Tumor tissue highly heterogeneous peripheral tumors adenocarcinoma. Medical search. Frequent questions

It is considered that the proportional distribution of cells in peripheral blood count may reflect the severity of inflammation in the tumor microenvironment. (researchsquare.com)
The tumor microenvironment typically consists of host components including chronic inflammatory cells, stromal cells, growing vascular cells, and inflammatory infiltrate. (researchsquare.com)
Tumor-associated macrophages (TAMs) are a well-known component of the inflammatory infiltrate in the tumor microenvironment, originating from monocytes. (researchsquare.com)
Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of tumor-infiltrating lymphocytes and programmed death-ligand 1 (PD-L1) expression. (aacrjournals.org)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
However, the tumour may evade immune responses through regulatory T-cell-mediated immune suppression in the tumour microenvironment, defective antigen presentation, and production of immunosuppressive cytokines (5). (cambridgemedicine.org)
T regulatory (Treg) cells are known for their immunosuppressive role in the tumor microenvironment, but surprisingly, their death might only make them stronger. (acir.org)
observed that while live CD4+Foxp3+ Tregs are heavily recruited to tumors, they also undergo apoptosis in the tumor microenvironment (TME). (acir.org)
Targeting Tregs to reestablish the proinflammatory and immunogenic tumor microenvironment (TME) is an increasingly attractive strategy for cancer treatment and has been emphasized in recent years. (biomedcentral.com)
Previous studies unraveled that extracellular adenosine concentration was elevated in the tumor microenvironment [ 8 ]. (biomedcentral.com)
Recently, CD73-adensine was found to be a significant pathway involved in the formation of immunosuppressive microenvironment in distinct tumors [ 3 ]. (biomedcentral.com)
Conclusion: Our study suggests that the RANKL/RANK pathway contributes to the development and maintenance of the immunosuppressive tumor microenvironment and denosumab may be a promising adjuvant therapy targeting TAMs in cancer of apocrine origin. (iiarjournals.org)
Of these, tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) create an immunosuppressive microenvironment through various pathways. (iiarjournals.org)
For example, Paget's cells release soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) into the tumor microenvironment, stimulating RANK + TAMs to produce CCL17, which recruits Tregs into the lesional skin of patients with extramammary Paget's disease (EMPD) ( 11 , 17 ). (iiarjournals.org)
Accordingly, investigating the characteristics of cancer-related factors is important to determine the immunological background of the tumor microenvironment in each type of skin cancer. (iiarjournals.org)

Previous studies have shown a relationship between monocyte count and prognosis in some solid tumors. (researchsquare.com)
Heterogeneous antigen expression is a key barrier influencing the activity of chimeric antigen receptor (CAR) T cells in solid tumors. (nature.com)
To improve the response rate in B cell malignancies and translate the success of CAR T cells to solid tumors, the optimization of this class of therapeutics is required. (nature.com)
What makes the response of PDAC to immunotherapy different from the responses of other solid tumors is the specific host tissue. (biomedcentral.com)

Adenocarcinomas are most often highly heterogeneous peripheral tumors, and are thought to arise from malignant transformation of primitive cells that can exhibit differentiation characteristics of Club cells, Type II pneumocytes, bronchiolar surface cells, bronchial gland cells, or goblet cells. (wikipedia.org)
Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
Uterine carcinosarcoma, also known as malignant mixed Mullerian tumor (MMMT), is a rare and aggressive form of corpus uteri tumor. (cytojournal.com)
It is the most frequent malignant tumor of the biliary tract and is the second most common primary hepatic tumor after hepatoma. (medscape.com)
The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)
The frequency of the type of neoplasm was higher for lung cancer, followed by malignant colon tumor. (cdc.gov)

CSF1R inhibition for the depletion of tumor-associated macrophages (TAMs) seemed like a promising therapeutic strategy, but while TAM depletion occurred as expected, antitumor efficacy has been incredibly limited. (acir.org)
iii) to accelerate the conversion of anti-tumor type 1 macrophages into pro-tumor type 2 macrophages [ 9 ]. (biomedcentral.com)
As we previously reported, receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL)/RANK signaling on M2 macrophages promotes the production of chemokines and proinflammatory cytokines to maintain the immunosuppressive tumor environment of extramammary Paget's disease (EMPD). (iiarjournals.org)
Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK + M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7. (iiarjournals.org)
The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)

More importantly, they also carry the risk of seeding tumor cells around the sampling area. (artizanat-online.ro)

