• Gan N, Zou S, Hang W, Yang D, Zhang X, Yin Y. Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma. (jcancer.org)
  • Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. (jcancer.org)
  • Oropharyngeal Squamous Cell Carcinoma Oropharyngeal cancer refers to cancer of the tonsil, base and posterior one third of the tongue, soft palate, and posterior and lateral pharyngeal walls. (msdmanuals.com)
  • Squamous cell carcinoma comprises over. (msdmanuals.com)
  • Heavy long-term users of tobacco and alcohol have an almost 40-fold greater risk of developing squamous cell carcinoma. (msdmanuals.com)
  • Long-term exposure to sunlight and the use of tobacco products are the primary causes of squamous cell carcinoma of the lower lip. (msdmanuals.com)
  • B cell-derived tumors arose at high incidence and displayed Ig gene rearrangement with downregulated expression of B cell-associated antigens, which are features of PEL. (jci.org)
  • Interestingly, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocytic/dendritic cell markers. (jci.org)
  • Furthermore, growth of orthotopically implanted tumors in vivo is inhibited by blocking PVRL4-driven cell-to-cell attachment with monoclonal antibodies, demonstrating a novel strategy for targeted therapy of cancer. (elifesciences.org)
  • It is estimated that up to 90% of cancers in humans originate in epithelial tissue, and the cells within such tumors are known to survive and divide even when they are no longer attached to the extracellular matrix. (elifesciences.org)
  • Normally, the PVRL4 gene is not active in breast epithelial cells, but its activity is detected in many breast, lung, and ovarian tumors. (elifesciences.org)
  • This behavior is particularly evident in the cells that divide aggressively to form tumors that subsequently migrate and colonize other tissues around the body. (elifesciences.org)
  • used genetic techniques to silence PVRL4 in cells from breast tumors, they found that it reduced the formation of clusters by the cancer cells and also reduced their ability to grow in the absence of attachment. (elifesciences.org)
  • The volume and weight of tumors was measured and analyzing the ability of purified DU145 cells isolated from the tumors to migrate and proliferate. (jcancer.org)
  • The volume and weight of tumors were significantly higher in mice transplanted with DU145 and stromal cells from PZ. (jcancer.org)
  • The purified DU145 cells isolated from the tumors with DU145 and stromal cells in PZ had increased ability to migrate and proliferate, and had increased expression of C-Kit. (jcancer.org)
  • Evolving research in stem cells and cancer biology have provided strong evidence for the existence of cancer stem cells (CSCs) in various human solid tumors, including brain, breast, bone marrow, prostrate, colon, and lung [ 3 , 4 ]. (oncotarget.com)
  • Alteration or exacerbation of malignant tumor cell migration and dissemination is the principal cause of death due to solid tumors 5 . (nature.com)
  • suppressor gene (Hanemann 2008 Biallelic inactivation also underlies several sporadic tumors from the anxious system including virtually all schwannomas 50 of meningiomas and 29-38% of ependymomas (Hanemann 2008 In corroboration of in either Schwann or arachnoidal cells develop human-like schwannomas or meningiomas respectively (Giovannini et al. (hiv-proteases.com)
  • Failure of programmed cell death and differentiation as causes of tumors: Some simple mathematical models. (ox.ac.uk)
  • The development and progression of tumors is taught on a molecular genetic and cell biological basis. (tum.de)
  • CD44, a cell surface component that interacts with the extracellular matrix, has been found to be highly expressed in CSCs of several solid tumors. (elsevierpure.com)
  • These observations suggest that PGE 2 -mediated inflammatory signaling and Wnt signaling cooperatively trigger the expansion of CD44 + slow-cycling stem-like cells in SCJ, leading to development of lethal gastric tumors in mice. (elsevierpure.com)
  • In the cell lines studied, cyclopamine showed a high inhibitory growth of subcutaneous tumors in the D283 Med and DAOY lines. (scholars.direct)
  • Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell (SC)-lineage-derived sarcomas. (elsevierpure.com)
  • The specific binding of hFSH were demonstrated in three tumors of epithelial origin (serous cystadenoma and mucinous cystadenoma) and in two of sex cord-stromal origin (theca cell tumor and granulosa cell tumor). (nii.ac.jp)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas, multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order to evade growth constraints associated with the loss of matrix attachment. (elifesciences.org)
