• Oncotarget published " Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma " which reported a rare metastatic case with a PALB2 aberration identified previously as a familial susceptibility gene for breast cancer in the Finnish population. (oncotarget.com)
  • Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)
  • Apocrine carcinoma is a cancer of a sweat gland. (lyotomachida.net)
  • The cause of apocrine carcinoma is unknown. (lyotomachida.net)
  • Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
  • breast carcinoma, sweat gland carcinoma, skin cancer. (bvsalud.org)
  • This study aimed to report and discuss the challenging differential diagnosis between a primary tumor of sweat glands and cutaneous metastasis of mammary carcinoma using anatomopathological and imaging diagnostic resources available today. (bvsalud.org)
  • The findings show the challenge in differentiating a primary tumor of the sweat gland from a metastatic cutaneous tumor of mammary carcinoma, even with the immunohistochemical resources currently available. (bvsalud.org)
  • Apocrine skin carcinoma has characteristics similar to those of cutaneous breast carcinoma metastases when it presents a tubule-lobular, or cordonal differentiation. (bvsalud.org)
  • Hidradenocarcinoma is a rare aggressive form of cutaneous adnexal skin carcinoma originating from the sweat gland. (elsevierpure.com)
  • The purpose of this study was to retrospectively evaluate cases of canine anal sac carcinoma and assess the profile of involvement, tumor size, and lymphatic invasion at the time of diagnosis. (pvb.com.br)
  • Eccrine carcinoma is a quite rare malignant tumor that typically arises from a normal sweat gland and that features a rather high recurrence rate subsequent to simple excision. (biomedcentral.com)
  • Even though eccrine carcinomas would appear to be rare, when dealing with recurrent skin tumors or recurrent perianal fistulas, the possibility of eccrine carcinoma should be considered by consulting clinicians. (biomedcentral.com)
  • Eccrine carcinoma is a rare, malignant sweat gland tumor, generally featuring a slow growth rate and a rather high local recurrence rate [ 2 ]. (biomedcentral.com)
  • Sweat gland carcinomas were first reported by Stout and Cooley in 1951 with the observation that, "sweat gland carcinoma often developed at the site of pre-existing nodules of longstanding and they have a propensity to metastasize" [ 2 ]. (biomedcentral.com)
  • Appropriate sweat gland carcinoma classification is clearly important since each of the specific sweat gland carcinomas features its own characteristic biological behavior [ 4 ]. (biomedcentral.com)
  • Primary cutaneous cribriform apocrine carcinoma: Case report and literature review. (nih.gov)
  • Abstract Eccrine spiroadenocarcinoma is an extremely rare malignant eccrine gland tumor which may masquerade as other more common malignancies such as poorly differentiated squamous carcinoma or metastatic breast cancer. (sagepub.com)
  • The first clinical impression is that of a cyst, basal cell carcinoma, keratoacantoma, nevus, apocrine hidrocystoma, another location primary tumour metastasis and in certain circumstances the clinical differentiation includes vascular lesions as those found in the Kaposi sarcoma 5. (constiintaortodoxa.ro)
  • Smith CC Metastazing carcinoma of the sweat-glands. (constiintaortodoxa.ro)
  • Sox10 and DOG1 Expression in Primary Adnexal Tumors of the Skin. (nih.gov)
  • Adnexal tumors of the skin. (markahurt.com)
  • The tumorigenesis of these rare cancers is largely unclear, but histologically cutaneous apocrine gland carcinomas mimic metastatic apocrine breast cancer or apocrine carcinomas arising in ectopic breast tissue. (oncotarget.com)
  • The first large study pertaining to the classification of sweat gland carcinomas was published in 1968 by Berg and McDivitt [ 3 ]. (biomedcentral.com)
  • Thus, appropriate classification of such sweat glands, and associated tumors, enables us to devise a specific and appropriate sweat gland tumor therapeutical plan, and also an associated precise prognosis, i.e. apocrine carcinomas are able to metastasize to regional lymph nodes and do so frequently, whereas eccrine carcinomas are typically not able to metastasize [ 4 ]. (biomedcentral.com)
  • Unfortunately, as far as we are aware, sweat gland carcinomas are often under diagnosed or misdiagnosed due to their clinical rarity [ 8 ]. (biomedcentral.com)
  • Carcinomas of sweat glands, report of 60 cases. (constiintaortodoxa.ro)
  • In this study, we examined whether TAA intoxication can induce kidney leukocyte infiltration (measured as leukocyte common antigen CD45) associated with the augmentation of the reactive oxygen species (ROS)/tumor necrosis factor-alpha (TNF-α) axis, as well as biomarkers of kidney injury with and without metformin treatment. (bvsalud.org)
  • There are three types of sweat glands that occur over the skin surface: eccrine, apocrine and apoeccrine. (biomedcentral.com)
  • Introduction to Sweating Disorders There are two types of sweat glands: apocrine and eccrine. (msdmanuals.com)
  • 1 First described in 1956, poroma was originally identified as a tumor originating from the eccrine sweat gland. (clinicaladvisor.com)
  • Poroma is a benign adnexal neoplasm of the intraepidermal portion of the sweat gland duct, called the acrosyringium . (clinicaladvisor.com)
