Tumorigenesis inhibits apoptosis. Medical search. Frequent questions

TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, 5-ethynyl-2′-deoxyuridine assay, propidium iodide (PI) staining, annexin V-fluorescein isothiocyanate/PI staining, and transwell assay were employed to test the proliferation, apoptosis, migration ability, and invasiveness of COAD cells. (hindawi.com)
Upregulating the level of miR-323a-3p impaired the proliferation, migration, and invasion of COAD cells and promoted apoptosis, whereas supplementing NEK6 alleviated the damage of the proliferation, migration, and invasion of COAD cells caused by miR-323a-3p and inhibited miR-323a-3p-induced apoptosis. (hindawi.com)
These findings indicate that miR-323a-3p regulates the proliferation, migration, invasion, and apoptosis of COAD cells by targeting NEK6. (hindawi.com)
Although KLF6 overexpression in human cancer cells inhibits cell proliferation, induces apoptosis, and attenuates cell migration, the effects of KLF6 on oral cancer remains poorly elucidated. (medsci.org)
KLFs regulate a wide range of cellular functions, including cell proliferation, apoptosis, differentiation, and neoplastic transformation, by binding to GC-rich promoter regions [ 1 , 2 ]. (medsci.org)
Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
Overexpression of Per2 promoted autophagy and apoptosis in OSCC cells and inhibited proliferation. (jcancer.org)
When the AKT activator SC79 was added to Per2-overexpressing OSCC cells, the increased autophagy, apoptosis and decreased proliferation were significantly rescued. (jcancer.org)
In conclusion, our research results demonstrate that Per2 suppresses OSCC progression by motivating autophagy, as well as inhibiting cell proliferation and promoting apoptosis, which were mediated by autophagy, in a PI3K/AKT/mTOR pathway-dependent manner. (jcancer.org)
Furthermore, the blockade of p53 attenuates the function of TC2N knockdown within the regulation of cell apoptosis and proliferation. (columbiagypsy.net)
General, these results uncover a job for the p53 inactivator TC2N in regulating the proliferation and apoptosis of lung cancers Rabbit Polyclonal to OPN3 cells. (columbiagypsy.net)
adenocarcinoma, squamous cell carcinoma Desk 2 Multivariate evaluation AVE5688 of different prognostic elements in individual lung cancers patients (threat ratio, confidence period TC2N promotes lung cancers cell proliferation and inhibits apoptosis in vitro To explore the potential function of TC2N in tumorigenesis, we transfected TC2N little hairpin RNA (shRNA) as well as the wild-type (WT) full-length TC2N Flag-tagged fusion vector into H460 and HBE cell lines. (columbiagypsy.net)
Open in a separate window Fig. 2 Effects of ectopic expression of TC2N on lung cancer cell proliferation and apoptosis in vitro. (columbiagypsy.net)
While knockout circIFT80 in HT29 cell or SW480 cells, the proliferation, and migration of the cells were inhibited, the cell cycle was arrested in G2/M phase, and the cell apoptosis was increased. (hindawi.com)
For example, circRNA_000166 can function as an oncogene by promoting the proliferation of CRC cells and by limiting apoptosis. (hindawi.com)
β -Catenin is a transcription factor that plays an important role in cell proliferation, cellular differentiation, apoptosis, and metastasis [ 10 ]. (hindawi.com)
Previous research has demonstrated that β -catenin can contribute to malignant progression and distant metastasis in CRC by promoting proliferation, limiting apoptosis, and accelerating epithelial-mesenchymal transition [ 11 , 12 ]. (hindawi.com)
Whey and collagen hydrolysates inhibit melanoma cell proliferation. (greenmedinfo.com)
In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
The PI3K/Akt/mTOR signal pathway is involved in multiple cellular functions including proliferation, differentiation, tumorigenesis, and apoptosis. (biomedcentral.com)
PI3K activates a number of signaling molecules, among which the Akt/mTOR pathway is of particular interest because of its role in inhibiting apoptosis and promoting cell proliferation [ 3 ]. (biomedcentral.com)
Recently, we reported that the ubiquitin E3 ligase ITCH negatively regulates LATS1, thereby increasing YAP activity, which leads to increased cell proliferation and decreased apoptosis. (oncotarget.com)
The Hippo kinase pathway is emerging as a conserved signaling pathway that controls cell proliferation, apoptosis, contact inhibition, cell migration, cell differentiation, stem cell self-renewal, genetic stability, and epithelial-to-mesenchymal transition (EMT). (oncotarget.com)
Both of these mechanisms prevent YAP and TAZ translocation to the nucleus and binding to TEAD transcription factors, thereby inhibiting transcription of downstream target genes implicated in proliferation, anti-apoptosis and EMT [ 9 ]. (oncotarget.com)
These compounds are almost structurally similar or possess identical pharmacological activities and offer various potential applications including the ability to inhibit cell growth, proliferation and inflammation [ 22 ]. (biomedcentral.com)
PKB has emerged as a crucial regulator of widely divergent cellular processes including apoptosis, proliferation, differentiation and metabolism. (justia.com)
In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)

