Tumor viruses. Medical search. Frequent questions

OXFORD, England and SAN FRANCISCO , Nov. 15, 2018 /PRNewswire/ -- PsiOxus Therapeutics Limited (PsiOxus) and the Parker Institute for Cancer Immunotherapy (Parker Institute) today announced a research project to investigate the use of PsiOxus' virus-based gene therapy for treating solid tumors that have been historically resistant to immunotherapy. (biospace.com)
One of the challenges in treating solid tumors with immunotherapy is the tumor microenvironment, which is very suppressive and effectively prevents the immune system from attacking the tumor," said Fred Ramsdell , Ph.D., vice president of research at the Parker Institute. (biospace.com)
Our work is product and platform based with a focus on discovering and developing gene-based immuno-oncology therapies for the treatment of solid tumors. (biospace.com)
It's pipeline products include Voyager-V1 for solid tumors, MV-NIS for bladder cancer, Voyager-V1 + pembrolizumab for non-small cell lung cancer, head and neck cancer, Voyager-V1 + cemiplimab for multiple cancer indications among others. (pharmaceutical-technology.com)
Seneca Valley Virus has already demonstrated its cancer-fighting abilities in Phase I clinical trials in pediatric solid tumors and Phase II trials in small-cell lung cancers. (oist.jp)
In this study, we compared immune responses to the BNT162b2 mRNA Coronavirus Disease 2019 vaccine in patients with solid tumors ( n = 53) who were on active cytotoxic anti-cancer therapy to a control cohort of participants without cancer ( n = 50). (nature.com)
However, the success of BiTEs in the treatment of solid tumors appears more limited, at least in part due to: (i) poor delivery kinetics and penetration into tumors, and (ii) on-target off-tumor activity, leading to dose-limiting toxicities. (ox.ac.uk)
Conclusions ICVB-1042 is a novel, potent, tumor selective, systemically administrable oncolytic virus with the potential to treat a broad range of solid tumors. (bmj.com)
The Mayo Clinic pitted a combination of CAR-T cells and oncolytic viruses against solid tumors in mouse models. (freethink.com)
Now, researchers at the Mayo Clinic have formed an unlikely squad from souped-up immune system cells, called CAR-T cells, with cancer-killing viruses, also known as oncolytic viruses, to take down solid tumors. (freethink.com)
Researchers at the Mayo Clinic have combined souped-up immune system cells, called CAR-T cells, with cancer-killing viruses to take down solid tumors. (freethink.com)
CAR-T therapy comes up short when it comes to fighting the fortified solid tumors, however, leading researchers to find new ways to empower the cells. (freethink.com)
CAR-T cells ferry a payload of oncolytic viruses straight to the solid tumors. (freethink.com)
To get at solid tumors, Mayo Clinic team partnered their CAR-T cells with oncolytic viruses. (freethink.com)
The combined therapy addresses two of the main challenges CAR-T cells face when dealing with solid tumors. (freethink.com)
Gene therapies have been tested for other solid tumors for quite some time - for decades. (medscape.com)

In effect, the T-SIGn viruses work by turning tumor cells into "drug factories" to express gene therapy products, such as cytokines or antibodies, designed to engage the immune system to attack cancer cells. (biospace.com)

Conversely, the Steinmetz immunotherapy strategy can "flip the switch" by turning off the immune-suppressive environment and turning on the cancer immunity cycle to elicit a potent immune response against the tumor. (case.edu)
Data by Steinmetz and Fiering [Steinmetz, Fiering, Nature Nanotechnology, 2016] show that the proposed nanoparticle cancer immunotherapy generates a highly potent anti-tumor immunity response even in cancers such as melanomas, which are resistant to attack by the immune system. (case.edu)
Solid Tumor Immunotherapy with T Cell Engager-Armed Oncolytic Viruses. (ox.ac.uk)
One viable strategy for reverting the immunosuppressive conditions is the use of an oncolytic virus (OV) in combination with other immunotherapy approaches. (bvsalud.org)
These changes in the tumor may improve responses to immunotherapy , including immune checkpoint blockade. (bvsalud.org)
The Mayo team's study, published in Science Translational Medicine , combined two different types of cancer-fighting therapies: CAR-T immunotherapy and oncolytic virus therapy. (freethink.com)
Combining a cancer-targeting virus with radiation to treat brain cancer in mice was more effective than either therapy on its own according to University of Alberta research, providing hope for new treatments that combine immunotherapy with traditional surgery, chemotherapy or radiation. (uwinhealth.com)

