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  • small bowel
  • This study will evaluate members in families with a history of small bowel carcinoid cancer to study the natural history of those family members that have the disease, determine ways to improve early detection by performing surveillance on those at risk but without disease and to identify the gene(s) that may cause the tumors. (clinicaltrials.gov)
  • For tumors in other parts of the small intestine, treatment is either local excision for small tumors or small bowel resection (removal of a piece of intestine as well as some surrounding blood vessels and lymph nodes) for larger tumors. (cancer.org)
  • endoscopic
  • Therefore, family members who have up to a 50% lifetime risk of harboring a carcinoid tumor will undergo an intensive diagnostic evaluation using biochemical, endoscopic and imaging modalities at initial and subsequent two year follow up encounters. (clinicaltrials.gov)
  • If the tumor is small, endoscopic surgery may still be an option. (cancer.org)
  • Some small tumors in the duodenum (the first part of the small intestine) can often be removed through the endoscope (endoscopic resection). (cancer.org)
  • often
  • It is known that these tumors occur more often in some families and are then passed from one generation to the next by inherited genes. (clinicaltrials.gov)
  • The tumors don't tend to grow into the deeper layers of the stomach or spread to other organs or tissues, and are often treated by removing them completely through an endoscope. (cancer.org)
  • Like type 1 tumors they are often small and there may be more than one at a time. (cancer.org)
  • Because many patients have more than one carcinoid tumor, the surgeon will often check the rest of the colon for other tumors during surgery. (cancer.org)
  • look
  • 18 FDOPA Positron emission tomography (PET) with CT for localization: Nuclear imaging scan to look at tumor activity. (clinicaltrials.gov)
  • Still, other factors, such as the way the tumor cells look under the microscope, the patient's age, general health, and the patient's degree of worry about the possibility of the cancer coming back, might also be used to determine whether more treatment is needed. (cancer.org)
  • either
  • These tumors need to be removed, either through an endoscope or in a regular operation through an incision in the abdomen that removes the tumor and some surrounding stomach tissue. (cancer.org)
  • progression
  • In conclusion, NCL inhibition is a new anti-tumor therapeutic strategy that dually blocks tumor progression and normalizes tumor vessels improving the delivery and efficacy of chemotherapeutic drugs in PDAC cancers. (aacrjournals.org)
  • Collectively, the SIRT1 expression was gradually decreased during carcinogenesis and tumour progression. (bmj.com)
  • Piccard H, Muschel RJ, Opdenakker G. On the dual roles and polarized phenotypes of neutrophils in tumor development and progression. (springer.com)
  • The presence or absence of IM is a flag for cancer risk, and its presence or absence in background mucosa may be used to differentiate groups of tumors with potentially different underlying pathogenesis and molecular pathways of development and progression. (redorbit.com)
  • Alternatively spliced forms of RHAMM may be up regulated in some tumor types, promoting tumor progression. (wikipedia.org)
  • epithelial
  • The polymeric immunoglobulin receptor (PIgR) is a protein involved in the transport of immunoglobulin A (IgA) across mucosal membranes, from the basolateral aspect of epithelial cells to the luminal surface.24,25 PIgR is highly expressed in intestinal epithelial cells and is downregulated in adenocarcinomas of the colon.26 PIgR is not present in normal gastric mucosa. (redorbit.com)
  • Because PIgR is associated with the intestinal epithelial cell defense functions, PIgR may be differentially expressed in upper GI tumors in a manner related to the intestinal phenotype and may correlate with the presence of IM in the background mucosa. (redorbit.com)
  • Additionally, the WHO scheme recognizes mixed tumors with both neuroendocrine and epithelial carcinoma features, such as goblet cell cancer, a rare gastrointestinal tract tumor. (wikipedia.org)
  • Other presenting symptoms described have included: flu-like syndrome with cough and fever, FA is an epithelial tumor whose cells and architecture resemble that of fetal lung tissues in the pseudoglandular stage of development (which occurs at about 10-16 weeks gestation in the human), with complex glandular structures and morules with cell nuclei that appear clear due to the accumulation of biotin. (wikipedia.org)
