• revealed for the first time carcinoma ex microcystic adenoma in which the tumor, without metastases, showed inherent malignant changes [ 7 ]. (hindawi.com)
  • A malignant mucinous neoplasm is called a mucinous carcinoma. (wikipedia.org)
  • When found within the skin, mucinous carcinoma is commonly a round, elevated, reddish, and sometimes ulcerated mass, usually located on the head and neck. (wikipedia.org)
  • 669 Mucinous carcinoma of the breast: Gross pathology (upper left) of mucinous carcinoma shows gelatinous areas. (wikipedia.org)
  • To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature. (hindawi.com)
  • A few studies have reported tumors coexisting with SMBTs, such as endometrioid adenocarcinoma [ 4 ] and squamous cell carcinoma [ 5 ]. (hindawi.com)
  • Frozen section examination (FSE) revealed free tumor margins and absence of carcinoma. (ispub.com)
  • The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities. (researchgate.net)
  • Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
  • CC is the second commonest primary liver tumour worldwide, after hepatocellular carcinoma (HCC). (bmj.com)
  • Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. (sncrf.org)
  • Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. (sncrf.org)
  • Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. (sncrf.org)
  • Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract. (sncrf.org)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • We describe the case of a 67-year-old female patient who presented with an unclear swelling on the right supraclavicular neck, two years after resection of a mucinous carcinoma on the right mastoid. (asploro.com)
  • However, as no other primary tumor could be detected at that time, a Primary Mucinous Carcinoma of the Skin (PMCS) was also debated. (asploro.com)
  • Using a variety of other markers, we were unable to detect neither significant morphological nor immunohistochemical characteristics that distinguished the lesion from a mucinous carcinoma of mammary origin. (asploro.com)
  • This report demonstrates the limitations of currently used histopathological and immunohistochemical differentiation in metastatic mucinous carcinoma. (asploro.com)
  • A 67-year-old female presented with a suspicious swelling on the right supraclavicular region two years after resection of a mucinous carcinoma on the surface of the skin overlying the right mastoid. (asploro.com)
  • The mastoid skin lesion was originally diagnosed by two separate institutes to be most likely a metastatic mucinous carcinoma. (asploro.com)
  • Tumors of the pancreas that contain substantial cystic components include mainly mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, solid pseudopapillary tumor, and cystadenomas (which encompass microcystic, macrocystic/oligocystic, and rare solid serous adenomas). (hindawi.com)
  • The histopathological examination of the mass of the ampulla of Vater demonstrated intraductal papillary mucinous neoplasm. (ispub.com)
  • After surgery, the histopathological examination of the mass of the ampulla of Vater demonstrated an intraductal papillary mucinous neoplasm (Figure 2). (ispub.com)
  • A mucinous neoplasm (also called colloid neoplasm) is an abnormal and excessive growth of tissue (neoplasia) with associated mucin (a fluid that sometimes resembles thyroid colloid). (wikipedia.org)
  • Serous cystadenoma (SCA) is a relatively rare pancreatic neoplasm which accounts for only 2% of pancreatic tumors (1-3). (spg.pt)
  • Multi-Center Follow-up Study to Develop a Classification System Which Differentiates Mucinous Cystic Neoplasm of the Liver and Benign Hepatic Cyst Using Machine Learning. (cdc.gov)
  • The two main types of appendix cancer are called carcinoid tumors and carcinomas. (mskcc.org)
  • Over 40 percent of all mucinous carcinomas are colorectal. (wikipedia.org)
  • There was no significant correlation of ploidy status or SPF with the tumor grades of mucoepidermoid carcinomas. (researchgate.net)
  • The literature repeatedly describes difficulties in diagnosing PMCS, especially when attempting to differentiate the metastases from mucinous carcinomas of other origins. (asploro.com)
  • Mucinous skin carcinomas are mostly seen in the head and neck region and isolated specimens from this area should raise suspicion for a PMCS. (asploro.com)
