• Thrombospondin type 1 domain-containing 7A ( THSD7A ) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). (hindawi.com)
  • Therefore, it is important to explore candidate genes that could have significance to the clinical diagnosis, as well as the treatment of esophageal squamous cell carcinoma (ESCC) at the molecular level [ 4 ]. (hindawi.com)
  • The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)
  • To explore the pathologic significance of calponin 2 in esophageal squamous cell carcinoma, the expression level of calponin 2 proteins in the tumor tissue of 190 esophageal squamous cell carcinoma patients was examined with immunohistochemistry while the expression level of calponin 2 messenger ribonucleic acid was analyzed by using the data from The Cancer Genome Atlas database. (ijpsonline.com)
  • Both the calponin 2 messenger ribonucleic acid and protein level were increasingly expressed in the tumor tissues of esophageal squamous cell carcinoma patients compared with the adjacent non-tumor tissue and correlated negatively with the tumor grade. (ijpsonline.com)
  • Calponin 2 was shown to be an independent factor influencing the overall survival of the esophageal squamous cell carcinoma patients. (ijpsonline.com)
  • Esophageal Squamous Cell Carcinoma (ESCC) and esophageal adenocarcinoma[ 2 , 3 ]. (ijpsonline.com)
  • For esophageal squamous cell cancer, we consider standard therapy to be definitive chemoradiation with observation. (cancernetwork.com)
  • Distant metastases arise in 20-30% of patients with squamous cell carcinoma of the head and neck (HNSCC) in the 2 years following treatment. (cipsm.de)
  • This article refers to a review about head and neck squamous cell carcinoma (HNSCC), which involves about 90% of all head and neck cancers, originated from the squamous lining of the upper aero digestive tract, including the oral cavity, pharynx, larynx and sinonasal tract. (bvsalud.org)
  • In the upcoming years, understanding the immunobiology of head and neck squamous cell carcinoma will be accompanied simultaneously by important advances in the early detection of high-risk patients, based on the identification of biomarkers, on the manipulation of the immune system and on the understanding of the pharmacogenomics. (bvsalud.org)
  • One was a chordoma, a rare type of bone cancer, and the other was a squamous cell carcinoma of the head and neck. (medscape.com)
  • Cancer stem cells (CSC) drive growth, therapy resistance, and recurrence in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
  • SIGNIFICANCE: Inhibiting protein elongation with SVC112 reduces tumor growth in head and neck squamous cell carcinoma and increases the effects of radiation by targeting the cancer stem cell pool. (nih.gov)
  • These membranes are made up of squamous cells and the head and neck cancers that grow in these cells are called squamous cell carcinomas. (cancer.gov)
  • 1 In 2010, about 36,000 Americans are estimated to have been diagnosed with head and neck cancers and an estimated 7,880 were expected have died of squamous cell carcinomas. (cancer.gov)
  • The integration of HPV, a virus harboring oncoproteins E6 and E7 that cause HPV positive head and neck squamous cell carcinomas, is linked to increased somatic copy number variants. (cancer.gov)
  • Molecular characteristics may help clinicians improve the specificity of the diagnosis and treatment of head and neck squamous cell carcinomas. (cancer.gov)
  • Head and Neck Squamous Cell Carcinoma Study was originally published by the National Cancer Institute. (cancer.gov)
  • Since many basal or squamous cell carcinomas are on the face and neck, surgery to remove them can leave people with facial scars. (kidshealth.org)
  • The purpose of this work was to evaluate the potential of functional imaging with 18 F-FDG PET, 18 F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI to provide an appropriate and reliable biologic target for dose painting in radiotherapy for head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
  • Since its introduction in the previous decade, intensity-modulated radiotherapy has been widely applied in head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
  • BACKGROUND: Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding of fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). (lu.se)
  • Metallothionein stroma reaction in tumor adjacent healthy tissue in head and neck squamous cell carcinoma and breast adenocarcinoma. (nel.edu)
  • The aim of our study was to evaluate the MT expression in head and neck squamous cells carcinoma and breast adenocarcinoma and their histologically healthy adjacent tissue. (nel.edu)
  • Mutations in the CDKN2A gene are found in up to one-quarter of head and neck squamous cell carcinomas (HNSCC). (medlineplus.gov)
  • Malignant tumors of the oral cavity account for approximately 30% of all head and neck cancers and for 5% of all cancers in the United States. (medscape.com)
  • Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor and is ranked the eighth leading cause of cancer worldwide. (nature.com)
  • We are presently exploiting such intra-tumor diversity as a basis to improve the marginal efficacy of current targeted agents in head and neck cancer therapy with new drug combinations. (upenn.edu)
  • The introduction of HPV vaccines has also drawn more attention to the fact that HPV is associated not only with cervical cancer and genital warts but also with other tumors, such as head neck and anogenital cancers ( 3 ). (cdc.gov)