  • Various genetic alterations have been identified that promote the initiation and progression of colon tumorigenesis. (oncotarget.com)
  • Laminin-332 or laminin-5," "oral dysplastic cells," "potentially malignant disorders" that correlated the progression, progression and / or invasion of the tumor progression process with laminin-332 or the expression of that glycoprotein in dysplasias and carcinoma oral. (bvsalud.org)
  • The aims of the current study were to clarify patterns and intensities of cMYC expression in follicular cell-derived thyroid carcinomas across a spectrum of cancer morphologies and disease aggressivities, to correlate cMYC with BRAF V600E expression, and to evaluate the potential role of cMYC in progression of well-differentiated thyroid carcinomas into less well-differentiated carcinomas. (biomedcentral.com)
  • Cancer microenvironment is critical for tumorigenesis and cancer progression. (biomedcentral.com)
  • Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. (biomedcentral.com)
  • Renal cell carcinoma (RCC), the most common kidney neoplasm, originates in renal tubular epithelial cells and accounts for 85-90% of adult renal malignancies [ 1 ]. (biomedcentral.com)
  • Early identification of VHL is important because of the increased risk of serious complications (eg, renal cell carcinoma) to foster more effective treatment options and better prognoses. (medscape.com)
  • Here, we have revealed the role of viral FLICE-inhibitory protein (vFLIP) in the initiation of PEL and MCD by specifically expressing vFLIP at different stages of B cell differentiation in vivo. (jci.org)
  • These results define immunological functions for vFLIP in vivo and reveal what we believe to be a novel viral-mediated tumorigenic mechanism involving B cell reprogramming. (jci.org)
  • Furthermore, in vivo administration of IL-6 to DSS-treated Apc Min/+ mice effectively weakened the inhibitory effects of berberine on tumorigenesis and EGFR-ERK signaling in colon tissues. (nih.gov)
  • The growth and metastasis abilities of cells are evaluated in vitro and in vivo. (biomedcentral.com)
  • We extended our investigation in vivo and confirmed that mice injected with USP19 depleted cells display increased tumor-free survival, as well as a delay in the onset of the tumor formation and a significant reduction in the appearance of metastatic foci, indicating that tumor cell invasion and dissemination is impaired. (nature.com)
  • In contrast, overexpression of USP19 increased cell invasiveness both in vitro and in vivo, further validating our findings. (nature.com)
  • In vivo, Dclk1+ cells are necessary for pancreatic regeneration following injury and chronic inflammation. (bepress.com)
  • For the in vivo assay, for each cell line, each experimental group consisted of 6 mice injected subcutaneously with control cells on the right flank, and cells treated with cyclopamine or GLI1 siRNA on the left flank. (scholars.direct)
  • Overexpression of the RNA-binding protein HuR (ELAVL1) occurs during colon tumorigenesis and is abnormally present within the cytoplasm, where it post-transcriptionally regulates genes through its interaction with 3'UTR AU-rich elements (AREs). (oncotarget.com)
  • 2005 Hence how Merlin coordinately regulates Rac1 and Ras signaling from parts of cell:cell get in touch with remains to become defined. (hiv-proteases.com)
  • SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells. (nih.gov)
  • In the present study, we found that berberine effectively inhibited colitis-associated tumorigenesis and colonic epithelium hyperproliferation in dextran sulfate sodium (DSS)-treated Apc Min/+ mice. (nih.gov)
  • An in vitro study on cell lines identified that berberine treatment of Raw 264.7 macrophages resulted in conditioned media with fewer proliferative effects on a cell line with a heterozygous Apc mutation (Immorto-Min colonic epithelium, IMCE). (nih.gov)
  • In exposing these particles to NIR, the efficacy of Au was measured through the decrease of EFGR in oral squamous carcinoma cells. (wikipedia.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • PIK3CA/p110α phosphorylation at Y317 and Y508 play important role in tumorigenesis of colorectal cancer through two independent pathways. (biomedcentral.com)