  • In contrast, metastases located in the axillary region are more likely to be related to a primary tumor in the breast while metastases on the lower trunk are mostly seen in colorectal carcinomas. (asploro.com)
  • In 1987, the staging of ampullary carcinomas was added to the tumor, node, metastases (TNM) classification of malignant tumors by the International Union Against Cancer (now the Union for International Cancer Control), and since then, this classification has been used widely. (medscape.com)
  • Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)
  • They are a type of gastrointestinal neuroendocrine tumor (NET). (mskcc.org)
  • Gastrointestinal stromal tumor (GIST) (closed to accrual 09/26/2018) 38. (sncrf.org)
  • The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. (lu.se)
  • Pancreatic cystic tumors fall into the serous or mucinous category. (hindawi.com)
  • They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. (hindawi.com)
  • Seromucinous borderline tumors (SMBTs) are characterized by papillary architecture reminiscent of serous tumors but composed of mucinous epithelium similar to that of the endocervix. (hindawi.com)
  • Many of the cysts and the low papillary growth lesions were lined by tall columnar mucinous or cuboidal ciliated serous cells (Figure 2(b) ). (hindawi.com)
  • Carcinoid tumors are the most common appendix cancers, making up about half of those diagnosed. (mskcc.org)
  • Most pancreatic cancers are exocrine tumors that develop from ductal and acinar cells. (msdmanuals.com)
  • MUC2 was negative in all primary lung cancers, but positive only in less than half of pulmonary metastases from mucinous adenocarcinomas from other organs. (lu.se)
  • Combining six GI markers did not perfectly separate primary lung cancers from pulmonary metastases including subgroups such as mucinous adenocarcinomas or CK7-positive GI tract metastases. (lu.se)
  • Periampullary cancers can be broadly considered as tumors arising within 1 cm of the ampulla of Vater and include ampullary, distal bile duct, pancreatic, and duodenal cancers. (medscape.com)
  • Almost all primary papillary cancers are adenocarcinomas, although sarcomas, lymphomas, carcinoid, and islet-cell cancers also have been reported. (medscape.com)
  • Other types include islet cell tumors, pancreatic lymphoma, and cystic tumors, such as intraductal papillary mucinous neoplasms (IPMN or IPMT). (bidmc.org)
  • Thirteen individuals with FPC (6.1%) underwent surgical resection for a suspected PRL, but only four (1.9%) had high-risk lesions (ie, high-grade intraductal papillary mucinous neoplasms or grade 3 pancreatic intraepithelial neoplasms). (medscape.com)
  • Aim: The aim of this study is to investigate the DNA ploidy and S-Phase Fraction (SPF) of some Salivary Gland Tumors (SGTs) in Egyptian patients and to investigate the correlation between these two biological parameters and the presumptive behavior of these neoplasms. (researchgate.net)
  • Papillary tumors are unusual entities, making up less than 5% of all new digestive tract neoplasms in the United States. (medscape.com)
  • Although malignant tumors of the main papilla are more common, a number of benign neoplasms also may arise in the periampullary area, including benign adenomas (tubular and villous), lipomas, hamartomas, fibromas, and neurogenic tumors. (medscape.com)
  • Malignant transformation of cystic adenomas of the pancreas was first described in 1989 wherein the tumor showed invasion into surrounding structures and into the liver [ 4 ]. (hindawi.com)
  • Microcystic adenoma of the pancreas is a tumor that is benign in nature. (hindawi.com)
  • Any pancreatic tumor, as well as benign conditions such as pancreatitis, require diagnosis and treatment by expert specialists. (bidmc.org)
  • For example, for ovarian mucinous tumors, approximately 75% are benign, 10% are borderline and 15% are malignant. (wikipedia.org)
  • Methods: Flow cytometric analysis of DNA pliody and S-Phase Fraction (SPF) was done in 50 fresh tumor tissue sections of SGTs which diagnosed as 15 benign and 35 malignant tumors. (researchgate.net)
  • Results: 93.3% of the benign SGTs tumors were diploid, while only 34% of malignant tumors were diploid and 66% were aneuploid. (researchgate.net)
