• We retrospectively analysed the data of 70 patients (41 boys and 29 girls) with Rhabdoid tumors (RT) regardless of localisation, recorded in the German Childhood Cancer Registry (GCCR) from 1984 to 1999. (wordpress.com)
  • The preponderance of these tumours in women, especially premenopausal, has led to the hypothesis that hormones are implicated in the pathogenesis of these tumours in the breast, however, up to date, no oestrogen or progesterone receptors have been found on the tumour cells in any of the cases so far reported in the literature. (biomedcentral.com)
  • The histogenesis of GCT remains uncertain, the hypothesis of a neural or neuroectodermal origin is supported by the presence of the S-100 protein, typically expressed by these neoplastic cells, and by the similar ultrastructural features of the tumour cells and the Schwann cells. (biomedcentral.com)
  • Granular cell tumors are unusual, typically benign tumors deriving from Schwann cells. (clinmedjournals.org)
  • The underlying tumor revealed large cells with abundant fine granular cytoplasm. (clinmedjournals.org)
  • Immunostaining for the S100 protein highlighted the nuclei of the tumor cells with only weak staining of the cytoplasm, which is consistent with a granular cell tumor (Figure 1). (clinmedjournals.org)
  • C) High magnification view (20X) of immunostaining of tumor cells for S100 protein which highlights the nuclei while only weakly staining the cytoplasm's. (clinmedjournals.org)
  • We review histopathologic and imaging features of granular cell tumors as well as the natural history of these lesions. (clinmedjournals.org)
  • Significantly decreased expression of mature Let-7a and the miR-200 family (responsible for mesenchymal-to-epithelial transition) in miRNAPG mutant tumors is associated with an undifferentiated blastemal histology. (bcm.edu)
  • We report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors). (bcm.edu)
  • The primary tumor was located in the kidney in 32 cases, in the central nervous system (CNS) in 13 cases and in the soft tissue in 25 cases. (wordpress.com)
  • Macroscopically the tumour appeared to be originating from the lateral border of the pectoralis major muscle and not from the breast and was excised with an ellipse of normal muscle tissue. (biomedcentral.com)
  • Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. (bcm.edu)
  • Comprehensive analysis of 77 FHWTs indicates that tumors with SIX1/2 and/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are significantly associated with both perilobar nephrogenic rests and 11p15 imprinting aberrations. (bcm.edu)
  • The combination of SIX and miRNAPG mutations in the same tumor is associated with evidence of RAS activation and a higher rate of relapse and death. (bcm.edu)
  • Granular cell tumors can very rarely involve the anal sphincters. (clinmedjournals.org)
  • The perianal region is a rare location for granular cell tumors, and it is even more unusual to present with involvement of the anal sphincter muscles. (clinmedjournals.org)
  • Higher-grade cancer tumors are characterized by faster growth and spread rates. (medicalnewstoday.com)
  • In the new study, the researchers focused on N-acetyl-aspartyl-glutamate (NAAG), saying that this neurotransmitter may be a relevant new target when it comes to treating higher-grade cancer tumors. (medicalnewstoday.com)
  • Specifically, their experiments revealed that NAAG is more abundant in fast-developing cancer tumors than in other types of cancer. (medicalnewstoday.com)
  • Also, the scientists found evidence to suggest that this neurotransmitter is a source of glutamate - an important cell nutrient - to certain cancer tumors, thus aiding their growth. (medicalnewstoday.com)
  • Also, this neurotransmitter was more abundant in human high-grade ovarian cancer tumors than in primary ovarian cancer tumors. (medicalnewstoday.com)
  • In short, fast-growing cancer contained significantly higher levels of NAAG than slower-growing cancer tumors. (medicalnewstoday.com)
  • Then, working with mouse models in which they had implanted human ovarian cancer tumors, the scientists tried to fight GCPII activity by using an inhibitor called 2-PMPA. (medicalnewstoday.com)
  • Finally, when looking at mice with human-derived pancreatic cancer tumors, the scientists saw that by attacking glutaminase - which is an enzyme that converts glutamine into glutamate - as well as GCPII, they were able to shrink cancer tumors even further. (medicalnewstoday.com)
