Tumors aurora kinase b. Medical search. Frequent questions

This communication describes the discovery of a novel series of Aurora kinase inhibitors. (rcsb.org)
We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. (rcsb.org)
Mount Sinai researchers have developed a novel method to identify aggressive early-stage lung cancers and target drugs known as aurora kinase inhibitors to tumors that are especially likely to respond. (bio-itworld.com)
The Mount Sinai team used a genomics network model to measure tumor invasiveness-distinguishing aggressive tumors from so-called "indolent" ones, which often cannot be told apart via chest CT scan-and identify those that will respond to aurora kinase inhibitors, molecules that can inhibit gene signature regulators. (bio-itworld.com)
They identified and tested aurora kinase inhibitors, including AMG900, as an effective treatment to intercept lung cancer progression in the models. (bio-itworld.com)
Pharmacological response data for targeted inhibitors of SRC, WNT, GSK3b, aurora kinase, PI3 kinase, and mTOR, showed significant differences in sensitivity across cell lines assigned to different subtypes. (tudelft.nl)
Rearranged during transfection ( RET ) rearrangements occur in 1% to 2% of lung adenocarcinomas as well as other malignancies and are now established targets for tyrosine kinase inhibitors. (nih.gov)
These data highlight the utility of new RET+ models to elucidate differences in response to tyrosine kinase inhibitors and downstream signaling regulation. (nih.gov)
These data offer important insight into regulation of response to RET tyrosine kinase inhibitors and other potential therapeutic targets. (nih.gov)
Our results suggest the potential for therapeutic application of Aurora kinase B inhibitors in the treatment of Group 3 medulloblastoma. (oncotarget.com)
Tyrosine kinase inhibitors like vandetanib and lenvatinib have shown promising clinical activity in RET -positive tumours, and convincing results were obtained with the next-generation ALK inhibitors ceritinib, alectinib and brigatinib. (memoinoncology.com)
4. Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response. (mutalig.eu)
However with almost 5,000 miles of shoreline and greater than 4 hundred islands, it's no small … Mount Sinai researchers have developed a novel approach to find out aggressive early-stage lung cancers and goal remedy typically generally known as aurora kinase inhibitors to tumors which can be particularly likely to reply them. (amorcatz.com)

The Xenopus, Drosophila, and Caenorhabditis elegans genomes, on the other hand, contain orthologues only to Aurora A and Aurora B. In all studied species, the three Aurora mitotic kinases localize to the centrosome during different phases of mitosis. (wikipedia.org)
Aurora A and Aurora B kinases play important roles in mitosis. (wikipedia.org)
Finally, Aurora A helps orchestrate an exit from mitosis by contributing to the completion of cytokinesis- the process by which the cytoplasm of the parent cell is split into two daughter cells. (wikipedia.org)
Though the exact mechanism by which Aurora A aids cytokinesis is unknown, it is well documented that it relocalizes to the mid-body immediately before the completion of mitosis. (wikipedia.org)
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. (nature.com)
The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. (rcsb.org)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
One of the key regulatory kinases involved in multiple stages of mitosis is Aurora kinase B. We hypothesized that medulloblastoma cells that overexpress MYC would be uniquely sensitized to the apoptotic effects of Aurora B inhibition. (oncotarget.com)
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. (lookformedical.com)
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
Aurora-A phosphorylates and modulates the power of RASSF1A to associate with microtubule during mitosis (17). (healthandwellnesssource.org)
Puma Biotechnology, Inc. a biopharmaceutical company, announced an agreement with Takeda to license the worldwide research and development and commercial rights to alisertib, a selective, small-molecule, orally administered inhibitor of aurora kinase A. Alisertib is an adenosine triphosphate-competitive and reversible inhibitor of aurora kinase A and results in disruption of mitosis leading to apoptosis of rapidly proliferating tumor cells that are dependent on aurora kinase A. Alisertib h. (biotechnology.report)
Aurora kinases play an important role during mitosis for chromosome alignment, segregation, and cytokinesis. (cancer-research-network.com)
Aurora A and B are essential in mitosis. (cogershop.com)
however, Aurora C can complement Aurora B kinase activity in mitosis. (cogershop.com)

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. (wikipedia.org)
Aurora A is a member of a family of mitotic serine/threonine kinases. (wikipedia.org)
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)
Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. (cogershop.com)
Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. (cogershop.com)

Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)