The tumor cells then express the encoded genes, producing biologic therapies to alter the tumor microenvironment. (biospace.com)
Changing the tumor microenvironment is believed to enhance the activation of cancer-fighting immune cells so they can eradicate the tumor. (biospace.com)
The result is a revolutionary way to deliver biological anti-cancer therapeutics that act locally within the tumor microenvironment for the treatment of cancer. (biospace.com)
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Modulation of the tumor microenvironment by armed vesicular stomatitis virus in a syngeneic pancreatic cancer model. (bvsalud.org)
Infection of PDAC cells with a robust OV can change the tumor microenvironment and increase tumor antigen release by its lytic activities. (bvsalud.org)
The improved OV, VSV-S, was shown to drastically alter the immune suppressive tumor microenvironment when intratumorally injected. (bvsalud.org)

This virus that targets cells that are very important for brain growth in babies, we could use that now to target growing tumors," explained study researcher Michael Diamond, The BBC reported. (medicaldaily.com)

Now, an international team led by researchers at Imperial College London has had promising results using specialised viruses called bacteriophages or 'phages' to target cancer cells in the brains of mice. (imperial.ac.uk)
We have generated cancer-targeting viruses that do not enter healthy cells and are therefore safe for use in human tissues. (imperial.ac.uk)
They used a genetically modified virus called an M13 phage to target tumours and deliver a killer payload to the cancer cells. (imperial.ac.uk)
At the cellular level the virus was able to target and destroy three types of cells within glioblastomas. (imperial.ac.uk)
Along with the cancer cells themselves, the virus killed cells of the new blood vessels feeding the tumour. (imperial.ac.uk)
The virus may only target specific cells that are particularly dangerous to brain cancer patients. (medicaldaily.com)
Research on human brain tissue samples showed that the virus was able to kill certain cells that traditional brain cancer treatments, such as chemotherapy, radiotherapy, and surgery, struggle to reach. (medicaldaily.com)
The Zika virus affects brain stem cells in particular, which are involved with creating new cells, the study notes. (medicaldaily.com)
Researchers believe that the Zika virus won't damage the adult human brain because it has very few stem cells. (medicaldaily.com)
By targeting only the cells involved with reproduction, the Zika virus could potentially treat these tumors and leave other important brain cells untouched. (medicaldaily.com)
Zika virus has oncolytic activity against glioblastoma stem cells. (medicaldaily.com)
The viruses first selectively infect and replicate only in tumor cells. (biospace.com)
While delivered systemically, PsiOxus' T-SIGn gene therapy products act locally within the tumor micro-environment, replicating only in tumor cells. (biospace.com)
In effect, the T-SIGn viruses turn the tumor cells into "drug factories" to express combination gene therapy. (biospace.com)
On April 26, 2018, a Brazilian study was published in the journal Cancer Research utilizing the Zika Virus to kill CNS tumor cells. (labroots.com)
They wondered if the virus could attack tumor stem cells in the CNS, given its modus operandi in healthy tissue. (labroots.com)
The mechanism for Epstein-Barr virus infection of progenitor cells and neoplastic transformation has been an area of interest and conjecture. (allenpress.com)
If you have a virus that targets cancer cells and nothing else, that's the ultimate cancer fighting tool," said Prof. Matthias Wolf, principal investigator of the Molecular Cryo-Electron Microscopy Unit at OIST and co-senior author of the study. (oist.jp)
Type 1 of this receptor is selectively expressed in up to 60% of human cancer cells and allows the virus to infect and destroy them while not affecting healthy cells. (oist.jp)
Anticancer viruses tend to target tumors while sparing the healthy cells around them, and many already exist in nature. (oist.jp)
Seneca Valley Virus stands out as a potential virotherapy for one key reason: it selectively targets a receptor found coating tumor cells in over 60 percent of human cancers. (oist.jp)
Seneca Valley Virus doesn't bind with the similar receptor on healthy cells -- it only shows strong affinity for ANTXR1. (oist.jp)
You want the virus to evade the immune system, continue to replicate and kill the cancer cells. (oist.jp)
An oncolytic virus is a virus that has the ability to infect and destroy tumour cells, also known as having an "oncolytic" effect. (thebraintumourcharity.org)
The virus preferentially targets cancerous cells, leaving normal cells unharmed. (thebraintumourcharity.org)
It also triggers an immune response, which helps the body's own immune system recognise and attack the tumour cells. (thebraintumourcharity.org)
Researchers have long known that a person's immune system has the potential to recognize and destroy tumor cells. (case.edu)
With tumor growth, cancer cells release substances known as tumor-associated antigens into the blood stream. (case.edu)
The antigen-presenting cells capture the tumor-associated antigens and transport them to another class of specialized immune cells known as cytotoxic T lymphocytes. (case.edu)
The antigen-presenting cells "train" the cytotoxic T lymphocytes (killer T cells) to recognize and kill the tumor cells using the tumor-associated antigens. (case.edu)
Traveling through the blood stream, the activated killer T cells, in turn, recognize the cancer cells (based on the tumor-associated antigen training) and proceed to kill the cancer cells. (case.edu)
The present disclosure provides, at least in in part, methods and compositions for detecting and/or selectively targeting tumor cells, for example, for the diagnosis and/or treatment of cancer (e.g., ocular cancer). (justia.com)
