor manipulation and surgical excision. (vin.com)
Inhibition of polyamine by DFMO in animal experiments reduced tumor growth and decreased the amount of metastasis, resulting in prolonged survival of the animals.ix With the introduction of the present "Intume Oxidant," polyamine synthesis will be halted by ClO2 oxidation of existing PA, along with oxidation of PA precursor molecules, arginine and ornithine. (justia.com)

There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract. (sncrf.org)

Gliomas are the most common primary brain tumors. (spandidos-publications.com)
The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)
Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
1 - 3 Intracranial brain tumors, most commonly medulloblastoma [ Figure 2 ], can metastasize to the peritoneal cavity via ventriculo-peritoneal shunts used to divert excess cerebrospinal fluid. (cytojournal.com)

Wilms tumor is often associated with variants (also called mutations) in the WT1 gene, CTNNB1 gene, or AMER1 gene. (medlineplus.gov)
On average, we identify 43 mutations per tumour, excluding four cases with a mutator phenotype that harboured inactivating mutations in mismatch repair genes. (nih.gov)
These tumors may show microsatellite instability and have mutations in PTEN , PIK3CA , KRAS , and CTNNB 1. (msdmanuals.com)
While analysis of isoform expression is important for discovering tumor-specific isoform signatures and interpreting relevant genomic mutations, there is currently no web-based, easy-to-use, and publicly available platform for this purpose. (biomedcentral.com)
Compared to AR- tumors, AR+ tumors had significantly less frequent mutations on KRAS (4.6% vs. 10%, p=4.2E-11), PIK3CA (4.5% vs. 8%, p=1.85E-06), SMAD4 (0.1% vs. 0.5%, p=0.03) and GNAS (0 vs. 0.3%, p=0.03), and more frequent AKT1 (0.7% vs. 0.3%, p=0.03) mutations. (carislifesciences.com)

While treatments directed against this receptor have successfully lowered mortality rates, many primary tumors initially or later exhibit resistance. (biomedcentral.com)
Incidence and occurrence of second primary tumors. (cancercentrum.se)

However, the risk that the cancer will come back (recur) is between 15 and 50 percent, depending on traits of the original tumor. (medlineplus.gov)
Tumors usually recur in the first 2 years following treatment and develop in the kidneys or other tissues, such as the lungs. (medlineplus.gov)
Low-grade tumors may recur and infiltrate adjacent structures. (medscape.com)

Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)

Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)

Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
It is unknown if AR status confers similar prognostic and treatment benefit in other tumor types. (carislifesciences.com)
Exercise-induced IL-15 acted as a positive prognostic implication and tumor-suppressed role in pan-cancer. (cdc.gov)
Comprehensive genetic profiling is increasingly important for the clinical workup of hematologic tumors, as specific alterations are now linked to diagnostic characterization, prognostic stratification and therapy selection. (bvsalud.org)

Wilms tumor is a form of kidney cancer that primarily develops in children. (medlineplus.gov)
Wilms tumor is the most common kidney cancer in children. (medlineplus.gov)
The incidence of Wilms tumor seems to vary among populations, with African Americans having a higher-than-average risk of developing this cancer and Asians having a lower-than-average risk. (medlineplus.gov)
Genetic conditions that share a genetic cause with Wilms tumor can also have this cancer as a feature. (medlineplus.gov)
At the epicenter of this dynamic and complex TME lies the cancer stem cell (CSC), which is believed to be the root of the tumor and the cell responsible for chemoresistance and disease relapse. (mdpi.com)
His research program spans a range from basic studies in molecular cancer genetics and tumor immunology to translational clinical cancer research testing novel immunotherapeutic strategies and targeted compounds in vivo for the treatment of gynecologic malignancies. (yale.edu)
We compared levels of transcripts in the ERα-associated "luminal" signature that defines this subtype of tumors in women and transcripts enriched in various mammary epithelial lineages to other well-studied genetically modified murine models of breast cancer. (biomedcentral.com)
Specifically, recent studies show that aberrant regulation of alternative splicing frequently occurs in cancer to affect tumor cell transformation and growth. (biomedcentral.com)
Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (sncrf.org)
The following text points out several possibilities and chemical pathways in which "Intume" chlorine dioxide intervention can destroy tumors and prevent proliferation of cancer cells. (justia.com)
Chlorine dioxide (ClO2), a strong oxidant, can safely be injected into a subject's body, including a tumor, although the compound has not yet been utilized as a cancer treatment in this manner. (justia.com)
Cancer cells are rich in polyamines which is necessary for survival and growth of tumors. (justia.com)
This can be used before surgery to shrink the tumour, or after surgery to kill any remaining cancer cells. (withoutaribbon.org)
TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma. (cdc.gov)

Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
Hence altogether, the final report concluded that carcinosarcoma is the most likely correct diagnosis. (cytojournal.com)
The frozen section diagnosis was at least mucinous borderline tumor. (hindawi.com)

Thirty seven women with granulosa cell tumor were enrolled for the study between 2000 and 2013. (uwi.edu)
Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)
Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome. (cancercentrum.se)
Bjorkholm E, Silfversward C. Granulosa- and theca-cell tumors. (cancercentrum.se)