  • However, she specifies that the recent findings are only relevant to cancer tumors that express GCPII. (medicalnewstoday.com)
  • Scientists for the first time have used gene therapy to successfully destroy cancer tumors in patients with advanced disease -- a goal that has taken 20 years to achieve. (ibtimes.com)
  • DETROIT - An incisionless robotic surgical procedure is offering patients a new option to remove certain head and neck cancer tumors without visible scarring, while preserving speech and the ability to eat. (scienceblog.com)
  • Experiments in mice showed that the combination of celecoxib - a prescription-only non-steroidal anti-inflammatory drug (NSAID) - and a cream commonly used to treat nonmelanoma skin cancer was up to 35 percent more effective in reducing the number of skin cancer tumors than treating such lesions with the cream alone. (scienceblog.com)
  • New research suggests that combining the chemotherapy drug paclitaxel with very low doses of the HIV-fighting drug AZT may shrink or even eradicate certain types of cancer tumors. (scienceblog.com)
  • The researchers discovered that an antibody against a signaling molecule of the vascular system causes the lymphatic vessels in the tumor to die, suppresses metastasis and thus prolongs the survival of the mice. (sciencecodex.com)
  • The surgical removal of the primary tumor enabled the researchers to simulate a disease situation that corresponded to that of a cancer patient after surgery: Daughter tumors and not the primary tumor became crucial for survival. (sciencecodex.com)
  • The researchers found that the messenger substance angiopoietin 2 ensures the survival of lymph endothelial cells in tumors. (sciencecodex.com)
  • A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. (nih.gov)
  • By comparing the gene expression profiles of endothelial cells from regenerating liver to those derived from tumor-bearing livers, the researchers found 13 distinct genes that were selectively overexpressed (turned on to a greater degree than other genes) during disease-related angiogenesis. (nih.gov)
  • Doctors don't know what causes brain tumors, but researchers think there may be genetic and environmental causes. (kidshealth.org)
  • Using 3D printing, researchers have made a tumor-like lump of cancer cells in the lab, and they say this lump shows a greater resemblance to natural cancer than do the two-dimensional cultured cells grown in a lab dish. (huffingtonpost.com)
  • This more realistic representation of a tumor could aid studies on cancer and drug treatments, the researchers said. (huffingtonpost.com)
  • To build the tumor-like structure, the researchers mixed gelatin, fibrous proteins and cervical cancer cells, then fed the resulting mixture into a 3D cell printer they had developed. (huffingtonpost.com)
  • That structure resembles the fibrous proteins that make up the extracellular matrix of a tumor, the researchers said. (huffingtonpost.com)
  • However, compared with such 2D cell cultures, the additional dimension of a 3D culture better reveals the tumor cells' characteristics, including their shape, their proliferation, and gene and protein expression, the researchers said. (huffingtonpost.com)
  • Researchers can now iteratively search MTB for mouse models of human cancer using multiple faceted filter lists with the new Faceted Tumor Search form. (jax.org)
  • Now, researchers have succeeded in revealing the effect of IFN-beta on migration of pro-tumour neutrophils. (eurekalert.org)
  • WASHINGTON (Reuters) - Studies on whether mobile phones can cause cancer, especially brain tumors, vary widely in quality and there may be some bias in those showing the least risk, researchers reported on Tuesday. (reuters.com)
  • The presence of tumor-infiltrating lymphocytes predicts the length of remission after chemotherapy and the overall survival of patients with ovarian cancer, according to researchers from the Abramson Cancer Center and the Center on Women's Health at the University of Pennsylvania School of Medicine. (scienceblog.com)
  • Walnut consumption slows the growth of prostate cancer in mice, and has beneficial effects on multiple genes related to the control of tumor growth and metabolism, researchers have found. (mercola.com)
  • In the case of cancer, researchers have found that this is a good thing: some tumors seem to be much less aggressive in the microgravity environment of space compared to their behavior on Earth. (flickr.com)