  • Cytokeratin is also a surface marker that is presented on epithelial cells, is stained histochemically and favors the diagnosis of epithelial tumors like adenocarcinoma. (wikipedia.org)
  • A malignant mixed Müllerian tumor, also known as malignant mixed mesodermal tumor, MMMT and carcinosarcoma, is a malignant neoplasm found in the uterus, the ovaries, the fallopian tubes and other parts of the body that contains both carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components. (wikipedia.org)
  • the "combination" theory is most widely held, and is due to evidence that the tumors develop from a single line of cells, developing in a fashion similar to the fundus of the uterus from the Müllerian duct - first from a stem cell into a population of cells, that then differentiates into epithelial and stromal components. (wikipedia.org)
  • There is evidence that some tumors are better explained by the composition theory, due to the aggressive nature of the epithelial cells involved which tend to metastasize much more readily than the sarcomal component. (wikipedia.org)
  • alternatively, the tumor may contain two distinct and separate epithelial and mesenchymal components. (wikipedia.org)
  • whole-tumor
  • Conclusions: The feasibility of whole-tumor perfusion imaging using 128-slice CT was demonstrated in patients with pancreatic adenocarcinoma. (ugent.be)
  • Using increments of 5% to describe the amount of each subtype present, the predominant subtype is used to classify the whole tumor. (wikipedia.org)
  • While FA can be diagnosed via biopsy, bronchial brushings, and immunocytochemistry, examination of the whole tumor is required to rule out biphasic pulmonary blastoma, a mixed tumor of higher aggressiveness, wherein FA occurs admixed with primitive blastoma cells. (wikipedia.org)
  • Histological
  • Histological examination of the specimen revealed a mixed neoplasm: (1) a well differentiated adenocarcinoma, neoplastic blasts of which are extended focally to the submucosa without invading the muscular layer, and (2) a low differentiated NEC consisting of solid clusters and pagetoid formations. (hindawi.com)
  • Placing a given tumor into one of categories depends on well-defined histological features: size, lymphovascular invasion, mitotic counts, Ki-67 labelling index, invasion of adjacent organs, presence of metastases and whether they produce hormones. (wikipedia.org)
  • In such cases, resected tumors should be classified by comprehensive histological subtyping. (wikipedia.org)
  • Signet ring and clear cell adenocarcinoma are no longer histological subtypes, but rather cytological features that can occur in tumour cells of multiple histological subtypes, most often solid adenocarcinoma. (wikipedia.org)
  • The naming issue to a certain extent reflects histological characteristics and development of the tumors, in which the different types of tissues are believed to either develop separately and join into a single mass (the "collision" theory), that an adenocarcinoma stimulates the stroma to create a tumor (the "composition" theory), or that the tumor is the result of a stem cell that differentiates into different cell types (the "combination" theory). (wikipedia.org)
  • cancers
  • Polymeric immunoglobulin receptor (PIgR) expression has been found in gastric mucosa and gastric cancers, but it is not known whether PIgR expression is related to background intestinal metaplasia nor the patterns of PIgR expression in tumors arising in the distal esophagus and gastroesophageal (GE) junction. (redorbit.com)
  • Nearly 40% of lung cancers in the US are adenocarcinoma, which usually originates in peripheral lung tissue. (wikipedia.org)
  • FA is a rare tumor, with a relative incidence estimated to be no more than 0.5% of all lung cancers. (wikipedia.org)
  • Cancer
  • Immunostaining may identify tumour markers potentially targetable in future adjuvant treatments for pancreatic cancer. (uio.no)
  • Tumour cell proliferation (Ki-67) in non-small cell lung cancer: a critical reappraisal of its prognostic role. (springer.com)
  • Shen M, Hu P, Donskov F, Wang G, Liu Q, Du J. Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. (springer.com)
  • Hence depending on the context, LT-α may function to prevent growth of cancer cells or facilitate the development of tumors. (wikipedia.org)