With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
Due to multiple, potential underlying molecular tumor aberrations, clinical treatment protocols are not well-defined. (bvsalud.org)

Changes in any of several genes are involved in the formation of Wilms tumor. (medlineplus.gov)
Wilms tumor has also been seen in individuals with Beckwith-Wiedemann syndrome , which can be caused by changes in the genomic imprinting of the IGF2 and H19 genes. (medlineplus.gov)
Wilms tumor can be a feature of other genetic conditions caused by variants in other genes. (medlineplus.gov)
Many children with Wilms tumor do not have identified variants in any of the known genes. (medlineplus.gov)
It is likely that other, unknown genes are also associated with the development of Wilms tumor. (medlineplus.gov)

WT1 , CTNNB1 , and AMER1 gene variants all lead to the unchecked proliferation of cells, allowing tumor development. (medlineplus.gov)

In most cases of Wilms tumors involving one kidney and nearly all cases involving both kidneys, the tumors are thought to arise from immature kidney tissue that never developed properly. (medlineplus.gov)
Nonepithelial malignant neoplasms sometimes arise in mucinous tumors, typically as mural nodules. (hindawi.com)
Carcinosarcomas typically arise within the endometrial cavity. (medscape.com)

In multivariate regression analyses tumor differentiation was found to be significantly associated with the disease recurrence (OR:8.2,CI 95%: 0,019-0,771). (uwi.edu)
Tumor differentiation is found to be a significant confounder for the disease recurrence after adjustment for the stage. (uwi.edu)
These tumors were distinct from mouse mammary tumor virus (MMTV)-neu tumors, and contained elevated transcripts for factors associated with luminal/alveolar expansion and differentiation, suggesting that they arose from physiologic targets of prolactin. (biomedcentral.com)
These features were shared by ERα+ and ERα- tumors, suggesting a common origin, although the former exhibited transcript profiles reflecting greater differentiation. (biomedcentral.com)

The purpose of this report is to describe the features of angiosarcoma arising in mucinous tumor that was misinterpreted as a benign vascular proliferation during the intraoperative consultation. (hindawi.com)

Carcinosarcoma is unique in that it contains two types of cells: Carcinomatous (epithelial tissue) and sarcomatous (connective tissue). (gcsproject.org)

The cervical smear findings showed both cellular components which raised the suspicion of carcinosarcoma. (cytojournal.com)
These findings highlight the importance of the dysregulation of chromatin remodelling in carcinosarcoma tumorigenesis and suggest new avenues for personalized therapy. (nih.gov)

Histopathological examination of the tumor mass revealed an admixture of spindle cells and epithelioid cells. (cytojournal.com)

1, 2016, entitled "A New Method for Promoting Tumor Necrosis" and provisional application Ser. (justia.com)

Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03/20/2018) 11. (sncrf.org)
Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) 29. (sncrf.org)
Adrenal cortical tumors (closed to accrual 06/27/2018) 32. (sncrf.org)

When AR+/ER-/PR- tumors were compared to AR-/ER-/PR- tumors, KRAS (1.5% vs. 10.8%, p=1.5E-6) and PIK3CA (3.4% vs. 9.3%, p=0.001) differences and cMET expression (11.3% vs. 19%, p=0.001) remain significant. (carislifesciences.com)

Different patterns of malignant change occur in pleomorphic adenoma , of which true malignant mixed tumor (carcinosarcoma) is one form. (medscape.com)

The focus was gene expression profiles based on proteome and RNA measurements of intra-tumor heterogeneity from the same patient and inter-tumor heterogeneity in nodular, infiltrative, and superficial BCC tumor subtypes from different patients. (bvsalud.org)
We observed significant overlap in intra- and inter-tumor variability of proteome and RNA expression profiles, showing significant multisite heterogeneity of protein expression in the BCC tumors. (bvsalud.org)

Large prospective epidemiologic studies have correlated circulating levels of PRL with an increased risk of particularly estrogen receptor positive (ERα+) invasive tumors [ 2 ]. (biomedcentral.com)

In some cases of Wilms tumor, abnormalities in the process of genomic imprinting on chromosome 11 lead to a loss of H19 gene activity and increased activity of the IGF2 gene in kidney cells. (medlineplus.gov)

Diseases8

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Information Science1

Health Care1

Uterine15

Germ cell t6

Ovarian11

Uterus11

Neoplasm3

MMMT5

Pathology1

Solid tumors5

Mammary tumors2

Biphasic tumor1

Serous Carcinoma1

Mesodermal1

Ovary10

Epidemiology1

Endometrium1

Extragonadal germ tumors1

Stromal3

Carcinomas4

Mesenchymal5

Group of tumors1

Salivary9

Sarcomatoid3

Developing Wilms tumor1

Origin of carcinosarcomas2

Adenocarcinoma7

Metastasis2

Neuroendocrine2

Brain tumors4

Mutations5

Primary tumors2

Recur3

Metastatic2

Original tumor1

Prognostic4

Cancer14

Diagnosis3

Granulosa4

Molecular2

Genes5

Variants1

Arise3

Differentiation4

Proliferation1

Connective tissue1

Findings2

Spindle1

Necrosis1

20183

PIK3CA1

Pleomorphic1

Heterogeneity2

Invasive1

Genomic1