  • We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
  • Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)
  • Overview of Head and Neck Tumors Head and neck cancer develops in almost 65,000 people in the United States each year. (msdmanuals.com)
  • 90% of head and neck cancers are squamous cell (epidermoid) carcinomas. (msdmanuals.com)
  • The shells of tumors that metastasize to the head and neck are richer in vascularity than the tumor tissue itself. (medscape.com)
  • A nomogram based on a gene signature for predicting the prognosis of patients with head and neck squamous cell carcinoma. (cdc.gov)
  • Diagnostic Tumor Markers in Head and Neck Squamous Cell Carcinoma (HNSCC) in the Clinical Setting. (cdc.gov)
  • Interference of tumour mutational burden with outcome of patients with head and neck cancer treated with definitive chemoradiation: a multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group. (cdc.gov)
  • About 2 out of 10 skin cancers are squamous cell carcinomas (also called squamous cell cancers). (hospiceofqueenannes.com)
  • These cancers start in the flat cells in the upper (outer) part of the epidermis. (hospiceofqueenannes.com)
  • Larger squamous cell cancers are harder to treat, and fast-growing cancers have a higher risk of coming back. (hospiceofqueenannes.com)
  • In rare cases, squamous cell cancers can spread to lymph nodes or distant parts of the body. (hospiceofqueenannes.com)
  • Esophageal adenosquamous carcinoma (ASC) is a rare tumor with characteristics of adenocarcinoma (AC) and squamous cell carcinoma (SCC), the two most common esophageal cancers. (nih.gov)
  • Cell cycle proteins are altered in differently in HPV-positive and HPV-negative cancers, suggesting that treating these cancers should be treated according to their subtype. (cancer.gov)
  • The main treatment for skin cancers is cutting the tumors out. (kidshealth.org)
  • Once universally fatal, Pancoast tumors are currently treatable with outcomes similar to those of other stage-matched non-small cell lung cancers. (medscape.com)
  • Pancoast tumors are a subset of lung cancers that invade the apical chest wall. (medscape.com)
  • Melanocytes are a type of skin cells, and cancers that grow from these cells are called melanoma skin cancers. (medicalnewstoday.com)
  • The p53 tumour suppressor protein is a key component of one such stress-response pathway, and virtually all cancers loose functionality of the p53-stress response pathway. (southampton.ac.uk)
  • In general, most patients who develop squamous cell cancers have comorbidities, since this is a cancer related to smoking and drinking. (cancernetwork.com)
  • Large-cell carcinomas are a group of cancers with large cells that tend to start along the lungs' outer edges. (webmd.com)
  • They're rarer than adenocarcinoma or squamous cell carcinoma, making up 10%-15% of lung cancers. (webmd.com)
  • Small-cell lung cancer makes up 10%-15% of lung cancers. (webmd.com)
  • This study estimated the relative frequencies of oral and pharyngeal cancers among Yemeni cancer patients registered in 2007 and 2008 and determined patients' demographic and tumour characteristics. (who.int)
  • La présente étude a estimé les fréquences relatives du cancer de la cavité buccale et du pharynx chez des patients yéménites atteints de cancers enregistrés en 2007 et 2008. (who.int)
  • Lips cancers are relatively uncommon tumors in the black people. (bvsalud.org)
  • It is a tumor suppressor in various tumors, including LC and breast cancer (BC). (hindawi.com)
  • MicroRNA-143 serves as a tumor suppressor in many human malignancies. (geneticsmr.com)
  • Tumor protein 53 ( TP53 ) is a recognized tumor suppressor gene located on chromosome 17q13.1. (spandidos-publications.com)
  • The p53 protein is an important tumor suppressor that is essential for regulating cell division, senescence, and self-destruction (apoptosis). (medlineplus.gov)
  • It can also turn off tumor suppressor genes, which help protect the body from cancerous growths. (medicalnewstoday.com)
  • In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
  • Prognosis and treatment effectiveness varies based on type of cancer, degree of local tissue destruction, evidence of spread to other organs (metastasis) and location of the tumor. (wikipedia.org)
  • The K-M survival analysis indicated that SCARA5 expression quantity was not related to prognosis, but tumor volume and T classification were both the independent prognostic factors. (hindawi.com)
  • Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor−node−metastasis prognosis classification. (nature.com)
  • Standard multimodal management of OSCC is based on the tumor−node−metastasis (TNM) classification 2 , in which the tumor size and location and the presence of metastasis are used to define OSCC prognosis and treatment in the clinical setting 3 . (nature.com)
  • [ 7 ] notably Sudan and Egypt, where squamous cell carcinoma ranges from two thirds to three quarters of all malignant tumors of the bladder. (medscape.com)
  • Liposarcomas are malignant tumors of the lipocytes ( fat cells ) and are not commonly found in pet birds. (ivis.org)
  • Esophageal cancer is one of the most common malignant tumors. (spandidos-publications.com)
  • Malignant tumors can spread and cause harm to the animal. (merckvetmanual.com)
