• Neoplasms and other masses originating from vascular or mesenchymal tissues also occur in this area. (medscape.com)
  • The liposarcoma is a malignant tumour of the adipose tissue that arises from the primitive mesenchymal cells. (giornalechirurgia.it)
  • UCP1 expression in a few non-adipose soft tissue sarcomas may possibly reflect origin of tumour cells from a common mesenchymal stem cell precursor and/or developmental pathway. (biomedcentral.com)
  • Angiomyolipoma (AML) is a rare mesenchymal neoplasm of the tumor, composed of a varying heterogeneous mixture of three tissue components: blood vessels, smooth muscle and adipose cells. (biomedcentral.com)
  • Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females. (biomedcentral.com)
  • Of these, inflammatory or pelioid pattern usually presents as a focal finding within the tumor, but very rarely, they become the predominant pattern [ 4 ], creating great diagnostic confusion with other tumors such as inflammatory myofibroblastic tumor (IMT), follicular dendritc cell (FDC) tumor and other hepatic mesenchymal neoplasms. (biomedcentral.com)
  • The second explanation was more plausible, where neoplastic Schwann cells can transform into rhabdomyoblasts, suggesting the possibility of some mesenchymal tissue derivation from neuroectodermal cells. (hindawi.com)
  • The patient was alive with no tumor recurrence or metastasis at 2 years of follow-up. (biomedcentral.com)
  • Metastasis in this malignant tumor occurs very quickly and attacks other, often distant organs (e.g. lungs). (medicalwholesome.com)
  • VEGF messenger RNA (mRNA) is widely overexpressed in tissues and is associated with metastasis, recurrence, and prognosis [ 2 ]. (hindawi.com)
  • Solid tumors, which typically take the form of neoplasms in epithelial cells or in bones, tissue, or adipose (fat), are different than hematologic cancers in that they form a mass of cells, thereby maintaining multiple layers of protection. (wikipedia.org)
  • A malignant neoplasm of epithelial cells in glandular or glandlike pattern. (wordquests.info)
  • Cachexia is thought to be caused by bioactive molecules produced by the tumor, such as alpha-lymphotoxin (tumor necrosis factor [TNF] alpha), peptides, and nucleotides, which are able to affect metabolism. (medscape.com)
  • Fibrolipoma excision, like that described in this report, sometimes may be laborious, because fibrous bands appear to be focally infiltrating adjacent tissues, giving rise to some doubts about the nature of the lesion. (springer.com)
  • Intraoperatively, the excision was more laborious at some points because fibrous bands appeared to be focally infiltrating surrounding tissues, and the neoformation was hard to detach (giving rise to some doubts about the nature of the lesion). (springer.com)
  • Among sarcomas, there are bone sarcomas (formed in bone or cartilage) and soft tissue sarcomas (formed in adipose, muscle and fibrous tissue). (medicalwholesome.com)
  • 2. A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (wordquests.info)
  • Which of the following is true about the majority of fat forming solitary fibrous tumor cases? (pathologyoutlines.com)
  • Fat forming solitary fibrous tumor, previously known as lipomatous hemangiopericytoma, is a rare variant of solitary fibrous tumor (SFT) ( Korean J Pathol 2014;48:69 ). (pathologyoutlines.com)
  • Histologically, masses and nodules consisted of a collagen-rich fibrous stroma with multifocal areas of increased cellularity represented by spindle cell proliferations with moderate lymphoplasmacellular infiltrates ( Figure 1 , panel C). The tonsils and mandibular and axillary lymph nodes showed similar foci of fibrovascular tissue. (cdc.gov)
  • Not long afterward, other surgeons began to approach abnormalities of the anterior mediastinum, specifically tumors and infections of the thymus and anterior mediastinal lymph nodes. (medscape.com)
  • Benign and malignant tumours of adipose differentiation represent a large category of soft tissue tumours, many of which are frequently encountered in diagnostic pathology [ 1 ]. (biomedcentral.com)
  • The lipomatous and myomatous patterns were regarded as morphologic variations on a continuous spectrum, depending on the degree of adipose and myoid differentiation. (biomedcentral.com)
  • A malignant neoplasm consists of cells with low differentiation (so-called immature), it has the ability to penetrate tissues and attack other organs. (medicalwholesome.com)