SPIN1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of human cancer cells. (elifesciences.org)
We also studied whether IKK blockage induces apoptosis andor inhibits PC cell growth. (dtic.mil)
This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)

Silibinin inhibits adipocyte differentiation through a potential up-regulation of insig-1 and insig-2 at an early phase in adipocyte differentiation. (wikipedia.org)

Therefore, mitochondrial survivin orchestrates a novel pathway of apoptosis inhibition, which contributes to tumor progression. (umassmed.edu)
TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
In this project we proposed to test the hypothesis that activation of IKKs and down-stream NF-kB survival signaling pathway is a critical event during tumorigenesis in prostate. (dtic.mil)
Mechanistically, TC2N attenuates p53 signaling pathway through inhibiting Cdk5-induced phosphorylation of p53 via inducing Cdk5 degradation or disrupting the connections between Cdk5 and p53. (columbiagypsy.net)
Furthermore, downregulated TC2N is normally mixed up in apoptosis of lung AVE5688 cancers cells induced by doxorubicin, resulting in p53 pathway activation. (columbiagypsy.net)
circITGA7 serves as a tumor suppressor in CRC by inhibiting growth and metastasis by suppressing the Ras signaling pathway [ 8 ]. (hindawi.com)
These results suggest that chemotherapeutic agent 5-Fu may down-regulate telomerase activity at both transcriptional level and PI3K/Akt/mTOR pathway-dependent post-transcriptional level to facilitate hepatocellular carcinoma cell apoptosis. (biomedcentral.com)
The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential for organ growth and tumorigenesis. (oncotarget.com)

On the other hand, Triphala failed to induce apoptosis or activate ERK or p53 in normal human pancreatic ductal epithelial (HPDE-6) cells. (biomedcentral.com)
Isoprenoid alcohol induce apoptosis (in various malignant cells and inhibit tumorigenesis in several in-vivo models). (medicosplexus.com)

The mechanisms of apoptosis inhibition by NS5A in liver cancer cells remains unclear. (spandidos-publications.com)
It was found that inhibition of autophagy attenuated the NS5A‑mediated apoptosis inhibition of HepG2 cells. (spandidos-publications.com)
Tumorigenesis could possibly be inhibited by either very high levels of FOXO3a/CITED2 activity that would cause complete inhibition of HIF1 or very low levels that would permit HIF1-induced apoptosis under hypoxic stress. (genengnews.com)
CONCLUSION: It is suggested that a mechanism for tumorigenesis inhibition may involve the caspases cascade and apoptosis. (greenmedinfo.com)
In 2004, Dmitry published a series of articles regarding the Wip1 phosphatase inhibition of tumorigenesis through p38 MAP kinase , and after establishing his lab in 2004 at IMCB in Singapore, he continued interrogating the role of Wip1 phosphatase in cancer but also in aging . (lifeboat.com)