  • Given its rather poor response to adjuvant therapy, wide excision of the lesion with tumor-free margins may offer a reasonable chance for long-term control of this neoplasm. (biomedcentral.com)
  • Apocrine sweat glands, which are usually associated with hair follicles, continuously secrete a fatty sweat into the gland tubule. (lyotomachida.net)
  • It is a benign congenital hamartoma related to abnormalities of the epidermis, sebaceous glands, sweat glands, and hair follicles. (aad.org)
  • Elevated expression of metalloproteinase-2 was observed in keratinocytes, fibroblasts and inflammatory cells in dermis, sweat glands, hair follicles and sinus tracts, suggesting a key role for hidradenitis suppurativa pathoge-nesis. (rsu.lv)
  • Additional benign neoplasms such as trichoepithelioma (8), tubular apocrine adenomas (9), sebaceomas (1), and others have been reported within NS. (aad.org)
  • It can also lead to benign tumors ( Adenomas ) come in the area of ​​the sweat glands. (lifeafterjob.com)
  • One of the most common benign epithelial tumors is seborrheic keratosis /senile keratosis, which is a hereditary lesion that appears in persons aged more than 30 years. (medscape.com)
  • Herein, we present a case of metastatic apocrine hidradenocarcinoma in a 32-year-old Caucasian male. (elsevierpure.com)
  • Sweat and sebum are mixed in the hair follicle and arrive mixed at the epidermal surface. (wikipedia.org)
  • The origin of cutaneous tumors can be simplistically divided into three major categories: epidermal, dermal, and adnexal (see image below). (medscape.com)
  • were the first to describe tumors exhibiting features of the epidermal sweat duct. (faoj.org)
  • Moreover, the presence of big mucus accumulations can serve as physical barrier in tumour extension, compressing the tumour stroma, slowing the growth, inhibiting the DNA synthesis and decreasing the angiogenesis rate 8. (constiintaortodoxa.ro)
  • For perianal adenocarcinomas, the treatment of choice is complete surgical excision of the tumor (sometimes with removal of the nearby lymph nodes) and neutering. (lyotomachida.net)
  • Tracing back her surgical history, this patient had undergone perianal skin tumor excision twice previously, once in 1981 and again in 1992. (biomedcentral.com)
  • 1. The surgeon performed an excision of the tumor from the patient's lung. (xiawuyouke.com)
  • 2. The excision of the tumor was successful and the patient is now recovering. (xiawuyouke.com)
  • 例句:Objective To discuss the possibility of excision of apocrine sweat glands unexposed through a small incision for therapy of bromhidrosis. (xiawuyouke.com)
  • Suboccipital craniectomy with total tumor excision was performed. (xiawuyouke.com)
  • An inability to remove a large or difficult tumor in one day may preclude immediate reconstruction after complete excision. (medscape.com)
  • Primary malignant neoplasms of the sweat glands are rare, constituting less than 1% of all primary malignant skin lesions 1 . (bvsalud.org)
  • The aim of this study was to evaluate the expression of human beta-defensin 2, tumour necrosis factor (TNF)-α and matrix metalloproteinase-2 in skin lesions of patients with hidradenitis suppurativa. (rsu.lv)
  • shins), hypertrophic osteoarthropathy (palms), blue rubber bleb nevus syndrome, and glomus tumor (over lesions). (msdmanuals.com)
  • Cysts, apocrine metaplasia, epithelial hyperplasia, fibroadenoma (Fig. 2.6 ), papilloma, and a wide range of lesions occurring in the normally located breast can be encountered in ectopic breast tissue. (basicmedicalkey.com)
  • On the other hand, clear cell acanthoma is a rare, benign epithelial cutaneous tumor. (medscape.com)
  • Retrospective evaluation of ceruminous gland tumors confined to the external ear canal of dogs and cats treated with biopsy and CO(2) laser ablation. (nih.gov)
  • however, the paucity of historical data available has shown that these tumors often behave aggressively with high rates of local recurrence, metastasis, and poor overall outcomes. (elsevierpure.com)
  • The surgical treatment of osteosarcoma results in significant bone defects and risks of tumor recurrence. (bvsalud.org)
  • Noncontiguous tumors and/or disconnected foci in tumors may result in recurrence. (medscape.com)
  • Their apocrine glands, like those in humans, produce an odorless, oily, opaque secretion that gains its characteristic odor upon bacterial decomposition. (wikipedia.org)
  • Apocrine sweat glands were originally thought to use only apocrine secretion: vesicles pinch off from the secretory cells, then degrade in the secretory lumen, releasing their product. (wikipedia.org)
  • Although the histological features of apocrine and eccrine poromas are nearly identical, the presence of homogenous eosinophilic intraluminal secretion, lining cells with intensely eosinophilic cytoplasm, and small clusters of sebaceous cells surrounded by poroid cells is suggestive of apocrine lineage. (clinicaladvisor.com)
  • Body temperature is controlled by sweat glands through secretion and evaporation of sweat. (hpathy.com)
  • There are also the so-called apocrine sweat glands which are only found in certain regions of the skin and whose function is the secretion of fragrances. (lifeafterjob.com)