  • Malignant tumors can invade surrounding tissue and spread to distant organs. (merckvetmanual.com)
  • Although malignant tumors of the floor of the mouth develop most commonly after the fifth decade of life, they are not uncommon in younger persons. (medscape.com)
  • This was originally thought to be benign based on FNA findings however was found to harbor invasive squamous cell carcinoma on final pathology . (bvsalud.org)
  • Targeting α5β1 integrins might not only prevent metastasis of HNSCC but also delay the development of the primary tumor by reducing tumor cell viability. (cipsm.de)
  • We further provided evidence that IL-37 inhibited effectively tumor metastasis in vitro and in vivo . (nature.com)
  • Given the crucial roles of Rac1 in tumor angiogenesis and metastasis, intracellular mature IL-37 might serve as a potential strategy for the control of Rac1 activity and tumor progression. (nature.com)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • In summary, we identify a robust signature, which may enhance prognostic decisions in OSCC and better guide treatment to reduce tumor recurrence or lymph node metastasis. (nature.com)
  • SVC112 had greater antiproliferative effects on HNSCC cells compared with the FDA-approved translation inhibitor omacetaxine mepesuccinate (HHT). (nih.gov)
  • SVC112 alone inhibited the growth of patient-derived xenografts (PDX), and SVC112 combined with radiation resulted in tumor regression in HPV-positive and HPV-negative HNSCC PDXs. (nih.gov)
  • In HNSCC, 18 F-FDG PET has a clear impact on both primary tumor delineation and cervical lymph node staging ( 5 , 6 ). (snmjournals.org)
  • However, most findings come from an era when p16-negative HNSCC was the dominant tumor type. (lu.se)
  • The estimated α/β-ratio for p16-positive oropharyngeal tumors aligns with previous HNSCC studies, whereas the impact of prolonged OTT was slightly less than previously reported. (lu.se)
  • Accumulating evidences indicate that it is also involved in tumor progression. (nature.com)
  • SVC112 increased cell-cycle progression delay and slowed DNA repair following radiation, enhancing colony and sphere formation radiation effects. (nih.gov)
  • These findings validate the clinical significance of miR-143 in OSCC and reveal that it may be an intrinsic regulator of tumor progression and a potential prognostic factor for this disease. (geneticsmr.com)
  • However, binding of p16(INK4A) blocks CDK4's or CDK6's ability to stimulate cell cycle progression. (medlineplus.gov)
  • Patients with CD24-high tumors also tended to have a higher risk of disease progression and cancer-related death. (scienceblog.com)
  • furthermore, age correlated with progression free survival and cancer-specific survival, regardless of tumor histology. (scienceblog.com)
  • As a result, rapid compensation to targeting these pathways occurs not only at the level of signaling networks in individual cells but also through dynamics among diverse cell states cooperatively sustaining cancer progression. (upenn.edu)
  • Because many urothelial carcinomas contain a minor squamous cell component, a diagnosis of squamous cell carcinoma of the bladder should be rendered only when the tumor is solely composed of a squamous cell component in the absence of a conventional urothelial carcinoma component. (medscape.com)
  • Adeno-carcinoma is the predominant type and is included in the criteria established by Finn and Javert for diagnosis of primary carcinoma of fallopian tube [2]. (amrita.edu)
  • The final histologic diagnosis is commonly squamous cell carcinomas (SCC) in older animals. (ivis.org)
  • Prior to the revision of the TNM staging, the most important conventional prognostic factor for patient survival was tumor stage at the time of diagnosis, including tumor size, pleura invasion, involvement of regional lymph nodes and metastatic spread to distant organs. (scienceblog.com)
  • That ultimately led to my diagnosis of lacrimal sac squamous cell carcinoma with metastases to the parotid gland. (mdanderson.org)
  • however, early SCC has been shown to hide within benign appearing lesions, such as vascular tumors , resulting in missed diagnoses and delay in treatment . (bvsalud.org)
  • Colloid carcinoma begins as a benign cyst called an intraductal papillary mucinous neoplasm (IPMN). (uclahealth.org)
  • These tumors can be benign or cancerous. (uclahealth.org)
  • Tumors may be benign or malignant (cancerous). (merckvetmanual.com)
  • Benign tumors are not invasive, do not spread to other areas of the body, and are easy to remove surgically. (merckvetmanual.com)
  • Distinguishing a benign tumor from a cancerous tumor requires specialized knowledge and laboratory equipment. (merckvetmanual.com)
  • For benign tumors that are not ulcerated and do not impair the dog's normal routine, treatment may not be necessary. (merckvetmanual.com)
  • There are several treatment options for cancerous tumors and benign tumors that inhibit normal activities or are cosmetically unpleasant. (merckvetmanual.com)
  • The tumor grows quickly and is highly invasive. (ivis.org)
  • Hemangiosarcomas are locally invasive and multicentric ( having two or more primary tumors ). (ivis.org)
  • We report a case of simultaneous Squamous cell carcinoma(SCC) of cervix and fallopian tube (invasive). (amrita.edu)
  • These apical lung tumors tend to be locally invasive early. (medscape.com)
