• An extensive body of studies has reported that long noncoding RNAs (lncRNAs) are involved in tumor invasion and metastasis by regulating EMT [ 6 ]. (aging-us.com)
  • β-catenin, when translocating to and accumulating in the nucleus, induces transcription of other oncogenes involved in tumor progression, malignancy and metastasis ( 15 ). (spandidos-publications.com)
  • Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. (oncotarget.com)
  • Our data demonstrated that in brain glioma cells, the decrease of EZH2 level could suppress cell proliferation and tumorigenesis potency, and meanwhile inhibit the expressions of oncogenes including c-myc and Akt. (medscimonit.com)
  • While in lung cancer, IRS-1 has been confirmed to suppress tumor metastasis ( 11 ). (spandidos-publications.com)
  • Results Surprisingly, hepatocyte-restricted GPx4 loss does not suppress hepatocellular tumourigenesis. (bmj.com)
  • Tumor microenvironment has been recognized as a key determinant of tumor formation and metastasis, but how tumor microenvironment is affected by nanomaterial s is essentially unknown. (cdc.gov)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • Dr. Pienta's research interests include the ecology of cancer, tumor microenvironment, metastasis, biomarker development and novel therapeutic development. (hopkinsmedicine.org)
  • Immunology, tumour microenvironment & metastasis - is a technical and knowledge-based forum for cancer researchers at Lund University with specific interest in immunology, tumour microenvironment & metastasis. (lu.se)
  • The tumour microenvironment plays a fundamental role during tumorigenesis and holds great opportunities in future cancer therapies. (lu.se)
  • This study investigated the impact of adolescent alcohol consumption on mammary tumorigenesis and progression and compared it to that of adult alcohol exposure in animal models. (harvard.edu)
  • Identification of therapeutic targets Efforts to identify parallel aberrant signaling pathways that are critical for tumor progression and metastasis are critical for cancer treatment. (unclineberger.org)
  • Previous studies mainly focused on its roles in metabolism, but recently it was reported to be correlated with cancer progression and metastasis ( 5 ). (spandidos-publications.com)
  • Aberrant expression of CA125/MUC16 is associated with pancreatic ductal adenocarcinoma (PDAC) progression and metastasis. (unc.edu)
  • Here, we show that MUC16 expression is associated with disease progression, basal-like and squamous tumor subtypes, increased tumor metastasis, and short-term survival of PDAC patients. (unc.edu)
  • Detection of breast cancer metastasis at the earliest stage is important for the management and prediction of breast cancer progression. (iiarjournals.org)
  • CTCs are recognized as playing important roles in the metastasis of carcinomas ( 11 , 12 ) and their analysis enables the prediction of metastatic relapse and progression ( 11 ). (iiarjournals.org)
  • This review is primarily focused on various mechanisms by which plakoglobin may inhibit tumorigenesis and metastasis. (oncotarget.com)
  • Previous studies have revealed that some anesthetics inhibit cancer metastases, not only via blocking perioperative stress responses, but also through inducing anticancer effects [ 8 , 9 ]. (aging-us.com)
  • These findings suggest that lncRNA JPX, a mediator of Twist1 signaling, could predispose lung cancer cells to metastasis and may serve as a potential target for targeted therapy. (biomedcentral.com)
  • Although many advances have been made in the diagnosis and treatment of lung cancer in recent years, metastasis still remains the main challenge posed by advanced lung cancer leading to high mortality [ 3 ]. (biomedcentral.com)
  • As an oncogene, JPX affected the tumor size, TNM staging, and metastasis of lung cancer. (biomedcentral.com)
  • Since early symptoms of cervical cancer are not obvious, late lymph node metastasis is common, leading to poor prognosis. (hindawi.com)
  • The anti-cancer impact of propofol on cervical cancer cells growth in vivo was determined by means of xenograft tumor model and lung metastasis model. (aging-us.com)
  • Despite the progress in the improvement of treatment options and targeted drugs, the overall survival for patients with cervical cancer is still unsatisfactory owing to recurrence and metastasis [ 2 , 3 ]. (aging-us.com)
  • Prior studies have suggested that propofol (2, 6-diisopropylphenol), one of the most extensively used intravenous anesthetic agents during cancer surgical excision, influences the biological behaviors of cancer cell, including growth, invasiveness, and metastasis [ 10 , 11 ]. (aging-us.com)
  • For example, propofol restrains pancreatic cancer cells growth and metastases via elevating miR-328 and depressing ADAM Metallopeptidase Domain 8 (ADAM8) [ 12 ]. (aging-us.com)
  • In colorectal cancer, propofol inhibits cancer cells proliferation and metastasis by regulating miR-124-3p.1/AKT3 [ 13 ]. (aging-us.com)
  • The key factor of cancer associated morbidity and mortality is principally attributable to the development of metastases. (intechopen.com)
  • In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
  • Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
  • Khan K, Wale A, Brown G, Chau I. Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