  • Interestingly, in other studies, mice with gene knockout of LT-α showed enhanced tumor growth, implicating possible protective role of LT-α in cancer. (wikipedia.org)
  • Rare tumor, the U.S. incidence is 3 cases per 100,000 people each year Gallbladder cancer is more common in South American countries, Japan, and Israel. (wikipedia.org)
  • There are many differences between mammary tumors in animals and breast cancer in humans, including tumor type, malignancy, and treatment options. (wikipedia.org)
  • Less common types of ovarian cancer include germ cell tumors and sex cord stromal tumors. (wikipedia.org)
  • Cholangiocarcinoma is a relatively rare neoplasm that is classified as an adenocarcinoma (a cancer that forms glands or secretes significant amounts of mucins). (wikipedia.org)
  • Cholangiocarcinoma is considered to be an incurable and rapidly lethal cancer unless both the primary tumor and any metastases can be fully removed by surgery. (wikipedia.org)
  • however, among people who have smoked fewer than 100 cigarettes in their lifetimes ("never-smokers"), adenocarcinoma is the most common form of lung cancer. (wikipedia.org)
  • The adenocarcinoma has an increased incidence in smokers, and is the most common type of lung cancer seen in non-smokers and women. (wikipedia.org)
  • FA can occur in combination with other forms of lung cancer, particularly other variants of adenocarcinoma. (wikipedia.org)
  • Analysis of body fluids like urine and blood from circulation from different types of cancer for example colorectal cancer, Burkitt cancer, lung adenocarcinoma showed increase level of Perlipin 2. (wikipedia.org)
  • atypical
  • The behavior of MMMT overall is more related to the type and grade of the epithelium than the sarcoma, which suggests the sarcomal portion is an atypical "bystander" than primary driver of the tumor. (wikipedia.org)
  • tissue
  • Hela (Human cervix Adenocarcinoma) cell membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. (genetex.com)
  • Compared with the normal pancreas, a 60% reduction in BF and BV was observed in the tumor tissue. (ugent.be)
  • No significant differences were observed when comparing normal pancreas and healthy pancreatic tissue in adenocarcinoma patients. (ugent.be)
  • Perfusion CT provides additional information compared with image assessment based on density measurements (Hounsfield units) and allows noninvasive assessment of vascularization in the tumor tissue. (ugent.be)
  • Methods SIRT1 protein expression, determined by immunohistochemistry, was investigated in human normal colonic mucosa, adenoma, adenocarcinoma and metastatic tissue samples. (bmj.com)
  • 1 H high-resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy using intact tissues was applied to analyze metabolites in PP tissue samples ( n = 17) and intact tumor samples ( n = 106), obtained from 106 patients undergoing surgical resection for PA. (biomedcentral.com)
  • benign
  • The benign tumors include ceruminous adenoma, ceruminous pleomorphic adenoma, and ceruminous syringocystadenoma papilliferum. (wikipedia.org)
  • metastases
  • In some tumors, notably those arising from the colon and rectum, apparently solitary metastases or metastases to one or other lobes may be resected. (wikipedia.org)
  • A careful search for other metastases is required, including local recurrence of the original primary tumor (e.g., via colonoscopy) and dissemination elsewhere (e.g., via CT of the thorax). (wikipedia.org)
  • anti-tumor
  • As consequence of N6L-induced tumor vessel normalization, pre-treatment with N6L efficiently improved chemotherapeutic drug delivery and increased the anti-tumor properties of gemcitabine in PDAC mice. (aacrjournals.org)
  • In other words, LT-α interactions with LT-β receptors can increase anti-tumor effects through direct destruction of tumor cells. (wikipedia.org)
  • gastric
  • These groups are (1) gastric adenocarcinomas, (2) adenocarcinomas of the distal esophagus and GE junction with background intestinal metaplasia, and (3) adenocarcinomas of the distal esophagus and GE junction without background intestinal metaplasia. (redorbit.com)
  • Expression of PIgR and CDX2 in nonneoplastic mucosa, intestinal metaplasia, and adenocarcinomas was examined by immunohistochemistry in 42 cases: 14 gastric and 28 from the distal esophagus and GE junction, including 13 with esophageal or GE junction intestinal metaplasia. (redorbit.com)
  • Risk factors for gastric lymphoma include the following: Helicobacter pylori Long-term immunosuppressant drug therapy HIV infection These lymphomas are difficult to differentiate from gastric adenocarcinoma. (wikipedia.org)