  • The researchers hypothesize that the bacteria release enzymes that destroy the tumor cells, and then they feast on the debris. (sciencemag.org)
  • Injecting spores from the bacterium into the brain tumors of rats extended the animals' survival, the researchers found. (sciencemag.org)
  • The bacteria not only destroy tumor cells, but they also spur immune cells to attack the cancer, the researchers previously showed. (sciencemag.org)
  • The researchers plan to continue their safety trial and want to determine which types of tumors will respond to bacterial therapy, he says. (sciencemag.org)
  • Researchers from the University of Nottingham and University of Maastricht found that an ancient strain of harmless bacteria, which is common in the soil, can be used to kill tumors by using it as a drug delivery vehicle. (ibtimes.com)
  • The authors hope their findings will lead to improvements in patient care, perhaps by helping researchers find ways to prime tumors to succumb to lower doses of radiation. (scientificamerican.com)
  • In addition to the oxygen sensors, researchers have equipped the device with sensors to monitor pH, another indicator of tumor growth. (technologyreview.com)
  • To attack the tumors, researchers targeted the methyl groups with the drug 5-azacytidine in the hopes of reversing cancer development. (healthcentral.com)
  • The mice are still under close observation, but researchers believe the tumors will not grow back. (healthcentral.com)
  • An international group of researchers detected a facial tumor in the fossilized jawbone of a dwarf dinosaur ( Telmatosaurus transsylvanicus ), also known as a hadrosaur. (drugs.com)
  • The researchers speculate the tumor probably wasn't painful or the direct cause of the dinosaur's death. (drugs.com)
  • The Neuro-ICU cares for patients with all types of neurosurgical and neurological injuries, including stroke, brain hemorrhage, trauma and tumors. (ucla.edu)
  • Coffin CM, Dehner LP (1993) Vascular tumors in children and adolescents: a clinicopathologic study of 228 tumors in 222 patients. (springer.com)
  • Patients who have that characteristic in their tumor have a poor prognosis," Bane says. (redorbit.com)
  • A nonrandom association of sarcoidosis in patients with gastrointestinal stromal tumor and other sarcomas. (nih.gov)
  • He noted the hedgehog pathway was responsible for about 20 percent of medulloblastomas, and future trials will involve only those patients whose tumors have activated hedgehog pathways. (reuters.com)
  • He also reported the results of EChT in 20 lung cancer patients with 26 tumors in which he used the "skinny needle" he had developed for biopsy purposes as an electrode. (hindawi.com)
  • Charts were reviewed retrospectively for 85 patients with 89 small-bowel tumors (22 primary malignant, 23 primary benign, and 44 metastatic) over a 10-year period (1986-1996) at Louisiana State University Medical Center-Shreveport and two affiliated hospitals in Shreveport. (nih.gov)
  • In addition, patients with benign tumors were more commonly presented with gastrointestinal hemorrhage, and those with metastatic tumors were more likely to present with obstruction. (nih.gov)
  • Among the 22 primary malignant tumors, curative resections were performed in 11 patients (for 9 carcinoids and 2 adenocarcinomas) and palliative resections were performed in 10 patients (for 9 adenocarcinomas and 1 myxoliposarcoma). (nih.gov)
  • All operations for 39 (of 44) patients with metastatic tumors were palliative. (nih.gov)
  • If the overall survival of patients with small-bowel tumors is to be improved, clinicians must have a high index of suspicion and be willing to perform exploratory celiotomy early. (nih.gov)
  • Compared with most young patients, children with an inherited form of the disease have a higher risk of developing tumors at an earlier age, having tumors in both kidneys, and being born with other abnormalities. (mskcc.org)
  • To meet the unique needs of brain tumor patients, the American Brain Tumor Association (ABTA) and the American Association of Neuroscience Nurses (AANN) announce the availability of the first ever clinical practice guidelines (CPG) for the treatment of adults with brain tumors. (prweb.com)
  • As leaders in their fields, both organizations spearheaded the project in order to ensure that health care professionals caring for brain tumor patients have the information necessary to deliver optimal patient care. (prweb.com)