  • The malignant SGTs had higher SPF than the benign tumors but with no significant difference. (researchgate.net)
  • The only characteristic appearance distinguishing between benign and malignant disease is the presence of an ulcerative tumor mass, which has been observed in 21% of patients with malignancy and in no patients with benign disease. (medscape.com)
  • The most common benign tumor of the ampulla is the villous adenoma. (medscape.com)
  • Tumors of the ampulla of Vater are rare histopathological conditions and have relatively good prognosis after resection. (ispub.com)
  • Circumferential resection margin (CRM) or depth of penetration of the tumor through the bowel wall. (cancer.gov)
  • Skin metastases in the face from colorectal cancer are very rare and may indicate tumour relapse several years after primary resection. (biomedcentral.com)
  • Malignant papillary tumors have a more favorable course after resection when compared with pancreatic cancer. (medscape.com)
  • Most resection specimens contain tumors 1-2cm in size. (medscape.com)
  • Currently, surgical resection is the only potentially curative treatment for PDAC, but in approximately 80% of symptomatic patients, the tumor is already unresectable at the time of diagnosis. (medscape.com)
  • Metastasis of adenocarcinoma was confirmed histologically, and local excision was performed. (biomedcentral.com)
  • A small 0.5 cm diameter ulcer on the upper lip developed after 42 months following the removal of the primary tumor, and biopsy confirmed metastasis of the colorectal adenocarcinoma (Figure 1a . (biomedcentral.com)
  • This CK staining pattern suggested that the skin tumor was a metastasis from the previously resected rectal cancer. (biomedcentral.com)
  • The American Joint Committee on Cancer (AJCC) tumor/node/metastasis (TNM) classification and staging systems for gastric cancer are provided below. (medscape.com)
  • Therefore, preoperative and postoperative monitoring of serum PSA titers in patients with adenocarcinomas of the female urethra or periurethral glands (or both) should be considered. (nih.gov)
  • This may be due to late diagnosis of these tumors in our patients as most cases diagnosed at advanced stage and the sections were taken from deep tumor tissue to increase the number of tumor cells in our samples. (researchgate.net)
  • Mismatch repair deficiency occurs in 5% to 10% of patients with rectal adenocarcinomas. (cancer.gov)
  • Afatinib may prove effective and tolerable in patients with advanced or metastatic solid tumors with NRG1 gene fusions, according to the rationale for a prospective real-world outcomes study that was presented as a trial in progress at the 2022 ASCO Annual Meeting. (onclive.com)
  • Afatinib, an irreversible pan-ERbB TKI, has already demonstrated durable responses in individual patients with NRG1 fusion-positive tumors, representing a potential treatment option in this setting. (onclive.com)
  • Enrollment criteria stipulate that patients must have histologically or cytologically confirmed advanced, unresectable, or metastatic non-hematologic tumors with an NRG1 fusion, with any coding gene as the fusion partner. (onclive.com)
  • In this study, afatinib will be administered on a single-patient protocol as an investigational new drug to patients with tumors harboring NRG1 fusions. (onclive.com)
  • We analysed tumour and matched normal material from 230 previously untreated lung adenocarcinoma patients who provided informed consent ( Supplementary Table 1 ). (nature.com)
  • Results Sixty-two patients underwent biliary stenting alone, 5 patients underwent both biliary and pancreatic stenting, and 237 patients were not stented in the adenocarcinoma group without chronic pancreatitis. (thieme-connect.de)
  • Since these patients do not respond as well to chemotherapy and immunotherapy, there is a need to find a more targeted therapy for the subset of patients whose tumors harbor NRG1 fusions, Carrizosa concludes. (onclive.com)
  • This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. (sncrf.org)
  • Objective To evaluate the clinicopathological features and survival outcomes of mucinous ovarian cancer (MOC) patients in an Asian population. (thieme-connect.de)