  • 2003 Stokowski and Cox 2000 Although the exact mechanisms by which Merlin confers contact dependent inhibition of cell growth remain unclear it appears to involve rules of receptor tyrosine kinases (RTKs) and downstream mitogen-activated protein kinase (MAPK) pathways. (hiv-proteases.com)
  • Using protein-protein interaction screening, we found that FOXO3a interacted with ER-alpha and ER-beta proteins in the human breast carcinoma cell line MCF-7, suggesting that there exists a crosstalk between the FOXO3a and ER signaling pathways in estrogen-dependent breast cancer cells. (ntu.edu.tw)
  • Her lab is currently investigating cell signaling pathways involved in wound healing with attention to the regeneration of the ocular surface epithelial cells and corneal nerves. (upenn.edu)
  • We use large-scale sequencing and array-based analyses of bulk and single cells as well as experimental systems to understand whether aneuploidy is always associated with chromosomal instability (CIN) and to delineate the pathways by which aneuploidy arise. (lu.se)
  • In the case of Huntington's Disease (HD), p53 mediates cytotoxicity in HD cells and animal models, whereas its inhibition prevents this phenotype. (units.it)
  • Inhibition of Ser46 phosphorylation by targeting HIPK2, PKCδ, or ATM kinases, as well as inhibition of Pin1, prevented mHtt-dependent apoptosis of neuronal cells. (units.it)
  • Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses in non-transformed intestinal cells had no appreciable effects. (oncotarget.com)
  • Collectively, our studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cell-autonomous dependence on GLS for cancer therapy. (johnshopkins.edu)
  • The Merlin/tumor suppressor restrains cell tumorigenesis and growth by controlling contact-dependent inhibition of proliferation. (hiv-proteases.com)
  • 2010 As cells reach Lactacystin confluency Merlin is definitely recruited to cell junctions where it coordinates the establishment of intercellular contacts with the concomitant inhibition of cell proliferation. (hiv-proteases.com)
  • Enhancer of zeste homolog 2 (EZH2) belongs to poly-sulfur protein family and can mediate cell proliferation and differentiation via the modulation of various genes expressions. (medscimonit.com)
  • We study the development of blood cells and the emergence of leukemia by focusing on the molecular genetics of self-renewal and its connection to differentiation into functional cells of the innate immune system, like macrophages, granulocytes, and dendritic cells. (mdc-berlin.de)
  • Dysregulation of these master switches may affect differentiation, which can lead to "confused" cells as the potential progenitors of leukemia. (mdc-berlin.de)
  • Both C/EBPs command and control molecular programs of proliferation and differentiation into innate immune cells , including various types of myeloid cells. (mdc-berlin.de)
  • We apply targeted mouse genetics in combination with experimental hematopoiesis, genetic engineering of hematopoietic cells, human iPSC hematopoietic differentiation, proteomics and biochemistry. (mdc-berlin.de)
  • Hematopoietic transcription factors (= gene regulatory proteins) concertedly control cell proliferation, lineage commitment, and cell differentiation. (mdc-berlin.de)
  • A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt. (ox.ac.uk)
  • Our new models incorporate plausible fluctuation in the parameters of the model and introduce nonlinearity by assuming that the parameters depend on the numbers of cells in each state of differentiation. (ox.ac.uk)
  • The WT1 protein mediates the mesenchymal-epithelial transition and differentiation during morphogenesis of the kidney and gonad by repressing genes that encode cell proliferation factors and by activating genes that encode markers of epithelial cell differentiation. (medscape.com)
  • Other phenolic constituents such as phytic acid was shown to exhibit anticancer properties through the regulation of vital cellular functions such as signal transduction, cell proliferation and differentiation ( Vucenik and Shamsuddin, 2006 ). (scialert.net)
  • They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. (bvsalud.org)
  • Altogether, the results of our studies have revealed that berberine inhibits the development of CACRC by interfering with inflammatory response-driven EGFR signaling in tumor cell growth. (nih.gov)
  • In colon-derived cell lines where Yap is overabundant, its depletion strongly reduces beta-catenin and Notch signaling and inhibits proliferation and survival. (harvard.edu)