In some instances, the methods and compositions provided herein can be used to selectively kill cancerous tumor cells without damaging healthy cells. (justia.com)
For example, viral-like nanoparticles that comprise (e.g., are conjugated to) photosensitive molecules may be selectively delivered to tumor cells and photoactivated by exposure to light. (justia.com)
Scholars@Duke publication: Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on the surfaces of normal murine cells. (duke.edu)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Cancer-targeting viruses don't enter healthy cells and are safe for use in human tissues. (liveforever.club)
In general, tumors occur when cells divide and grow excessively in the body. (medlineplus.gov)
Vesicular stomatitis virus , a rapid replicating OV, was armed to express the Smac protein during virus infection (VSV-S). Adaptation by limited dilution largely increased the selective infection of pancreatic cancer cells by VSV-S. The engineered OV was propagated to a large quantity and evaluated for their antitumor activities in an animal model . (bvsalud.org)
In a syngeneic KPC model, intratumoral injection of VSV-S inhibited tumor growth , and induced increasing tumor infiltration of neutrophils and elimination of myeloid derived suppressor cells and macrophages in the tumor . (bvsalud.org)
Background A major challenge in oncolytic virotherapy is to engineer potent tumor-killing viruses that can be delivered systemically for treatment of metastatic disease while leaving normal cells unharmed. (bmj.com)
Tumor cell selectivity was assessed by testing the replication of ICVB-1042 in a comprehensive panel of primary normal human cells compared to tumor cells. (bmj.com)
10,000-fold greater than the concentration of virus required to kill tumor cells. (bmj.com)
The in vitro and in vivo results presented demonstrate ICVB-1042's selective replication in tumor cells compared to quiescent primary normal cells, broad tumor tropism, and safety and anti-tumor efficacy with IV dosing. (bmj.com)
Integration of avian sarcoma virus DNA in chicken cells. (wikidata.org)
THURSDAY, June 30, 2022 - A therapy that uses a virus to kill tumor cells can be safely given to children with a rare, incurable form of brain cancer, an early study has found. (feedavenue.com)
The premise is based on the fact that some viruses can infect and kill tumor cells. (feedavenue.com)
Virus therapy involves viruses that have been modified in the lab to infect and reproduce efficiently inside cancer cells while leaving healthy cells alone. (feedavenue.com)
Here, the researchers used a modified cold virus, called DNX-2401, which has been shown to kill DIPG cells in lab animals. (feedavenue.com)
According to Galanis, researchers initially believed oncolytic viruses might work by directly killing tumor cells - replicating within them until the cells burst. (feedavenue.com)
Tumors have numerous techniques for evading the immune system, including decoy molecules, genetic changes which work like camouflage, immune cell-zapping surface proteins, and corrupting nearby cells to create shields. (freethink.com)
The viruses then infect the cancer cells, replicate, and rend them open - not only killing the cancer cells directly but also calling in the immune system. (freethink.com)
The viruses then infect the cancer cells, replicate, and rend them open - not only killing the cancer cells directly but sparking a general immune response to the area. (freethink.com)
When the researchers tested their platooned CAR-T cells and oncolytic viruses in mouse models of melanoma and brain tumors, they were able to cure the tumors at multiple sites without causing high levels of toxicity. (freethink.com)
The combined therapy was more effective than either CAR-T cells or oncolytic viruses alone. (freethink.com)
This allows us to give a boost with the virus at a later time point, which in turn makes the CAR-T cells wake up again and undergo additional rounds of killing the tumor. (freethink.com)
Within a mouse xenograft style of ovarian cancers the shot of contaminated carrier cells resulted in a significant reduced amount of tumor quantity and prolonged success in comparison to the shot of pathogen alone. (crispr-reagents.com)
In parallel, as the virus became more aggressive, cells that were resistant to infection emerged, displaying escape mechanisms operative at the level of viral entry, HCV RNA replication, or both. (nih.gov)
The virus causes cytopathic effects (CPEs) of extensive syncytial formation in tumor cells but minimal damage or cell killing in normal cells. (elsevierpure.com)
Using a virally encoded soluble marker peptide to provide a quantitative readout of the level of viral gene expression, we determined that tumor cells and normal cells expressed comparable levels of viral proteins. (elsevierpure.com)
Using engineered cells expressing a range of CD46 densities, we determined that whereas virus entry increased progressively with CD46 density, cell fusion was minimal at low receptor densities but increased dramatically above a threshold density of CD46 receptors. (elsevierpure.com)
It is well established that tumor cells express abundant CD46 receptors on their surfaces compared with their normal counterparts. (elsevierpure.com)
At higher densities typical of tumor cells, infection leads to extensive cell fusion. (elsevierpure.com)
Differential effect of ionizing radiation on mammary tumor virus activity associated with blood cells and mammary tumor cells. (jax.org)
Activation of blood-derived and intrahepatic macrophages with a panel of Toll-like receptor agonists induce soluble mediators that promote hepatitis C virus (HCV) entry into polarized hepatoma cells. (ox.ac.uk)
This treatment had demonstrated some efficacy when put inside the bladder, but largely due to the limited dwell time and the exposure of the interferon protein to the bladder tumor cells, it ultimately did not pan out as an effective treatment choice. (medscape.com)
These treatments target specific genetic characteristics of the tumor cells. (msdmanuals.com)

