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  • Genes
  • Conversely, many host genes have been incorporated into large DNA viruses, such as herpesviuses and poxviruses, as well as oncogene-bearing retroviruses. (royalsocietypublishing.org)
  • Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis. (asm.org)
  • Structures of herpes simplex virus type 1 genes required for replication of virus DNA. (asm.org)
  • Functional mapping of Autographa california nuclear polyhedrosis virus genes required for late gene expression. (asm.org)
  • Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. (asm.org)
  • Immune response genes control T killer cell response against Moloney tumor antigen cytolysis regulating reactions against the best available H-2 + viral antigen association. (histrecmed.fr)
  • In Burkitt's lymphoma, the so-called 'variant' translocations, T(2:8) or T(8:22), found in about 20% of such tumors, juxtapose immunoglobulin kappa or lambda light chain genes to the PVT1 locus. (biomedcentral.com)
  • The virus integrates into the cellular genome and inserts its DNA near or within genes, which leads to various outcomes: (i) The insertion site is too far away from a protooncogene and thus does not activate it. (biomedcentral.com)
  • Viral
  • The AKR murine leukemia viruses do not contain acute transforming oncogenes ( 4 ) and are thought to transform cells as a result of activating cellular proto-oncogenes in the vicinity of viral integration into chromosomal DNA ( 5 ). (jimmunol.org)
  • Khoury G., May E. Regulation of early and late simian virus 40 transcription: overproduction of early viral RNA in the absence of a functional T-antigen. (medkursor.ru)
  • Gross, L. 1958 Viral etiology of "spontaneous" mouse leukemia: A review. (springer.com)
  • Integration of viral DNA into host DNA was first discerned for the prophage of the temperate bacteriophage lambda by Andre Lwoff in 1950 and for the simian DNA virus SV40 in cultured mammalian cells in 1968 [ 8 ]. (royalsocietypublishing.org)
  • For small DNA tumour viruses, the full replication cycle occurs via non-integrated circular viral genomes, whereas viral integration into host DNA usually leads to abortive infection and sometimes to cell transformation. (royalsocietypublishing.org)
  • This indicates that some human cells express a protein on their surface that acts as a receptor for MCF viruses and allows MCF viral entry. (umassmed.edu)
  • Antibodies against synthetic peptides of herpes simplex virus type 1 glycoprotein D and their capability to neutralize viral infectivity in vitro. (asm.org)
  • A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. (asm.org)
  • Translation of nonviral and viral mrna's in extracts from uninfected and infected ehrlich ascites tumor cells. (jax.org)
  • Our group first documented that viral infections and virus-induced transformations can significantly affect class I gene expression. (springer.com)
  • Meruelo, D. and Kramer, J., H2-D control of radiation leukemia virus induced neoplasia: Evidence for interaction of viral and H-2 genomic information, Transplant. (springer.com)
  • Virol
  • Pampeno, C. L. and Meruelo, D., Isolation of a retroviruslike sequence from the TL locus of the C57BL/10 murine major histocompatibility complex, J. Virol. (springer.com)
  • proteins
  • Naso R. E., Brown R. L. Synthesis and cleavage of Rauscher leukemia virus precursor proteins in synchronized cells. (medkursor.ru)
  • Gatehouse D. M., Duesberg P. H. RNA and proteins of the Kirsten sarcomaxenotropic leukemia virus complex propagated in rat and duck cells. (medkursor.ru)
  • Gallis B. M., Eisenman R. N., Dtggelmann H. Synthesis of the precursor to avian RNA tumor virus internal structural proteins early after infection. (medkursor.ru)
  • A new packaging cell line, called MPAC, was created to package defective retroviral vectors in virus particles with envelope proteins derived from a Moloney mink cell focus-inducing (Mo-MCF) virus. (umassmed.edu)
  • Distinctive properties of the hepatitis B virus envelope proteins. (asm.org)
  • Monoclonal antibody to spleen focus-forming virus-encoded gp52 provides a probe for the amino-terminal region of retroviral envelope proteins that confers dual tropism and xenotropism. (asm.org)
  • Identification of a nonvirion protein of Aleutian disease virus: mink with Aleutian disease have antibody to both virion and nonvirion proteins. (asm.org)