  • 2007 Another research shows that Merlin inhibits contact-dependent recruitment of energetic Rac1 towards the plasma membrane in endothelial cells (Okada et al. (hiv-proteases.com)
  • Conversely, disruption of TAZ/YAP activity alleviates tumor burden in Lats1/2-deficient mice and inhibits human MPNST cell proliferation. (elsevierpure.com)
  • The encoded protein also inhibits cell migration and tumorigenesis. (nih.gov)
  • In order to identify novel molecular targets of tumor cell migration and invasion we performed a genetic screen with an shRNA library against ubiquitination pathway-related genes. (nature.com)
  • More importantly, we demonstrated that USP19 catalytic activity is important for the control of tumor cell migration and invasion, and that its molecular mechanism of action involves LRP6, a Wnt co-receptor. (nature.com)
  • To identify novel molecular targets within the ubiquitination pathway that positively regulate migration we conducted a loss-of-function genetic screen using an epithelial cell line derived from human triple-negative breast cancer (MDAMB231) infected with a pooled shRNA interference library. (nature.com)
  • General basics of molecular cell biology are also taught, especially in the first part, while the second part focuses on translational aspects. (tum.de)
  • After successful completion of the module, students will have in-depth knowledge of cell biology and molecular biology from all aspects of tumor biology. (tum.de)
  • 2) Textbook of Molecular Cell Biology, Alberts et al. (tum.de)
  • The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
  • They found that the gene that codes for a protein called poliovirus receptor-like 4 (PVRL4) allows attachment-free cell growth and also makes cells cluster together once detached from the matrix. (elifesciences.org)
  • also showed that interactions between the PVRL4 in one cell and a related protein called PVRL1 in a neighboring cell were responsible for holding the cells together in clusters. (elifesciences.org)
  • The ubiquitination pathway plays a fundamental role in the maintenance of protein homeostasis both in normal and stressed conditions and its dysregulation has been associated with malignant transformation and invasive potential of tumor cells, thus highlighting its value as a potential therapeutic target. (nature.com)
  • The recruitment of Merlin to cell junctions is vital for its tumor suppressive function as patient-derived mutations that impair Merlin junctional localization render the protein inactive (Deguen et al. (hiv-proteases.com)
  • Outcomes Merlin associates using the Angiomotin/Patj/Pals1 complicated To identify protein that form steady complexes with Merlin we produced individual embryonic kidney (HEK293) cell lines stably expressing. (hiv-proteases.com)
  • B-cell lymphoma-2 (Bcl-2) is an antiapoptotic protein known to be important in the regulation of apoptosis in various cell types. (cdc.gov)
  • The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)
  • Cyclopamine, an inhibitor of the SMO oncogenic protein, and GLI1 siRNA were used as inhibitory agents of the Shh pathway in the two cell lines. (scholars.direct)
  • This gene provides instructions for making one part (subunit) of an enzyme called protein kinase A, which promotes cell growth and division (proliferation). (medlineplus.gov)
  • The lack of this subunit causes protein kinase A to be turned on more often than normal, which leads to uncontrolled cell proliferation. (medlineplus.gov)
  • The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)
  • DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
  • Hexavalent Chromium (Cr(VI) induces malignant cell transformation in normal bronchial epithelial (BEAS-2B) cells. (uky.edu)
  • Lats1/2 deficiency in Schwann cells induces hyperactivation of TAZ/YAP and increased PDGFR signaling, leading to the development of MPNST in mice. (elsevierpure.com)
  • Ablation of the kinases Mst1 and Mst2, orthologs of the Drosophila antiproliferative kinase Hippo, from mouse intestinal epithelium caused marked expansion of an undifferentiated stem cell compartment and loss of secretory cells throughout the small and large intestine. (harvard.edu)
  • Thus, supraphysiologic Yap polypeptide levels are necessary to drive intestinal stem cell proliferation. (harvard.edu)
  • of the relationship between cells in three compartments of the intestinal crypt: stem cells, semi-differentiated cells and fully differentiated cells. (ox.ac.uk)