  • Rhabdomyoblastic differentiation in a malignant peripheral nerve sheath tumor (MPNST) is termed malignant triton tumor (MTT), a rare neoplasm that poses a diagnostic dilemma in the differential diagnosis of neck masses and portends poor prognosis. (hindawi.com)
  • Tumors with skeletal muscle differentiation and malignant Schwann cells are classified as a subtype or a histologic variant of MPNST [ 9 , 10 ] and are referred to as malignant triton tumor (MTT) [ 11 ]. (hindawi.com)
  • Another opinion suggested a differentiation-metaplasia capacity of neuroectodermal tissue [ 20 ]. (hindawi.com)
  • Malignant neoplasm, as the name suggests, is more dangerous than a benign, benign neoplasm. (medicalwholesome.com)
  • A benign neoplasm composed of glandular and adipose tissues. (wordquests.info)
  • Benign lipomatous tumors. (ufrgs.br)
  • Some tumors contain only mature adipose tissue, whereas others contain multivacuolated lipoblasts and may have areas resembling atypical lipomatous tumor (ALT) ( Am J Surg Pathol 2011;35:1177 ). (pathologyoutlines.com)
  • These delivery mechanisms serve to address the limitations of CAR-T cells in translational experimentation and clinical trials, including shelf-life, off-target effects, and tumor infiltration. (wikipedia.org)
  • Malignant neoplasm spreads in the body by growing into the cells of the surrounding tissues (the so-called infiltration), which leads to the disturbance of their functions. (medicalwholesome.com)
  • Our findings reveal that NRPs may be a potential prognostic marker associated with immune infiltration, tumour mutations, and tumour microenvironment, particularly in bladder urothelial carcinoma (BLCA). (hindawi.com)
  • histopathological examination revealed infiltration of adipose tissue cells within the muscle belly and tendon sheath of the deep digital flexor muscle. (thieme-connect.com)
  • This differentiates between intermuscular and intramuscular lipomas, describing not only their anatomical location but also their biological behaviour: that is, expansive, benign growth between muscle bellies for the intermuscular type and with tissue infiltration within the muscle compartment for the intramuscular type. (thieme-connect.com)
  • Immunohistochemical staining of normal (axillary) BAT and subcutaneous/abdominal white adipose tissue (WAT) as well as a wide range of benign and malignant primary soft tissue tumours (n = 171) was performed using a rabbit polyclonal antibody to UCP1. (biomedcentral.com)
  • This mesenchyme tumor is commonly mistaken with lipoma due to its soft texture and subcutaneous site and often requires histopathology to confirm its diagnosis. (ufrgs.br)
  • Computed tomography of the chest showed an expansive mass of uptake only from the edges of the soft tissues of the right subcutaneous ventrolateral region. (ufrgs.br)
  • Lipomas are common benign neoplasms originating from subcutaneous tissue adipocytes, with no tendency to metastasize. (thieme-connect.com)
  • UCP1 is highly expressed in brown adipose tissue (BAT), including hibernomas, but its expression in other adipose tumours is uncertain. (biomedcentral.com)
  • UCP1 has also been found in other tissues (e.g. smooth muscle) but whether it is expressed in non-adipose benign and malignant soft tissue tumours is unknown. (biomedcentral.com)
  • UCP1 was not expressed in WAT or other adipose tumours with the exception a few tumour cells in pleomorphic liposarcoma. (biomedcentral.com)
  • UCP1 is strongly expressed in BAT but not WAT and is found in all hibernomas and a few pleomorphic liposarcomas but not in other adipose tumours. (biomedcentral.com)
  • In specific subtypes of benign and malignant adipose tumours there may be lipoblasts and/or atypical adipose cells with large or small, single or multiple, fat vacuoles as well as cells with pleomorphic or spindle-shaped nuclei [ 1 ]. (biomedcentral.com)
  • In addition, as UCP1 has been reported in other cell types, we have examined whether UCP1 is expressed in a wide range of non-adipose benign and malignant soft tissue tumours. (biomedcentral.com)
  • We have also determined whether tumour markers other than UCP1 can be used to distinguish hibernoma from other adipose/non-adipose soft tissue tumours. (biomedcentral.com)
  • Soft Tissue Tumours. (ufrgs.br)
  • Tumours with adipose tissue as the sole or one of the major components were selected for review. (bmj.com)
  • Mature adipocytes and thick-walled blood vessels were focally observed at the boundaries between the tumor and surrounding liver tissues. (biomedcentral.com)
  • Angiolipoma is a benign tumor composed of endothelial cells and mature adipocytes. (ufrgs.br)