A case of combined small cell lung carcinoma featuring components of FA and cells resembling those from carcinoid tumor has been reported, illustrating the unique complexity and heterogeneity of divergent histogenesis and cell differentiation in lung cancer. (wikipedia.org)
Imaging plays an important role in the noninvasive detection, localization, grading, and staging of prostate carcinoma and in carrying out biopsies for histopathologic analysis of the tumor. (medscape.com)
[ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
Primary cutaneous apocrine carcinoma (PCAC) is a rare and highly aggressive tumor entity. (iiarjournals.org)
Primary cutaneous apocrine carcinoma (PCAC) is rare and highly aggressive, being highly metastatic to lymph nodes and other organs, including bone ( 1 - 4 ). (iiarjournals.org)
Compared with other tumors, they are less cellular and have relatively few well-differentiated carcinoma cells in a dense connective tissue stroma. (medscape.com)

The first capillary bed that a metastatic cell encounters depends colorectal cancer review article the blood circulation pattern near the primary tumor. (artizanat-online.ro)
In the case of CRC, HCC, and PDAC, the primary tumor is connected to the vascular draining territory of the mesenteric and portal venous system, whereas lung cancer is linked to the pulmonary vein. (artizanat-online.ro)
To search for possible modes of action of retinoids as novel therapeutic options, primary tumor cell cultures were treated in vitro with all-trans-RA (ATRA), 9cis-RA, fenretinide and combinations of retinoids and a histone deacetylase (HDAC) inhibitor. (uni-wuerzburg.de)
In vitro testing of primary tumor cultures provided clear evidence of a potential utility of retinoids in Wilms tumor treatment based on the analysis of gene expression, proliferation, differentiation and apoptosis. (uni-wuerzburg.de)
1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)

While all these entities are characterized by proliferation of highly atypical, anaplastic CD30+ T cells, the expression of T-cell specific antigens in the tumor cells is not consistently detectable. (uni-wuerzburg.de)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
In 1959, Lewis Thomas suggested that the human immune system can recognise tumour-specific antigens on the surface of newly developing tumour cells as 'foreign' and eliminate them (3). (cambridgemedicine.org)
Following this, in 1971, Sir Frank Mac Farlane Burnet hypothesised that tumour cell antigens induced immunological reaction against cancer and postulated the "immune surveillance theory" (4). (cambridgemedicine.org)
CAR T-cells are T-cells that have been engineered to express receptors that specifically target tumour-associated antigens (8). (cambridgemedicine.org)
Study therapy included two cycles of docetaxel 75 mg/m 2 on days 1 and 29 to treat the tumor, release hidden antigens and produce lymphopenia. (biomedcentral.com)
All 4 patients had evidence of specific antibody responses against potential tumor antigens. (biomedcentral.com)
In addition to mutated proteins, NSCLC can over-express a number of non-mutated proteins that can induce both humoral and cytotoxic T cell responses [ 10 ], and also have the potential to serve as tumor rejection antigens [ 11 ]. (biomedcentral.com)

TAMs are known to play an important role in tumor angiogenesis and growth. (researchsquare.com)

However, with the advent of magnetic resonance cholangiopancreatography (MRCP), easy visualization of stricture-causing tumors is possible. (medscape.com)

It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. (cancerindex.org)
Genes deregulated in high risk tumors showed opposite changes upon treatment suggesting a positive effect of retinoids. (uni-wuerzburg.de)
In primary GC tissues, higher methylation of H. pylori infection associated genes correlated with CIMP-positive and its related features, such as MLH1 methylated cases. (hokudai.ac.jp)

Although the principles of cancer immunoediting have largely been defined in mice with immunogenic tumors, it has now been demonstrated that an immune reaction against cancer can also occur in humans ( 4 ). (aacrjournals.org)
Tumor-derived autophagosome vaccines (DRibbles) have the potential to broaden immune response to poorly immunogenic tumors. (biomedcentral.com)

Gallium‐68 ( 68 Ga)‐1,4,7,10‐tetraazacyclo‐dodecane‐1,4,7,10‐tetraacetic acid DOTA‐peptides highlight neuroendocrine tumors ( NETs ) through binding the somatostatin receptors that are overexpressed on the surfaces of their cells. (radiologykey.com)

In this review, we discuss the common and distinct metabolic profiles of Tregs in peripheral tissues and the TME, as well as the differences between Tregs and other conventional T cells in their metabolic preferences. (biomedcentral.com)

Due to the high mortality rate of esophageal cancer, exploration of new prognostic biomarkers for this tumor is of paramount importance. (researchsquare.com)