The released NF-kB factors then translocate to the nucleus and activate kB-responsive genes involved in cell growth, apoptosis, and metastasis. (dtic.mil)
Cav-1 not only promoted tumorigenesis in a xenograft mouse model but also metastasis of the transformed cells to neighboring tissues. (oncotarget.com)
Furthermore, while overexpression of ITCH expression in breast cells is associated with increased incidence of mammary tumor formation and progression, its knockdown inhibited breast cancer cell tumorigenicity and metastasis. (oncotarget.com)

Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. (degruyter.com)
Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)
An in vivo tumorigenesis assay also confirmed that overexpression of Per2 suppresses the growth of OSCC. (jcancer.org)
The most important findings had been that the knockdown of TC2N in H460 cells significantly increased the percentage of early apoptotic cells and late apoptotic cells and that the overexpression of TC2N inhibited HBE cell apoptosis (Fig.?2d). (columbiagypsy.net)
They further revealed that apoptosis was induced by cannabidiol as shown by increased subG0/G1 and apoptosis through annexin V. Apoptosis was confirmed by overexpression of p53, caspase 3 and bax. (biomedcentral.com)
Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)

Lan et al ( 2 ) demonstrated that HCV NS5A suppresses p53-mediated transcriptional transactivation and apoptosis during HCV infection, contributing to hepatocarcinogenesis. (spandidos-publications.com)
In conclusion, our findings demonstrate that knockdown of lncRNA PVT1 suppresses VSMC apoptosis, ECM disruption, and serum pro-inflammatory cytokines in a murine Ang II-induced AAA model. (molcells.org)
2006. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. . (oregonstate.edu)

miRNAs expressed in a wide variety of human cancers can regulate posttranscriptional gene expression by binding to the 3′ untranslated region of the target mRNAs and act as oncogenes or tumor suppressors to regulate cell signaling pathways, affecting tumorigenesis and tumor progression [ 17 ]. (hindawi.com)
In the present study, the function and underlying molecular mechanisms of miR‑320 in breast cancer tumorigenesis and progression were investigated. (spandidos-publications.com)
Collectively, these results indicated that miR‑320 acts as a tumor suppressor in breast cancer tumorigenesis and progression. (spandidos-publications.com)
Therefore, an improved understanding of the functions and the underlying molecular mechanisms of these proteins, particularly in epithelial-mesenchymal transition, may provide novel insights into the breast tumorigenesis and progression, and enable the development of effective anti-cancer therapeutics. (spandidos-publications.com)

Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. (molcells.org)
Furthermore, animal studies showed the inhibitory effect of Bcl-2 knockdown on the tumorigenesis of Cr(VI)-transformed cells. (cdc.gov)
Knockdown of Bcl-2 in the H460 cells inhibited malignant and tumorigenic properties of the cells, indicating the general role of Bcl-2 in human lung tumorigenesis. (cdc.gov)

Guanylyl cyclase C (GCC), the intestinal receptor for the paracrine hormones guanylin and uroguanylin whose early loss characterizes transformation, has emerged as a component of developmental programs organizing spatiotemporal patterning along the crypt-surface axis whose loss promotes tumorigenesis through hyperproliferation and genetic instability. (jefferson.edu)

Although these functions suggest that INO80 acts as a tumor suppressor, its specific role in tumorigenesis has remained obscure. (ewha.ac.kr)
These results show that in contrast to our original prediction that INO80 acts as a tumor suppressor, INO80 actually functions oncogenically to promote colon tumorigenesis. (ewha.ac.kr)

However, the effect of Tan IIA on apoptosis and its underlying mechanism remains elusive in oral squamous cell carcinoma (OSCC). (jcancer.org)