In addition, OVs can be engineered to deliver biological therapeutics directly to tumors, offering unique opportunities to design multimodal anticancer strategies. (ox.ac.uk)

Using bacteria-killing viruses to deliver cancer therapies could help to tackle deadly brain cancers, according to new early-stage research. (imperial.ac.uk)
For the trial , researchers in Spain, the Netherlands and United States turned to oncolytic virus therapy , an approach that has been under study for certain cancers, including other brain tumors. (feedavenue.com)
Body 2 HF10 decreases tumor development within a subcutaneous (s.c.) ovarian cancers model. (crispr-reagents.com)

Glioblastoma can spread rapidly through the brain, requiring surgery or radiotherapy to remove the tumour and treat affected parts of the brain. (imperial.ac.uk)
The brain stem is difficult to access, making it impossible to surgically remove the tumour using current technology. (thebraintumourcharity.org)

Cell reproduction in glioblastomas, the most common type of brain tumor, is detrimental because it can cause the tumor to grow even after intense treatment. (medicaldaily.com)
In addition to being the most common type of brain tumor, glioblastomas are also one of the most difficult to treat, and therefore, very deadly. (medicaldaily.com)
DURHAM, N.C. - By targeting a common virus, doctors may be able to extend the lives of patients diagnosed with the most prevalent and deadly type of brain tumor, according to a study led by researchers in Duke's Preston Robert Tisch Brain Tumor Center. (dukehealth.org)

But there's one problem: the body builds up immunity to the virus within three weeks and squashes the bug before its work is done. (oist.jp)
But as a tumor progresses, it may respond to the body's natural immunity system by activating immune-suppressive mechanisms, essentially turning off the body's own cancer-defense mechanisms. (case.edu)
In addition to melanoma, the proposed therapy exhibits clear treatment efficacy and similar anti-tumor immunity performance in metastatic ovarian and metastatic breast tumor models. (case.edu)
Oncolytic viruses (OVs) are novel anticancer agents that combine direct cancer cell killing with the stimulation of antitumor immunity. (ox.ac.uk)

These viruses, which resemble a kind of alien lunar lander, latch onto the surface of a bacterium and insert their genetic material into the cell, ultimately destroying the bacterium. (imperial.ac.uk)
When the viruses come into contact with a cancer cell and insert their genetic material, the therapeutic gene is activated and produces a protein that destroys the cell. (imperial.ac.uk)
The team proposed that genetic differences in horse species could allow for papillomavirus-induced sarcoid (skin) tumors to grow in some horses and not others. (cornellsun.com)
In this way, sarcoid tumors are considered a complex disease, impacted by both a genetic and an environmental component. (cornellsun.com)
The genetic component is the histocompatibility gene that allows the horse to acquire the papillomavirus, while the environmental component is the exposure to the virus itself. (cornellsun.com)
It's a tumor, it's an infection which causes a tumor, there's a genetic basis, there's lots of variation that we don't understand and it's an important disease in humans, of course. (cornellsun.com)
With advances in molecular and genetic profiling of tumors, researchers and providers found that the combination of CNS tumor biodiversity and their unique molecular markers really define brain tumor types. (labroots.com)
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. (cdc.gov)
The genetic characteristics of tumors. (msdmanuals.com)
With rapidly evolving clinical applications in sequencing of the human genome as well as the genomes of tumors, the traditional anatomic descriptions of cancer types will be supplemented by molecular classification based on tumor genetic aberrations. (cdc.gov)

Obviously, the size of the tumor, its location and how fast it's growing all converge to tell the story. (roryd.org)

Less than one month after treatment, those mice receiving the phage-targeted therapy plus TMZ showed not only a lack of tumour growth but a substantial reduction in the size of the tumours - in both adult and child glioblastomas. (imperial.ac.uk)
What's more, they found that phage therapy plus TMZ showed the greatest survival benefit compared to TMZ or phage therapy alone - on average, mice receiving phage-TMZ therapy outlived the either treatment alone, and control animals, in some cases surviving more than 84 days after tumour implantation. (imperial.ac.uk)
In a new study published online in the Journal of Experimental Medicine , scientists successfully used the Zika virus to infect and kill cancerous brain tumors in adult mice, and hope to use the same treatment on humans with these tumors, though that's a ways off, The BBC reported. (medicaldaily.com)
Biodistribution and pharmacokinetics were evaluated in human tumor xenograft models and in CD46 transgenic mice. (bmj.com)
The combination proved effective in mouse models of cancer, curing brain tumors and melanomas in multiple sites in mice, and helping mice live longer, with a booster shot of the virus extending protection against tumors forming again. (freethink.com)
The researchers treated mice with glioblastoma brain tumors simultaneously with high-dose radiation and a genetically engineered oncolytic vaccinia virus, a virus that has been used safely as a vaccine against smallpox. (uwinhealth.com)
However, 67 per cent of the mice treated with both therapies were cleared of their tumors. (uwinhealth.com)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)