However, PDAC is characterized by an abundant tumor stroma that includes a heterogeneous mixture of immune cells, fibroblasts, endothelial cells, neurons and some molecular events. (biomedcentral.com)

Signaling pathways involving signal transducer and activator of transcription 3 (STAT3) play key roles in the aggressiveness of pancreatic ductal adenocarcinoma (PDAC), including their tumorigenesis, invasion, and metastasis. (bvsalud.org)
Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer that is difficult to diagnose early, and there is no cure other than surgery. (bvsalud.org)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. (biomedcentral.com)
Biliary ductal dilatation is easily demonstrated with US, but the tumor mass is seldom localized with it. (medscape.com)
Extrahepatic tumors are divided into proximal, middle, and distal ductal tumors. (medscape.com)

Tissue resembling FA can also be found admixed with a component made up of primitive blastoma-like cells. (wikipedia.org)
In such cases, these biphasic tumors are classified as a form of pulmonary blastoma because the presence of the blastomatous cells dramatically worsens the prognosis. (wikipedia.org)
FA is an epithelial tumor whose cells and architecture resemble that of fetal lung tissues in the pseudoglandular stage of development (which occurs at about 10-16 weeks gestation in the human), with complex glandular structures and morules with cell nuclei that appear clear due to the accumulation of biotin. (wikipedia.org)
While FA can be diagnosed via biopsy, bronchial brushings, and immunocytochemistry, examination of the whole tumor is required to rule out biphasic pulmonary blastoma, a mixed tumor of higher aggressiveness, wherein FA occurs admixed with primitive blastoma cells. (wikipedia.org)
In this review we will discuss how combinations and fusions of different -omic workflows on a single cell level can be used to examine cellular phenotypes, immune effector functions, and even dynamic changes, such as metabolomic state of different cells in a sample or even in a defined tissue location. (frontiersin.org)
The HIV/AIDS pandemic in the 1980s then gave a dramatic impulse to the technology of counting specific cells, since it became clear that the quantification of peripheral blood CD4+ T cells was crucial to follow the course of the infection, and eventually for monitoring response to therapy ( 2 ). (frontiersin.org)
A critical requirement for developing such agents is to identify druggable targets required for the proliferation or survival of tumor cells, but not of other cell types. (cancerindex.org)
Indeed, detached cells can be cleared by interstitial fluids to lymph nodes, or into the veins draining the tissue, thus entering the circulation. (artizanat-online.ro)
In fact, very few of the tumor cells released into the circulation will form metastases Kessenbrock et al. (artizanat-online.ro)
In fact, very few of the tumor cells released into the circulation will detoxifierea organismului galina tomas metastases Kessenbrock et al. (ceas-mana.ro)
SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
In tumors, there are all types of immune cells that can have various effects on tumor progression, and a spectrum of soluble cytokines and chemokines that regulates the entry of different types of infiltrating immune cells. (aacrjournals.org)
These cells can be located in the tumor centre (CT), in the invasive margin (IM), or in the adjacent tertiary lymphoid structures (TLS). (aacrjournals.org)
Furthermore, by investigating the impact of hinge (CD8 and IgG4) and TM (CD8 and CD28) on D4 CAR T cells, we discover that IgG4H-CD28TM mediated D4 CAR dimerization, leading to enhanced T-cell signaling and tumor regression in pancreatic cancer models with low antigen density. (nature.com)
however, the presence of large rhabdoid cells and tissue fragments of round to oval hyperchromatic nuclei with scant cytoplasm cells excluded adenocarcinoma. (cytojournal.com)
Histopathological examination of the tumor mass revealed an admixture of spindle cells and epithelioid cells. (cytojournal.com)
However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
Additionally, these cells show highly flexible and dynamic plasticity and are extremely easily polarized into regulatory phenotypes. (explorationpub.com)
These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering option, where T-cells obtained from a patient's blood are engineered ex vivo to express specific tumour antigen receptors. (cambridgemedicine.org)
The immune system interacts closely with tumour cells via complex mechanisms and can result in either eradication of the tumour or immune evasion by the tumour (5). (cambridgemedicine.org)
Consequently, immune cells fail to recognise and kill tumour cells. (cambridgemedicine.org)
The second-generation CAR T-cells consist of one additional co-stimulatory component (mainly CD28, CD137 or CD134) in the intracellular domain, which amplifies anti-tumour responses in vivo (8). (cambridgemedicine.org)
Dendritic cells (DCs) within the lymphatic tissues are the key initiators of adaptive immune responses during immunization or in the. (acir.org)
On the one hand, tumor cells are under immunosurveillance in the presence of various proinflammatory cells, such as CD8 + cytotoxic T cells, CD4 + type 1 helper T (Th1) cells, and natural killer cells. (biomedcentral.com)
Dissemination of tumour cells and metastatic spread as well as cancer resistance to standard treatment are still the common cause of treatment failure and eventually death in prostate cancer patients. (uni-hamburg.de)
Metastatic outgrowth of disseminated tumor cells is thought to be fueled by clonal cooperation of tumor clones from early and late stages of cancer evolution. (uni-hamburg.de)
Circulating tumor cells (CTCs) can be detected in the peripheral blood and peritoneal liquid in most of the ovarian cancer patients in the different stages of the disease. (uni-hamburg.de)
This study will elucidate the metastatic cascade of ovarian cancer by investigating the natural cancer evolution through the analysis of single tumor cells on genomic, transcriptomic, proteomic, and methylomic (multi‐omic) level. (uni-hamburg.de)
Immune cells engage in extensive and dynamic crosstalk with stromal components in the tumor tissue in addition to tumor cells, which subsequently impacts tumor suppression or promotion to a large extent. (biomedcentral.com)
In this review, we discuss how infiltrating immune cells influence PDAC development and explore the contributions of complex components to the immune landscape of tumor tissue. (biomedcentral.com)
A cell line derived from cultured tumor cells. (lookformedical.com)
Autologous vaccine generated from tumor cells harvested from pleural effusions was administered to patients with advanced NSCLC with the objectives of assessing safety and immune response. (biomedcentral.com)
Three of four patients had tumor cells available for testing. (biomedcentral.com)
DRibble vaccine given with GM-CSF appeared safe and capable of inducing an immune response against tumor cells in this small, pilot study. (biomedcentral.com)
This study was designed to test a novel immunotherapy strategy using a vaccine enriched for short-lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from autologous tumor cells. (biomedcentral.com)
Tumor cells were cultured in vitro with the proteasome inhibitor bortezomib, which stabilizes SLiPs and DRiPs, shunting proteins into the autophagy pathway [ 12 ]. (biomedcentral.com)
The clinical manifestations of IgG4-RD are usually tumor-like masses or organ enlargement, which result from dense tissue infiltration by immune cells and expansion of the extra-cellular matrix. (msdmanuals.com)