  • primarily based on better understanding of the molecular complexity of colorectal cancer coupled with aggressive approach in management of colorectal liver metastases. (wjgnet.com)
  • Breast cancer metastases are most commonly found in bone, an indication of poor prognosis. (degruyter.com)
  • Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the etiology and promoting new therapeutic approaches. (degruyter.com)
  • A total of 61 DEGs, included 27 down-regulated and 34 up-regulated, were found to be significant in breast cancer bone metastasis. (degruyter.com)
  • DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)
  • Bone cancer metastases usually occur in the axial skeleton, in areas with active hematopoiesis and high red marrow content. (degruyter.com)
  • In this study, we explore different signaling pathways and associated molecular mechanisms of underlying primary breast cancer development, along with the formation of metastases in the bone. (degruyter.com)
  • Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis. (nih.gov)
  • To date, the role of insulin receptor substrate 1 (IRS-1) in tumorigenesis and metastasis of head and neck cancer has not been elucidated. (spandidos-publications.com)
  • We propose that IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9. (spandidos-publications.com)
  • IRS-1 has been identified as both a positive and negative regulator of metastasis in breast cancer ( 8 - 10 ). (spandidos-publications.com)
  • Dr. Yeh received his doctoral degree at National Defense Medical Center in Taiwan, where he studied cancer metastasis and gene regulation. (aacr.org)
  • The fellowship represents an excellent opportunity to achieve my research goals of providing new insights in the field of cancer metabolism and identifying prognostic and therapeutic strategies to prevent cancer metastasis. (aacr.org)
  • Dr. Pienta's laboratory has championed the concept that cancer tumorigenesis and metastasis can best be understood utilizing the principles of ecology. (hopkinsmedicine.org)
  • Invasive micropapillary carcinoma of the breast (IMPC) is a rare subtype of breast cancer that has a high frequency of lymph node (LN) involvement and metastasis to distant organs. (jcancer.org)
  • Breast cancer metastasis accounts for the majority of deaths from breast cancer. (iiarjournals.org)
  • Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. (iiarjournals.org)
  • Additionally, a deeper understanding of the metastatic cascade in breast cancer will be critical for developing therapeutic interventions to combat breast cancer metastasis. (iiarjournals.org)
  • In this review, the current and novel methods for detection of breast cancer metastasis, as well as the mechanisms involved in metastasis and the treatment of breast cancer metastasis, are discussed. (iiarjournals.org)
  • The majority of deaths from breast cancer are not due to the primary tumor itself, but are the result of metastasis to other organs in the body ( 2 ). (iiarjournals.org)
  • Currently, detection of breast cancer metastasis relies on clinical manifestations of the spread to distant organs, biopsies of affected organs, radiological evaluations, imaging methods and serum tumor markers ( 3 , 4 ). (iiarjournals.org)
  • Metastasis is a complex prosess in which cancer cells leave the original tumour site and migrate to other parts of the body and establish a secondary tumour. (lu.se)
  • Metastases represent the end products of a multistep cell-biological process termed the invasion metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites. (medscape.com)
  • M describes metastasis (spread of cancer to other parts of the body). (medscape.com)
  • L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
  • AXL significantly promotes tumour cell migration, invasion and metastasis, as well as angiogenesis. (cancerindex.org)
  • This study investigated the effect of EZH2 expression on proliferation and tumorigenesis of brain glioma cells. (medscimonit.com)
  • This is due to the high propensity of lymph node (LN) involvement as well as early regional and distant metastasis seen in IMPC [ 1 - 5 ]. (jcancer.org)
  • Furthermore, adolescent-initiated alcohol exposure activated PAK1 and p38γ MAPK, critical regulators of mammary tumorigenesis and aggressiveness, respectively, while adult-initiated alcohol exposure activated only p38γ MAPK. (harvard.edu)
  • CONCLUSIONS: Adolescent-initiated alcohol exposure enhanced both tumorigenesis and aggressiveness of mammary tumors, while adult-initiated alcohol exposure mainly promoted tumor metastasis. (harvard.edu)
  • Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion. (rochester.edu)
  • Ma Z, Gibson SL, Byrne MA, Zhang J, White MF and Shaw LM (2006) Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. (scielo.br)
  • B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2. (nih.gov)
  • Lymphoma cells are reported to over-express chemokine receptors that favors leukocyte infiltration, promotes tumorigenesis, angiogenesis, immune evasion, and metastasis. (aacrjournals.org)
  • Therefore, identifying the crucial proteins and clarifying mechanisms that contribute to metastasis will be significant to provide biomarkers for prognosis and targets for treatment. (spandidos-publications.com)
