• Benign lesions include placental site nodule and hydatidiform moles while malignant lesions have four subtypes including invasive mole, gestational choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). (wikipedia.org)
  • Placental side trophoblastic tumor (PSTT) is differentiated by low β-hCG levels because it is a neoplastic proliferation of intermediate trophoblastic cells. (wikipedia.org)
  • [ 2 ] The modified WHO prognostic scoring system is not applicable to patients with placental-site trophoblastic disease (PSTT) or epithelioid trophoblastic tumor (ETT). (medscape.com)
  • Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)
  • Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site trophoblastic tumors (PSTTs) and epithelioid trophoblastic tumors (ETTs). (johnshopkins.edu)
  • Tumors arising from the placental tissue include two distinct histological types: the benign vascular tumor, chorangioma, and very rarely, choriocarcinoma. (biomedcentral.com)
  • This case is possibly the first report on this kind of a placental tumor which has been examined using both immunohistochemistry and chromosome analysis. (biomedcentral.com)
  • A rare benign smooth muscle neoplasm involving the placental parenchyma is presented. (biomedcentral.com)
  • This case report is of interest to the clinical specialty of obstetrics and gynecology and will advance our knowledge of the etiology of placental tumors. (biomedcentral.com)
  • whether the tumor is a primary placental or uterine neoplasm. (biomedcentral.com)
  • A patient with a placental smooth muscle tumor that appears to be a uterine leiomyoma entrapped entirely in the placenta during its growth is presented. (biomedcentral.com)
  • Tru-cut placental site trophoblastic tumor biopsy: A novel way for diagnosis. (peertechzpublications.org)
  • A Placental Site Trophoblastic Tumor (PSTT) is a rare form of gestational trophoblastic disease and usually manifests itself with abnormal uterine bleeding and elevated β-hCG serum levels even months or years after any antecedent pregnancy event. (peertechzpublications.org)
  • The patient performed a hysteroscopy with simultaneous tru-cut biopsy of the lesion under US guidance and a placental site trophoblastic tumor was diagnosed by histological examination. (peertechzpublications.org)
  • Placental Site Trophoblastic Tumor (PSTT) is a rare form of gestational trophoblastic disease accounting for about 1% - 2% of all trophoblastic tumors [1]. (peertechzpublications.org)
  • Gestational trophoblastic diseases (GTD) encompass a spectrum of interrelated conditions: Hydatidiform mole (HM) Invasive mole (IM) Choriocarcinoma (CC) Placental site trophoblastic tumour (PSTT) This article is available only as. (annals.edu.sg)
  • Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. (atlasgeneticsoncology.org)
  • This disease is classified two types in origin, gestational choriocarcinoma and nongestational germ cell tumor. (atlasgeneticsoncology.org)
  • The nongestational type is as a component of a mixed germ cell tumor and a pure ovarian choriocarcinoma is a very rare malignant tumor. (atlasgeneticsoncology.org)
  • In nongestational choriocarcinoma, no factors have been associated with the etiology of germ cell tumor, apart from an increased incidence associated with dysgenetic gonads. (atlasgeneticsoncology.org)
  • Nongestational choriocarcinoma arises in women under 40 years old because of germ cell tumor, and the frequency is reported less than 0.6% of all ovarian tumors. (atlasgeneticsoncology.org)
  • Smith HO, Kohorn E, Cole LA. Choriocarcinoma and gestational trophoblastic disease. (medscape.com)
  • Stage I - Disease confined to the uterus Stage II - GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) Stage III - GTN extends to the lungs, with or without known genital tract involvement Stage IV - All other metastatic sites All types of gestational trophoblastic neoplasia originate from the placenta. (wikipedia.org)
  • OBJECTIVE: To relate the distance traveled from the patient's residence to the gestational trophoblastic neoplasia (GTN) reference center (RC) and the occurrence of unfavorable clinical outcomes, as well as to estimate the possible association between this distance and the risk of metastatic disease at presentation, the need for multiagent chemotherapy to achieve remission and loss to follow-up before remission. (bvsalud.org)
  • A malignant metastatic form of trophoblastic tumors. (umassmed.edu)
  • This proposed Phase I clinical trial of SON-DP is an FIH, open-label, Phase Ia/Ib dose escalation and expansion study to evaluate the safety, tolerability, PK, and PD of SON-DP in participants with relapsed/refractory/intolerant to standard of care therapies, for advanced/ metastatic solid tumors. (policylab.us)
  • 5-day methotrexate for women with metastatic gestational trophoblastic disease. (medscape.com)
  • What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
  • Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
  • The response to treatment is generally favourable but the associated complications of HIV, comorbidities, poor performance status and extent of metastatic disease in gestational trophoblastic neoplasm patients receiving chemotherapy, compromises the outcome and survival. (sun.ac.za)
  • To evaluate the efficacy and toxicity of a regimen of etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine in patients with metastatic, high-risk gestational trophoblastic tumors. (elsevierpure.com)
  • Conclusions: Chemotherapy with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine is well tolerated and highly effective for metastatic, high-risk gestational trophoblastic disease. (elsevierpure.com)
  • Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). (mycancergenome.org)
  • Benign leiomyomas, in contrast, are very common tumors of the uterine wall and occur in 0.1% to 12.5% of all pregnant women. (biomedcentral.com)
  • Histologically, the tumor was a benign leiomyoma and this finding was supported by immunohistochemistry. (biomedcentral.com)
  • They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
  • A benign or malignant neoplasm arising from tissues that do not include fluid areas. (mycancergenome.org)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • To describe the prevalence of inadequate nutritional status of children and adolescents with malignant neoplasm at hospital admission in childhood cancer reference centers in Brazil. (bvsalud.org)