  • Differentiation
  • Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. (uio.no)
  • To identify clinicopathologic features of tumors associated with PIgR expression and to determine whether PIgR expression is associated with intestinal differentiation of tumors and intestinal metaplasia in background mucosa in 3 groups of upper gastrointestinal adenocarcinomas. (redorbit.com)
  • aggressiveness
  • RHAMM is also one of 3 biomarkers associated with aggressiveness in a multivariate analysis of human prostate tumors and elevated levels of RHAMM are associated with both androgen deprivation therapy and castration resistant disease. (wikipedia.org)
  • histology
  • Only the histology of the resected surgical specimen proved the presence of a mixed adenocarcinoid tumor involving the terminal ileum. (springer.com)
  • The associations between SIRT1 expression and clinicopathological parameters revealed that loss of SIRT1 expression was associated with proximal tumour location, mucinous histology and defective mismatch repair protein expression. (bmj.com)
  • suppressor
  • With respect to tumourigenesis, there have been conflicting data supporting whether SIRT1 act as a tumour promoter or as a tumour suppressor. (bmj.com)
  • MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met. (springer.com)
  • liver
  • The most common physical indications of cholangiocarcinoma are abnormal liver function tests, jaundice (yellowing of the eyes and skin occurring when bile ducts are blocked by tumor), abdominal pain (30%-50%), generalized itching (66%), weight loss (30%-50%), fever (up to 20%), and changes in the color of stool or urine. (wikipedia.org)
  • Tumor emboli entering the sinusoids through the liver blood supply appear to be physically obstructed by the Kupffer cells, but if tumor emboli are larger, they tend to become lodged in the portal venous branches. (wikipedia.org)
  • Cross section of a human liver, taken at autopsy examination, showing multiple large pale tumor deposits. (wikipedia.org)
  • surgical
  • All 18 lymph nodes of the specimen were free of neoplastic disease and the surgical margins of the specimen were tumor-free. (hindawi.com)
  • The disease is diagnosed through a combination of blood tests, imaging, endoscopy, and sometimes surgical exploration, with confirmation obtained after a pathologist examines cells from the tumor under a microscope. (wikipedia.org)
  • invasiveness
  • In this study, we developed a deep learning system based on 3D convolutional neural networks and multi-task learning, which automatically predicts tumor invasiveness, together with 3D nodule segmentation masks. (aacrjournals.org)
  • cervix
  • The Hela (Human cervix Adenocarcinoma) cell was frozen in liquid nitrogen immediately after excision and then stored at -70oC. (genetex.com)
  • For quality control purposes, the isolated Hela (cervix Adenocarcinoma) cell membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. (genetex.com)
  • The isolated Hela (cervix Adenocarcinoma) cell membrane protein is then Western analyzed by either GAPDH or beta-actin antibody to confirm there is no signal or very weak signal. (genetex.com)
  • Abstract
  • article{1898628, abstract = {Objective: Computed tomography (CT) perfusion studies can provide valuable information regarding tumor vascularization. (ugent.be)
  • carcinogenesis
  • The molecular carcinogenesis of canine mammary tumors are not completely understand. (wikipedia.org)
  • However, the increasing information on molecular pathways involved in the carcinogenesis of this canine tumor has potential to complement and refine the current diagnostic and therapeutic approach to this tumor type. (wikipedia.org)
  • pancreas
  • Coexistence of NEC with adenocarcinoma of the pancreas is a very rare entity presenting significant challenges regarding its adjuvant treatment and the treatment of distant relapse. (hindawi.com)
  • We report on a study assessing CT perfusion characteristics in the normal pancreas and in patients with pancreatic adenocarcinoma. (ugent.be)
  • They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung and the rest of the body. (wikipedia.org)
  • The tumor is an adenocarcinoma derived from a primary lesion in the body of the pancreas. (wikipedia.org)
  • abdominal
  • The typical symptoms of an LMP tumor can include abdominal distension or pelvic pain. (wikipedia.org)