  • abstract = "Similar to normal tissue stem cells, cancer stem cells (CSCs) are thought to be quiescent or slow-cycling and, thereby, insensitive to chemo- and radiotherapies. (elsevierpure.com)
  • Her primary research program is focused on the biology of wound healing and tumorigenesis. (upenn.edu)
  • A standard chemotherapy drug injures surrounding non-cancer cells, which can then awakens dormant cancer cells and promotes cancer growth, according to a new study publishing September 12th in the open access journal PLOS Biology by Ramya Ganesan of Emory University, US, and colleagues. (news-medical.net)
  • BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
  • Here, we performed a long-term diet study in mice to follow tumorigenesis and characterize structural and metabolic changes in colon mucosa associated with WD and predisposition to colorectal cancer. (helsinki.fi)
  • We have previously reported a mouse model in which Brca1 exon 11 is eliminated in mammary epithelial cells through Cre-mediated excision. (nih.gov)
  • explored which genes enable epithelial cells from the human mammary gland to grow without being attached to the extracellular matrix. (elifesciences.org)
  • Using a genetically engineered mouse model, we generated mammary-specific Dusp4 -deleted primary epithelial cells to investigate the necessary conditions in which DUSP4 loss may drive breast cancer oncogenesis. (biomedcentral.com)
  • In this study, we tested whether Dusp4 loss, together with other oncogenic events, could promote mammary tumorigenesis. (biomedcentral.com)
  • Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
  • A single-cell layer of epithelium is separated from the tissues beneath it by a supporting substance called the extracellular matrix. (elifesciences.org)
  • Moreover, cancerous cells tend to cluster together when they are detached from the extracellular matrix. (elifesciences.org)
  • Moreover, PVRL4 triggers a form of signaling between the cells called integrin β4 signaling that allows them to survive without being anchored to the extracellular matrix. (elifesciences.org)
  • The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, a. (biomedcentral.com)
  • The tumour microenvironment is composed of both cellular components including cancer cells, immune cells, endothelial cells, fibroblasts, and many more cell types, as well as acellular components of the tissue including extracellular matrix components, metabolites, oxygen, acidity, and nutrition's among others. (lu.se)
  • Using genetic lineage tracing, we show that Doublecortin-like kinase-1 (Dclk1) labels a rare population of long-lived, quiescent pancreatic cells. (bepress.com)
  • For example, it can manipulate our genetic make-up, take over specific cell-to-cell signaling processes, and mutate key enzymes to promote tumor growth, resist therapies, and hasten its spread from the original site to the bloodstream or other organs. (news-medical.net)
  • Researchers at the University of Houston are working to make T-cell immunotherapy safer, developing a tool called CrossDome, which uses a combination of genetic and biochemical information to predict if T-cell immunotherapies might mistakenly attack healthy cells. (news-medical.net)
  • Here we show that a gastric gland residing at the squamo-columnar junction (SCJ) in normal mouse stomach contains CD44 + stem cell-like slow-cycling cells and that this characteristic CD44 + gland was expanded by prostaglandin E2 (PGE 2 ) and Wnt signaling in K19-Wnt1/C2mE mouse, a genetic mouse model for gastric tumorigenesis. (elsevierpure.com)
  • G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. (atsbio.com)
  • Using gene manipulation strategies, we reveal for the first time that Cav-1 plays an essential role in CSC regulation and aggressiveness of SWCNT-transformed cells partly through p53 dysregulation, consistent with their suggested role by microarray and gene ontology analysis. (oncotarget.com)
  • From our screen, we identified the Ubiquitin-specific protease 19 (USP19) as a candidate gene associated with the regulation of cell migration. (nature.com)
  • We found that Dusp4 loss alone is insufficient in mediating tumorigenesis, but alternatively converges with loss in Trp53 and MYC amplification to induce tumorigenesis primarily through chromosome 5 amplification, which specifically upregulates Dbf4 , a cell cycle gene that promotes cellular replication by mediating cell cycle checkpoint escape. (biomedcentral.com)
  • Key gene regulatory proteins control cell multiplication and instruct cells to adopt distinct cell fates. (mdc-berlin.de)