  • Under microscopy, the histological sections showed neoplasm of mature adipocytes and of endothelial cells of blood vessels benign were filled with a marked amount of red blood cells. (ufrgs.br)
  • An understanding of the embryology of this area, and of the anatomic relations of the normal structures within the mediastinum, is essential for the proper diagnosis of a mass or tumor located in this area. (medscape.com)
  • Heuer noted that at that time, dermoid cysts and teratomas were the most commonly found tumors of the mediastinum. (medscape.com)
  • He also described successful removal of neurogenic tumors from the posterior mediastinum and described a number of types of thymic tumors. (medscape.com)
  • Any discussion of masses and tumors of the mediastinum requires delineation of the boundaries of that area. (medscape.com)
  • Usually, the mediastinum is subdivided into three spaces or compartments (ie, anterior, middle, and posterior) when the location or origin of specific masses or neoplasms is being discussed. (medscape.com)
  • These neoplasms have been usually found in the soft tissues of limbs, trunk, mediastinum, retroperitoneum and occasionally in the spermatic cord. (giornalechirurgia.it)
  • BAT and hibernomas were also stained by immunohistochemistry with monoclonal and polyclonal antibodies to adipose/non-adipose tumour markers in order to characterise the immunophenotype of BAT cells. (biomedcentral.com)
  • Hematological and chemical studies, including tumor markers such as α-fetoprotein and carcinoembrionic antigen, gave normal results. (biomedcentral.com)
  • Because a number of mediastinal tumors and other masses are found most commonly in particular mediastinal locations, many authors have artificially subdivided the area for better descriptive localization of specific lesions. (medscape.com)
  • Less commonly, masses associated with aberrant parathyroid or thyroid tissue are found. (medscape.com)
  • Fat forming SFT usually arises in middle aged adult males ( Am J Surg Pathol 1999;23:1201 ) and has a wide intra and extrathoracic anatomical distribution but the deep soft tissues of the retroperitoneum and thigh are the most commonly affected sites ( Br J Radiol 2011;84:e203 , In Vivo 2018;32:649 ). (pathologyoutlines.com)
  • It can occur in association with neurofibromatosis type 1 (NF-1) or sporadically accounting for 5-10% of soft tissue sarcomas [ 1 - 4 ]. (hindawi.com)
  • Lipomas are the most common soft tissue tumors in the human body, but only 15-20% of cases occur in the oral and maxillofacial region. (ijohr.org)
  • In a broad sense, these syndromes are collections of symptoms that result from substances produced by the tumor, and they occur remotely from the tumor itself. (medscape.com)
  • Lipoma is a benign tumor infrequent in the oral cavity, particularly in the tongue: indeed, lipomas only represent approximately 0.3% of all tongue neoplasia. (springer.com)
  • Kaposi's sarcoma herpesvirus (KSHV), a member of the genus Rhadinovirus , is the causative agent of Kaposi sarcoma ( 1 ), an endothelial neoplasm of the dermis, oral cavity and intestinal organs. (cdc.gov)
  • The first was that Schwann cells in neurogenic tumor could be stimulated by motor nerve to differentiate into rhabdomyoblastic component. (hindawi.com)
  • The microenvironment within tumors differs from that of healthy tissues, especially oxygen delivery is poor leading to hypoxia. (lu.se)
  • Herein, we comprehensively analysed the correlation of NRP expression with prognosis and tumour microenvironment landscape in 33 cancer types. (hindawi.com)
  • However, in this study, it was found that the neoplasm on screening presented a behavior like that of lipomas, with noninvasive growth and the absence of local recurrence. (ufrgs.br)
  • In the present case series, lipomas showed multiple site involvement in the oral and maxillofacial region with the mean size of tumor being 3 cm (ranges 1.5-4.5 cm). (ijohr.org)
  • Lipomas of oral and maxillofacial region are relatively uncommon tumors. (ijohr.org)
  • Lipomas are benign soft tissue neoplasms of mature adipose tissue. (ijohr.org)
  • We found eight cases of lipoma amongst 205 cases of benign soft tissue tumors reported as none of the cases of lipomas reported before 2009. (ijohr.org)
  • Il liposarcoma è un tumore maligno del tessuto adiposo che origina delle cellule mesenchimali primitive. (giornalechirurgia.it)
  • Various tumors, cysts, and other abnormalities related to the thymus can develop. (medscape.com)
  • Because of its histological characteristics, abundance of connective and secondary changes/atrophy, fibrolipoma may appear as infiltrating adjacent tissues and may cause doubts of differential diagnosis with malignant infiltrating lesions. (springer.com)