  • In adolescents or children with ovarian tumors, symptoms can include severe abdominal pain, irritation of the peritoneum, or bleeding. (wikipedia.org)
  • NSCLC
  • Here we present a genome-wide DNA methylation analysis of NSCLC samples and paired lung tissues, where we combine MethylCap and next generation sequencing (MethylCap-seq) to provide comprehensive DNA methylation maps of the tumor and paired lung samples. (ox.ac.uk)
  • We identified 57 differentially methylated regions (DMRs) present in all NSCLC tumors analyzed by MethylCap-seq. (ox.ac.uk)
  • In January 2015 a Phase III trial in people with NSCLC suggested the drug extended life expectancy in stage IV NSCLC adenocarcinoma with EGFR Mutation type del 19-positive tumors, compared to cisplatin-based chemotherapy by a year (33 months vs. 21 months). (wikipedia.org)
  • metastatic disease
  • Exclusion criteria were distant metastatic disease (M1), T1N0 tumors, different multimodality treatments and tumors of the gastric stump. (springer.com)
  • Activating mutations of the Ras protein and upstream elements of the Ras protein may play a role in more than two thirds of all human cancers, including most metastatic disease, which suggests that Reolysin may be an effective therapeutic for many Ras-activated tumor types and potentially for some cell proliferative disorders. (wikipedia.org)
  • gastric adenocarcinoma
  • This retrospective study included patients with pathologically confirmed gastric adenocarcinoma who underwent surgical treatment with curative intent in a single cancer center in Brazil, between 1998 and 2008. (springer.com)
  • This is a retrospective study, which included patients with pathologically confirmed gastric adenocarcinoma who underwent surgical treatment with curative intent in a single cancer center in Brazil, in the period between September 1998 and December 2008. (springer.com)
  • This includes patients diagnosed with gastric adenocarcinoma (especially those with early-stage disease), patients found to have atrophic gastritis or intestinal metaplasia, as well as first-degree relatives of patients with gastric adenocarcinoma since the relatives themselves are at increased risk of gastric cancer partly due to the intrafamilial transmission of H. pylori. (wikipedia.org)
  • lung adenocarcinoma
  • Dr. Chao will highlight previously announced laboratory and animal data that demonstrates the potential for L-DOS47 to bind to and debilitate and destroy human lung adenocarcinoma cells. (drugs.com)
  • L-DOS47 combines Helix's proprietary DOS47 new drug candidate with a highly specific, single-domain antibody to form a potential new targeted drug product for the treatment of lung adenocarcinoma, the most common form of cancer today. (drugs.com)
  • induce
  • Tumors induce the proliferative vascular response of host blood vessels by influencing the local balance of angiogenic regulators, a rate-limiting step termed the angiogenic switch [ 9 , 10 ]. (hindawi.com)
  • Patients with MALT lymphoma should also be tested and treated for H. pylori since eradication of this infection can induce remission in many patients when the tumor is limited to the stomach. (wikipedia.org)
  • Bladder
  • Primary SRCC tumors are most often found in the glandular cells of the stomach (SRCC originates in the stomach in 90 percent of patients), and less frequently in the breast, gallbladder, urinary bladder, and pancreas. (wikipedia.org)
  • rectal cancer
  • Gunderson LL, Jessup JM, Sargent DJ, Greene FL, Stewart A. Revised tumor and node categorization for rectal cancer based on surveillance, epidemiology, and end results and rectal pooled analysis outcomes. (springermedizin.de)
  • Secure scope in place with Martin Arm Courtesy Peter Cataldo, MD TEM Technique Direct view through stereoscope or on monitor Courtesy Peter Cataldo, MD Technique Inject lesion with lidocaine w/ epinephrine Courtesy Peter Cataldo, MD ENDOSCOPIC VIEW Multifocal Dysplastic Adenoma (TEM Specimen) T1 Polypoid Cancer TEM specimen T2 Adenocarcinoma of Mid Rectum TEM VIDEO TEM for Rectal Cancer? (slidegur.com)
  • lymph
  • Apocrine gland anal sac adenocarcinomas also have a tendency to metastasize to the regional lymph nodes, spleen, and eventually lungs and, less commonly, bones. (wikipedia.org)
  • The sublumbar (iliac) lymph nodes are the most common site of metastasis and can become larger than the original tumor. (wikipedia.org)
  • Isolate
  • REOLYSIN is a non-pathogenic, proprietary isolate of the unmodified reovirus that: induces selective tumor lysis and promotes an inflamed tumor phenotype through innate and adaptive immune responses. (wikipedia.org)