  • Remarkable progress in science and technology has led to the development of powerful tools for genome sequencing and editing increasing ability to study gene expression and function at multiple levels from cells to populations. (cdc.gov)
  • Most mutations in the PRKAR1A gene that cause Carney complex result in an abnormal type 1 alpha subunit that is quickly broken down (degraded) by the cell. (medlineplus.gov)
  • Carney complex is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
  • The existence of adult pancreatic progenitor cells has been debated. (bepress.com)
  • Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis. (bvsalud.org)
  • In addition, we found that upon oncogene activation BRD7 restrains, independently of p53, the acquisition of malignant phenotypes, such as migration/invasion and stem cell traits. (units.it)
  • El-Sayed et al found that the malignant cells that had undergone incubation in AuNPs conjugated with anti-epithelial growth factor receptor (EGFR) required half the energy to destroy a cell than a benign cell. (wikipedia.org)
  • To effectively target the malignant cells, the AuNPs were conjugated by polyethylene glycol, a process known as PEGylation. (wikipedia.org)
  • BRD7 takes part into SWI/SNF and PRC2 chromatin remodelling complexes, whose pleiotropic roles in tumorigenesis make them appealing targets for cancer therapy. (units.it)
  • Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 cells subcutaneously injected into athymic nude mice. (jcancer.org)
  • Understanding how cancerous cells gain this ability may lead to new approaches to stopping tumor cells from dividing and colonizing tissues around the body. (elifesciences.org)
  • Glioma tumor tissues were collected from 3 patients who received surgery, and the glioma stem cells were then separated, cultured, and identified by flow cytometry. (medscimonit.com)
  • Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. (jcancer.org)
  • In addition, there was a strong positive correlation between mTORC1 activity and OPN expression in OSCC tissues and cell lines. (jcancer.org)
  • Cav-1 not only promoted tumorigenesis in a xenograft mouse model but also metastasis of the transformed cells to neighboring tissues. (oncotarget.com)
  • Tissues and Cells. (lu.se)
  • Tumor cell dissemination in cancer patients is associated with a significant reduction in their survival and quality of life. (nature.com)
  • We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. (jcancer.org)
  • The C-Kit inhibitor, imatinib mesylate, was administrated to confirm the effect of stromal cells on the tumorigenesis. (jcancer.org)
  • In contrast, the data was significantly lower with DU145 and stromal cells from TZ than DU145 alone. (jcancer.org)
  • These effects of the stromal cells in the PZ on DU145 cells could be blocked using imatinib mesylate. (jcancer.org)
  • in contrast, the stromal cells in the TZ inhibit it through down-regulating the expression of C-Kit. (jcancer.org)
  • And more recently, we discovered that C. tropicalis promoted colitis-associated colon cancer (CAC) through enhancing the accumulation and immunosuppressive activity of myeloid-derived suppressor cells (MDSCs) [ 10 ]. (biomedcentral.com)
  • These CSCs, which were found to overexpress tumor promoter caveolin-1 (Cav-1), displayed aggressive cancer phenotypes of apoptosis resistance and enhanced cell invasion and migration compared with their non-CSC counterpart. (oncotarget.com)
  • Mutation at Y317 of p110α reduces the proliferation, migration, and invasion of cancer cells through Src-MLC2 pathway, while mutation at Y508 of p110α impairs AKT signaling. (biomedcentral.com)
  • A gain of function screen for genes that enable proliferation independently of matrix anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. (elifesciences.org)
  • The expression patterns of stem cell-specific genes of these DU145 cells were examined. (jcancer.org)
  • Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. (oncotarget.com)
  • DUSP4 alterations lead to hyperactivation of MAPK signaling in many cancers, including breast cancer, which often harbor mutations in cell cycle checkpoint genes, particularly in TP53. (biomedcentral.com)
  • Interestingly, replication stress in Brca2-null cells activates p53 and the expression of its target genes, including senescence-inducing Ink4/Arf. (biomedcentral.com)
