Loading...
  • patients
  • Tekmira has enrolled a total of 36 patients in a population of advanced cancer patients with solid tumors. (globenewswire.com)
  • Of the 36 patients enrolled, three out of the four ACC patients (75%) treated with TKM-PLK1 achieved stable disease, including one patient who saw a 19.3% reduction in tumor size and is still on study receiving TKM-PLK1. (globenewswire.com)
  • Of the two GI-NET patients enrolled, both experienced clinical benefit: one patient had a partial response based on RECIST criteria, and the other GI-NET patient achieved stable disease and showed a greater than 50% reduction in Chromogranin-A (CgA) levels, a key biomarker used to predict clinical outcome and tumor response. (globenewswire.com)
  • The ongoing TKM-PLK1 Phase I/II clinical trial, which is currently targeting GI-NET and ACC patients for enrollment, is a multi-center, single arm, open label study designed to measure efficacy using RECIST and tumor biomarkers for GI-NET patients, as well as to evaluate TKM-PLK1's safety, tolerability and pharmacokinetics. (globenewswire.com)
  • It is expected that approximately 20 patients with advanced GI-NET or ACC tumors will be enrolled in this trial, with a minimum of 10 GI-NET patients to be enrolled. (globenewswire.com)
  • liver
  • In an exploratory laparotomy, a 15 cm-size hepatic tumor was located in the right lobe with multiple satellite lesions in both lobes of the liver. (nagasaki-u.ac.jp)
  • genetic
  • Although the gene that causes tumors in people with the MEN1 syndrome has been found, genetic testing for MEN1 is not widely available. (cancer.org)
  • small
  • Smoking may increase the risk of getting a carcinoid tumor of the small intestine, according to some research. (cancer.org)
  • risk
  • People with this syndrome have a very high risk of getting tumors of 3 glands: the pituitary, parathyroid, and pancreas. (cancer.org)
  • patient
  • After surgery for operable colon carcinoma, the patient received chemotherapy and biological therapy for both tumors. (diva-portal.org)
  • cancer
  • People with von Hippel Lindau disease have an inherited tendency to develop blood vessel tumors of the brain, spinal cord, or retina, as well as kidney cancer. (cancer.org)
  • disease
  • This disease often runs in families and is characterized by many neurofibromas (benign tumors that form in nerves under the skin and in other parts of the body). (cancer.org)
  • feed tumors in mice
  • A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. (nih.gov)
  • cancers
  • They found that the CD276 protein was overexpressed in tumor-associated blood vessels from colon, lung, breast, esophageal and bladder cancers. (nih.gov)
  • Depending on their location, the spinal cord tumors can be: Extradural - outside the dura mater lining (most common) Intradural - part of the dura Intramedullary - inside the spinal cord Extramedullary- inside the dura, but outside the spinal cord Extradural tumors are mostly metastases from primary cancers elsewhere (commonly breast, prostate and lung cancer). (wikipedia.org)
  • Neuroendocrine tumors are uncommon in many of these areas, and frequently represent only a very small proportion of the tumors or cancers at these locations. (wikipedia.org)
  • See: Tumor-associated endothelial cells 80-90% of cancer are carcinomas, or cancers that form in the epithelial tissue. (wikipedia.org)
  • solid tumors
  • Hypoxic microenvironements in solid tumors are a result of available oxygen being consumed within 70 to 150 μm of tumour vasculature by rapidly proliferating tumor cells thus limiting the amount of oxygen available to diffuse further into the tumor tissue. (wikipedia.org)
  • While angiogenesis can reduce this affect, the partial pressure of oxygen is below 5 mm Hg (venous blood has a partial pressure of oxygen at 40 mm Hg) in more than 50% of locally advanced solid tumors. (wikipedia.org)
  • hypoxic
  • Having an increased level of GLUT1, in the case of hypoxic tumors, increases the flux of glucose into the cells allowing for a higher rate of glycolysis and thus greater risks of metastasis (as elaborated upon below). (wikipedia.org)
  • In hypoxic tumors, hexokinase mRNA abundance is significantly increased as well as protein levels. (wikipedia.org)
  • This inflammation effect is not only seen in tumors, but in hypoxic areas of cardiac muscles following a myocardial infarction (MI or heart attack). (wikipedia.org)