  • The presence of erythroplasia strongly suggests an invasive tumor. (medscape.com)
  • Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) and inner tumor to identify differentially expressed proteins. (nature.com)
  • The first is the location of the tumor, and the second is the histology of the cancer. (cancernetwork.com)
  • Disappearance of Cav1 enables cells to undergo epithelial-mesenchymal transition (EMT). (cipsm.de)
  • Is squamous cell carcinoma an epithelial tumor? (hospiceofqueenannes.com)
  • Is carcinoma an epithelial cancer? (hospiceofqueenannes.com)
  • Carcinoma refers to a malignant neoplasm of epithelial origin or cancer of the internal or external lining of the body. (hospiceofqueenannes.com)
  • Carcinomas, malignancies of epithelial tissue, account for 80 to 90 percent of all cancer cases. (hospiceofqueenannes.com)
  • Does squamous cell carcinoma affect epithelial tissue? (hospiceofqueenannes.com)
  • What is epithelial carcinoma? (hospiceofqueenannes.com)
  • What does epithelial squamous mean? (hospiceofqueenannes.com)
  • The squamous epithelium is composed of epithelial cells that are distinctively flat and scale-like. (hospiceofqueenannes.com)
  • SCCs arise from epithelial tissues that can be classified as stratified squamous epithelium (which includes epithelia of skin, oesophagus and oral cavity) and non-squamous epithelia (which include airway epithelium). (hospiceofqueenannes.com)
  • SCARA5 expression is significantly downregulated in various tumor tissues including liver cancer (LC), rectal cancer, and glioblastoma [ 15 , 16 ] and might affect cell proliferation and invasion abilities by the focal adhesion kinase (FAK) signaling pathway and epithelial-mesenchymal transition (EMT) [ 5 , 17 - 20 ]. (hindawi.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • Mixed mesenchymal and epithelial tumors are of Mullerian origin. (cytojournal.com)
  • In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. (degruyter.com)
  • In addition, SCARA5 repressed OSCC cell epithelial-mesenchymal transformation (EMT), evidenced by increased E-cadherin expression and reduced N-cadherin expression. (degruyter.com)
  • For example, the epithelial−mesenchymal transition phenotype presents more cells with a lower degree of differentiation and greater cell dissociation in the ITF than in other tumor areas 14 , 15 . (nature.com)
  • The May edition of the Journal of Thoracic Oncology features a study aimed to clarify expression patterns of a novel cancer biomarker, CD24, in non-small cell lung carcinomas (NSCLC) and to correlate the findings to clinicopathologic variables, such as performance status, age, gender and prognostic significance. (scienceblog.com)
  • However, high viral loads within cells are strongly correlated with more severe clinical signs and aggressive lesions. (wikipedia.org)
  • Tumor-related studies have shown the clinical application and research prospects of this gene, suggesting that it might play the important role in the treatment of tumors. (hindawi.com)
  • Al-Arashi MY, Byers HR. Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization. (dermnetnz.org)
  • Although other tumors may have a similar clinical presentation because of their location at the thoracic inlet, the most common cause is believed to be a bronchogenic carcinoma arising in or near the superior sulcus and invading adjacent extrathoracic structures by direct extension. (medscape.com)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
  • Oral squamous cell carcinoma (OSCC) is the most common malignancy affecting the oral cavity and commonly presents as an exophytic lesion with red or white granular ulcerations. (bvsalud.org)
  • The goal of this case report is to provide a background on the variable presentations of OSCC, vascular tumors , and uncommon presentations for which specialists should be aware of in their practice. (bvsalud.org)
  • However, its involvement in oral squamous cell carcinoma (OSCC) is still unclear. (geneticsmr.com)
  • Further, the effects of miR-143 on the biological behavior of OSCC cells were investigated. (geneticsmr.com)
  • miR-143 expression was significantly downregulated in OSCC tissue samples and cell lines. (geneticsmr.com)
  • Summary Objective The treatment strategies for advanced oral squamous cell carcinoma (OSCC), especially with necrotic changes, are not effective. (ntu.edu.tw)
  • Moderate-to strong HIF-1α nuclear staining in >10% and cell surface PD-L1 expression in >5% of OSCC cells were recorded as a positive result. (ntu.edu.tw)
  • Results For advanced OSCC with necrotic changes, there was substantial agreement in primary tumor (kappa value 0.54) and almost perfect agreement in metastatic LN (kappa value 0.86) between HIF-1α and PD-L1 expression. (ntu.edu.tw)
  • Oral squamous cell carcinoma (OSCC) is a common tumor in the world. (degruyter.com)
  • Mali showed that p-STAT3 was positively expressed in OSCC cell lines [ 15 ]. (degruyter.com)
  • A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • Recently, in Finland, the United Kingdom, the Netherlands, the United States, and Sweden, incidence of OSCC has increased, and an increase in the proportion of HPV-positive tumors was noted. (cdc.gov)
  • HPV infection has been reported to correlate with several cancer types, especially squamous cell carcinomas. (biochain.com)
