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  • patient's
  • The strategy requires cryopreservation of the patient's tumor at surgery so the tumor cells can be used to manufacture a personalized vaccine programmed to attack the cancer. (ascopost.com)
  • infiltration
  • We therefore examined the ability of tumor lysate-pulsed DCs to activate peripheral tumor-reactive CTL activity and CD8+ T-cell infiltration into tumors in situ in recurrent malignant glioma patients. (aacrjournals.org)
  • The immune response following mTH3 DNA minigene vaccination was mediated by CD8+ T-cells as indicated by infiltration of primary tumors and TH specific cytolytic activity in vitro. (openthesis.org)
  • After just two intradermal vaccinations, we observe multiple changes at the tumor site, including the up-regulation of many genes connected to T and natural killer cell activation, as well as genes responsible for improved infiltration of immune cells into the tumor via chemotaxis. (wiley.com)
  • genes
  • The researchers describe how three of the genes found in the study are frequently altered in the disease, suggesting that the genes drive the development of tumors. (technologynetworks.com)
  • To determine which genes are altered in serous endometrial cancer, Dr. Bell and her team undertook a comprehensive genomic study of tumors by sequencing their exomes, the critical 1 to 2 percent of the genome that codes for proteins. (technologynetworks.com)
  • They next looked for genes that were mutated in more than one of the tumors. (technologynetworks.com)
  • One way to do this is to home in on genes that are mutated in more than one tumor, because we know from experience that frequently mutated genes are often driver genes. (technologynetworks.com)
  • To get a clearer picture of driver gene status among the other six genes, the researchers sequenced each gene in 40 additional serous endometrial tumors. (technologynetworks.com)
  • An interfering RNA screen of 500 genes - with 2,000 unique siRNA sequences -identified 27 genes that, when silenced, altered the sensitivity of colon tumor cells to oxaliplatin, causing damage to the cancer cells' DNA and inhibiting the cancer cells' ability to reproduce and survive, the study said. (technologynetworks.com)
  • idiotype
  • Feasibility of idiotype vaccination was statistically compared among five different B-cell malignancies in first relapse. (lymphomation.org)
  • When based on hybridoma production techniques, idiotypic vaccination for relapsed B-cell malignancies was consistently feasible only in follicular lymphoma patients, whereas the main cause of failure in other settings was the short survival of idiotype-producing hybridomas. (lymphomation.org)
  • immunogenicity
  • Increasing evidence suggests that MSC-derived exosomes might represent a novel cell-free therapy with compelling advantages over parent MSCs such as no risk of tumor formation and lower immunogenicity. (springer.com)
  • therapeutic vaccination
  • Here, we demonstrate for the first time effective therapeutic vaccination followed by eradication of established spontaneous neuroblastoma metastases using a tyrosine hydroxylase (TH) DNA minigene vaccine. (openthesis.org)
  • In summary, we demonstrate effective therapeutic vaccination against neuroblastoma with a novel rationally designed tyrosine hydroxylase minigene vaccine without induction of autoimmunity providing an important base line for clinical application of this strategy. (openthesis.org)
  • Cells Engineered
  • Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma," Nature Medicine , vol. 14, no. 11, pp. 1264-1270, 2008. (hindawi.com)
  • survival
  • Conversely, tumor antigen-specific vaccination in combination with focal radiation therapy reversed tolerance and improved survival. (aacrjournals.org)
  • Increasing success with BMT is offering improved survival to pediatric and adult patients with acute leukemia, chronic leukemia, lymphomas, and a variety of solid tumors as well as severe aplastic anemia. (stanford.edu)
  • immune system
  • In addition, the June Laboratory has a cadre of faculty researchers focused on developing ways to enhance the ability of the natural immune system to recognize and eliminate tumor cells. (upenn.edu)
  • Additionally
  • Additionally, tumor therapy studies have shown that when tumor-bearing mice are vaccinated with S. cerevisiae constructs expressing the appropriate point-mutated Ras protein, tumor growth is slowed ( 11 , 14 ). (aacrjournals.org)
  • mice
  • Cytokine analysis of tissues from brain tumor-bearing mice detected elevated TGF-β secretion from microglia and in the serum and TGF-β signaling blockade reversed tolerance of tumor antigen-directed CD8 T cells. (aacrjournals.org)
  • Transfer of purified polyclonal T cells from FBL (Friend MuLV-induced erythroleukemia cell line) vaccinated mice in naive animals can protect these mice against subsequent tumor challenge. (rupress.org)