Since viral replication occurs relatively independently of cellular processes, the virus also replicates in the insect vector. (wikipedia.org)
In this Special Issue, we seek to explore novel mechanisms of cellular transformation by oncogenic viruses, the role of viral infection in cancer development in understudied body sites and the potential role of novel viral pathogens in cancer development. (e-booksdirectory.com)
The T-SIGn gene therapy platform is based on the company's oncolytic virus, enadenotucirev, which has properties that allow systemic IV delivery and payload capacity to deliver genes as a viral vector. (biospace.com)
They predict their results will help scientists develop the virus, and other viral drug candidates, for clinical use. (oist.jp)
A "photosensitive viral-like nanoparticle," (also referred to herein as a "photosensitive virus-like particle") refers to a viral-like nanoparticle conjugated to a photosensitive molecule. (justia.com)
Surprisingly, conjugation of photosensitive molecules to viral-like nanoparticles does not interfere with the tissue/tumor tropism of the nanoparticles (e.g., the specificity of the viral-like nanoparticles for a particular host tumor tissue or tumor cell). (justia.com)
Viral-like nanoparticles (also referred to as virus-like particles (VLPs)) of the present disclosure, generally, are assembled from L1 capsid proteins, or a combination of L1 and L2 capsid proteins, and the photosensitive molecules, in some embodiments, are conjugated to a capsid protein that forms the viral-like nanoparticle. (justia.com)
Thus, various aspects of the disclosure provide tumor-targeting viral-like nanoparticles that comprise photosensitive molecules conjugated to capsid proteins. (justia.com)
Using a specially designed cannula (a thin tube), the researchers slowly infused the viral therapy into the tumors of 12 children and teens newly diagnosed with DIPG. (feedavenue.com)
This virus is spread by mosquito bites and is an important cause of viral meningitis in most of the United States. (medlineplus.gov)

7 TNF, tumor necrosis factor. (cdc.gov)
Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner. (ox.ac.uk)
We identified tumor necrosis factor α (TNF-α) as the major cytokine involved in this process. (ox.ac.uk)

What is promising about the PsiOxus approach is its potential to overcome this suppression using a novel virus platform to deliver gene therapy. (biospace.com)
T-SIGn gene therapy products are "armed" through the addition of genes that cause the tumor to express combinations of biologics including antibodies, cytokines, immunomodulatory proteins, or nucleotides (RNA). (biospace.com)
From this, Antczak proposed that Standardbred horses are missing a specific gene that would otherwise allow for sarcoid tumors to grow. (cornellsun.com)
The virotherapy contains an attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with the gene expression. (pharmaceutical-technology.com)
However, there are many new biomarkers that have been incorporated into the AJCC 8th Edition as a component of prognostic stage and will be collected starting in January 2018, if they are not already part of routine surveillance (such as breast cancer gene expression profiling and human papilloma virus). (cdc.gov)
Other tumor-related genome markers are rapidly maturing providing prognostic indicators for survival and response to therapy (e.g. gene expression profiling in prostate cancer ). (cdc.gov)

Avian leukosis viruses (ALV) are retroviruses that can induce tumors in chicken. (ogu.edu.tr)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

Recent advances in tumor metastasis research have led to improved diagnosis and clinical management of cancer. (e-booksdirectory.com)
Tumors are surgically removed and then biopsied to determine a diagnosis, prognosis, and treatment determinations. (labroots.com)
An "integrated diagnosis", based on the new edition of WHO brain tumor classifications will be more precise and include: histological diagnosis, WHO histological grade, and molecular information. (labroots.com)
Demonstration of Epstein-Barr virus infection by in situ hybridization within tumor cell remains critical for the diagnosis. (allenpress.com)
The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules. (justia.com)
If the tumor is cancerous, the outcome depends on the type and stage of the tumor at diagnosis. (medlineplus.gov)
This is probably the worst tumor diagnosis we give to families," said Chi, who was not involved in the new study. (feedavenue.com)
Cancer surveillance traditionally is conducted based on tumor anatomic location, histologic features, size, involvement of lymph nodes and distant metastasis (i.e., anatomic stage) at diagnosis. (cdc.gov)