  • The clinical aspect is frequently a complaint of scrotal or inguinal painless mass, mimicking to an inguinal hernia and the diagnosis of tumor is performed mainly during surgery, as in our patient. (giornalechirurgia.it)
  • The most frequent application is the diagnosis of neoplasms of the female breast . (lookformedical.com)
  • The spectrum is complemented by the treatment of head and neck tumors (functional and minimally invasive interventions, laser surgery and plastic reconstructive surgery), diseases of the nose and paranasal sinuses (microscopic and endoscopic techniques, intraoperative navigation) and skull base pathologies. (bookinghealth.com)
  • In the majority of reported cases, triton tumors are located across peripheral nerves, usually close to the spine, in the head and neck region, or in the upper and lower extremities [ 16 ]. (hindawi.com)
  • To further elucidate the natural history and prognosis of this rare neoplasm in the head and neck, we present a case of sporadic MTT arising in the neck with an unusual prognosis. (hindawi.com)
  • A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. (lookformedical.com)
  • The occurrence of this neoplasm in dogs is uncommon, and the data reported in the veterinary medicine literature are scarce. (ufrgs.br)
  • Separation or ectopia of glands or glandular tissue from their usual anatomical sites, e.g., pancreatic glands in the wall of the small intestine, gastric glands in the wall of the esophagus. (wordquests.info)
  • When a tumor arises, the body may produce antibodies to fight it by binding to and destroying tumor cells. (medscape.com)
  • A 63-year-old woman was admitted to the First Affiliated Hospital of China Medical University in June of 2010 for further examination of the liver tumor which was detected by ultrasonography in the annual health check. (biomedcentral.com)
  • Fat forming SFT often presents as a heterogeneous lesion, with solid enhancing regions and scattered low attenuating adipose areas on CT examination. (pathologyoutlines.com)
  • Intra tumor hypoxia leads to poor response to several cancer therapies including anti-estrogens, chemo and radiation. (lu.se)
  • In parallel we investigate how the presence of intra-tumor hypoxia correlates to patient outcome. (lu.se)
  • Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue neoplasm with a poor prognosis. (hindawi.com)
  • The inflammatory AML should be distinguished from other tumors with inflammatory background such as inflammatory myofibroblastic tumor and follicular dendritic cell tumor and deserves wider recognition for its occurrence as a primary hepatic tumor. (biomedcentral.com)
  • The ectopic occurrence or diffuse implantation of adenomatous tissue in muscle (usually smooth muscle). (wordquests.info)
  • They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. (lookformedical.com)
  • These antigens are found on red blood cells, plasma glycoproteins, and other cell types in various tissues. (anthropogeny.org)
  • Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. (lookformedical.com)
  • In fact, the location, large size, and tumor stage are found to affect survival [ 15 , 18 ]. (hindawi.com)
  • A white crystalline base found in various animal and vegetable tissues as one of the purine base constituents. (wordquests.info)
  • In the case of a firm not reducible painless inguinal mass without signs and symptoms of bowel obstruction, an abdominal tumor with inguinal or scrotal extension should be suspected and preoperatively excluded. (giornalechirurgia.it)
  • These tumors are thought to arise from Schwann cells, their precursors, or a preexisting NF-1 [ 4 ]. (hindawi.com)
  • There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). (lookformedical.com)
  • Conventional ultrasonography revealed well-demarcated isoechoic tumor with a diameter of 30 mm in the segment V of the liver. (biomedcentral.com)
  • Fever may also be related to necrotic-inflammatory phenomena of the tumor and/or to alterations in liver function and consequent disorders of steroidogenesis. (medscape.com)
  • Most of these devices, currently still in the pre-clinical phase, are intended to be injected or surgically inserted directly into the solid tumor mass. (wikipedia.org)
  • In each case, the clinical presentation, location of the tumour, and the outcome for the patient were studied. (bmj.com)
  • Clinical data, such as age and gender of the patient, site and size of the tumor, origin, progress, duration of the lesion, treatment and follow-up were obtained from the patient's records. (ijohr.org)