Recent studies revealed that CD73 plays a pivotal role in tumor escape from immune surveillance. (biomedcentral.com)

For example, in a mouse model of pancreatic cancer, CTCs with metastatic potential are already shed during the formation of the primary pancreatic adenocarcinoma, before it becomes detectable by histologic methods Rhim et al. (artizanat-online.ro)

We review this stratification and the latest in a series of results that shed light on new approaches for rationally designing ideal combination cancer therapies based on tumor immunology. (aacrjournals.org)
Last week, the ACIR team attended the AACR Tumor Immunology and Immunotherapy conference in Boston, MA. (acir.org)

Monocyte, an element of the immune system, is a heterogeneous cell showing different responses to different stimuli. (researchsquare.com)

Intrahepatic cholangiocarcinoma constitutes about 15% of all primary liver tumors. (medscape.com)

Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)
Increasing evidence suggested that CD73 highly expressed in a wide range of cancer types, including breast cancer, colorectal cancer, glioblastoma, melanoma, prostate cancer, ovarian cancer, and non-small-cell lung cancer (NSCLC). (biomedcentral.com)

The tumor is composed of two cellular components: Epithelial and mesenchymal. (cytojournal.com)
ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)

The process of growing the tumor from the "utside in"maybe one of the mechanisms of maintaining tumor heterogeneity and has significant clinical implications. (uni-hamburg.de)

PDAC is classified as an adenocarcinoma that has limited effective anticancer drug and molecular-targeted therapies compared to adenocarcinoma found in other organs. (bvsalud.org)
However, chimeric antigen receptor T (CAR-T) cell immunotherapy and immune checkpoint blockade (ICB), which have produced unprecedented clinical benefits in a variety of different cancers, produce promising results in only some highly selected patients with PDAC. (biomedcentral.com)

Fewer reports have tested the hypothesis that the chances of capturing and detecting CTCs might be higher in vessels closer to the tumor, especially in the main veins that drain blood from the organ colorectal cancer review article by the cancer. (artizanat-online.ro)
They propose that when mismatch repair (MMR) mechanisms are disrupted in colorectal tumors, new mutations, and thus new potential neoantigens, continually arise. (acir.org)