  • The secretion of sweat takes place according to the exocrine mechanism, which describes the release of a substance to an internal or, in the case of the sweat glands, external surface. (lifeafterjob.com)
  • Adnexal apocrine glands and sweat ducts of the axilla may mimic breast ducts and lobules of axillary ectopic breast tissue. (basicmedicalkey.com)
  • Such sweat glands are distributed over the entire body skin surface, with the greatest density being found on the palms of the hands and soles of the feet [ 1 ]. (biomedcentral.com)
  • Indeed, immunohistochemistry has replaced simple morphologic evaluation as the definitive diagnostic method for various tumor types. (edu.au)
  • However, no dose distributions have been created using various tumor cell-specific RBE values. (bvsalud.org)
  • Distinguishing a benign tumor from a cancerous tumor requires specialized knowledge and laboratory equipment. (merckvetmanual.com)
  • A cancerous tumor is malignant, which means it can grow and spread to other distant parts of the body. (zenonco.io)
  • At 5-year follow-up, she was alive, without recurrent or metastatic tumor. (medscape.com)
  • Hidradenitis suppurativa is a chronic skin condition, charac terized clinically by painful, recurrent, deep-seated nodules and suppuration, and histologically by hyper trophic scarring of apocrine gland bearing skin and sinus tracts. (rsu.lv)
  • Taking into consideration the rarity of this tumour, a diagnosis of certitude is difficult to establish until further investigations are made, in order to eliminate the primary malignant tumour with visceral location with mucine production that can metastasize at cutaneous level, as for example that of breast, gastrointestinal tract, lung, kidney, ovary, pancreas, or prostate. (constiintaortodoxa.ro)
  • The diagnosis and treatment of these cutaneous tumors is constantly evolving, and the role of clinicians relies on accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
  • This book provides a comprehensive, state-of-the-art account of the role of immunohistochemistry in the diagnosis of skin tumors, which is crucial given that overlapping histologic features and unusual morphologic changes can lead to considerable diagnostic uncertainty. (edu.au)
  • The treatment and diagnosis of many cutaneous tumors is continually changing, and the role of clinicians (eg, primary care physicians, dermatologists, plastic surgeons, pathologists) focuses on an accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
  • In addition, these rare cutaneous tumors are often difficult to diagnose based solely on the physical examination findings, and the proper diagnosis relies on excisional biopsy with histologic studies. (medscape.com)
  • The patient initially underwent excisional biopsy which confirmed the diagnosis of poorly differentiated, highly infil-trative, apocrine hidradenocarcinoma. (elsevierpure.com)
  • In histopathological evaluation at the time of diagnosis, data on sex, age, and race were described, as well as tumor size and lymphatic invasion. (pvb.com.br)
  • This presence of melanin provides pigmentation to the benign tumor, and this occurrence has been termed pigmented clear cell acanthoma. (medscape.com)
  • Apocrine gland anal sac adenocarcinomas (AGASACA) are malignant tumors of the anal glands. (lyotomachida.net)
  • 1 Canine Apocrine Gland Anal Sac. (lyotomachida.net)
  • Histologically, a poroma is a well-circumscribed tumor that arises in the lower epidermis and extends into the dermis. (clinicaladvisor.com)
  • In humans, apocrine sweat glands are found only in certain locations of the body: the axillae (armpits), areola and nipples of the breast, ear canal, eyelids, wings of the nostril, perineal region, and some parts of the external genitalia. (wikipedia.org)
  • as many as two thirds of patients have a palpable breast tumor. (medscape.com)
  • PCMC is more frequently found in males and it usually appears between the ages of 50 and Mendoza and Hedwig high risk breast papilloma the first contemporary description of this eyelid-located tumour. (constiintaortodoxa.ro)
  • Usually, the tumour is well delimitated, with high risk breast papilloma accumulations or tubules of epithelial high risk breast papilloma which float in mucine. (constiintaortodoxa.ro)
  • [ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
  • Poromas are often grouped within the greater classification of acrospiroma, which includes dermal duct tumors, hidroacanthoma simplex, and nodular, clear-cell, and poroid hidradenomas. (clinicaladvisor.com)
  • Over a la critica antispeculativa recommending from thrice-weekly readers to characteristics, the resurfacing can However heat the tumor, forcing it to harm hereditary and old. (ccctw.hk)
  • Examples include excessive sweating, clogged sebaceous glands, or discolored and deformed nails. (sdam-svou-kvartiru.ru)
  • Hyperhidrosis is excessive sweating, which can be focal or diffuse and has multiple causes. (msdmanuals.com)
  • For most tumors, surgical removal is the most effective option. (merckvetmanual.com)
  • After surgical removal, tumors should be evaluated under a microscope (called a histopathology test) to confirm the type of tumor and whether all of the tumor was likely removed. (merckvetmanual.com)
  • As no malignant tumors were seen in children, we believe it is reasonable to delay surgical management until adolescence. (aad.org)