  • [ 29 ] The presence of eggs was associated with the development of cancer at a younger age and with a predominance of squamous cell carcinoma, relative to egg-negative cases. (medscape.com)
  • What is the difference between cancer and carcinoma? (hospiceofqueenannes.com)
  • Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. (hospiceofqueenannes.com)
  • Like other types of cancer, carcinomas are abnormal cells that divide without control . (hospiceofqueenannes.com)
  • Does carcinoma mean cancer? (hospiceofqueenannes.com)
  • The cancer is larger than 2 centimeters across, and has not spread to nearby organs or lymph nodes , or a tumor of any size with 2 or more high risk features. (hospiceofqueenannes.com)
  • Squamous-cell carcinoma is the second-most prevalent skin cancer, followed by melanoma. (wikipedia.org)
  • Blood Test Positive for Cancer, but Is There Really a Tumor? (medscape.com)
  • Experiments in the literature on liver cancer (LC) were repeated to verify the functions of these genes in different tumors. (hindawi.com)
  • SVC112 preferentially inhibited cancer cells compared with patient-matched cancer-associated fibroblasts, whereas HHT was equally toxic to both. (nih.gov)
  • Dublin, May 26, 2023 (GLOBE NEWSWIRE) -- The "Squamous-Cell Carcinoma of the Larynx in the United States, 2022-2042: Cancer Populations USA Report and Data Dashboard" report has been added to ResearchAndMarkets.com's offering. (globenewswire.com)
  • Cancer cells frequently display intrinsic or acquired resistance to chemically diverse anticancer drugs, limiting therapeutic success. (nature.com)
  • A rare pancreatic cancer made up of squamous cells that originate in the pancreatic ducts. (uclahealth.org)
  • This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. (rush.edu)
  • The TP53 gene mutation is the most common gene alteration in many tumors, including esophageal cancer. (spandidos-publications.com)
  • Previous studies demonstrated that p53 was highly expressed in esophageal cancer tissue and was associated with tumor malignancy ( 15 - 17 ). (spandidos-publications.com)
  • Carcinoma cervix is not the only cancer caused by HPV. (cytojournal.com)
  • Further, in esophageal cancer tumor tissue, calponin 2 gene was found to co-express with genes associated with tight junction and the expression level of calponin 2 was observed to correlate significantly with the number of infiltrating immune cells. (ijpsonline.com)
  • These results supported the idea that calponin 2 is involved in esophageal cancer and may function as a tumor inhibitor probably through modulating cancer cells tight junction and tumor immunity. (ijpsonline.com)
  • An accumulation of genetic alterations forming the field of cancerization is an important event for the transformation from normal to cancer cell in multistep carcinogenesis. (nel.edu)
  • Histopathologically healthy tumor adjacent tissue might be considered as a cancerization field which is typified by genetic changes required for the development of cancer. (nel.edu)
  • Without one of these tumor suppressors, cells can grow and divide unchecked, leading to the development of cancer. (medlineplus.gov)
  • Mutations in the CDKN2A gene are also associated with melanoma, a type of skin cancer that begins in pigment-producing cells called melanocytes. (medlineplus.gov)
  • CDKN2A gene mutations involved in cancer impair production of functional p16(INK4A) or, less commonly, p14(ARF), which can result in uncontrolled cell growth and tumor formation. (medlineplus.gov)
  • Stress-response pathways play a key role in the patho-physiology and treatment of many diseases, including cancer.At almost every stage of the development of a tumour, cells are exposed to some form of stress. (southampton.ac.uk)
  • Many current and prospective treatments for cancer work by either inhibiting, or re-activating stress response pathways.Our work focuses on the role of regulators of gene transcription in the response of cancer cells to stress. (southampton.ac.uk)
  • We have also developed interests in other pathways which regulate gene transcription and cancer cell proliferation in response to stress and changes in cell metabolism. (southampton.ac.uk)
  • In the late 1990s work from a number of groups, including Blaydes et al , demonstrated that HDM2 could be targeted in cancer cells to re-activate the p53 stress-response pathway. (southampton.ac.uk)
  • We have undertaken a series of projects examining how HDM2, and its paralogue HDMX is regulated in cancer cells (see Phillips et al, 2010, 2008, 2007, 2006a, 2006b and Phelps et al 2005, 2003). (southampton.ac.uk)
  • Role of CtBP transcriptional repressors in cancer cell proliferation and survival In common with p53, CtBP1 and CtBP2 proteins were discovered through their physical association with a viral oncoprotein. (southampton.ac.uk)
  • To discuss current and emerging therapy options for esophageal cancer, ONCOLOGY spoke with Geoffrey Y. Ku, MD, a medical oncologist at Memorial Sloan Kettering Cancer Center in New York, who specializes in the treatment of malignancies of the gastrointestinal tract, including esophageal tumors. (cancernetwork.com)
  • and a type III tumor is a proximal gastric cancer extending upwards to the gastroesophageal junction. (cancernetwork.com)
  • The CROSS trial, conducted in the Netherlands, reported a pathologic response rate of almost 50% for patients with squamous cell cancer of the esophagus who received chemoradiation. (cancernetwork.com)