Further, only one study has reported that miR-637 can inhibit tumorigenesis through disruption of signal transducers and activation of transcription 3 signalings in hepatocellular carcinoma [9]. (scirp.org)
This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 ( PVT1 ) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. (molcells.org)
This novel role in restricting the proliferating compartment and organizing the crypt-villus axis suggests that dysregulation of GCC, reflecting loss of endogenous ligands, might contribute to tumorigenesis by potentiating hyperproliferation which, in turn, may amplify disruption of genomic integrity. (jefferson.edu)

Here, we investigated the role of ITCH in breast tumorigenesis. (oncotarget.com)

Experiments using tumors obtained from Apc min/+ mice and cells from human colon cancers showed that this Ino80 defect induced stalled replication forks, the concomitant activation of ATR-Chk1 signaling and an increase in apoptosis, suggesting that Ino80 haploinsufficiency inhibited colon cancer tumorigenesis by activating replication stress-induced ATR-Chk1 signaling to increase apoptosis. (ewha.ac.kr)
Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)

Several studies have reported that miRNA dysfunction could cause tumorigenesis [7]. (scirp.org)
But people in the field have hypothesized that spindle misorientation might cause tumorigenesis or even contribute to cancer development. (stowers.org)

According to a previous study, NS5A inhibits cell apoptosis in vivo and in vitro ( 4 ). (spandidos-publications.com)
Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
These results strongly suggest that EETs exert protective functions during the growth and apoptosis of CSMCs, via the JNK/c-Jun and mTOR signaling pathways in vitro. (molcells.org)

Our findings suggest that miR-637 inhibits glioma invasion and migration and could be a potential diagnostic marker for gliomas. (scirp.org)
These CSCs, which were found to overexpress tumor promoter caveolin-1 (Cav-1), displayed aggressive cancer phenotypes of apoptosis resistance and enhanced cell invasion and migration compared with their non-CSC counterpart. (oncotarget.com)
Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)

In addition, Beclin 1 gene deletion results in tumor cell apoptosis, specifically in hypoxic regions ( 12 ). (spandidos-publications.com)
Recent research also revealed an anticancer role for HIF1 that is mediated by the initiation of apoptosis in response to severe hypoxic stress, according to the researchers. (genengnews.com)

It increases the shedding of malignant cells into the blood and lymphatic circulations, inhibits their apoptosis and potentiates their invasion capacity. (ki.se)
Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells. (cdc.gov)
However, its role in malignant transformation and tumorigenesis of human lung cells is not well understood. (cdc.gov)
The role of Bcl-2 in malignant transformation and tumorigenesis was confirmed by gene silencing experiments using human lung carcinoma NCI-H460 cells. (cdc.gov)
Together, our results indicate the novel and multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of human lung epithelial cells chronically exposed to Cr(VI). (cdc.gov)