It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
How does the immune system sculpt the tumor genome even before the tumor adapts counteracting immune evasion mechanisms? (acir.org)
Molecular mechanisms of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) remain unclear in Japanese patients. (hokudai.ac.jp)
Some tumor cell-inherent resistance mechanisms, such as the tumor mutational burden and aberrant expression of oncogenic pathways, restrain antitumor immunity [ 10 ]. (biomedcentral.com)

Seventy percent of prostate cancers arise in the peripheral zone, 15-20% in the central zone, and 10-15% in the transition zone. (medscape.com)

FA is a rare tumor, with a relative incidence estimated to be no more than 0.5% of all lung cancers. (wikipedia.org)
Adenocarcinomas constitute 95% of prostate cancers are. (medscape.com)
Whereas pleural mesothelioma is highly associated with asbestos exposure , nonmesotheliomatous cancers have generally not been proven to result from exposure to airborne asbestos. (medscape.com)
Molecular imaging with whole‐body positron emission tomography (PET)/CT or PET/MRI utilizes metabolic and receptor‐based strategies for tumor detection in staging and restaging various cancers. (radiologykey.com)

Landscape of tumor suppressor long noncoding RNAs in breast cancer. (cancerindex.org)
The landscape and biological functions of tumor suppressor long noncoding RNAs in breast cancer are still unknown. (cancerindex.org)
Data from whole transcriptome sequencing of 33 breast specimens in the Harbin Medical University Cancer Center cohort and The Cancer Genome Atlas was applied to identify and validate the landscape of tumor suppressor long noncoding RNAs, which was further validated by The Cancer Genome Atlas pancancer data including 33 cancer types and 12,839 patients. (cancerindex.org)
Next, the expression model, prognostic roles, potential biological functions and epigenetic regulation of tumor suppressor long noncoding RNAs were investigated and validated in the breast cancer and pancancer cohorts. (cancerindex.org)
Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. (cancerindex.org)

Glioblastoma multiforme and medulloblastoma are the most frequent high-grade brain tumors in adults and children, respectively. (cancerindex.org)

In this study, we sought to determine the expressions of miR-127 in the lung tissues of sodium taurocholate-induced AP models in rats and that in plasma of AP patients and to preliminarily explore the association of miR-217 levels and LI. (hindawi.com)

After years of controversy, it is now recognized that the immune system can play a role in the control of tumor growth and progression ( 1 ), a process known as cancer immunoediting ( 2 ). (aacrjournals.org)

Compared with other techniques, endoscopic retrograde cholangiopancreatography (ERCP) more definitively depicts the periampullary tumor. (medscape.com)
Compared with the other techniques, endoscopic retrograde cholangiopancreatography (ERCP) is a more definitive investigation that can depict the periampullary tumor. (medscape.com)

The host immune system can also contribute to the efficacy of some cancer therapies where the tumor death induced may be "immunogenic" ( 3 ). (aacrjournals.org)

Significant parameters used in the determination of the prognosis and survival of esophageal cancer include tumor stage, surgical margin, and metastatic lymph node status. (researchsquare.com)
Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)

Most FA's are well or moderately differentiated tumors, although high-grade, poorly differentiated variants have been described. (wikipedia.org)
FA can occur in combination with other forms of lung cancer, particularly other variants of adenocarcinoma. (wikipedia.org)

Low-grade tumors may recur and infiltrate adjacent structures. (medscape.com)

The papillary tumors are friable and vascular and tend to bleed easily, causing hemobilia. (medscape.com)

Immunoglobulin G4-related disease (IgG4-RD) is a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses and/or painless enlargement of multiple organs. (msdmanuals.com)

Cryobiopsy has been recommended for diagnosing parenchymal lung diseases, including diffuse and peripheral lung lesions, because of its safety and high diagnostic yield rate [ 3 , 4 ]. (hindawi.com)
[ 16 ] Disadvantages of MRCP include its inability to distend the duct and equivocal findings because of long segments and minimal narrowing in diffuse sclerosing tumors. (medscape.com)
CT may demonstrate the tumor if the malignancy is nodular and masslike, but tumors of the diffuse sclerosing variety are difficult to detect. (medscape.com)

Anecdotal reports suggest that FA is rarely highly sensitive to cytotoxic drugs or radiation. (wikipedia.org)

Finally, EPB41L4A-AS2 was selected to validate our novel finding, and the tumor suppressive roles of EPB41L4A-AS2 in breast cancer were examined. (cancerindex.org)