  • GLS is being explored as a cancer therapeutic target, but whether GLS inhibitors affect cancer cell-autonomous growth or the host microenvironment or have off-target effects is unknown. (johnshopkins.edu)
  • The tumour microenvironment plays a fundamental role during tumorigenesis and holds great opportunities in future cancer therapies. (lu.se)
  • The model will be useful for understanding the mechanisms by which the prostatic stem cell niche controls the tumorigeneis of prostatic cancer stem cells. (jcancer.org)
  • Together with the associated research group of Dr. Alexander Mildner we perform ATACseq, ChIPseq and single cell analysis to disclose fundamental epigenetic mechanisms in hematopoiesis, homeostasis, autoimmune diseases, and in leukemogenesis. (mdc-berlin.de)
  • However, the relevancy between CD44 + cells and slow-cycling cells and the underlying mechanisms for the emergence of CD44 + CSCs during tumorigenesis have not been elucidated. (elsevierpure.com)
  • Our previous study has revealed that Candida tropicalis ( C. tropicalis ) promotes colorectal tumorigenesis by enhancing immunosuppressive function of myeloid-derived suppressor cells (MDSCs) and increasing accumulation of MDSCs, but the underlying mechanisms remain unestablished. (biomedcentral.com)
  • We find that together with loss-of-function mutations in p53 and, to some degree, potentiated by cMyc overexpression, Dusp4 deletion aids in cell cycle checkpoint escape while simultaneously potentiating hallmarks of replicative stress, including multinucleation and Chk1 phosphorylation. (biomedcentral.com)
  • Our study suggests that nuclear overexpression of cMYC correlates with tumorigenesis / dedifferentiation in follicular cell derived thyroid carcinomas, a concept that has not been shown before on whole tissue sections. (biomedcentral.com)
  • Rearrangement or overexpression of c-rel can cause tumorigenesis. (bvsalud.org)
  • Heterozygous mutation of Trp53 decreases p53 and results in attenuated apoptosis and G1-S checkpoint control, allowing Brca1Delta11/Delta11 cells to proliferate. (nih.gov)
  • Cr(VI)-transformed cells exhibit increased level of antioxidants, are resistant to apoptosis, and are tumorigenic. (uky.edu)
  • 1] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)
  • WD increased colon tumor numbers, and mucosa proteomic analysis indicated severe deregulation of intracellular bile acid (BA) homeostasis and activation of cell proliferation. (helsinki.fi)
  • WD also increased crypt depth and colon cell proliferation. (helsinki.fi)
  • Overall, our results suggest that WD increases cancer risk by FXR inactivation, leading to BA deregulation and increased colon cell proliferation. (helsinki.fi)
  • Yap is overexpressed in 68 of 71 human colon cancers and in at least 30 of 36 colon cancer-derived cell lines. (harvard.edu)
  • In this study we examined the preventive properties of Rice Bran (RB) and germ on the incidence of azoxymethane induced colon tumorigenesis in Fisher 344 male rats. (scialert.net)
  • We conclude that the protective effects of RB against colon tumorigenesis may possibly be attributed to the synergistic/additive actions of phytochemicals contained in RB. (scialert.net)
  • Metastasis is a complex prosess in which cancer cells leave the original tumour site and migrate to other parts of the body and establish a secondary tumour. (lu.se)
  • The N-terminal phosphorylation of RB by p38 bypasses its inactivation by CDKs and prevents proliferation in cancer cells. (nature.com)
  • This mechanism preserves the single-cell layer pattern throughout the body and prevents epithelial cells from growing in inappropriate locations. (elifesciences.org)
  • However, phosphorylation sites of PIK3CA/p110α and their underlying mechanism in tumorigenesis are largely unknown. (biomedcentral.com)
  • This study identifies a novel mechanism for breast tumorigenesis implicating Dusp4 loss and p53 mutations in cellular acquisition of Dbf4 upregulation as a driver of cellular replication and cell cycle checkpoint escape. (biomedcentral.com)
  • The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is constitutively activated in RCC and plays a crucial role in regulating cell growth [ 22 ]. (biomedcentral.com)
  • How it affects tumorigenesis is still poorly understood. (lu.se)
  • As a widely recognized standard regimen, R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) is able to cure two-thirds patients with diffuse large B cell lymphoma (DLBCL), and t. (biomedcentral.com)
  • We demonstrate that the transformation of breast cancer cells is dependent on PVRL4. (elifesciences.org)