Here we show that survivin, a member of the inhibitor of apoptosis gene family that is overexpressed in cancer, exists in a novel mitochondrial pool in tumor cells. (umassmed.edu)
Liu et al ( 13 ) reported that Beclin 1 gene deletion by either RNA interference or the autophagy inhibitor 3-methyladenine (MA) significantly enhances melatonin-induced apoptosis in mouse hepatoma H22 cells. (spandidos-publications.com)
Overall, our results revealed that Tan IIA exerted potent antitumor effects via promoting PUMA-mediated apoptosis in OSCC cells. (jcancer.org)
however, forced KLF6 expression in lung cancer cell lines can trigger cells to undergo apoptosis and reduce colony formation ability [ 6 ]. (medsci.org)
miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis. (degruyter.com)
HIF-1 induced apoptosis in normal and breast cancer cells was inhibited due to FOXO3a stimulating the transcription of the HIF1 target gene, CITED2, according to Dr. Mak. (genengnews.com)
BACKGROUND: Porcine skin gelatine presented anti-tumoral effect on murine hepatoma cells (MH134), inducing programmed cell death (apoptosis). (greenmedinfo.com)
Triphala-induced apoptosis was linked with phosphorylation of p53 at Ser-15 and ERK at Thr-202/Tyr-204 in Capan-2 cells. (biomedcentral.com)
Pretreatment of cells with pifithrin-α or U0126, specific inhibitors of p53 or MEK-1/2, significantly attenuated Triphala-induced apoptosis. (biomedcentral.com)
Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
We detected apoptosis of hepatocarcinoma cells by TUNEL assay. (biomedcentral.com)
Treating SMMC-7721 cells with 5-Fu leads to apoptosis of the cells, and reduction in telomerase activity, as well as a dramatic reduction in the activated form of p70 S6 kinase, a mTOR substrate. (biomedcentral.com)
Initially, the group did not observe such dire consequences: Gibson says that delaminating cells generally "fall out of the epithelium" and are killed off by apoptosis, a mechanism healthy tissues use to eradicate damaged cells. (stowers.org)
The impact of JPX on Twist1 expression, cell growth, invasion, apoptosis, and in vivo tumor growth were investigated in lung cancer cells by western blotting, rescue experiments, colony formation assay, flow cytometry, and xenograft animal experiment. (biomedcentral.com)
The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. (justia.com)
Also, PKB is overexpressed in 15% of ovarian cancers, 12% of pancreatic cancers and 3% of breast cancers, and was shown to produce a survival signal that protects cells from apoptosis thus contributing to resistance to chemotherapy. (justia.com)
Downregulation of Bcl-2 inhibited the invasive and proliferative properties of the cells as well as their colony forming and angiogenic activities, which are upregulated in the transformed cells as compared to control cells. (cdc.gov)

Moreover, Insig2 altered the expression of several additional apoptosis genes located in mitochondria. (wikipedia.org)

Interestingly, the effects of UA were significantly inhibited by administration of Brusatol, an inhibitor of Nrf2. (bvsalud.org)

Zymography assay demonstrated that KLF6 inhibited the activities of matrix metalloproteinase 9 (MMP-9) and weakened the expression of mesenchymal markers, such as snail, slug, and vimentin. (medsci.org)
Apoptosis was determined by cell death assay and western blotting. (biomedcentral.com)

Selective targeting of survivin to mitochondria enhances colony formation in soft agar, accelerates tumor growth in immunocompromised animals, and abolishes tumor cell apoptosis in vivo. (umassmed.edu)

Some studies also suggest that mTOR may be a cellular context-dependent, pleiotropic regulator of apoptosis, although conclusive demonstration of mTOR inactivation in such circumstances is lacking [ 19 ]. (biomedcentral.com)

In response to cell death stimulation, mitochondrial survivin is rapidly discharged in the cytosol, where it prevents caspase activation and inhibits apoptosis. (umassmed.edu)
Furthermore, it was confirmed that Beclin 1 expression by NS5A was involved in the negative regulation of starvation‑induced liver cancer apoptosis, which was accompanied by reduced p53 and apoptosis regulator Bax expression, as well as decreased caspase‑3/-7 activation. (spandidos-publications.com)
Apoptosis induction was further confirmed by morphological changes, an increase in Caspase 3/7 and a decrease in the ATP levels. (biomedcentral.com)

Our present research provides book insights in to the system of tumorigenesis in lung cancers. (columbiagypsy.net)

Evasion of apoptosis is a hallmark of cancer, but the molecular circuitries of this process are not understood. (umassmed.edu)
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. (spandidos-publications.com)
Bauer Research Foundation published on December 12, 2012 that Praziquantel , my other favorite parasite medication for liver flukes, synergistically enhances Paclitaxel (Taxol) efficacy to inhibit cancer cell growth (PloS ONE 7(12): e51721). (thehealthyplanet.com)
This study investigated the role of KLF6 in oral cancer tumorigenesis. (medsci.org)
Similarly, Triphala induced apoptosis in another pancreatic cancer cell line BxPC-3 by activating ERK. (biomedcentral.com)
He carried out his postdoctoral training at the National Cancer Institute, NIH in the USA, where he established a role of p38MAPK in negative regulation of tumorigenesis and the key role of phosphatase Wip1 as a potent human oncogene - both directions are now widely pursued in the cancer field. (lifeboat.com)
These molecular properties of PKB and its central role in tumorigenesis, implies that this protein kinase may be an attractive target for novel anti-cancer agents. (justia.com)