  • Gestational trophoblastic neoplasia (GTN) is group of rare diseases related to pregnancy and included in gestational trophoblastic disease (GTD) in which abnormal trophoblast cells grow in the uterus. (wikipedia.org)
  • Chest x-ray: It may be done if the tumor has spread outside of the uterus. (wikipedia.org)
  • Typically, tumors are confined into the uterus and secrete lower levels of β-hCG compared with other Gestational Trophoblastic Neoplasia (GTN). (peertechzpublications.org)
  • Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
  • This article reports a case of an ovarian mixed germ cell tumour, which presented with bleomycin-associated pulmonary toxicity. (sun.ac.za)
  • Extracranial and extragonadal germ cell tumors and melanoma were both significantly decreasing. (cdc.gov)
  • Neoplasms, Germ Cell and Embryonal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sdsu.edu)
  • Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. (sdsu.edu)
  • This graph shows the total number of publications written about "Neoplasms, Germ Cell and Embryonal" by people in this website by year, and whether "Neoplasms, Germ Cell and Embryonal" was a major or minor topic of these publications. (sdsu.edu)
  • Below are the most recent publications written about "Neoplasms, Germ Cell and Embryonal" by people in Profiles. (sdsu.edu)
  • Gestational trophoblastic neoplasia (GTN) is staged by the American Joint Committee on Cancer (AJCC) and the Féderation Internationale de Gynécologie et d'Obstétrique (FIGO) systems, based on the criteria below (see Table 1). (medscape.com)
  • Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. (medscape.com)
  • Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
  • Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
  • Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
  • No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
  • This study elucidates the effects of the intravenous (IV) lidocaine infusion on the biology of pancreatic circulating tumor cells (CTCs) isolated from patients undergoing robotic pancreatectomy for all types of pancreatic cancer. (policylab.us)
  • Circulating and disseminated tumor cell (CTC/DTC) and circulating cell-free (cf) DNA isolation from the blood, urine and bone marrow will increase understanding of cancer spread and advance knowledge to develop individualized the. (policylab.us)
  • Tumors or cancer of the LIVER. (lookformedical.com)
  • Tumors or cancer of the PANCREAS. (lookformedical.com)
  • Tumors or cancer of the SKIN. (lookformedical.com)
  • Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. (bjbms.org)
  • All met the National Cancer Institute criteria for high-risk gestational trophoblastic tumors. (elsevierpure.com)
  • Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. (mycancergenome.org)
  • CNS metastases from any gynecological neoplasia are a rare occurrence and amount to about 1% of all tumors of uterine, cervical, or ovarian origin. (clinsurgeryjournal.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • A case report of effusion cytology of a mucinous neoplasm is illustrated. (sun.ac.za)
  • Rapid escalation of weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease: a Gynecologic Oncology Group study. (medscape.com)
  • Suppressed follicle stimulating hormone in men with chorionic gonadotropin secreting testicular tumors. (umassmed.edu)
  • Although this group of diseases are highly susceptible to chemotherapy, prognosis depends on the type of GTN and whether the tumor has spread to other areas of the body. (wikipedia.org)
  • Kashef MA, Dehaghani AS, Naeimi S, Fattahi MJ, Ghaderi A. Interleukin-18 gene promoter polymorphisms in women with gestational trophoblastic diseases. (umassmed.edu)
  • Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. (medscape.com)
  • Management of liver metastasis from gestational trophoblastic neoplasia. (medscape.com)
  • ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. (bjbms.org)
  • It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (curehunter.com)
  • Liver neoplasms. (lookformedical.com)
  • Experimentally induced tumors of the LIVER. (lookformedical.com)
  • The cause of this disease is unknown but the identification of the tumor based on total beta-human chorionic gonadotropin (β-hCG) in the serum. (wikipedia.org)
  • Neoplasms of the placenta are uncommon. (biomedcentral.com)
  • The tumor was a uterine leiomyoma of maternal origin, which had become entrapped by the placenta. (biomedcentral.com)
  • The tumor has been separated from its original site in the placenta. (biomedcentral.com)
  • Renal metastases of gestational trophoblastic disease: a report of eight cases. (medscape.com)
  • Since these tumors are derivatives of fetal trophoblastic tissue, approximately 50% of GTN cases are expected to originate from a male conceptus and carry a Y-chromosomal complement according to a balanced sex ratio. (johnshopkins.edu)
  • The epub 7 tips to becoming a of neoplasm intestines destroyed on the medical complication is of Breast effect, initially least in stateSaving an tissue of the remission of Leipzig to the yellow paradoxical use. (ccctw.hk)
  • Serum tumor marker test: For GTN, the blood is checked for the level of β-hCG, a hormone that is made by the body during pregnancy. (wikipedia.org)
  • The levels of serum or urine beta-hCG are good tumor marker for the progression or remission of disease. (atlasgeneticsoncology.org)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
  • Although risk factors may impact on the development of the tumor, most do not directly cause of disease. (wikipedia.org)
  • Gestational Trophoblastic Disease: Current Evaluation and Management. (medscape.com)
  • Normalization of tumor marker values may indicate cure despite radiographic evidence of persistent disease. (medscape.com)
  • In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
  • Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance? (medscape.com)
  • Although the most common cause of an elevated HCG level in females is pregnancy, occasionally, a HCG-secreting tumor is suspected and other conditions such as gestational trophoblastic disease (GTD), nontrophoblastic neoplasms, or a pituitary source of HCG, must be considered. (sheppard-arts.com)
  • This is called persistent trophoblastic disease. (sheppard-arts.com)
  • Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease. (cdc.gov)