  • For more than 100 years, pathologists have observed cancer cells engulfing other live cells, but scientists are only now beginning to understand how it happens and what it means for tumorigenesis. (the-scientist.com)
  • arations verified the presence of cancer cells in all samples. (lu.se)
  • Immunohistochemical studies using specific monoclonal antibodies for cMYC and BRAF V600E were performed on tissue microarrays built from follicular cell-derived thyroid carcinomas (25 papillary, 24 follicular, 24 oncocytic variant of follicular, and 21 undifferentiated). (biomedcentral.com)
  • Herein, we utilized IHC for cMYC in a tissue microarray (TMA) study performed on a spectrum of follicular cell-derived thyroid carcinomas, including papillary ( n = 25), follicular ( n = 25), oncocytic variant of follicular ( n = 25), and undifferentiated ( n = 22) carcinomas. (biomedcentral.com)
  • Recent advances have been made by an accumulation of studies on Merkel cell polyomavirus (MCPyV), which is highly associated and integrated in most Merkel cell carcinomas ( 5 ). (cdc.gov)
  • Tumorigenesis and diagnostic practice applied in two oncogenic viruses: Epstein Barr virus and T-cell lymphotropic virus-1-Mini review. (physiciansweekly.com)
  • Given the previously reported role of DUSP4 as a p53 target, a potential cell cycle checkpoint, and in mediating senescence downstream of replication stress, we hypothesized that DUSP4 may be a critical oncogenic driver in breast cancer. (biomedcentral.com)
  • Our results suggests that SIRT3 plays an important role in mitophagy deficiency of Cr(VI)-transformed cells. (uky.edu)
  • This study investigated the role of Nrf2 in regulating metabolic reprogramming in Cr(VI)-transformed cells. (uky.edu)
  • We demonstrated that Nrf2 constitutive activation plays decisive role on metabolic reprogramming induction, and SIRT3 activation contributing to increased cancer cell proliferation and tumorigenesis. (uky.edu)
  • PI3K/AKT signaling pathway plays important role in tumorigenesis of human cancer. (biomedcentral.com)
  • Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. (johnshopkins.edu)
  • Surface area plays a very important role in drug delivery and per mg of gold, as diameters decrease, the surface areas needed to transport drugs increase to the point where a single 1mL volume of 1.8 nm spherical gold nanoparticles have the same surface area as a cell phone. (wikipedia.org)
  • Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. (biomedcentral.com)
  • In vitro, Dclk1+ cells proliferate readily and sustain pancreatic organoid growth. (bepress.com)
  • Human breast carcinoma cells infused with metal nanoparticles in vitro have been shown to have an increase in morbidity with exposure to near infrared (NIR). (wikipedia.org)
  • In vitro, photothermal therapy was used in oral epithelial cell lines, (HSC 313 and HOC 3 Clone 8) and one benign epithelial cell line (HaCaT). (wikipedia.org)
  • PVRL4 promotes anchorage-independence by driving cell-to-cell attachment and matrix-independent integrin β4/SHP-2/c-Src activation. (elifesciences.org)
  • At the earliest stages of T-cell development, cells with random chromosome gains and/or losses are selected against, but CIN eventually results in the expansion of progenitors with clonal chromosomal imbalances. (bvsalud.org)
  • Clonal selection leads to the development of T-cell lymphomas with stereotypic karyotypes in which chromosome 15 , containing the Myc oncogene , is gained with high prevalence . (bvsalud.org)
  • Experimental hematology, leukemia research, in combination with stem cell research strives to untangle the underlying "grammar" of transcription factor networks. (mdc-berlin.de)
  • The analysis of three transgenic mouse lines, K19-Wnt1, K19-C2mE and K19-Wnt1/C2mE, revealed that the expansion of CD44 + SCJ cells is triggered by PGE 2 -mediated signaling and is prominently enhanced by the addition of Wnt activation. (elsevierpure.com)
  • This study investigated the effect of EZH2 expression on proliferation and tumorigenesis of brain glioma cells. (medscimonit.com)
  • RNAseq analysis in Cr(VI)-transformed cells showed that expression of transcripts associated with mitochondrial oxidative phosphorylation is reduced, and the expression of transcripts associated with pentose phosphate pathway, glycolysis, and glutaminolysis are increased. (uky.edu)
  • Expression of mutant Kras in Dclk1+ cells does not affect their quiescence or longevity. (bepress.com)