  • I am studying skin cancer, particularly squamous cell carcinoma and keratoacanthoma. (yale.edu)
  • Oral cavity cancer treatment, particularly for advanced tumors (because of radical surgery), destroys the integrity of this area. (medscape.com)
  • Squamous cell carcinoma is cancer that begins in the squamous cells of the skin. (merckmanuals.com)
  • Squamous cell carcinoma is cancer of these cells. (merckmanuals.com)
  • However, people who have had more sun exposure to their skin have a higher risk of developing squamous cell skin cancer. (merckmanuals.com)
  • I was then referred to an ENT cancer specialist, who performed surgery to remove the tumor near my eye. (mdanderson.org)
  • Since the cancer cells had spread to my parotid gland, Dr. Gunn decided that I needed surgery before proton therapy and chemotherapy. (mdanderson.org)
  • In the process, we have developed the ability to analyze heterogeneity and phenotypic plasticity within cancer cell lines, patient-derived xenografts, and primary human cancer samples based on molecular and functional criteria. (upenn.edu)
  • My NIH-funded research enterprise brings a cutting edge molecular perspective to surgical cancer care while optimizing use of tumors that I remove from patients to advance the science of cancer therapy. (upenn.edu)
  • The two main types are non-small-cell lung cancer and small-cell lung cancer . (webmd.com)
  • RÉSUMÉ Des études en milieu hospitalier ont révélé des fréquences relatives très élevées du cancer oropharyngé au Yémen. (who.int)
  • For the included cases, Of the 541 cases of oropharyngeal are believed to reflect different preva- tumour staging was reclassified and cancer 19.2%, 11.8%, 8.7% and 7.8% lences and patterns of risk habits such coded according to the SEER summary were referred from Al-Hodeida, Taiz, as khat chewing and waterpipe smoking staging manual 2000 [16]. (who.int)
  • The registers of oropharangeal cancer cases the area in the world with the highest inci- were reviewed to collect personal and clini- dence of oral cancer was Melanesia (31.5 cal data about the site, size, histopathologi- per 100 000 in men and 20.5 per 100 000 cal type, grading and staging of the tumour. (who.int)
  • Using Diacarta's QuantiVirus™ HPV E6/E7 RNA test, BioChain offers HPV-characterized H&N and cervix squamous cell carcinoma tissue sections from various donors as control. (biochain.com)
  • Histologically, sarcoids are composed of fibroblasts (collagen producing cells) that invade and proliferate within the dermis and sometimes the subcutaneous tissue but do not readily metastasize to other organs. (wikipedia.org)
  • Tumors affecting the skin or the tissue just under the skin are the most commonly seen tumors in dogs. (merckvetmanual.com)
  • A veterinarian can perform a fine needle aspiration of cells or a biopsy (which removes a small amount of tissue from a tumor) for evaluation. (merckvetmanual.com)
  • If malignancy is suspected, tissue surrounding the tumor will also be removed to increase the chance that none of the tumor cells are left behind. (merckvetmanual.com)
  • Patients with higher calponin 2 in the tumor tissue were found to have longer overall survival time. (ijpsonline.com)
  • To explore the possible pathological significance of calponin in ESCC, in this study, we first examined the expression of calponin isoforms in the tumor tissue of ESCC patients and further explored their association with the disease. (ijpsonline.com)
  • Lung tissue that was scarred by a disease or infection, such as scleroderma or tuberculosis , becomes at risk for tumors in that tissue. (webmd.com)
  • Keratinous squamous metaplasia has been associated with an increased risk of developing squamous cell carcinoma, with approximately one half of the cases arising subsequent to the metaplasia. (medscape.com)
  • We report a case of chronic Schistosoma haematobium infection with pseudometastatic pulmonary nodules and high-grade squamous cell carcinoma in a 30-year-old man in Mali. (cdc.gov)
  • The lower anogenital squamous terminology (LAST), an acronym for LAST, incorporates the low- and high-grade squamous intraepithelial lesion (HSIL) terminology. (cytojournal.com)
  • The region where there is a transition from squamous to columnar epithelium in cervix is transformation zone. (cytojournal.com)
  • No benefit of addition of other biomarkers like p63 or ki67 is found in problem-solving in differentiation of HSIL from mimics or low-grade squamous intraepithelial lesion. (cytojournal.com)
  • Worldwide, the incidence of squamous cell carcinoma of the bladder varies. (medscape.com)
  • Cyclophosphamide chemotherapy has also been reported to increase the incidence of squamous cell carcinoma of the bladder. (medscape.com)
  • HPV-negative tumors contained novel co-amplifications of 11q13 and 11q22, an event that likely promotes the interaction of BIRC2 and FADD , genes that together work to inhibit cell death. (cancer.gov)
  • Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes. (rush.edu)
  • Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
  • Somatic mutations in other genes involved in cell growth are also needed for a melanoma to develop. (medlineplus.gov)
  • In other situations the response is cell cycle arrest or programmed cell death (apoptosis), providing a barrier to further tumour development that the tumour may ultimately circumvent through the acquisition of a mutation in one of the genes within the stress-response pathway. (southampton.ac.uk)