Increased chromosomal instability and aneuploidy have been implicated in tumor progression. (medscape.com)
These cells have emerged as an important contributor to tumor progression. (aacrjournals.org)
Reports on the accumulation of immune-suppressive myeloid cells associated with tumor progression were published sporadically beginning in the early 1970s ( 1 ). (aacrjournals.org)
RAN, a member of RAS superfamily, and its binding partner RANBP2 are related to the progression of multiple tumors. (jcancer.org)
The research team used a genetically engineered mouse model to define the role of aurora kinases in early progression of the disease. (bio-itworld.com)
This gene may play a role in tumor development and progression. (antikoerper-online.de)
Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression. (nih.gov)
A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. (nih.gov)
The tumor microenvironment (TME) promotes BCSC survival and cancer progression, and targeting the TME can aid in successful immunotherapy. (hindawi.com)
LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms. (childrensmercy.org)

Using both flank and intracranial cerebellar xenografts we demonstrate that tumors formed from MYC-overexpressing medulloblastoma cells show a response to Aurora B inhibition including growth impairment and apoptosis induction. (oncotarget.com)
Despite a decade-long analysis building RASSF1A as a significant tumor suppressor that has a crucial function in cell development control and apoptosis small is well known about its legislation at the proteins level. (healthandwellnesssource.org)

The kinase discovered, Eg2, is now referred to as Aurora A. However, Aurora A's meiotic and mitotic significance was not recognized until 1998. (wikipedia.org)
As the cell cycle progresses, concentrations of Aurora A increase and the kinase associates with the mitotic poles and the adjacent spindle microtubules. (wikipedia.org)
Right before mitotic exit, Aurora A relocalizes to the mid-zone of the spindle. (wikipedia.org)
Aurora A is critical for proper formation of mitotic spindle. (wikipedia.org)
Furthermore, Aurora A is necessary for the proper separation of the centrosomes after the mitotic spindle has been formed. (wikipedia.org)
Without Aurora A, the mitotic spindle, depending on the organism, will either never separate or will begin to separate only to collapse back onto itself. (wikipedia.org)
Clark's level, tumor thickness and mitotic rate were also determined. (biomedcentral.com)
Tumor thickness, Clark's level, mitotic rate, nuclear area and fractal dimension were significant risk factors in univariate Cox regressions. (biomedcentral.com)

The Aurora kinase A is associated with centrosome maturation and separation and thereby regulates spindle assembly and stability. (wikipedia.org)
Works in various organisms have revealed that the kinase is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. (lookformedical.com)

The Aurora kinase B is a chromosome passenger protein and regulates chromosome segregation and cytokinesis. (wikipedia.org)
Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. (cogershop.com)

Src is an important member of the non-receptor protein tyrosine kinase. (cancer-research-network.com)
A study from Victoria K Woodcock suggested that AZD0424 is an inhibitor of the proto-oncogenic non-receptor tyrosine kinases Src and ABL1. (cancer-research-network.com)
7. Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity. (mutalig.eu)

Since that time several RASSF1A kinases are also discovered including cyclin-dependent kinase-4 (18) PKC (19) MST1 (macrophage stimulating-1) (20) and Aurora-B (21) that have different results on RASSF1A function. (healthandwellnesssource.org)

By using a direct in vivo shRNA screen, we show that liver cancer cells that have mutations in the gene encoding the tumor suppressor protein p53 (Trp53 in mice and TP53 in humans) and that are driven by the oncoprotein NRAS become addicted to MYC stabilization via a mechanism mediated by aurora kinase A (AURKA). (scite.ai)

In this study, we investigated the effect of AKI603, a novel small molecule inhibitor of Aurora kinase A (AurA) to overcome resistance mediated by BCR-ABL-T315I mutation. (scite.ai)
SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. (cogershop.com)
SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent. (cogershop.com)

Moreover, the anti-tumor effect of AKI603 was proved in the BALB/c nude mice KBM5-T315I xenograft model. (scite.ai)

Aberrant splicing of the 5' UTR also has been noted in neuroblastoma cell lines and primary tumors, which could potentially cause destabilization of the mRNA sequence [ 10 ]. (biomedcentral.com)
Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) can visualize primary tumors, lymph node metastases, lung metastases, and other distant metastases. (medscape.com)

Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD , indicating a potential tumor suppressor function for this gene. (biomedcentral.com)
In order to further examine the possibility that PTPRD acts as a tumor suppressor gene in neuroblastoma, we initially analyzed the levels of PTPRD mRNA transcripts in a set of 88 neuroblastoma tumors using the R2: microarray analysis and visualization platform ( http://r2.amc.nl ) (University of Amsterdam). (biomedcentral.com)
Homozygous loss of band 9p21, the site for the tumor suppressor gene P16 , is a known early genetic event in the development of papillary carcinoma and urothelial carcinoma in situ (CIS). (medscape.com)
Nevertheless, the effects of the RAN and RANBP2 gene polymorphisms on the tumorigenesis of Wilms tumor remain unclarified. (jcancer.org)
For instance, aberrant splicing of WT1 , a pivotal cancer suppressor gene, increased the risk of Wilms tumor [ 8 ]. (jcancer.org)
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. (antikoerper-online.de)
The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)

Those transformed cells form tumours when implanted in immunodeficient mice, indicating that the kinase is an oncogene. (lookformedical.com)
In overall, to define the role of a target protein as oncogene or tumor suppressor in our cancer models, we induce its restoration or down-regulation and we evaluate the consequent biological outcomes. (mutalig.eu)

Lastly, we show the distribution of AZD1152-HQPA within the mouse brain and the ability to inhibit intracranial tumor growth and prolong survival in mice bearing tumors formed from MYC-overexpressing medulloblastoma cells. (oncotarget.com)

Disruption of this interplay is critical for tumor invasiveness. (biomasswars.com)
They performed molecular profiling of early-stage lung cancer samples with RNA sequencing and identified signature genes associated with tumor invasiveness. (bio-itworld.com)

A new experimental approach which integrates the molecular imaging and bioanalytical technologies MSI and IMC was developed to determine the biodistribution of total drug and drug metabolite delivered via PLA-PEG nanoparticles and to overlay this with imaging of the nanomedicine in the context of detailed tumor microenvironment markers. (thno.org)
By staining for multiple biomarkers of the tumor microenvironment on the same tumor sections using imaging mass cytometry, co-registering and integrating data from both imaging modalities it was possible to determine the features in regions with highest nanomedicine distribution. (thno.org)
Consequently, our pH-responsive genome editing nanotherapies deserve further development for the treatment of HPV-associated cervical cancer, and they can also serve as promising nanotherapies to improve efficacies of other immune therapies against different advanced cancers by regulating the immunosuppressive tumor microenvironment. (bvsalud.org)

We discovered that our RET + cell lines had differential regulation of the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B (AKT) pathways. (nih.gov)
This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (bvsalud.org)

The observations of the accumulation in spleens and tumors of large numbers of these cells with potent immune-suppressive activity were readily reproducible in most murine tumor models. (aacrjournals.org)
In particular, compound 21 (SNS-314) is a potent and selective Aurora kinase inhibitor that exhibits significant activity in pre-clinical in vivo tumor models. (rcsb.org)
The development of the phthalazinone template resulted in a potent Aurora-A selective series of compounds (typically >1000-fold selectivity over Aurora-B) that display good pharmacological profiles with significantly improved oral bioavailability compared to the well studied Aurora inhibitor VX-680. (rcsb.org)
A potent pan-Aurora kinase inhibitor. (biovisi.com)
Displays potent anti-tumor activity. (biovisi.com)
MK-5108, also known as VX689, is a novel small molecule with potent inhibitory activity against Aurora-A kinase. (xcessbio.com)

Meanwhile, research has been ongoing with regard to druggable genetic aberrations within the tumour cell. (memoinoncology.com)

Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION. (lookformedical.com)
A Bicher, C Levenback, E G Silva, T W Burke, M Morris, et al (1995) Ovarian malignant mixed müllerian tumors treated with platinum-based chemotherapy. (scholarena.co)
Rare type of cancerous (malignant) tumor made up of both epithelial cells (cells that make up the inner lining of hollow organs and glands in the body) and stromal cells (cells that make up the connective tissues that surround and support various organs in the body) [1]. (scholarena.co)
A malignant mixed Müllerian tumor most often develops in the uterus (uterus), ovaries, or fallopian tubes (the conduit through which eggs are delivered from the ovary to the uterus) [2]. (scholarena.co)

As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. (biomedcentral.com)
PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. (biomedcentral.com)
We further demonstrate that PTPRD has a tumor suppressor function in neuroblastoma through dephosphorylating and destabilizing AURKA, leading to a downstream decrease of MYCN protein. (biomedcentral.com)