  • A subset of chromosomal translocations in acute leukemias results in the fusion of the trithorax‐related protein HRX with a variety of heterologous proteins. (embopress.org)
  • In particular, leukemias with the t(11;19)(q23;p13.3) translocation express HRX-ENL fusion proteins and display features which suggest the malignant transformation of myeloid and/or lymphoid progenitor(s). (embopress.org)
  • Strains
  • We will also describe some of the characteristics of the germfree AKR mouse which make it somewhat different from other germfree inbred strains. (springer.com)
  • Lymphocytes
  • H-2 region product as determinant in immune cytolysis of syngeneic tumour cells by anti-MSV T lymphocytes. (histrecmed.fr)
  • Meruelo, D., A role for elevated H-2 antigen expression in resistance to RadLV-induced leukemogenesis: Enhancement of effective tumor surveillance by killer lymphocytes, J. Exp. (springer.com)
  • Cytolytic T lymphocytes (CTL) were identified during the late 1960's (1,2) and are thought to be important effector cells in immunity to viruses (3) and in allograft rejection (4), Despite considerable effort during the past decade, little has been learned about the biochemical basis for the killing event. (springer.com)
  • Martz, E. Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. (springer.com)
  • avian
  • Kurth R., Bosch V., Bolognesi D. P. Polypeptides of endogenous avian С - type viruses: their detection in the plasma membrane of normal and infected cells. (medkursor.ru)
  • Salden M. H. L., Bloemendal H. Transplantation of avian myeloblastosis virus RNA in a reticulocyte cell - free system. (medkursor.ru)
  • Hakomori S., Wyke J. A., Vogt P. K. Glycolipids of chick embryo fibroblasts infected with temperature - sensitive mutants of avian sarcoma viruses. (medkursor.ru)
  • The avian erythroblastosis virus erbA oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations. (asm.org)
  • Lack of exodeoxyribonuc lease activity and error - correcting function in avian myeloblastosis virus DNA polymerase. (medkursor.ru)
  • splenocytes
  • However, it was not detected on adult murine thymocytes, splenocytes, or bone marrow cells or on splenic LPS-activated B cells or Con A-activated T cells. (jimmunol.org)
  • X. Identification of an IgD-like molecule on the surface of murine splenocytes. (naver.com)
  • leukemogenesis
  • This suggests that the enhancers need only a few specific base changes relative to the injected virus to accelerate leukemogenesis. (umassmed.edu)
  • encodes
  • In one example, the gag gene from Friend Leukemia Virus encodes an H-2D d -restricted CTL target on the leukemia cell line, FBL-3 [ 22 ]. (pubmedcentralcanada.ca)
  • Thirteen years later, it was shown that the oncogene transduced by this virus encodes a serine/threonine protein kinase (AKT) (also known as PKB), which harbors an N-terminal regulatory domain (now known as the PH domain) and exhibits a high degree of homology with the kinases PKC and PKA ( 2 - 5 ). (sciencemag.org)
  • chromosomal
  • He postulated that RNA tumour viruses made DNA copies which then integrated into host chromosomal DNA, analogous to integration of prophage in bacteria. (royalsocietypublishing.org)
  • Biegeleisen K., Rush M. G. Association of herpes simples virus type I DNA with host chromosomal DNA during productive infection. (medkursor.ru)
  • Chromosomal abnormalities of 11q23 are seen in B‐lineage acute lymphoblastic leukemias (ALL) and myelomonocytic and monocytic subtypes of acute myeloid leukemias (AML). (embopress.org)
  • polymerase
  • Genetic evidence for vaccinia virus-encoded DNA polymerase: isolation of phosphonoacetate-resistant enzyme from the cytoplasm of cells infected with mutant virus. (asm.org)
  • translocations
  • In these tumors, Pvt1 is the site of reciprocal translocations to immunoglobulin loci. (biomedcentral.com)
  • A subset of acute leukemias carries translocations of chromosome band 11q23 with reciprocal partners located at 30 or more cytogenetically diverse loci (for a review, see Waring and Cleary, 1997 ). (embopress.org)
  • simian
  • Lai Ching-Juh, Nathans D. The ВС gene of simian virus 40. (medkursor.ru)
  • The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts. (asm.org)