It helps differentiate the cellular makeup of particular tumors that could not be determined prior. (labroots.com)
The structure shows how the virus binds to its cellular receptor, the Anthrax toxin receptor. (oist.jp)
The tumor virus B (TVB) locus transcribes the cellular receptor that mediates an infection through B, D, and E subgroups of avian leukosis virus. (ogu.edu.tr)
The virological and cellular consequences of persistent hepatitis C virus (HCV) infection have been elusive due to the absence of the requisite experimental systems. (nih.gov)

they thought a blockage of some sort was causing the difficulties, and, of course, they feared a cancerous brain tumor . (roryd.org)

These lesions are considered to be independent primary lesions rather than metastatic disease when multiple tumors are encountered in the same patient. (allenpress.com)
Clinically, delivering the therapy systemically is a potential advantage because you could possibly treat patients with metastatic disease without having to inject each tumor," Vile said. (freethink.com)

The topic of liver tumors is comprehensively reviewed in this book, with a focus on recent developments and improved techniques relevant to both researchers and clinicians. (e-booksdirectory.com)
Of course, there's still some risk in using a virus as a treatment, but researchers are addressing this problem by working to genetically alter Zika in order to make it less harmful than its natural form. (medicaldaily.com)
There's few things I can think of that sound scarier that a genetically modified version of herpes simplex virus type 1, but apparently that's exactly what researchers used to shrink tumors of the deadly skin cancer melanoma in a clinical trial, according to Amgen , which is developing the experimental cancer treatment. (zmescience.com)
Researchers have found a way to activate Epstein-Barr viruses inside tumors as a way to identify patients whose infection can then be manipulated to destroy their tumors. (algodonwineestates.com)
An international team of researchers at OIST and University of Otago have used the Nobel-winning cryo-electron microscopy method to reconstruct the structure of Seneca Valley virus, abbreviated SVV, at near-atomic resolution. (oist.jp)
The researchers found that the outer shell of the Seneca Valley Virus locks tightly onto specific structural features of ANTXR1 -- features that aren't conserved in ANTXR2. (oist.jp)

However, new research shows the virus has a silver lining: it may be useful in treating aggressive and difficult-to-reach brain cancer tumors called glioblastomas. (medicaldaily.com)
According to The American Brain Tumor Association , these types of tumors can grow rapidly as they are usually nourished with a good blood supply, and easily invade other parts of the brain. (medicaldaily.com)
Diffuse midline glioma, formerly known as diffuse intrinsic pontine glioma (DIPG)*, is a type of primary, high-grade brain tumour occurring in children. (thebraintumourcharity.org)
Piers is our dedicated and energetic PR Manager at The Brain Tumour Charity. (thebraintumourcharity.org)
Whether you've been diagnosed with a brain tumour or a family member or friend has, we are here to help. (thebraintumourcharity.org)
However, more than 80 percent of patients newly diagnosed with the brain cancer glioblastoma multiforme (GBM) exhibit detectable CMV in their blood as well as in their tumors. (dukehealth.org)
The Duke team thought this might provide an opportunity to target brain tumors by going after the virus. (dukehealth.org)
We knew there was a connection between this virus and the brain cancer, and we were hoping to take advantage of that connection to treat one by treating the other. (dukehealth.org)
The study was funded by the National Institutes of Health, The Brain Tumor Society and Accelerate Brain Cancer Cure Foundation. (dukehealth.org)
Benign tumors near or in the brain may be removed because of their location or harmful effect on the surrounding normal brain tissue. (medlineplus.gov)
But a benign tumor can sometimes cause severe problems, such as in or near the brain. (medlineplus.gov)
Complicating matters, the tumors are thread-like and interweave with normal brain tissue - making it impossible to surgically remove the cancer. (feedavenue.com)
Modified HSV-1 oncolytic viruses are approved by the FDA for fighting melanoma, while a small study showed that herpesviruses also have the potential to battle brutal pediatric brain cancer . (freethink.com)
It's difficult to assign any single symptom as a sign of a brain tumor, notes the Mayo Clinic website. (roryd.org)
Background: Parental occupational and childhood exposures to farm animals have been positively associated with childhood brain tumors, whereas associations with childhood leukemia are equivocal. (cdc.gov)

The World Health Organization (WHO) reclassified CNS tumors in 2016 based on this information. (labroots.com)
Following the 2016 revision to WHO classification, this tumour is now known clinically as "Diffuse Midline Glioma- Pontine Location H3 K27M. (thebraintumourcharity.org)

Problems with the body's immune system can lead to tumors. (medlineplus.gov)
In addition, when the virus is delivered, it turns the tumor into a very inflammatory environment, which the patient's own immune system then sees and starts to attack," Vile said. (freethink.com)
The developing immune system may be influenced by allergen, virus, or other exposures from animal sources, which may contribute to childhood cancer incidence. (cdc.gov)
Tumor antigens After a cell becomes cancerous, the immune system is often able to recognize it as abnormal and destroy it before it replicates or spreads. (msdmanuals.com)