  • Lovely adds that, in addition to monitoring and treatment of the patient, "the brain tumor clinical guidelines provide information on survivorship and how nurses can help patients better manage side effects in order to move toward an optimal quality of life. (prweb.com)
  • We'll work together with you, our patients and their families to manage rare and complex tumors of the pelvis and return patients to their communities as soon as possible. (childrens.com)
  • In the 1890s, he began injecting cancer patients with live Streptococcus bacteria to combat their tumors. (sciencemag.org)
  • Coley sometimes injected the bacteria into tumors and sometimes into the bloodstream, and many of his patients survived. (sciencemag.org)
  • For example, a clinical trial in which patients received intravenous doses of weakened Salmonella bacteria found that the treatment was safe but had little impact on tumors. (sciencemag.org)
  • According to Minton, this procedure would be more effective than surgeries especially for patients with high risk or difficult tumor locations. (ibtimes.com)
  • Interim results from a trial of 24 patients with metastatic melanoma-a form of skin cancer that has spread through the body and is difficult to treat-found that seven patients on Zymo's IL-21 had their tumors shrink by at least 25 percent, and eight people had their disease stabilize. (xconomy.com)
  • This gives us a level of expertise and experience that can translate into more successful outcomes for many brain tumor patients. (mdanderson.org)
  • We're studying new ways to prevent and treat brain tumors to give patients everywhere futures filled with hope. (mdanderson.org)
  • Patients come to the Brain Tumor Center from around the world, some with newly diagnosed tumors and others seeking care for recurrent or treatment-resistant tumors. (cincinnatichildrens.org)
  • Headache is the initial symptom in about half of brain tumor patients and is eventually experienced by the majority, at some point. (aans.org)
  • Seizures (Epileptic Seizures/Fits): Seizures are associated with brain tumors in almost 35 percent of patients. (aans.org)
  • This is reserved for tumors less than 4 cm in size if the opposite kidney is normal, and is the treatment of choice for patients with solitary kidney. (aiims.edu)
  • This is not a standard treatment option, but may be considered in patients who cannot tolerate tumor removal or ablation. (aiims.edu)
  • 5-ALA, which stands for 5-aminolevulinic acid, is a substance that patients drink that is rapidly taken up into the blood, directly to brain tumors. (foxnews.com)
  • Patients must have a stage 3 or 4 brain tumor, either newly diagnosed or recurrent. (foxnews.com)
  • A team of medical engineers in Germany has developed an implant to continuously monitor tumor growth in cancer patients. (technologyreview.com)
  • This means patients would have to pay fewer visits to the hospital for progression and postsurgery monitoring of tumors. (technologyreview.com)
  • New therapy improving lives of patients with neuroendocrine tumors Dec. 13, 2019, 10:00 p.m. (mayoclinic.org)
  • Magnetic resonance (MR) imaging was performed on 40 patients with intracranial tumors, before and after intravenous administration of gadolinium-DTPA (Gd-DTPA). (nih.gov)
  • After administration of Gd-DTPA (0.1 mmol/kg), increased signal intensity from the tumor was observed in all patients. (nih.gov)
  • The localized increase in signal intensity in the tumor considerably improved the tumor delineation in 36 of 40 patients. (nih.gov)
  • If the tumor is very big, surgeons may even use a curved surgical drill in order to remove the tumor. (buzzle.com)
  • By avoiding things that cause cancer, the risk of tumors can be greatly reduced, if not prevented. (hopkinsmedicine.org)
  • It found no significant association between the risk of tumors and overall use of mobile phones, including cellular and cordless phones. (reuters.com)
  • Myung's team said eight studies that employed "high quality" methods to blind participants against bias found a mild increased risk of tumors among people who used mobile phones compared with those who never or rarely did. (reuters.com)
  • This observation, reported in research published in February by the Federation of the American Societies for Experimental Biology (FASEB) Journal, could help scientists understand the mechanism involved and develop drugs targeting tumors that don't respond to current treatments. (flickr.com)