  • In single celled organisms these pathways are generally involved in ensuring the survival and replication of the individual cell. (southampton.ac.uk)
  • CtBP activity is modified by UV radiation and glycolytic metabolism, suggesting that CtBPs regulate cell survival in response to cellular stress. (southampton.ac.uk)
  • The average survival time of patients with tumor recurrence was 28 months postoperatively. (ivis.org)
  • Hypervascular floor of mouth tumor: Rare presentation of oral cavity squamous cell carcinoma. (bvsalud.org)
  • Early oral squamous cell carcinoma in the buccal mucosa arising from a chronic candidal leukoplakia in a person who smokes heavily. (medscape.com)
  • Tumor is sometimes visible in the oral or nasal cavities. (msdmanuals.com)
  • Tumour recurrence did not appear to reduce the life expectancy. (ivis.org)
  • Several studies have found an association between the presence of Bovine papillomavirus-1 and 2 and associated viral growth proteins in skin cells with sarcoid formation, but the exact mechanism that controls or induces epidermal proliferation remains unknown. (wikipedia.org)
  • In addition, upregulation of miR-143 in Tca8113 cells reduced cell proliferation, invasion, and migration, as well as promoted cell apoptosis in vitro . (geneticsmr.com)
  • Functional imaging, that is, modalities that offer information on factors that influence treatment outcome (e.g., tumor burden, proliferation, and hypoxia), is expected to provide the biologic target volume for such dose painting ( 2 , 3 ). (snmjournals.org)
  • Without p16(INK4A) to regulate cell growth and division (proliferation), cells can continue to grow and divide without control, which can lead to tumor formation. (medlineplus.gov)
  • SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
  • I am also interested in mechanisms of carcinogenesis, particularly as they relate to squamous cell carcinoma of the skin and a spontaneously regressing tumor called keratoacanthoma. (yale.edu)
  • Squamous carcinogenesis: Potential truncal mutations Tang H, Seykora J, Ko C . Squamous carcinogenesis: Potential truncal mutations. (yale.edu)
  • Are squamous cells always cancerous? (hospiceofqueenannes.com)
  • Other parts of the body including the lungs, mucous membranes, and urinary tract also have layers of squamous cells, which may also become cancerous . (hospiceofqueenannes.com)
  • This type of cancerous tumor occurs in the moist lining of the mouth, nose, and throat. (medlineplus.gov)
  • Recent advances in surgical techniques, particularly endoscopic techniques, can sometimes achieve complete tumor excisions, spare surrounding tissues, and achieve reconstruction. (msdmanuals.com)
  • Carcinomas may spread to other parts of the body, or be confined to the primary location. (hospiceofqueenannes.com)
  • Paired paraffin-embedded primary tumor and metastatic lymph nodes (LN) sections were stained with antibodies against hypoxia-inducible factor-1α (HIF-1α) and PD-L1. (ntu.edu.tw)
  • Congruently, primary tumor volume has proven to be an important parameter. (lu.se)
  • The current study aims to investigate the role of primary tumor volume, OTT and estimate α/β-ratio for p16-positive OPSCC, and to quantify the differences in radiosensitivity depending on p16-status. (lu.se)
  • METHODS: A cohort of 523 patients treated with RT was studied using a tumor control probability (TCP)-model that incorporates primary tumor volume (V) raised to an exponent c, OTT and α/β-estimation. (lu.se)
  • CONCLUSION: Primary tumor volume plays a crucial role in predicting local tumor response, particularly in p16-positive OPSCC. (lu.se)
  • Primary carcinoma of the fallopian tube is a rare neoplasm, accounting for only 0.3-1.1% of all gynecological malignancies [1]. (amrita.edu)
  • Squamous cells are the thin, flat cells that make up the epidermis, or the outermost layer of the skin. (hospiceofqueenannes.com)
  • UVA rays penetrate to the lower layers of the epidermis, where they trigger cells called melanocytes (pronounced: mel-AN-oh-sites) to produce melanin . (kidshealth.org)
  • Squamous cell carcinoma starts in the upper region of the epidermis, the top layer of skin. (medicalnewstoday.com)
  • Squamous cells (keratinocytes) are the main structural cells of the epidermis (the outer layer of skin). (merckmanuals.com)
  • HPV-associated, p16-positive, oropharyngeal tumors (OPSCC) are more radiosensitive and have better outcome. (lu.se)
  • Cytokeratin 7 in Oropharyngeal Squamous Cell Carcinoma: A Junctional Biomarker for Human Papillomavirus-Related Tumors. (tcd.ie)
  • The bulk of a true Pancoast tumor is extrathoracic, originating in an extreme peripheral location with a plaquelike extension over the lung apex and principally involving the chest wall structures rather than the underlying lung parenchyma. (medscape.com)
  • The overwhelming majority of cases of Pancoast syndrome are non-small cell lung carcinoma (NSCLC), with more than 95% located in the superior sulcus. (medscape.com)
  • No lung tumors were seen in control rats of either sex or in male rats exposed to either compound. (cdc.gov)
  • Both antimony -oxide and ore exposed females developed lung neoplasms, the first lung tumor being seen after 41 weeks exposure to antimony ore or 53 weeks antimony -oxide exposure. (cdc.gov)