  • The tumor microenvironment is often hypoxic. (wikipedia.org)
  • adrenal
  • This tumor causes excessive production of cortisol from the adrenal cortex which leads to the classic signs of alopecia (hair loss), polyuria (excessive urination), polydipsia (excessive water drinking), and a pot-bellied appearance of the abdomen due to muscle break down. (wikipedia.org)
  • allow tumor
  • In practice, brain tumors are generally considered to be malignant due to the delicate and poorly regenerative nature of neurons and restriction of the brain to the finite space of the cranium which does not allow tumor growth devoid of collateral damage to brain parenchyma. (wikipedia.org)
  • Genetic
  • Your doctor may ask about your family history of tumors or other problems to see if you might have an inherited genetic syndrome , such as multiple endocrine neoplasia, type I (MEN1). (cancer.org)
  • Doctors don't know what causes brain tumors, but researchers think there may be genetic and environmental causes. (kidshealth.org)
  • Some kids who have certain genetic conditions have a greater chance of developing brain tumors. (kidshealth.org)
  • Multiple types of heterogeneity have been observed between tumour cells, stemming from both genetic and non-genetic variability. (wikipedia.org)
  • gliomas
  • Then in 2000, they reported in the journal Nature Medicine that injections of synthetic THC eradicated malignant gliomas (brain tumors) in one-third of treated rats, and prolonged life in another third by six weeks. (norml.org)
  • vasculature
  • The enhanced permeability and retention effect (EPR effect) is the observation that the vasculature of tumors is often leaky and accumulates molecules in the blood stream to a greater extent than in normal tissue. (wikipedia.org)
  • parathyroid
  • This is a hereditary condition in which people have a very high risk of developing tumors of 3 glands: the pituitary, parathyroid, and pancreas. (cancer.org)
  • Brown tumors may be rarely associated with ectopic parathyroid adenomas or end stage renal osteodystrophy. (wikipedia.org)
  • Tumors with similar cellular characteristics in the pituitary, parathyroid, and adrenomedullary glands are sometimes included or excluded. (wikipedia.org)
  • bone
  • The brown tumor is a bone lesion that arises in settings of excess osteoclast activity, such as hyperparathyroidism. (wikipedia.org)
  • it may also be seen in giant cell tumors of the bone. (wikipedia.org)
  • Frequently these tumors appear in bone, and not in pre-existing cartilage tissue. (wikipedia.org)
  • The tumor microenvironment (TME) is the cellular environment in which the tumor exists, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules and the extracellular matrix (ECM). (wikipedia.org)
  • surgery
  • You might also be referred to other doctors, such as an endocrinologist (a doctor who treats diseases in glands that secrete hormones) or a neurosurgeon (a doctor who uses surgery to treat brain and pituitary tumors), who might order other tests. (cancer.org)
  • If imaging studies reveal a brain tumor, then surgery is likely to be the next step. (kidshealth.org)
  • Radiation treatment after breast-conserving surgery with negative margins may significantly reduce the local recurrence rate for borderline and malignant tumors. (wikipedia.org)
  • The authors of a 2012 study have derived a risk calculator for relapse risk of phyllodes tumors after surgery. (wikipedia.org)
  • radiation
  • Intracranial tumors (such as glioblastoma) more commonly rely on radiation therapy as surgical access to the tumor may be prohibitively dangerous. (wikipedia.org)
  • suppressor
  • Apart from being as a general tumor suppressor gene, p53 also plays an important part in regulating of metabolism. (wikipedia.org)
  • testes
  • Germ cell tumors usually form in the testes or ovaries but can also form in the brain and central nervous system. (kidshealth.org)
  • heterogeneity
  • This phenomenon occurs both between tumours (inter-tumour heterogeneity) and within tumours (intra-tumour heterogeneity). (wikipedia.org)
  • There are two models used to explain the heterogeneity of tumour cells. (wikipedia.org)
  • The models are not mutually exclusive, and it is believed that they both contribute to heterogeneity in varying amounts across different tumour types. (wikipedia.org)
  • The CSC model posits that the heterogeneity observed between tumour cells is the result of differences in the stem cells from which they originated. (wikipedia.org)