  • when used in the plural, adenoids, they refer to lymphoid tissue that normally exists in the nasopharynx of children and is known in medicine as the pharyngeal tonsil. (wordquests.info)
  • growth of lymphoid tissue in the upper part of the throat, behind the nose (they can swell up and obstruct breathing and speaking). (wordquests.info)
  • The animal had multiple oral tumors characterized by proliferation of latent nuclear antigen 1-positive spindle cells and was not co-infected with immunosuppressive simian viruses, suggesting that it had Kaposi sarcoma caused by this novel rhadinovirus. (cdc.gov)
  • The tumors are highly vascularized and characterized by proliferation of spindle cells that contain KSHV DNA and antigen ( 2 , 3 ). (cdc.gov)
  • Gel-based delivery of CAR-T cells involves implantation or injection of a hydrogel or polymer gel into the target solid tumor. (wikipedia.org)
  • One strength of gel-based delivery is that these systems are functionally biodegradable, so once the CAR-T cells have been administered, the depot does not stay in the body, reducing immunosuppressive conditions or tumor resistance. (wikipedia.org)
  • UCP1 was variably expressed by tumour cells in a few non-adipose sarcomas including leiomyosarcoma, rhabdomyosarcoma, alveolar soft part sarcoma, synovial sarcoma and clear cell sarcoma. (biomedcentral.com)
  • The tumor cells were spindled and histiocytoid in shape, with slightly eosinophilic cytoplasm, and arranged along the vessels or scattered among the inflammatory background. (biomedcentral.com)
  • The tumor cells were positive immunostaining for HMB-45, Melan-A, and smooth muscle actin. (biomedcentral.com)
  • Histologically similar to those in the kidney, hepatic AML consists of a mixture of myoid cells, adipose tissue and thick-walled vessels. (biomedcentral.com)
  • If a malignant tumor affects the bloodstream, it can be referred to as leukemia, which is the abnormal growth of white blood cells. (medicalwholesome.com)
  • Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
  • [ 9 ] For example, antibodies or T cells directed against the tumor may mistakenly attack normal nerve cells. (medscape.com)
  • However, these tissue samples do not fairly represent the distinctive traits of live cell behavior and are not amenable to genetic manipulation. (anthropogeny.org)
  • Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. (lookformedical.com)
  • Mature fat varies in amount but usually occupies approximately one quarter to three quarters of the area of tumor ( Am J Surg Pathol 1999;23:1201 ). (pathologyoutlines.com)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. (lookformedical.com)
  • The patient did not consent to tumor biopsy, and we could not rule out the possibility of malignancy due to the result of ultrasonography and CT scan. (biomedcentral.com)
  • Unfortunately, in some cases these antibodies cross-react with normal tissues and destroy them, which may result in a paraneoplastic disorder. (medscape.com)
  • In other cases, paraneoplastic syndromes result from the production and release of physiologically active substances by the tumor. (medscape.com)
  • Treatment with surgery, often combined with additional therapy such as radiation and anti-estrogens, relieves tumor burden. (lu.se)
  • A multidimensional bioinformatics analysis was performed to examine the relationship between NRP genes and prognostic and pathological features, tumour mutational burden (TMB), microsatellite instability (MSI), and immunological features based on public databases and find the potential prognostic value of NRPs in pancancer. (hindawi.com)
  • In 1939, Alfred Blalock reported the first case in which symptoms of myasthenia gravis (MG) were completely relieved by removal of a thymic tumor, thus initiating a surgical option in the treatment of that disease. (medscape.com)
  • Symptoms that may suggest the presence of a malignant neoplasm: palpable lump, change in shape, color and size of the nipples, specific discharge from the body orifices, ulcers or poorly healing wounds, as well as chronic digestive disorders. (medicalwholesome.com)
  • Preserved tissues are the main source for most comparative studies between humans, chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). (anthropogeny.org)
  • In animals, the pathogenesis of angiolipomas is not established, but in humans, it is based on theories that include the reaction to harmful stimuli and congenital malformation of adipose tissue. (ufrgs.br)