  • By the time of diagnosis, 90% of patients have locally advanced tumors that have involved retroperitoneal structures, spread to regional lymph nodes, or metastasized to the liver or lung. (msdmanuals.com)
  • Adenocarcinomas of the head of the pancreas cause obstructive jaundice (which can cause pruritus) in 80 to 90% of patients. (msdmanuals.com)
  • The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)
  • Tumour-associated activating mutations in EGFR can identify patients with NSCLC who are likely to have a good response to TKIs. (bmj.com)
  • Recent developments in technology may make the monitoring of changes in patients' tumour genotypes easier in clinical practice, which may enable patients' treatment regimens to be tailored during the course of their disease, potentially leading to improved patient outcomes. (bmj.com)
  • Magnetic Resonance Radiomics and Machine-learning Models: An Approach for Evaluating Tumor-stroma Ratio in Patients with Pancreatic Ductal Adenocarcinoma. (cdc.gov)
  • Pancreaticoduodenectomy Among Patients With Pancreatic Ductal Adenocarcinoma. (cancercentrum.se)
  • Mucinous cystadenocarcinoma account for about a fifth of appendix tumours, these produces mucin (a jelly-like substance). (cancerindex.org)
  • These tumors vary between 0.063 and 0.21% on autopsy investigations but the frequency of their diagnosis is increasing because of the extensive use of flexible endoscopy. (ispub.com)
  • Histopathological diagnosis of pulmonary tumors is essential for treatment decisions. (lu.se)
  • Conclusion: DNA aneuploidy may be a key indicator for tumors activity and malignancy in SGTs, while the SPF has a minor role in the evaluation of SGTs activity. (researchgate.net)
  • Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. (nature.com)
  • However, most lung adenocarcinomas either lack an identifiable driver oncogene, or harbour mutations in KRAS and are therefore still treated with conventional chemotherapy. (nature.com)
  • In comparison, SATB2 and CK20 showed higher specificity, with expression in 5% and 10% of mucinous primary lung adenocarcinomas and both in 0% of TTF-1-negative non-mucinous primary lung adenocarcinomas (25-50% and 5-16%, respectively, for GPA33/CDX2/CDH17). (lu.se)
  • Ovarian seromucinous borderline tumors (SMBTs) are rare. (hindawi.com)
  • SMBTs have been considered a subset of mucinous tumors and account for 15% of all mucinous borderline tumors [ 1 ]. (hindawi.com)
  • Microcystic adenoma of the pancreas is a rare tumor that presents indolently with features of slow growth and abdominal pain secondary to mass effect. (hindawi.com)
  • Pseudomyxoma Peritonei ( PMP ) is a more common name given to the "jelly belly" syndrome caused by mucinous adenoma and mucinous adenocarcinoma. (cancerindex.org)
  • Sections show fibrous connective tissue with dissecting pools of mucin associated with scanty strips of malignant glandular epithelium in keeping with metastatic mucinous adenocarcinoma. (cancer.org)
  • Histologically, well-differentiated adenocarcinoma G1 was identified. (biomedcentral.com)
  • Histologically a circumscribed tumor with lakes of mucin, neoplastic cells arranged in strands and nests, and apocrine secretion is frequently observed ( Fig-1 ) [4]. (asploro.com)
  • Histologically, papillary adenocarcinomas closely resemble adenocarcinomas of the colon. (medscape.com)
  • This immunohistochemical profile supports mucinous adenocarcinoma from a colorectal primary. (cancer.org)
  • Therefore, we compared the diagnostic value of several immunohistochemical markers in pulmonary tumors. (lu.se)
  • Because of positivity for GATA 3 ( an immunomarker found for example in breast and salivary glands but also in skin tumors [5,6] and expression of mammaglobin, an immunohistochemical marker found in breast cancer [7], mammography was done also and ultrasonography was performed to rule out a salivary gland origin because of its anatomic proximity. (asploro.com)
  • We suggest that these ovarian tumors and colonic lesions were also associated with separate endometriotic foci. (hindawi.com)
  • An abdominal computed tomography scan revealed bilateral ovarian tumors and uterine leiomyoma. (hindawi.com)
  • Metastatic lesions of the skin occur more frequently in cases of primary tumors of the lungs (up to 28.6% of all metastases) and breasts with equal distribution between males and females [ 2 ]. (biomedcentral.com)