We herein demonstrated that CADM1 interacts with Hippo pathway core kinases and enhances the phosphorylation of YAP1, and also that the membranous co-expression of CADM1 and LATS2 predicts a favorable prognosis in lung adenocarcinoma. (cancerindex.org)

The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)
These findings identify a new link between the TP53 pathway and the adaptive immune response in estrogen receptor (ER)-negative breast tumors, suggesting a connection between TP53 inactivation and failure of tumor immunosurveillance. (escholarship.org)

Ample evidence supports a key role for MDSCs in immune suppression in cancer, as well as their prominent role in tumor angiogenesis, drug resistance, and promotion of tumor metastases. (aacrjournals.org)

BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)

The molecular mechanism, however, by which PTPRD renders a tumor suppressor effect in neuroblastoma is unknown. (biomedcentral.com)
However the in-depth molecular systems where RASSF1A functions being a tumor suppressor stay to become elucidated recent proof signifies that cell routine legislation is an essential requirement of its function. (healthandwellnesssource.org)
The tumor suppressor TP53 is mutated in approximately 30% of breast adenocarcinomas, with varying frequency across molecular subtypes. (escholarship.org)

Finally, the disruption of tumour angiogenesis contributes to tailoring treatment to each patient's needs. (memoinoncology.com)

Importantly, some of these differences in sensitivity were in concordance with high expression of the targets or activation of the corresponding pathways in primary tumor samples of the same subtype. (tudelft.nl)
3. The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs. (mutalig.eu)

MK-5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. (xcessbio.com)

This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
1 nM IC 50 ) to inhibition of two cell cycle-regulating proteins, polo-like kinase 1 and Aurora kinase A. Finally, we show that two of these cell lines, CUTO32 and CUTO42, successfully establish xenografted tumors in nude mice. (nih.gov)
Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. (cogershop.com)

Novo SM, Wedge SR, Stark LA. Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib . (ncl.ac.uk)

Tenacigenin B had anti-tumor effects on lymphoma via regulation of Aurora-A in vitro and in vivo . (medscimonit.com)
We demonstrated that the RET inhibitor BLU-667 was effective at inhibiting tumor growth in CUTO42 tumors but had a much less profound effect in CUTO32 tumors, consistent with our in vitro experiments. (nih.gov)

Certainly the degrees of MMP appearance and activity are raised in nearly every type of individual cancer which correlates with advanced tumor stage elevated invasion and metastasis and poor prognosis.13 Coincident with a far more invasive phenotype abnormally proliferating cells within a hyperplastic lesion undergo a profound morphological change by which they eliminate their epithelial features and find a fibroblastic form. (biomasswars.com)
Although Wilms tumor have an overall survival rate of 80%, more than 15% of patients have a poor prognosis despite aggressive retreatment [ 5 ]. (jcancer.org)
Therefore, it is indispensable to find more effective therapies in order to improve the poor prognosis of Wilms tumor. (jcancer.org)
membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. (cancerindex.org)
Recurrent tumors are highly aggressive, potentially cross-drug resistant, highly metastatic, and have a poor prognosis. (hindawi.com)

The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
Obviously even more studies are had a need to investigate the regulation of the important tumor suppressor protein further. (healthandwellnesssource.org)

Wilms tumor, resulting from deviant cellular proliferation and differentiation, is currently one of the most concerned tumors in children [ 1 , 2 ]. (jcancer.org)

Neuroblastoma is derived from primitive cells of the sympathetic nervous system, and is the most common extracranial solid tumor in children accounting for 15% of all childhood cancer deaths [ 13 ]. (biomedcentral.com)
During breast cancer tumor development the luminal space from the mammary acinar device fills with proliferating epithelial cells that exhibit growth factor-independence cell attachment flaws and a far more invasive fibroblastic phenotype. (biomasswars.com)
One of the 1st methods of invasion is definitely migration during which cancer tumor cells detach from neighboring cells and the encompassing matrix. (biomasswars.com)
Here we report that a circumscribed exposure to the aurora kinase inhibitor, VX-680, selectively kills cells that overexpress Myc. (nih.gov)
However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. (aacrjournals.org)
The specific inhibition of Aurora kinase B was achieved in MYC- overexpressing medulloblastoma cells with AZD1152-HQPA. (oncotarget.com)
MYC overexpression sensitized medulloblastoma cells to cell death upon Aurora B inhibition. (oncotarget.com)