This papillomavirus is similar to one found in humans, known as Human Papillomavirus (HPV), and the group's findings could shed light on whether certain people are more susceptible to the virus and subsequently the cervical cancer it causes. (cornellsun.com)
Cervical cancer in humans is also a complex disease, except the virus of importance is HPV, a type of papillomavirus which is specific to humans. (cornellsun.com)
Although only one oncolytic virus has so far been approved by the U.S. Food and Drug Administration for use in humans and the virus is not yet approved in Canada, Hitt sees more becoming clinically available within the next decade. (uwinhealth.com)
Emergence of a novel swine-origin influenza A (H1N1) virus in humans. (cdc.gov)
For this reason, the infect humans, this virus can infect cordance between humans and ex- question about tumour site concor- several other species - including perimental animals. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)

Reduced levels of arginase 1, TGF-ß and IL-10 in the tumor also provided evidence for reversion of the immunosuppressive conditions by VSV-S infection . (bvsalud.org)
However, influenza A virus (IAV) infection releases virulent pneumococci from biofilms in vitro and in vivo. (lu.se)
Collectively, these results reveal the existence of coevolutionary events during persistent HCV infection that favor survival of both virus and host. (nih.gov)
High concentrations of HCV particles could stimulate macrophages to express TNF-α, providing a direct mechanism for the virus to promote infection. (ox.ac.uk)
CONCLUSION: This study shows a new role for TNF-α to increase virus entry and highlights the potential for HCV to exploit existing innate immune responses in the liver to promote de novo infection events. (ox.ac.uk)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)

The virus causes tumors to form on the plant at the stem and roots - with the root tumors being more severe. (wikipedia.org)
Lung immunopathology triggered by a specific virus is much less severe when tumour inflammatory response is inhibited. (alliedacademies.org)

Results ICVB-1042 displayed replication and cell killing against a broad range of human tumor cell lines including breast, prostate, bladder, lung, and glioblastoma. (bmj.com)

They are currently leading a phase 1 clinical trial in children with diffuse midline glioma to evaluate the safety, delivery and efficacy of an oncolytic virus called DNX-2401. (thebraintumourcharity.org)
Previous work has demonstrated the activation of this virus in patients with GBMs, so we took it one step further and tested a vaccine, in a small group of patients, that seems to show some efficacy in stalling the recurrence of these deadly tumors," said Duane Mitchell, M.D., Ph.D., a Duke researcher and lead investigator on the study. (dukehealth.org)
Anti-tumor efficacy was evaluated in multiple human xenograft immunocompromised mouse models. (bmj.com)
ICVB-1042 virus particles increased in both tumors and plasma over time suggesting virus replication in tumors, which correlated with efficacy. (bmj.com)
2023) Radiation combined with oncolytic vaccinia virus provides pronounced antitumor efficacy and induces immune protection in an aggressive glioblastoma model. (uwinhealth.com)

This disclosure relates to the field of tumor diagnostics and therapeutics. (justia.com)

There aren't many therapies for cancer that work really well on their own because the nature of tumors is that they are not uniform due to high mutation rates, so combinations of therapies have the greatest chance of success. (uwinhealth.com)

The team came to this conclusion based on a genomewide association study in which they compared the genomes of horses suffering from sarcoid tumors to those that were not. (cornellsun.com)

However, a more potent OV may be required for efficiently infecting pancreatic tumors that may be resistant to OV. (bvsalud.org)
Methods Using a proprietary iterative adenovirus design and screening platform, IconOVir has engineered ICVB-1042, a potent, tumor selective oncolytic adenovirus. (bmj.com)
Live attenuated Edmonston B strain of measles virus (MV-Edm) is a potent and specific oncolytic agent, but the mechanism underlying its tumor selectivity is unknown. (elsevierpure.com)

The company develops two oncolytic virus platforms such as Vesicular Stomatitis Virus (VSV) and Measles Virus (MV-NIS). (pharmaceutical-technology.com)

They examined the effects of Zika on three human tumor cell lines derived from medulloblastoma and atypical teratoid/rhabdoid tumors (AT/RT). (labroots.com)
Oncolytic Virus to Target CD46 and SLC5A5 for Oncology is under clinical development by Vyriad and currently in Phase I for Atypical Teratoid Rhabdoid Tumor. (pharmaceutical-technology.com)
According to GlobalData, Phase I drugs for Atypical Teratoid Rhabdoid Tumor does not have sufficient historical data to build an indication benchmark PTSR for Phase I. (pharmaceutical-technology.com)

The expression of the major glycoprotein, gp71, of murine leukemia virus was studied on the surfaces of a variety of normal murine cell lines with a monospecific rabbit antiserum raised against purified Friend murine leukemia virus gp71. (duke.edu)