  • Epithelial tumors of major salivary glands (closed to accrual 03/20/2018) 3. (sncrf.org)
  • Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018) 14. (sncrf.org)
  • Mixed mesenchymal and epithelial tumors are of Mullerian origin. (cytojournal.com)
  • There are several kinds of appendix tumors, some of which are cancerous and some of which are not. (mskcc.org)
  • Because there are no symptoms, these tumors are often detected after the appendix has been removed. (mskcc.org)
  • These tumors are usually found near the bottom or base of the appendix. (mskcc.org)
  • Fibromixoma and low grade mucinous adenocarcinoma (pseudomixoma peritonei) of the appendix and ovary (closed to accrual 03/20/2018) 8. (sncrf.org)
  • Two individuals (0.9%) in the FPC cohort had a pancreatic tumor, including one advanced PDAC and one early grade 2 neuroendocrine tumor. (medscape.com)
  • The tumor markers were within normal range. (ispub.com)
  • Methods Data of MOC were evaluated for demographics, tumor stage, clinical characteristics, tumor markers, treatment modalities, and outcomes from electronic Hospital Information System. (thieme-connect.de)
  • A collision tumor is one where histology shows the presence of two distinct primaries involving the same organ without intermixture of individual cell types, ie, a side by side pattern. (dovepress.com)
  • The colonic tumor exhibited crowded endometrial glands (Figure 2(e) ) as well as variation in the glandular architecture and cytology (Figure 2(f) ). (hindawi.com)
  • No apparent transitional lesions were noted between the different tumor components. (hindawi.com)
  • Lesions of endocrine origin have been termed carcinoid tumors. (medscape.com)
  • With recent advancements in pathology, gene expression profiling, identification of subtypes and various modalities available for exploring the GI tract, it has become possible to find the precise origin of mucinous tumors. (thieme-connect.de)
  • Duodenal carcinoids have morphologic and functional similarities to pancreatic islet-cell tumors. (medscape.com)
  • Daniel Carrizosa, MD, MS, discusses the prevalence of NRG1 gene fusions in solid tumors. (onclive.com)
  • Daniel Carrizosa, MD, MS, oncologist, Head and Neck Cancer Lung Cancer, Hematology and Medical Oncology (Cancer), Atrium Health Levine Cancer Institute (Thoracic-Pulmonary), discusses the prevalence of NRG1 gene fusions in solid tumors. (onclive.com)
  • PMCS is a rare tumor that infrequently metastasizes but has a high local recurrence rate [1]. (asploro.com)
  • 5 ] The location of a rectal tumor is usually indicated by the distance between the anal verge, dentate line, or anorectal ring and the lower edge of the tumor, with measurements differing depending on the use of a rigid or flexible endoscope or digital examination. (cancer.gov)
  • The distance of the tumor from the anal sphincter musculature has implications for the ability to perform sphincter-sparing surgery. (cancer.gov)
  • BACKGROUND: A long-standing (over 10 years) anal fistula is considered a fundamental cause of fistula-associated mucinous adenocarcinoma (FAMC). (bvsalud.org)
  • CASE PRESENTATION: A 68-year-old woman was admitted to our hospital because of progressive anal pain and a palpable tumor. (bvsalud.org)
  • Histopathology showed highly dysplastic cells lining the lumen of the anal fistula and poorly differentiated mucinous adenocarcinoma proliferating in the dermis and epidermis in the distal aspect of the fistula. (bvsalud.org)
  • One series of 34 primary papillary adenocarcinomas reported that 20% were well differentiated, 68% were moderately differentiated, and 6% were poorly differentiated. (medscape.com)
  • The endocervix is lined by columnar mucinous epithelium and in continuity with vaginal mucosa, the ectocervix is lined by squamous epithelium. (cytojournal.com)
  • Immunohistochemistry showed different staining patterns in tumor components. (hindawi.com)
  • Our efforts focused on comprehensive, multiplatform analysis of lung adenocarcinoma, with attention towards pathobiology and clinically actionable events. (nature.com)
  • Clinically the tumor presents as a solitary greyish, red, and purple skin lesion with telangiectasia [1]. (asploro.com)