  • Zvi Fuks, another co-author of the study, explains: "We need to understand, at the therapeutic dose range, the unique roles that the microenvironment and tumor cell components play in the overall response of the tumor to radiation to maximize the value of such treatments. (scientificamerican.com)
  • Treatments vary according to the type, invasiveness and spread of the tumour. (ehow.co.uk)
  • These very rare tumors can be detected on fetal sonograms at a gestational age of about 22 weeks. (childrens.com)
  • ZymoGenetics, the Seattle biotech company, said today that one of its experimental cancer drugs that it is seeking to outlicense showed an ability to shrink tumors in a clinical trial. (xconomy.com)
  • They are sometimes called carcinoid tumors, but it would be more accurate to consider these tumors as a sub-category of the larger family of neuroendocrine tumors. (encyclopedia.com)
  • Neuroendocrine tumors are most often found in the digestive system and the lung. (encyclopedia.com)
  • The majority of neuroendocrine tumors can give rise to metastases with time if they are left untreated. (encyclopedia.com)
  • Foregut tumors arise in the stomach or duodenum (first part of small intestine) and represent approximately 15% to 25% of neuroendocrine tumors. (encyclopedia.com)
  • Midgut neuroendocrine tumors. (encyclopedia.com)
  • Hindgut neuroendocrine tumors. (encyclopedia.com)
  • Additionally, neuroendocrine tumors are sub-classified into "functionally active" and "functionally inactive" tumors. (encyclopedia.com)
  • Bronchial neuroendocrine tumors (BNETs). (mayoclinic.org)
  • Mayo Clinic doctor and scientists are studying new ways to diagnose and treat neuroendocrine tumors. (mayoclinic.org)
  • See a list of publications about neuroendocrine tumors by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. (mayoclinic.org)
  • However, differentiation of the tumor from adjacent tissues was possible in only 17 of 40 cases. (nih.gov)
  • We found a large discrepancy in the association between mobile phone use and tumor risk by research group, which is confounded with the methodological quality of the research," they wrote in the Journal of Clinical Oncology. (reuters.com)
  • The Care of the Adult Patient with a Brain Tumor Clinical Practice Guideline was released today with an educational webinar to follow. (prweb.com)
  • Retrieved on May 23, 2019 from https://www.news-medical.net/health/Phyllodes-Tumors-e28093-Follow-Up-Care.aspx. (news-medical.net)
  • 2019. Phyllodes Tumors - Follow Up Care . (news-medical.net)
  • Rare primary central nervous system tumors. (nih.gov)
  • As a result, fewer daughter tumors formed in distant organs and the mice survived significantly longer. (sciencecodex.com)
  • The efficacy of electrochemical therapy (EChT) in mice with implanted Jensen sarcoma tumors was reported in 1953 by Reis and Henninger [ 1 ]. (hindawi.com)
  • this gene is known to regulate the cellular mitosis process and forced expression of this gene induces tumor formation in nude mice. (medscape.com)
  • A study shows that when mice with prostate tumors consume the equivalent of an amount of walnuts that could easily be eaten by a man, tumor growth is controlled. (mercola.com)
  • The mice that ate the human equivalent of 2.4 ounces of whole walnuts for 18 weeks had significantly smaller and slower-growing prostate tumors compared to the control group that consumed the same amount of fat but from other sources. (mercola.com)
  • That process, known as angiogenesis, hit the headlines in 1998 when cancer researcher Judah Folkman of Harvard Medical School discovered two natural compounds that shrank tumors in mice by cutting off the blood supply. (scientificamerican.com)
  • Abd El Azim MHM, El-Mesallamy AMD, El-Gerby M, Awad A (2014) Anti-Tumor, Antioxidant and Antimicrobial and the Phenolic Constituents of Clove Flower Buds (Syzygium aromaticum). (omicsonline.org)
  • A third had a strong anti-tumor response, and his cancer remains in check. (ibtimes.com)
  • So designing bacteria to actively move and seek out these distributed tumors, and express their anti-tumor proteins only in hypoxic, purine rich tumor regions is exciting," Ravi Bellamkonda, Vinik Dean of Duke's Pratt School of Engineering and corresponding author of the paper, said in a statement. (engadget.com)