Tan IIA administration inhibited CAL27-deprived xenograft tumor growth and increased PUMA expression in vivo. (jcancer.org)
In addition, xenograft tumor experiments showed that circIFT80 accelerated the tumorigenesis of CRC in vivo. (hindawi.com)

These protein kinases are currently seen as a target of choice to specifically inhibit NF- kB activity. (dtic.mil)
It can directly bind to the 3'-untranslated region of the target mRNA through its seed sequence and inhibit the expression of the encoded protein at the post-transcriptional level [3]. (scirp.org)
B-cell lymphoma-2 (Bcl-2) is an antiapoptotic protein known to be important in the regulation of apoptosis in various cell types. (cdc.gov)

The results of this study also reinforce the emerging notion that while genomic instability can promote tumorigenesis, in certain genetic contexts, it can also act as a tumor suppressor. (ewha.ac.kr)

Molecular Cell paper provides evidence that FOXO3a triggers transcription of HIF1 target gene, which in turn inhibits HIF-1 induced apoptosis. (genengnews.com)
Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)

Several anesthesia-related factors play an important role in perioperative tumorigenesis such as inhalational anesthetics, opiate analgesics, local anesthetics and regional anesthesia, all of which may impact short-term morbidity and long-term mortality. (ki.se)
In this article, the role of EET in the growth and apoptosis of CSMCs and the underlying mechanisms under oxygen glucose deprivation (OGD) conditions were addressed. (molcells.org)
Here, the role of GCC in regulating normal enterocyte dynamics along the crypt-villus axis and the corruption of those mechanisms in tumorigenesis were explored. (jefferson.edu)

Indeed, in colons of mice carrying mutations in Apc (ApcMin/+) or exposed to the carcinogen azoxymethane, elimination of GCC increased tumor initiation by corrupting genomic integrity in the context of disabled compensatory apoptosis. (jefferson.edu)

There is mounting experimental evidence that NF- kB is activated during tumorigenesis in different tissues, and that NF-kB is critically important for cell protection against apoptosis induced by different treatments including chemotherapeutic drugs and gamma-irradiation. (dtic.mil)

Rapamycin, an immunosuppressive macrocyclic lactone, specifically inhibits the activity of mTOR. (biomedcentral.com)

The significance of loss of GCC ligands early in intestinal tumorigenesis remains obscure because (patho)physiological roles of GCC signaling in intestine, beyond regulation of intestinal fluid and electrolyte homeostasis, are poorly defined. (jefferson.edu)

Apoptosis alteration is responsible for tumorigenesis and tumor resistance to therapies. (jcancer.org)

Thus, the present study hypothesized that NS5A inhibits apoptosis by inducing Beclin 1-dependent autophagy. (spandidos-publications.com)

2003. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. . (oregonstate.edu)

Triphala-mediated reduced cell survival correlated with induction of apoptosis, which was associated with reactive oxygen species (ROS) generation. (biomedcentral.com)

Anatomy23

Organisms10

Diseases36

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes58

Disciplines and Occupations1

Information Science3

Proliferation31

Induces3

Differentiation1

Pathway8

Induce apoptosis2

Inhibition5

Metastasis3

Overexpression6

Suppresses3

Progression4

Knockdown3

Promotes1

Acts as a tumor suppressor2

Squamous cell carc1

Disruption3

Breast tumorigenesis1

Tumors2

Cause tumorigenesis2

Vitro3

Migration3

Hypoxic2

Malignant5

Cells17

Genes1

Significantly1

Assay2

Colony formation1

Inactivation1

Caspase3

Lung1

Cancer7

Xenograft tumor2

Protein3

Instability1

Gene2

Role3

Genomic1

Tissues1

MTOR1

Intestinal1

Resistance1

Autophagy1

Suppression1

Survival1