  • This heterogeneity may give rise to subclones that possess an evolutionary advantage over the others within the tumour environment, and these subclones may become dominant in the tumour over time. (wikipedia.org)
  • This method is more associated with tumour heterogeneity than linear expansion. (wikipedia.org)
  • endothelial cells
  • By comparing the gene expression profiles of endothelial cells from regenerating liver to those derived from tumor-bearing livers, the researchers found 13 distinct genes that were selectively overexpressed (turned on to a greater degree than other genes) during disease-related angiogenesis. (nih.gov)
  • tissues
  • As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. (wikipedia.org)
  • In some cases tumors that formed in other tissues may produce a cartilage-like matrix, an example of this is the pleomorphic adenoma of the sexual reproduction salivary glands. (wikipedia.org)
  • tissue
  • However, blocking angiogenesis requires a delicate balance between tumor and normal cells as most angiogenesis-related molecules are also critical for normal blood vessel growth in the body - for example, during menstruation, pregnancy, or tissue repair. (nih.gov)
  • High-grade tumors can invade nearby tissue or spread to other areas in the body (metastasize), and they are more likely to come back after treatment to remove them. (kidshealth.org)
  • The neoplastic grading is a measure of cell anaplasia (reversion of differentiation) in the sampled tumor and is based on the resemblance of the tumor to the tissue of origin. (wikipedia.org)
  • The grade score (numerical: G1 up to G4) increases with the lack of cellular differentiation - it reflects how much the tumor cells differ from the cells of the normal tissue they have originated from (see 'Categories' below). (wikipedia.org)
  • They account for less than 2% of all soft tissue tumors. (wikipedia.org)
  • Cartilage tumors form in Cartilage tissue. (wikipedia.org)
  • This tissue is not vascularized, which prevents tumors from growing greater than 2mm in diameter without inducing new blood vessels. (wikipedia.org)
  • include
  • This may include exams to look for vision or nervous system problems that could be caused by a tumor. (cancer.org)
  • Palliative care tends to include corticosteroids to help reduce swelling and edema around tumors as well as anti-convulsant medications to control seizures. (wikipedia.org)
  • Tumor detection is based on the performance of the method and should include morphometric information (three axes dimensions, volume) and topographic information (number, location specifying liver segment and lobe/lobes). (wikipedia.org)
  • Less common tumors of the heart include lipoma and cystic tumor of the atrioventricular nodal region. (wikipedia.org)
  • Some would extend the spectrum to include malignant phyllodes tumors and frank sarcoma. (wikipedia.org)
  • NETs include certain tumors of the gastrointestinal tract and of the pancreatic islet cells, certain thymus and lung tumors, and medullary carcinoma of the parafollicular cells of the thyroid. (wikipedia.org)
  • tumours
  • The World Health Organization (WHO) classification scheme places neuroendocrine tumors into three main categories, which emphasize the tumor grade rather than the anatomical origin: well-differentiated neuroendocrine tumours, further subdivided into tumors with benign and those with uncertain behavior well-differentiated (low grade) neuroendocrine carcinomas with low-grade malignant behavior poorly differentiated (high grade) neuroendocrine carcinomas, which are the large cell neuroendocrine and small cell carcinomas. (wikipedia.org)
  • Linear expansion is less likely to reflect the endpoint of a malignant tumour because the accumulation of mutations is stochastic in heterogeneic tumours. (wikipedia.org)
  • glycolytic
  • While a lack of oxygen can cause glycolytic behavior in cells, tumor cells also undergo aerobic glycolysis, in which they preferentially produce lactate from glucose even given abundant oxygen, called the Warburg effect. (wikipedia.org)
  • In the PI3K/AKT/mTOR pathway, AKT1 (also known as Protein Kinase B or PKB), is an important driver of the tumor glycolytic phenotype and stimulates ATP generation. (wikipedia.org)
  • abnormally
  • This shift therefore demands that tumor cells implement an abnormally high rate of glucose uptake to meet their increased needs. (wikipedia.org)