At the heart of the approach are bacteriophages, or 'phages' - specialised types of virus that are perfectly evolved to target bacteria. (imperial.ac.uk)
Clinical trials are also ongoing with the unarmed enadenotucirev virus in different tumor types and in combination trials with a checkpoint inhibitor and with a chemotherapeutic. (biospace.com)
Another imaging test called positron emission tomography ( PET ) is used to find certain tumor types. (medlineplus.gov)
The outlook varies greatly for different types of tumors. (medlineplus.gov)
This combination of rationally designed modifications enables ICVB-1042 to be used for the treatment of a wide range of solid tumor types. (bmj.com)

During this last step, additional tumor-associated antigens are released and the cycle repeats itself. (case.edu)

Linking the production of BiTEs to OV replication provides an exciting means to restrict production to the tumor site, widen their therapeutic window, and synergize with direct oncolysis. (ox.ac.uk)
Here we report the nonclinical characterization of ICVB-1042, an optimized E2F-dependent oncolytic adenovirus rationally engineered with specific genomic modifications to confer tumor selective replication and enhanced tumor cell killing. (bmj.com)

Seneca Valley Virus capsid proteins are shown in blue, green, and red, and the ANTXR1 receptor is shown in magenta. (oist.jp)
ICVB-1042 has been further engineered with a chimeric fiber to enhance its tumor tropism and a modified capsid hexon protein to allow intravenous (IV) delivery. (bmj.com)

If you give a virus as a vaccine, you want an immune response -- there, the goal is the destruction of the virus," said Wolf. (oist.jp)
There were 21 patients enrolled in the trial, and the vaccine appears to have delayed the re-growth of tumors from a typical six to seven months after surgery to more than 12 months. (dukehealth.org)

GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Oncolytic Virus to Target CD46 and SLC5A5 for Oncology LoA Report. (pharmaceutical-technology.com)
CD46 mediates virus attachment, entry, and virus-induced cell-to-cell fusion. (elsevierpure.com)

These in vitro, and their expression in these human tumour virus. (who.int)

Characteristics of two new avian tumor virus subgroups. (wikidata.org)

Epstein-Barr virus-associated smooth muscle tumor is an uncommon neoplasm associated with immunodeficiency. (allenpress.com)
This paper reviews the clinicopathologic features of this uncommon neoplasm with detailed discussion of the role of Epstein-Barr virus in the pathogenesis. (allenpress.com)
Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is an uncommon neoplasm typically manifesting in immunodeficient individuals. (allenpress.com)
Epstein-Barr virus-associated SMT is an uncommon soft tissue neoplasm affecting both adult and pediatric populations. (allenpress.com)

The eBook Tumor Viruses Quizzes App Download: mycology, rna nonenveloped viruses, size and shape of virus, minor bacterial pathogens, tumor viruses test prep for bachelor degree online in 2 years. (mcqslearn.com)

Hervolution treats cancer by target tumor virus within the human genome. (hervolutiontx.com)

The virus is 22% RNA by weight, the other 78% being structural proteins. (wikipedia.org)
Structurally, the virus is constructed from 7 different structural proteins. (wikipedia.org)

Among the biological agents re- because species specificity limits the causes lymphoproliferative diseas- viewed in Volume 100B of the IARC feasibility of this approach for most of es in New World monkeys and in Monographs (IARC, 2012) are sever- these viruses. (who.int)

Here, we show that hepatitis C virus (HCV) co-opts the host protein CypA to aid evasion of antiviral responses dependent on the effector protein kinase R (PKR). (nih.gov)
Hepatitis C, Chronic Chronic hepatitis C is inflammation of the liver that is caused by the hepatitis C virus and that has lasted more than 6 months. (msdmanuals.com)

Such invaders include Microorganisms (commonly called germs, such as bacteria, viruses, and fungi) Parasites. (msdmanuals.com)

Anatomy13

Organisms86

Diseases42

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes50

Disciplines and Occupations1

Information Science4

Health Care2

Solid tumors16

Turning tumor cells1

Immunotherapy7

Microenvironment7

Target growin1

Cells67

Directly to tumors1

Cancers3

Remove the tumour2

Type of brain tumor3

Immunity4

Genetic10

Size of the tumor1

Mice9

Viral10

Necrosis factor3

Gene6

Induce2

Diagnosis8

Cellular4

Cancerous brain1

Metastatic2

Researchers6

Brain15

20162

Immune system4

Humans6

Infection6

Severe2

Lung1

Efficacy5

Therapeutics1

Therapies1

Genomes1

Potent3

Vesicular Stoma1

Atypical3

Murine1

Types5

Antigens1

Replication2

Capsid2

Vaccine2

CD462

Vitro1

Avian1

Neoplasm4

Pathogens1

Human genome1

Proteins2

Biological1

Hepatitis C vir2

Fungi1