Accumulating evidence shows that in addition to the characteristics of the tumor, the immune response of the patient is also highly important for determining the prognosis. (researchsquare.com)
Thus, the tumor has many strategies to evade an immune response. (aacrjournals.org)
Autologous tumor-specific immune response was seen in two of the three, manifested by IL-5 (1 patient after 3 doses), and IFN-γ, TNF-α, IL-5, IL-10 (after 4 doses in one patient). (biomedcentral.com)

Tumour classification systems provide the foundation for tumour diagnosis and patient therapy and a critical basis for epidemiological and clinical studies. (ersjournals.com)
There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
An international system of tumour classification is important for consistency in patient treatments and to provide the basis of epidemiological and biological studies. (ersjournals.com)

Results: The association of retinoid signaling and clinical parameters could be validated in a large independent tumor set, but its relevance in primary nephrectomy tumors from very young children may be different. (uni-wuerzburg.de)

He has also examined the cooperativity of Withaferin A with other interventions that are known to inhibit gliomas such as combination therapies of Withaferin A with temozolomide, with other ginsenosides and with alternating electric fields (known as tumor treating fields or TTFields). (stanford.edu)

Background CD30+ T-cell lymphoproliferations comprise a spectrum of clinically heterogeneous entities, including systemic anaplastic large cell lymphomas (ALK- and ALK+) and primary cutaneous CD30+ T-cell lymphoproliferative disorders. (uni-wuerzburg.de)
The distinction among these various tumors is important both clinically and epidemiologically. (medscape.com)

Two recent systematic reviews have shown that cryotechnology in bronchoscopy is useful for the diagnosis of lung diseases, including interstitial lung diseases and lung tumors [ 7 , 8 ]. (hindawi.com)

Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)

The expression of the identified long noncoding RNAs was downregulated in cancer tissue samples compared with normal tissue samples, and these long noncoding RNAs correlated with a favorable prognosis in breast cancer patients and the patients in the pancancer cohort. (cancerindex.org)
In particular, the outcome of pancreatic cancer is highly unpredictable, even in the case of resectable tumors, because predictive and prognosis markers are missing Zhou et al. (artizanat-online.ro)
Biopsy and FNAC are invasive procedures, especially in the case cancer rectal prognosis deeply located tumors, and may present severe complications such as infection, bleeding, or inflammation. (ceas-mana.ro)

The currently accepted nomenclature is solitary fibrous tumor. (medscape.com)
Solitary well-demarcated tumors are difficult to differentiate from primary hepatocellular carcinomas (HCCs). (medscape.com)

Highly dense tissues, such as bone or kidney stones, readily reflect echoes and, therefore, appear bright white on an ultrasound image. (medscape.com)

CAR T-cell potency is highly dependent on target antigen expression, and CARs often fail to exert their antitumor activities when antigen expression is low or below a certain threshold. (nature.com)

We find that a structurally rigid IgG4H and CD28TM domain brings the two D4 fragments in proximity, driving CAR dimerization and leading to enhanced T-cell signaling and tumor regression in pancreatic cancer models with low antigen density in female mice. (nature.com)

Intended therapeutic targets, though important, are detected in only a fraction of signatures, and cell line tissue of origin has been identified as a confounding factor throughout the signature detection procedure. (biomedcentral.com)

Anatomy18

Organisms8

Diseases92

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Phenomena and Processes42

Disciplines and Occupations1

Information Science5

Health Care14

Microenvironment17

Solid tumors4

Malignant6

Macrophages5

Seeding tumor cells1

Carcinoma8

Primary tumor5

Antigens8

TAMs1

Stricture-causin1

Genes3

Immunogenic tumors2

Neuroendocrine tumors1

Tregs1

Biomarkers1

Stroma1

Ductal5

Cells39

Role in tumor1

Pancreatic adenocarcinoma1

Immunology2

Responses1

Intrahepatic1

Melanoma2

Epithelial2

Heterogeneity1

PDAC2

Colorectal2

Mechanisms4

Arise1

Cancers4

Suppressor5

Frequent1

Lung tissues1

Progression1

Periampullary2

Efficacy1

Lymph2

Variants2

Infiltrate1

Vascular1

Organs1

Diffuse3

Cytotoxic1

Roles1

Immune response3

Classification3

Clinical1

Therapies1

Clinically2

Diagnosis1

Lymphoid1

Prognosis3

Solitary2

Dense1

Antitumor1

Antigen1

Therapeutic1