  • To evaluate the mechanisms underlying the role of AXL signalling in tumour metastasis, we screened a phage display library to generate a novel human monoclonal antibody, named DAXL-88, that recognizes both human and murine AXL. (cancerindex.org)
  • Our goal is to elucidate the molecular context and mechanisms by which aberrantly regulated genes contribute to breast and ovarian tumorigenesis. (lu.se)
  • Motivation: Tumorigenesis is an evolutionary process by which tumor cells acquire sequences of mutations leading to increased growth, invasiveness, and eventually metastasis. (sciweavers.org)
  • In contrast, while some studies have suggested a tumor promoting activity of plakoglobin in a cell/malignancy specific context, it generally acts as a tumor/metastasis suppressor. (oncotarget.com)
  • How plakoglobin acts as a growth/metastasis inhibitory protein has remained, until recently, unclear. (oncotarget.com)
  • We reported here that plakoglobin, as a key component in cell adhesion, can promote collective metastasis through facilitating IMPC clusters formation. (jcancer.org)
  • Patients in the report had a 5-year overall survival rate of 93.1%, although survival rates were lower in children who experienced symptoms, local recurrence, or metastasis or who did not undergo treatment with surgery or surgery plus radiotherapy. (medscape.com)
  • In addition, it is further related with occurrence and metastasis of malignant tumors. (medscimonit.com)
  • A major focus of the lab is to study novel candidate genes and their roles in tumorigenesis and metastasis. (unclineberger.org)
  • Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. (rochester.edu)
  • However, knowledge of the contribution of MUC16 to pancreatic tumorigenesis is limited. (unc.edu)
  • Activated T cells continue circulating throughout the whole system and sequentially function in unirradiated metastases. (nature.com)
  • Malignant cells often have increased interactions with surrounding ECM 3 proteins, which provide linkages and signals that promote several aspects of metastasis (6) . (aacrjournals.org)
  • The effect on tumorigenesis potency of glioma stem cells was determined by mouse transplantation assay. (medscimonit.com)
  • An emerging method to detect metastasis is the analysis of circulating tumor cells (CTCs), which has shown promise in filling the gaps left by other diagnostic methods. (iiarjournals.org)
  • CTCs are tumor cells originating from primary sites or metastases that circulate in the patients' bloodstream and are very rarely found in healthy individuals ( 9 , 10 ) ( Figure 1 ). (iiarjournals.org)
  • Infiltrated cells might proceed towards overt metastasis with or without an intervening period of latency (dormancy). (medscape.com)
  • CCDC43 was necessary for FOXK1- mediated EMT and metastasis in vitro and vivo. (karger.com)
  • His research focuses on the role of oxidative metabolism in tumorigenesis. (aacr.org)
  • Conclusion Our data highlight a context-specific ferroptosis-induced immune response that could be therapeutically exploited for the treatment of primary liver tumours and liver metastases. (bmj.com)
  • Metastasis to bone typically results in a poor prognosis, reducing life expectancy to 2-3 years post-diagnosis. (degruyter.com)
  • In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. (degruyter.com)
  • However, in most cases, reoperation is not attainable due to simultaneous distant metastases, vascular involvement, or poor physical condition ( 8 - 10 ). (frontiersin.org)
  • It is the process of metastasis that results in morbidity and eventual mortality. (medscape.com)
  • In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. (jcancer.org)
  • In this review we will discuss various treatment options available in management of colorectal liver metastases with potential guidance on how and when to choose these options along with consideration on future directions in management of this disease. (wjgnet.com)
  • The findings served as foundation for the identification of additional targets for combine therapy with ferroptotic inducer in the treatment of HCC and liver metastasis. (bmj.com)
  • The most frequent site of metastasis is the lung, followed by the liver, brain, and bone. (medscape.com)
  • However, the cellular and molecular machinery underlying metastasis is relatively poorly understood so far. (intechopen.com)
  • Nevertheless, a better understanding of the molecular events underlying the metastasis of IMPC will be important for its prevention, diagnosis, and treatment. (jcancer.org)
  • Although mammographic screening has reduced the mortality rate associated with metastasis as a result of early diagnosis ( 2 ), the methods described above are frequently inept at detecting metastasis at the earliest stage and at accurately predicting the clinical outcome of the disease ( 3 , 4 ). (iiarjournals.org)
  • In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. (spandidos-publications.com)
  • Orphan G protein-coupled receptor GPR56 plays a role in cell transformation and tumorigenesis involving the cell adhesion pathway. (medlineplus.gov)
  • Both adolescent- and adult-initiated alcohol exposure significantly increased lung metastasis. (harvard.edu)
  • PyV-induced tumorigenesis in laboratory animals, by simian virus 40 (SV40) or by multiple human PyVs, such as JC virus (JCV), is used extensively as a cell transformation model. (cdc.gov)