Loading...
  • roles
  • The combination of findings from current in vitro and in vivo studies has not yielded a comprehensive understanding of the mechanisms of menin's tumor suppressor activity or the specific role for menin in endocrine tumorigenesis, although its diverse interactions suggest possible pivotal roles in transcriptional regulation, DNA processing and repair and cytoskeletal integrity. (springer.com)
  • While the roles of STAT3 and STAT5 during mammary gland development and tumorigenesis are well studied, others members, e.g. (nih.gov)
  • Research
  • This manuscript summarizes recent research findings including studies of global gene expression in MEN1-associared neuroendocrine tumors and pivotal changes in intracellular signaling pathways associated with neuroendocrine tumorigenesis. (springer.com)
  • normal
  • We hypothesized that a miRNA must be involved in liver tumorigenesis if it is consistently dysregulated through each step going from normal liver to cirrhosis and cirrhosis to HCC. (pnas.org)
  • critical
  • Further, the critical transition phenomenon that occurs in tumorigenesis was identified using large-scale computer simulation analysis, which was the first hidden gene network principle to be identified. (news-medical.net)
  • human
  • By targeting the mouse orthologs of human DOK2 and DUSP4 genes, which were co-deleted in approximately half of human lung adenocarcinomas, we found that compound-heterozygous deletion of Dok2 and Dusp4 in mice resulted in lung tumorigenesis with short latency and high incidence, and that their co-deletion synergistically activated MAPK signaling and promoted cell proliferation. (jci.org)