  • Lung tumors were found in 27 percent of antimony -oxide exposed animals and 25 percent of those exposed to ore. (cdc.gov)
  • In one study from Egypt, 82% of patients with bladder carcinoma were found to harbor Schistosoma haematobium eggs in the bladder wall. (medscape.com)
  • Radiation is a feasible option for patients with squamous cell carcinoma of the anterior nasal cavity mucosa who refuse rhinectomy, according to our recent research. (mskcc.org)
  • Patients usually do not seek counseling until the tumors are large because small tumors cause little distress and may not be noticed by the patient. (cdc.gov)
  • Squamous cell carcinoma was found in all our patients. (bvsalud.org)
  • 63.15% of our patients underwent surgical resection of the tumor. (bvsalud.org)
  • Notre objectif était de discuter nos indications opératoires en les confrontant à la littérature tout en précisant notre particularité dans la prise en charge des patients dans un hôpital pédiatrique sénégalais. (bvsalud.org)
  • Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion. (tcd.ie)
  • Smoking-related tumors featured TP53 mutations, CDKN2A inactivation, and frequent copy number alterations. (cancer.gov)
  • Mutations in TP53 can lead to the loss of these functions, inducing uncontrolled cell growth and the promotion of tumor development ( 11 , 12 ). (spandidos-publications.com)
  • These mutations, classified as germline mutations, are typically inherited and are present in essentially all of the body's cells. (medlineplus.gov)
  • Together, the germline and somatic mutations impair the function of proteins that regulate division and senescence, leading to uncontrolled cell growth and the formation of a melanoma. (medlineplus.gov)
  • The tumor was considered free of node involvement and metastases. (cdc.gov)
  • Furthermore, even when standardized treatment is used and tumors are at the same stage and have similar histologic features, it is difficult to predict the outcome. (cdc.gov)
  • Squamous cell carcinoma of the urinary bladder is a malignant neoplasm derived from bladder urothelium with pure squamous phenotype. (medscape.com)
  • In the United States, squamous cell carcinoma constitutes around 2%-5% of all urinary bladder carcinomas. (medscape.com)
  • In certain parts of the African continent, the majority of bladder carcinomas are of the squamous cell type. (medscape.com)
  • [ 14 ] Bladder exstrophy has been associated with the development of squamous cell carcinoma at a younger age than usual. (medscape.com)
  • Smoking has a well-recognized role in the development of bladder carcinoma, with smoking duration and intensity directly related to an increased risk. (medscape.com)
  • As previously mentioned, schistosomiasis is the major cause of squamous cell carcinoma of the bladder in African countries. (medscape.com)
  • Schistosomiasis-induced squamous cell carcinoma of the bladder with pseudometastatic pulmonary nodules in a 30-year-old man from Mali. (cdc.gov)
  • Treatment for a particular tumor depends largely on the type of tumor, its location and size, and the overall physical condition of the dog. (merckvetmanual.com)
  • After surgical removal, tumors should be evaluated under a microscope (called a histopathology test) to confirm the type of tumor and whether all of the tumor was likely removed. (merckvetmanual.com)
  • This type of tumor can grow faster and often spreads to nearby lymph nodes and distant parts of the body. (webmd.com)
  • This type develops in cells in the top layer of the epithelium , called squamous cells. (hospiceofqueenannes.com)
  • The endocervix is lined by columnar mucinous epithelium and in continuity with vaginal mucosa, the ectocervix is lined by squamous epithelium. (cytojournal.com)
  • Chemicals, solar radiation, and viruses are just some of the things that can cause skin tumors. (merckvetmanual.com)
  • Examples include exposure to toxic compounds or radiation, loss of contact with other cells or the extra-cellular matrix, lack of oxygen (hypoxia), acidic pH, the activation of oncogenes, induction of cellular senescence, oxidative damage or depletion of essential metabolites. (southampton.ac.uk)
  • If not, the tumor can be treated with radiation. (msdmanuals.com)
  • High-risk genotypes 16 and 18 are associated with 70% of cervical and ~ 80% HPV positive cases are related to vulval and vaginal carcinoma. (biochain.com)
  • Both proteins are also involved in stopping cell division in older cells (senescence). (medlineplus.gov)
  • These proteins help regulate the cell cycle, which is the cell's way of replicating itself in an organized, step-by-step fashion. (medlineplus.gov)
  • The p14(ARF) and p53 proteins are often made in cells that are unable to undergo cell division. (medlineplus.gov)
  • Some Example Projects: Regulation of HDM2 and HDMX proteins The HDM2 oncoprotein is the major negative regulator of p53 function in the cell. (southampton.ac.uk)
  • Etiologies for the development of tumors include long-term exposure to ultraviolet ( UV ) light and a genetic predisposition. (ivis.org)
  • Hormonal abnormalities and genetic factors may also play a role in the development of skin tumors. (merckvetmanual.com)
  • My lab's work has pursued how multiple discrete subpopulations of malignant cells within these tumors cooperatively resist therapy via both tumor cell autonomous mechanisms and crosstalk with the stromal microenvironment. (upenn.edu)