  • Beth E., Cikes M., Schloen L. Interspecies species- and type - specific determinants of human papovaviruses (JC and BK) and of simian virus 40. (medkursor.ru)
  • suppressor
  • Tumor-associated macrophages, myeloid-derived suppressor cells, and regulatory T cells reduce effector functions of tumor-specific CTL. (pubmedcentralcanada.ca)
  • A replication competent MCF virus containing a bacterial amber suppressor tRNA gene ( supF ) was used to investigate the changes in the enhancer region following injection of MCF containing one enhancer in the LTR. (umassmed.edu)
  • Cancer
  • Until the 1960s, scientists considered the idea of a cancer-causing virus to be preposterous. (smithsonianmag.com)
  • It was only in 1976 that a virologist named Harald zur Hausen identified the human papillomavirus, one of the first viruses known to lead to human cancer. (smithsonianmag.com)
  • Way back in the 1950s, bacterialologist Sarah Stewart pioneered the concept that viruses could lead to cancer-and was almost thrown out of the scientific community for her heretical ideas. (smithsonianmag.com)
  • the first to identify a solid tumor stem cell (in breast cancer) and the first to demonstrate a molecular linkage of a self-renewal program used by normal mammary stem cells and breast cancer cells. (stanford.edu)
  • Through collaboration, his group pioneered and organized a team to use single cell genomics to understand complex tissue hierarchy in normal and malignant cells present in human breast, colon and head and neck cancer tumors. (stanford.edu)
  • Only a small minority of cancer cells had the capacity to form new tumors in a xenograft model. (stanford.edu)
  • His laboratory is pursuing the identification of cancer stem cells in other tumors so that they can be studied. (stanford.edu)
  • To see if a limited sampling of tumor tissue from human subjects is a feasible way to gather adequate tissue for cancer stem cell quantification. (stanford.edu)
  • replication
  • The recognition of the importance of Rous's discovery after such a long delay was largely owing to the cell transformation assay in monolayer culture of chick embryo fibroblasts reported by Temin & Rubin [ 7 ] in 1958 which enabled quantitative experimental studies of virus replication and cell transformation. (royalsocietypublishing.org)
  • These ERVs affect retrovirus-induced disease in a number of ways, including manipulation of the immune response, inhibition or facilitation of entry or other steps of virus replication, or as participants in the generation of infectious pathogenic viruses. (springer.com)
  • To address this issue, primary and immortalized human cells were tested for their ability to be infected by MCF packaged defective vectors as well as replication competent MCF virus. (umassmed.edu)
  • The cellular tropism of MPAC-packaged retroviral vectors was the same as replication competent MCF viruses. (umassmed.edu)
  • In addition, I show that some human cells fully support MCF virus replication while others either partially or fully restrict MCF virus replication. (umassmed.edu)
  • immune
  • Jeejeebhoy H. F. Stimulation of tumor growth by the immune response. (medkursor.ru)
  • Kumar V., Eckner R. J., Bennett M. Mechanism of genetic resistance to immune suppression by friend leukemia virus: the role of marrow - dependent cells. (medkursor.ru)
  • Research in the Levy laboratory is directed at understanding the interaction of viruses and the immune system in microbial pathogenesis. (ucsf.edu)
  • I. The role of immune mechanism in tumor transplants in the syngeneic host. (jax.org)
  • Immune responses to virus-induced tumours. (jax.org)
  • Rous
  • That was the year that Peyton Rous was awarded the Nobel Prize for Medicine or Physiology for the isolation of his eponymous virus published in 1911, representing a record 55 year incubation period between reporting a discovery and the award [ 6 ]. (royalsocietypublishing.org)
  • Genetic
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • Coffin JM (1986) Genetic variation in AIDS viruses. (springer.com)
  • Genetic diversity of enzootic isolates of vesicular stomatitis virus New Jersey. (asm.org)
  • cytotoxicity
  • Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. (springer.com)
  • Cross-reacting tstas in adeno 7 and 12 tumors demonstrated by 51cr- cytotoxicity and isograft rejection tests. (jax.org)