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  • characteristic
  • SRCC tumors grow in characteristic sheets, which makes diagnosis using standard imaging techniques, like CT and PET scans, less effective. (wikipedia.org)
  • The thin, fibrous wall circumscribing the tumor is highly characteristic of this lesion. (wikipedia.org)
  • proliferation
  • Due to the submucosal proliferation of the malignant cells, these tumors are easily missed on esophagogastroduodenoscopy and pose a diagnostic challenge. (gastrointestinalatlas.com)
  • MUC-4 is thought to play a role in cancer progression by repressing apoptosis and consequently increasing tumor cell proliferation. (wikipedia.org)
  • MUC4 expression in esophageal cancer often leads to increased tumor proliferation and migration. (wikipedia.org)
  • ovarian
  • Tumors of this type are also called ovarian adenocarcinoma. (wikipedia.org)
  • This group of tumors accounts for 90% to 95% of all cases of ovarian cancer. (wikipedia.org)
  • Benign, borderline, and malignant types of serous tumors account for about 30% of all ovarian tumors. (wikipedia.org)
  • The appearance can look similar to colonic or ovarian cancer, but typically originates from the appendix (see mucinous adenocarcinoma with clinical condition Pseudomyxoma peritonei). (wikipedia.org)
  • Krukenberg tumors can occasionally provoke a reaction of the ovarian stroma which leads to hormone production, that results in vaginal bleeding, a change in menstrual habits, or hirsutism, or occasionally virilization as a main symptom. (wikipedia.org)
  • Immunohistochemistry may help in diagnosing Krukenberg tumors from primary ovarian neoplasms but needs to be applied with discretion. (wikipedia.org)
  • Virilizing ovarian Krukenberg tumor in a 27-year-old pregnant woman. (wikipedia.org)
  • Cytokeratin
  • Immunohistochemical examination of this tumor revealed positive staining for Cytokeratin 20, Mucin 2, and CDX2, although Cytokeratin 7 and Mucin 6 were negative. (hindawi.com)
  • For example, tumors that are immunoreactive to CEA or cytokeratin 20 (CK20) and negative for cytokeratin 7 (CK7) may be more likely to be of colorectal origin. (wikipedia.org)
  • glycoprotein
  • The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al. (antibodies-online.com)
  • Recognizes a mucin-like glycoprotein larger than 200 kDa, expressing the CA 125 epitope. (agilent.com)
  • Like other mucins, MUC-4 is a high-molecular weight glycoprotein. (wikipedia.org)
  • intracytoplasmic
  • Electron microscopic studies in 3 cases described intracytoplasmic mucin, convoluted oval nuclei, prominent nucleoli, homogeneous euchromatin with peripheral chromatin condensation, microvilli, junctional complexes, and primitive lumen formation. (wikipedia.org)
  • abdominal cavity
  • These tumors vary in size from small and nearly imperceptible to large, filling the abdominal cavity. (wikipedia.org)
  • Classically it was thought that direct seeding across the abdominal cavity accounted for the spread of this tumor, but spread by way of the lymphatic is considered more likely. (wikipedia.org)
  • The tumors cause fibrosis of tissues and impede digestion or organ function, and if left untreated, the tumors and mucin they produce will fill the abdominal cavity. (wikipedia.org)
  • signet
  • SRCCs are named due to their resemblance to signet rings, which result from the formation of large vacuoles full of mucin that displace the nucleus to the cell's periphery. (wikipedia.org)
  • colon
  • The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. (wikipedia.org)