  • marker
  • It is a very stable and specific modification and therefore in principle a very suitable marker for epigenetic phenotyping of tumors. (ox.ac.uk)
  • PSAP was the first useful serum tumour marker and emerged in the 1940s and 1950s. (wikipedia.org)
  • antigens
  • and Adaptive immune response - antigen presenting cells (APCs) display tumor-associated antigens (TAA) and viral-associated antigens (VAA) to educate T-cells to recognize and destroy cancer cells. (wikipedia.org)
  • inhibitor
  • p16 (also known as cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 and as several other synonyms), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene. (wikipedia.org)
  • p16 is also known as: p16Ink4A p16Ink4 Cyclin-dependent kinase inhibitor 2A (CDKN2A) CDKN2 CDK 4 Inhibitor Multiple Tumor Suppressor 1 (MTS1) TP16 ARF MLM P14 P19 In humans, p16 is encoded by the CDKN2A gene, located on chromosome 9 (9p21.3). (wikipedia.org)
  • Adenoma
  • Bradley states that an adenoma, by definition, is a tumor confined to the appendiceal mucosa with absolutely no evidence of invasion beyond the muscularis mucosae. (wikipedia.org)
  • SCLC
  • Multiple endocrine neoplasia type I (MEN1)can be found in carcinoid tumor patients, but not those with LCNEC and SCLC. (wikipedia.org)
  • characteristic
  • SRCC tumors grow in characteristic sheets, which makes diagnosis using standard imaging techniques, like CT and PET scans, less effective. (wikipedia.org)
  • diagnosis
  • Anal sac adenocarcinomas are often suspected due to location (palpable masse in anal sac) and behavior, but a biopsy and histopathology is necessary for a definitive diagnosis. (wikipedia.org)
  • cells
  • This study will also look at specific substances called biomarkers in your blood, and in the tumor tissue which are involved in the growth of tumor cells, and determine if the levels of these biomarkers are related to your response to treatment or development of side effects. (clinicaltrials.gov)
  • Proliferation of vessel-forming endothelial cells is a limiting factor for tumor growth [ 4 - 7 ]. (hindawi.com)
  • The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix. (wikipedia.org)
  • endothelial
  • Colocalization of vascular endothelial growth factor receptor 2 (VEGFR-2) and platelet-derived growth factor receptor beta (PDGF-R β ) reduces pericyte ensheathment of tumor vessels. (hindawi.com)
  • In contrast to healthy vessels, tumor vessels are immature, often mal-shaped, irregular, and have a tortuous structure with a leaky endothelial cell lining [ 13 , 14 ]. (hindawi.com)
  • It may also be used to diagnose tumors of endothelial origin, such as angiosarcoma, variants of hemangioma, Kaposi sarcoma, and staging AML lymphoid tumors. (biocare.net)
  • Disease
  • Patients with node-positive disease had improved survival with adjuvant chemoradiotherapy, especially when we grouped patients with N1 and N2 tumors and a higher N-ratio. (springer.com)
  • protein
  • The ARF product functions as a stabilizer of the tumor suppressor protein p53, as it can interact with and sequester MDM2, a protein responsible for the degradation of p53. (wikipedia.org)
  • Upregulation of the DNA repair protein EYA3 in this tumour is mediated by the fusion protein transcription factor EWS/FLI1, which in turn is via repression of miR-708. (wikipedia.org)
  • Between 25 and 40 percent of dogs with these tumors will also develop hypercalcaemia through secretion of parathyroid hormone-related protein by the tumor. (wikipedia.org)
  • oxygen
  • While it may seem that an increase in blood vessel quantity would provide sufficient oxygen to tumors, the abnormal vessels deliver less oxygen leading to a hypoxic tumor environment [ 13 ]. (hindawi.com)
  • growth
  • Accordingly, targeting tumor vessel proliferation decreases blood flow and nutrient availability, thus slowing tumor growth [ 8 ]. (hindawi.com)
  • This will further stimulate tumor growth and aberrant angiogenesis [ 22 , 23 ]. (hindawi.com)
  • survival
  • The Intergroup US 0116 Trial (INT 0116)[ 7 ] demonstrated survival improvement with the addition of chemoradiotherapy after negative-margin resection of tumors without distant metastases. (springer.com)
  • Small
  • Apocrine gland anal sac adenocarcinomas first appear as small lumps associated with one of the anal sacs (rarely bilateral), but they can grow to a large size. (wikipedia.org)
  • high
  • Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies. (semanticscholar.org)