These tumors are particularly noted for extensive heterogeneity in clinical behaviour, ranging from spontaneous regression to aggressive clinical course and death from disease. (biomedcentral.com)
Ovarian carcinosarcoma (OSC), also known as mixed mesodermal tumor or mixed müllerian tumor, is a rare ovarian tumor, known to be highly aggressive representing less than 2% of ovarian cancers, it is characterized by the association of a carcinomatous component and a sarcomatous component. (scholarena.co)
Ovarian carcinosarcoma (OSC) also known as mixed mesodermal tumor or mixed mullerian tumor, is a rare, aggressive, ovarian tumor that accounts for less than 2% of ovarian cancers. (scholarena.co)

This tumor affects 1 in 10000 children and constitutes 8% of pediatric cancers [ 4 ]. (jcancer.org)

In this study of 1,420 breast tumors, we tested for interaction between TP53 mutation status and tumor subtype determined by PAM50 and integrative cluster analysis. (escholarship.org)

MYCN amplification enhances promoted the development of Wilms tumor through multiple mechanisms [ 9 ]. (jcancer.org)

The association of lymphocytic invasion of ER-negative breast tumors with the retention of wild-type TP53 implies a novel protective connection between TP53 function and tumor immunosurveillance. (escholarship.org)

Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle. (wikipedia.org)
Intriguingly, abolishment of Aurora A through RNAi interference results in different mutant phenotypes in different organisms and cell types. (wikipedia.org)
It combines image analysis and machine learning methods for automated 3D segmentation and cell-cycle state identification of individual cell-nuclei with widely varying morphologies embedded in complex tumor environments. (nature.com)
Application of this stratification to four CRC cell line panels comprising 74 different cell lines, showed that the tumor subtypes are well represented in available CRC cell line panels. (tudelft.nl)
Ectopic kinase overexpression in any culture cell line leads to polyploidy and centrosome amplification. (lookformedical.com)
However, overexpression of aurora-A in particular cell lines such as NIH3T3 is sufficient to induce growth on soft agar. (lookformedical.com)
Novel approaches address targets that are not confined to the tumour cell, which had been at the centre of treatment considerations for a long time. (memoinoncology.com)
MK-5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. (xcessbio.com)

Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. (cogershop.com)

2021) Mixed Mullerian Tumors of the Ovaire: A Case Report . (scholarena.co)

proteins kinase cascade. (biomasswars.com)

A genomic network model is used to identify aurora kinase inhibitor-sensitive lung tumors, new Illumina Accelerator start-ups are announced, AI algorithms are being used to improve prostate cancer identification and treatment, and a blood-based DNA methylation test can detect liver cancer. (bio-itworld.com)

2. A novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models. (mutalig.eu)

Although there is evidence to suggest that Aurora C might be a chromosomal passenger protein, the cellular function of it is less clear. (wikipedia.org)

Methods We applied a new unsupervised, iterative approach to stratify CRC tumor samples into subtypes based on genome-wide mRNA expression data. (tudelft.nl)

In human, aurora-A has focused a lot of attention, since its overexpression has been found to be correlated with the grade of various solid tumours. (lookformedical.com)

Nanomedicine delivered drug was associated with regions higher in macrophages, as well as more stromal regions of the tumor. (thno.org)

Anatomy9

Organisms1

Diseases6

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes29

Information Science2

Inhibitors13

Mitosis17

Serine7

Functions as a tumor suppressor1

Progression10

Apoptosis2

Mitotic8

Spindle assembly and stability2

Cytokinesis2

Tyrosine3

Cyclin-Depend1

Suppressor protein p531

Inhibitor of aurora3

Anti-Tumor Effect1

Primary tumors2

Gene7

Oncogene2

Inhibit1

Invasiveness2

Microenvironment3

Mitogen-activated2

Potent6

Genetic Aberrations1

Malignant4

AURKA3

Interacts1

Receptor2

Role in tumor1

Chemotherapy1

Molecular3

Disruption1

Pathways2

Histone H31

Mice3

Colorectal1

Vitro2

Prognosis5

Regulation2

Cellular proliferation1

Cells7

Aggressive3

Cancers1

Mutation1

MYCN1

Breast1

Cell8

Consistent1

20211

Proteins1

Lung1

Lymphoma1

Chromosomal1

MRNA expression1

Overexpression1

Stromal1